lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	653509
Symbol	SFTPA1
Synonymous	COLEC4\|PSAP\|PSP-A\|PSPA\|SFTP1\|SFTPA1B\|SP-A\|SP-A1\|SPA\|SPA1
Full name	surfactant protein A1
Gene description	35 kDa pulmonary surfactant-associated protein\|alveolar proteinosis protein\|collectin-4\|pulmonary surfactant-associated protein A1\|surfactant protein A1 variant AB'D' 6A\|surfactant protein A1 variant AB'D' 6A2\|surfactant protein A1 variant AB'D' 6A3\|surfa
Cytoband	10q22.3
Gene type	protein-coding
Synonymous	MIM:178630; HGNC:HGNC:10798; Ensembl:ENSG00000122852; Vega:OTTHUMG00000018565

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.639C>T; p.F213F; 10:79613960-79613960	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.686G>A; p.G229E; 10:79614007-79614007	urinary_tract; bladder	carcinoma	Substitution - Missense
c.23-5T>A; p.?; 10:79611798-79611798	liver	carcinoma	Unknown
c.23-5T>A; p.?; 10:79611798-79611798	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.653G>A; p.G218E; 10:79613974-79613974	skin	malignant_melanoma	Substitution - Missense
c.653G>A; p.G218E; 10:79613974-79613974	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.267G>A; p.G89G; 10:79612361-79612361	skin	malignant_melanoma	Substitution - coding silent
c.705_706delAA; p.K236fs*14; 10:79614026-79614027	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Deletion - Frameshift
c.275G>T; p.G92V; 10:79612369-79612369	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.281C>A; p.P94H; 10:79612375-79612375	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.122G>T; p.C41F; 10:79611902-79611902	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.770G>A; p.R257Q; 10:79614091-79614091	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.122G>T; p.C41F; 10:79611902-79611902	prostate	carcinoma	Substitution - Missense
c.647C>T; p.S216L; 10:79613968-79613968	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.141C>T; p.I47I; 10:79611921-79611921	skin	malignant_melanoma	Substitution - coding silent
c.279C>T; p.A93A; 10:79612373-79612373	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.537C>T; p.V179V; 10:79613858-79613858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.597T>C; p.Y199Y; 10:79613918-79613918	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.90C>A; p.A30A; 10:79611870-79611870	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.226G>A; p.G76S; 10:79612320-79612320	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.627C>T; p.S209S; 10:79613948-79613948	skin	malignant_melanoma	Substitution - coding silent
c.420C>T; p.L140L; 10:79613741-79613741	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.627C>T; p.S209S; 10:79613948-79613948	skin	malignant_melanoma	Substitution - coding silent
c.313G>A; p.E105K; 10:79612407-79612407	skin	malignant_melanoma	Substitution - Missense
c.700C>T; p.R234W; 10:79614021-79614021	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.683G>A; p.R228Q; 10:79614004-79614004	skin	malignant_melanoma	Substitution - Missense
c.694G>A; p.A232T; 10:79614015-79614015	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.327G>A; p.R109R; 10:79612421-79612421	prostate	adenoma	Substitution - coding silent
c.327G>A; p.R109R; 10:79612421-79612421	liver	carcinoma	Substitution - coding silent
c.622C>T; p.P208S; 10:79613943-79613943	skin	malignant_melanoma	Substitution - Missense
c.674A>G; p.N225S; 10:79613995-79613995	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.681C>T; p.Y227Y; 10:79614002-79614002	skin	malignant_melanoma	Substitution - coding silent
c.640C>T; p.R214C; 10:79613961-79613961	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.702G>A; p.R234R; 10:79614023-79614023	central_nervous_system; brain	glioma	Substitution - coding silent
c.465C>T; p.S155S; 10:79613786-79613786	thyroid	other; neoplasm	Substitution - coding silent
c.540A>T; p.P180P; 10:79613861-79613861	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.265G>A; p.G89R; 10:79612359-79612359	skin	malignant_melanoma	Substitution - Missense
c.101T>C; p.V34A; 10:79611881-79611881	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.101T>C; p.V34A; 10:79611881-79611881	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.101T>C; p.V34A; 10:79611881-79611881	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.586T>C; p.Y196H; 10:79613907-79613907	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.322G>A; p.E108K; 10:79612416-79612416	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.320G>A; p.G107D; 10:79612414-79612414	liver	carcinoma	Substitution - Missense
c.320G>A; p.G107D; 10:79612414-79612414	liver	carcinoma	Substitution - Missense
c.320G>A; p.G107D; 10:79612414-79612414	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.162C>T; p.H54H; 10:79611942-79611942	thyroid	other; neoplasm	Substitution - coding silent
c.753G>A; p.R251R; 10:79614074-79614074	skin	malignant_melanoma	Substitution - coding silent
c.379C>A; p.H127N; 10:79613230-79613230	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.41G>A; p.R14K; 10:79611821-79611821	skin; mucosal	malignant_melanoma	Substitution - Missense
c.177G>A; p.R59R; 10:79611957-79611957	skin	malignant_melanoma	Substitution - coding silent
c.231A>G; p.P77P; 10:79612325-79612325	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.288C>T; p.I96I; 10:79612382-79612382	breast	carcinoma	Substitution - coding silent
c.111G>C; p.V37V; 10:79611891-79611891	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.777C>T; p.T259T; 10:79614098-79614098	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	thyroid	other; neoplasm	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193C>G; p.L65V; 10:79611973-79611973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.418C>G; p.L140V; 10:79613739-79613739	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.712C>A; p.Q238K; 10:79614033-79614033	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.553G>A; p.E185K; 10:79613874-79613874	skin; trunk	malignant_melanoma	Substitution - Missense
c.328G>A; p.G110S; 10:79612422-79612422	skin	malignant_melanoma	Substitution - Missense
c.410G>A; p.R137K; 10:79613261-79613261	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation