lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6566
Symbol	SLC16A1
Synonymous	HHF7\|MCT\|MCT1\|MCT1D
Full name	solute carrier family 16 (monocarboxylate transporter), member 1
Gene description	MCT 1\|monocarboxylate transporter 1\|solute carrier family 16 (monocarboxylic acid transporters), member 1\|solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Cytoband	1p12
Gene type	protein-coding
Synonymous	MIM:600682; HGNC:HGNC:10922; Ensembl:ENSG00000155380; HPRD:02816; Vega:OTTHUMG00000012129

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1285G>A; p.V429I; 1:112914109-112914109	breast	carcinoma	Substitution - Missense
c.867G>C; p.K289N; 1:112917539-112917539	breast	carcinoma	Substitution - Missense
c.904C>T; p.L302F; 1:112917502-112917502	skin	malignant_melanoma	Substitution - Missense
c.41_42insC; p.D15fs*34; 1:112929267-112929268	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.41_42insC; p.D15fs*34; 1:112929267-112929268	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.996C>A; p.F332L; 1:112917410-112917410	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.522G>T; p.W174C; 1:112917884-112917884	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1001C>T; p.A334V; 1:112917405-112917405	skin	malignant_melanoma	Substitution - Missense
c.1284C>T; p.V428V; 1:112914110-112914110	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.432A>G; p.P144P; 1:112917974-112917974	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1260_1265delATACAC; p.T422_Y423delTY; 1:112914129-112914134	lung	carcinoma; non_small_cell_carcinoma	Deletion - In frame
c.1284C>T; p.V428V; 1:112914110-112914110	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1260_1265delATACAC; p.T422_Y423delTY; 1:112914129-112914134	lung	carcinoma; adenocarcinoma	Deletion - In frame
c.383T>G; p.L128W; 1:112918023-112918023	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.205A>T; p.M69L; 1:112929104-112929104	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.793C>T; p.L265L; 1:112917613-112917613	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1164C>T; p.S388S; 1:112917242-112917242	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1281C>T; p.G427G; 1:112914113-112914113	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.753G>A; p.Q251Q; 1:112917653-112917653	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.303T>A; p.I101I; 1:112922048-112922048	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1115C>T; p.S372F; 1:112917291-112917291	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1426G>T; p.E476*; 1:112913968-112913968	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.240G>A; p.V80V; 1:112922111-112922111	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1470T>A; p.D490E; 1:112913924-112913924	thyroid	other; neoplasm	Substitution - Missense
c.1068C>T; p.F356F; 1:112917338-112917338	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.292T>C; p.C98R; 1:112922059-112922059	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.292T>C; p.C98R; 1:112922059-112922059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.248A>G; p.Y83C; 1:112922103-112922103	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1033A>G; p.M345V; 1:112917373-112917373	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1379A>T; p.E460V; 1:112914015-112914015	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1231C>T; p.R411W; 1:112914163-112914163	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.727C>T; p.R243*; 1:112917679-112917679	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.727C>T; p.R243*; 1:112917679-112917679	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1325G>T; p.G442V; 1:112914069-112914069	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.780C>G; p.H260Q; 1:112917626-112917626	central_nervous_system; temporoparietal	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1238A>G; p.N413S; 1:112914156-112914156	liver	carcinoma	Substitution - Missense
c.1238A>G; p.N413S; 1:112914156-112914156	liver	carcinoma	Substitution - Missense
c.1434C>A; p.T478T; 1:112913960-112913960	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1314C>T; p.F438F; 1:112914080-112914080	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.825delT; p.F275fs*37; 1:112917581-112917581	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.825delT; p.F275fs*37; 1:112917581-112917581	liver	carcinoma	Deletion - Frameshift
c.1448C>G; p.S483C; 1:112913946-112913946	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.527G>T; p.G176V; 1:112917879-112917879	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1133delT; p.L378fs*1; 1:112917273-112917273	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.530G>T; p.S177I; 1:112917876-112917876	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.471C>T; p.F157F; 1:112917935-112917935	breast	carcinoma	Substitution - coding silent
c.457G>T; p.G153C; 1:112917949-112917949	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.524G>A; p.R175K; 1:112917882-112917882	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.982C>T; p.R328*; 1:112917424-112917424	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.33C>T; p.Y11Y; 1:112929276-112929276	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1250G>A; p.G417E; 1:112914144-112914144	breast	carcinoma	Substitution - Missense
c.1250G>A; p.G417E; 1:112914144-112914144	breast	carcinoma	Substitution - Missense
c.474C>G; p.L158L; 1:112917932-112917932	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1235T>A; p.L412H; 1:112914159-112914159	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.294T>C; p.C98C; 1:112922057-112922057	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.851T>C; p.L284P; 1:112917555-112917555	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>A; p.W174*; 1:112917884-112917884	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.983G>A; p.R328Q; 1:112917423-112917423	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.983G>A; p.R328Q; 1:112917423-112917423	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1111A>T; p.S371C; 1:112917295-112917295	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1431T>G; p.V477V; 1:112913963-112913963	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1336C>T; p.R446*; 1:112914058-112914058	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.301A>G; p.I101V; 1:112922050-112922050	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.767C>T; p.T256I; 1:112917639-112917639	skin	malignant_melanoma	Substitution - Missense
c.1265C>A; p.T422K; 1:112914129-112914129	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1A>G; p.M1V; 1:112929308-112929308	liver	carcinoma	Substitution - Missense
c.1A>G; p.M1V; 1:112929308-112929308	liver	carcinoma	Substitution - Missense
c.214G>A; p.G72R; 1:112929095-112929095	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1106G>T; p.W369L; 1:112917300-112917300	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.463C>T; p.P155S; 1:112917943-112917943	skin	malignant_melanoma	Substitution - Missense
c.1202C>T; p.P401L; 1:112917204-112917204	skin	malignant_melanoma	Substitution - Missense
c.530G>A; p.S177N; 1:112917876-112917876	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1110C>G; p.L370L; 1:112917296-112917296	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.486C>G; p.A162A; 1:112917920-112917920	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.578C>T; p.A193V; 1:112917828-112917828	skin	malignant_melanoma	Substitution - Missense
c.582C>T; p.L194L; 1:112917824-112917824	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.938G>T; p.R313L; 1:112917468-112917468	urinary_tract; bladder	carcinoma	Substitution - Missense
c.751C>T; p.Q251*; 1:112917655-112917655	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.600C>T; p.P200P; 1:112917806-112917806	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.697C>A; p.L233I; 1:112917709-112917709	breast	carcinoma	Substitution - Missense
c.565T>G; p.C189G; 1:112917841-112917841	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1402A>G; p.I468V; 1:112913992-112913992	liver	carcinoma	Substitution - Missense
c.594C>T; p.I198I; 1:112917812-112917812	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.643G>C; p.E215Q; 1:112917763-112917763	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1298C>T; p.S433L; 1:112914096-112914096	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.643G>C; p.E215Q; 1:112917763-112917763	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.916G>A; p.A306T; 1:112917490-112917490	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.41delC; p.P14fs*10; 1:112929268-112929268	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.41delC; p.P14fs*10; 1:112929268-112929268	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.41delC; p.P14fs*10; 1:112929268-112929268	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.81C>G; p.F27L; 1:112929228-112929228	breast	carcinoma	Substitution - Missense
c.256C>T; p.R86C; 1:112922095-112922095	breast	carcinoma	Substitution - Missense
c.561C>A; p.N187K; 1:112917845-112917845	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1322T>C; p.M441T; 1:112914072-112914072	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1245G>C; p.M415I; 1:112914149-112914149	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.731C>T; p.S244L; 1:112917675-112917675	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1007C>T; p.S336F; 1:112917399-112917399	breast	carcinoma	Substitution - Missense
c.86C>T; p.S29F; 1:112929223-112929223	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation