lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6494
Symbol	SIPA1
Synonymous	SPA1
Full name	signal-induced proliferation-associated 1
Gene description	GTPase-activating protein Spa-1\|p130 SPA-1\|signal-induced proliferation-associated gene 1\|signal-induced proliferation-associated protein 1\|sipa-1
Cytoband	11q13
Gene type	protein-coding
Synonymous	MIM:602180; HGNC:HGNC:10885; Ensembl:ENSG00000213445; HPRD:03713; Vega:OTTHUMG00000166541

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.2566C>T; p.P856S; 11:65649601-65649601	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.9G>A; p.M3I; 11:65640930-65640930	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1368C>A; p.H456Q; 11:65646325-65646325	thyroid	other; neoplasm	Substitution - Missense
c.205C>T; p.R69C; 11:65641126-65641126	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1098G>A; p.L366L; 11:65645068-65645068	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.595G>A; p.E199K; 11:65641516-65641516	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2798C>A; p.S933*; 11:65650001-65650001	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.2990C>T; p.A997V; 11:65650576-65650576	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.508G>A; p.G170R; 11:65641429-65641429	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3084C>T; p.L1028L; 11:65650670-65650670	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1271_1273delGGA; p.R424_K425>Q; 11:65646228-65646230	breast	carcinoma	Complex - deletion inframe
c.404T>G; p.M135R; 11:65641325-65641325	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1021C>T; p.R341W; 11:65644991-65644991	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1200G>C; p.Q400H; 11:65645894-65645894	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2294G>T; p.G765V; 11:65647646-65647646	thyroid	other; neoplasm	Substitution - Missense
c.2863G>C; p.E955Q; 11:65650152-65650152	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2046C>T; p.G682G; 11:65647398-65647398	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.54G>T; p.A18A; 11:65640975-65640975	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2015T>C; p.V672A; 11:65647049-65647049	thyroid	other; neoplasm	Substitution - Missense
c.359A>G; p.D120G; 11:65641280-65641280	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2307G>T; p.R769S; 11:65649262-65649262	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1216T>G; p.F406V; 11:65645910-65645910	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2661C>T; p.G887G; 11:65649780-65649780	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1206C>T; p.H402H; 11:65645900-65645900	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2753C>T; p.S918L; 11:65649956-65649956	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1291G>A; p.D431N; 11:65646248-65646248	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1247C>G; p.P416R; 11:65645941-65645941	breast	carcinoma	Substitution - Missense
c.2481G>A; p.E827E; 11:65649436-65649436	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.546C>T; p.S182S; 11:65641467-65641467	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2896G>A; p.D966N; 11:65650185-65650185	urinary_tract; bladder	carcinoma	Substitution - Missense
c.874_875CC>TT; p.P292L; 11:65642529-65642530	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.998G>A; p.R333H; 11:65644968-65644968	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2728C>T; p.R910W; 11:65649847-65649847	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.2728C>T; p.R910W; 11:65649847-65649847	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1404G>A; p.T468T; 11:65646361-65646361	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1230G>A; p.T410T; 11:65645924-65645924	skin	malignant_melanoma	Substitution - coding silent
c.203C>T; p.P68L; 11:65641124-65641124	skin	malignant_melanoma	Substitution - Missense
c.776A>T; p.H259L; 11:65642346-65642346	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1022G>A; p.R341Q; 11:65644992-65644992	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.341G>A; p.R114Q; 11:65641262-65641262	central_nervous_system; brain	glioma	Substitution - Missense
c.2016G>T; p.V672V; 11:65647050-65647050	thyroid	other; neoplasm	Substitution - coding silent
c.2470C>G; p.L824V; 11:65649425-65649425	ovary	other; neoplasm	Substitution - Missense
c.2354delG; p.A787fs*12; 11:65649309-65649309	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2354delG; p.A787fs*12; 11:65649309-65649309	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1285G>A; p.G429S; 11:65646242-65646242	skin	malignant_melanoma	Substitution - Missense
c.1562C>T; p.A521V; 11:65646596-65646596	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2613T>C; p.A871A; 11:65649648-65649648	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2655C>T; p.P885P; 11:65649774-65649774	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1116G>T; p.R372R; 11:65645086-65645086	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2721G>T; p.L907F; 11:65649840-65649840	pancreas	carcinoma	Substitution - Missense
c.2721G>T; p.L907F; 11:65649840-65649840	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.3054G>A; p.A1018A; 11:65650640-65650640	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2704T>C; p.F902L; 11:65649823-65649823	liver	carcinoma	Substitution - Missense
c.2704T>C; p.F902L; 11:65649823-65649823	liver	carcinoma	Substitution - Missense
c.2781C>T; p.D927D; 11:65649984-65649984	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.468G>A; p.S156S; 11:65641389-65641389	central_nervous_system; brain	glioma	Substitution - coding silent
c.1693C>G; p.R565G; 11:65646727-65646727	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.234C>T; p.A78A; 11:65641155-65641155	skin	malignant_melanoma	Substitution - coding silent
c.903G>A; p.P301P; 11:65642558-65642558	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.903G>A; p.P301P; 11:65642558-65642558	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.848C>T; p.P283L; 11:65642503-65642503	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.189delC; p.T64fs*112; 11:65641110-65641110	prostate	carcinoma	Deletion - Frameshift
c.616G>A; p.A206T; 11:65641537-65641537	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2543C>A; p.A848D; 11:65649578-65649578	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.208G>A; p.A70T; 11:65641129-65641129	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1080C>T; p.F360F; 11:65645050-65645050	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.680-1G>A; p.?; 11:65642249-65642249	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.165C>T; p.S55S; 11:65641086-65641086	pancreas	carcinoma	Substitution - coding silent
c.926G>A; p.R309H; 11:65642581-65642581	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1968G>A; p.A656A; 11:65647002-65647002	skin	malignant_melanoma	Substitution - coding silent
c.2530C>G; p.L844V; 11:65649565-65649565	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1331C>A; p.P444H; 11:65646288-65646288	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2796C>G; p.I932M; 11:65649999-65649999	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2760G>A; p.A920A; 11:65649963-65649963	thyroid	other; neoplasm	Substitution - coding silent
c.870G>A; p.L290L; 11:65642525-65642525	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2641A>T; p.R881W; 11:65649760-65649760	liver	carcinoma	Substitution - Missense
c.2641A>T; p.R881W; 11:65649760-65649760	liver	carcinoma	Substitution - Missense
c.2967G>A; p.Q989Q; 11:65650464-65650464	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2967G>A; p.Q989Q; 11:65650464-65650464	skin	malignant_melanoma	Substitution - coding silent
c.1384C>T; p.R462W; 11:65646341-65646341	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2759C>T; p.A920V; 11:65649962-65649962	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2825T>C; p.I942T; 11:65650028-65650028	skin	malignant_melanoma	Substitution - Missense
c.2576T>A; p.L859H; 11:65649611-65649611	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.2205T>G; p.T735T; 11:65647557-65647557	thyroid	other; neoplasm	Substitution - coding silent
c.2205T>G; p.T735T; 11:65647557-65647557	thyroid	other; neoplasm	Substitution - coding silent
c.2205T>G; p.T735T; 11:65647557-65647557	thyroid	other; neoplasm	Substitution - coding silent
c.778A>G; p.S260G; 11:65642348-65642348	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1352G>A; p.R451H; 11:65646309-65646309	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1037C>T; p.S346L; 11:65645007-65645007	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3044G>A; p.R1015Q; 11:65650630-65650630	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.793G>A; p.V265M; 11:65642363-65642363	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2407A>G; p.T803A; 11:65649362-65649362	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.510G>A; p.G170G; 11:65641431-65641431	pancreas	carcinoma	Substitution - coding silent
c.803C>T; p.T268M; 11:65642373-65642373	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2982+2T>G; p.?; 11:65650481-65650481	breast	carcinoma	Unknown
c.2154G>C; p.E718D; 11:65647506-65647506	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2513T>C; p.L838P; 11:65649468-65649468	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.199_200insG; p.S67fs*25; 11:65641120-65641121	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Insertion - Frameshift
c.1565G>A; p.R522H; 11:65646599-65646599	liver	carcinoma	Substitution - Missense
c.395C>T; p.S132F; 11:65641316-65641316	skin	malignant_melanoma	Substitution - Missense
c.1565G>A; p.R522H; 11:65646599-65646599	liver	carcinoma	Substitution - Missense
c.2928G>T; p.E976D; 11:65650425-65650425	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2558A>C; p.N853T; 11:65649593-65649593	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1398C>T; p.P466P; 11:65646355-65646355	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2894C>T; p.S965F; 11:65650183-65650183	skin	malignant_melanoma	Substitution - Missense
c.2631G>C; p.L877L; 11:65649666-65649666	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2696G>T; p.R899M; 11:65649815-65649815	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2639A>C; p.D880A; 11:65649758-65649758	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.724G>A; p.A242T; 11:65642294-65642294	skin	malignant_melanoma	Substitution - Missense
c.191C>T; p.T64M; 11:65641112-65641112	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2999C>T; p.A1000V; 11:65650585-65650585	lung	carcinoma	Substitution - Missense
c.2999C>T; p.A1000V; 11:65650585-65650585	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1351C>T; p.R451C; 11:65646308-65646308	skin	malignant_melanoma	Substitution - Missense
c.431G>T; p.G144V; 11:65641352-65641352	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.360C>G; p.D120E; 11:65641281-65641281	breast	carcinoma	Substitution - Missense
c.2014G>T; p.V672L; 11:65647048-65647048	thyroid	other; neoplasm	Substitution - Missense
c.2306+8T>G; p.?; 11:65647666-65647666	pancreas	carcinoid-endocrine_tumour	Unknown
c.2680C>T; p.P894S; 11:65649799-65649799	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation