lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6693
Symbol	SPN
Synonymous	CD43\|GALGP\|GPL115\|LSN
Full name	sialophorin
Gene description	galactoglycoprotein\|leukocyte sialoglycoprotein\|leukosialin\|sialophorin (gpL115, leukosialin, CD43)
Cytoband	16p11.2
Gene type	protein-coding
Synonymous	MIM:182160; HGNC:HGNC:11249; Ensembl:ENSG00000197471; HPRD:06770

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.737G>A; p.R246Q; 16:29664465-29664465	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1189delG; p.A398fs*>3; 16:29664917-29664917	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.215A>G; p.N72S; 16:29663943-29663943	prostate	adenoma	Substitution - Missense
c.833G>A; p.R278H; 16:29664561-29664561	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1138G>A; p.E380K; 16:29664866-29664866	urinary_tract; bladder	carcinoma	Substitution - Missense
c.419C>T; p.P140L; 16:29664147-29664147	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.475G>C; p.E159Q; 16:29664203-29664203	breast	carcinoma	Substitution - Missense
c.498A>G; p.G166G; 16:29664226-29664226	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.263C>T; p.P88L; 16:29663991-29663991	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.458C>T; p.T153M; 16:29664186-29664186	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.230T>A; p.L77H; 16:29663958-29663958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.255T>C; p.T85T; 16:29663983-29663983	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.881G>A; p.G294D; 16:29664609-29664609	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.881G>A; p.G294D; 16:29664609-29664609	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.881G>A; p.G294D; 16:29664609-29664609	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.881G>A; p.G294D; 16:29664609-29664609	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.916C>T; p.P306S; 16:29664644-29664644	pancreas	carcinoma	Substitution - Missense
c.916C>T; p.P306S; 16:29664644-29664644	pancreas	carcinoma	Substitution - Missense
c.658G>A; p.G220R; 16:29664386-29664386	skin	malignant_melanoma	Substitution - Missense
c.920C>T; p.A307V; 16:29664648-29664648	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.387C>T; p.T129T; 16:29664115-29664115	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.649G>A; p.G217R; 16:29664377-29664377	skin	malignant_melanoma	Substitution - Missense
c.742C>T; p.P248S; 16:29664470-29664470	skin	malignant_melanoma	Substitution - Missense
c.551G>A; p.G184E; 16:29664279-29664279	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.22_23insT; p.G9fs*29; 16:29663750-29663751	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.239C>T; p.S80F; 16:29663967-29663967	skin	malignant_melanoma	Substitution - Missense
c.1166C>A; p.P389H; 16:29664894-29664894	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.269C>A; p.P90H; 16:29663997-29663997	prostate	adenoma	Substitution - Missense
c.742C>A; p.P248T; 16:29664470-29664470	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1152G>A; p.V384V; 16:29664880-29664880	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.602C>G; p.T201S; 16:29664330-29664330	liver	carcinoma	Substitution - Missense
c.602C>G; p.T201S; 16:29664330-29664330	liver	carcinoma	Substitution - Missense
c.375A>G; p.L125L; 16:29664103-29664103	skin	malignant_melanoma	Substitution - coding silent
c.598A>G; p.T200A; 16:29664326-29664326	liver	carcinoma	Substitution - Missense
c.832C>T; p.R278C; 16:29664560-29664560	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.598A>G; p.T200A; 16:29664326-29664326	liver	carcinoma	Substitution - Missense
c.477G>A; p.E159E; 16:29664205-29664205	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.738G>A; p.R246R; 16:29664466-29664466	oesophagus	carcinoma	Substitution - coding silent
c.387C>A; p.T129T; 16:29664115-29664115	prostate	adenoma	Substitution - coding silent
c.480C>A; p.T160T; 16:29664208-29664208	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.798G>A; p.A266A; 16:29664526-29664526	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.49G>A; p.A17T; 16:29663777-29663777	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.49G>A; p.A17T; 16:29663777-29663777	skin; leg	malignant_melanoma; superficial_spreading	Substitution - Missense
c.109A>T; p.S37C; 16:29663837-29663837	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.594T>A; p.T198T; 16:29664322-29664322	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.609C>A; p.P203P; 16:29664337-29664337	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.112G>A; p.E38K; 16:29663840-29663840	skin	malignant_melanoma	Substitution - Missense
c.381C>A; p.S127S; 16:29664109-29664109	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.865G>A; p.V289M; 16:29664593-29664593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.26G>C; p.G9A; 16:29663754-29663754	liver	carcinoma	Substitution - Missense
c.334G>A; p.A112T; 16:29664062-29664062	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.366A>G; p.A122A; 16:29664094-29664094	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.957_958GG>AA; p.G320R; 16:29664685-29664686	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.969G>A; p.G323G; 16:29664697-29664697	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.675C>G; p.S225R; 16:29664403-29664403	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.178G>A; p.D60N; 16:29663906-29663906	skin	malignant_melanoma	Substitution - Missense
c.475G>T; p.E159*; 16:29664203-29664203	breast	carcinoma	Substitution - Nonsense
c.31_32CT>AA; p.L11>?; 16:29663759-29663760	lung	carcinoma; adenocarcinoma	Complex
c.79C>T; p.P27S; 16:29663807-29663807	skin; trunk	malignant_melanoma	Substitution - Missense
c.967delG; p.G324fs*38; 16:29664695-29664695	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.942C>T; p.A314A; 16:29664670-29664670	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.346C>A; p.P116T; 16:29664074-29664074	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.99G>T; p.L33F; 16:29663827-29663827	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.229C>T; p.L77F; 16:29663957-29663957	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.411G>A; p.T137T; 16:29664139-29664139	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1124C>A; p.P375Q; 16:29664852-29664852	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1112_1113GG>AA; p.G371E; 16:29664840-29664841	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.575A>T; p.D192V; 16:29664303-29664303	thyroid	other; neoplasm	Substitution - Missense
c.8C>T; p.T3M; 16:29663736-29663736	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.8C>T; p.T3M; 16:29663736-29663736	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.622A>G; p.T208A; 16:29664350-29664350	liver	carcinoma	Substitution - Missense
c.622A>G; p.T208A; 16:29664350-29664350	liver	carcinoma	Substitution - Missense
c.640_648delCCCTCCAGC; p.P214_S216delPSS; 16:29664368-29664376	liver	carcinoma	Deletion - In frame
c.640_648delCCCTCCAGC; p.P214_S216delPSS; 16:29664368-29664376	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - In frame
c.640_648delCCCTCCAGC; p.P214_S216delPSS; 16:29664368-29664376	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - In frame
c.864C>T; p.L288L; 16:29664592-29664592	skin	malignant_melanoma	Substitution - coding silent
c.838C>T; p.R280W; 16:29664566-29664566	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.629G>A; p.G210D; 16:29664357-29664357	liver	carcinoma	Substitution - Missense
c.629G>A; p.G210D; 16:29664357-29664357	liver	carcinoma	Substitution - Missense
c.296C>T; p.S99F; 16:29664024-29664024	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation