lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6434
Symbol	TRA2B
Synonymous	Htra2-beta\|PPP1R156\|SFRS10\|SRFS10\|TRA2-BETA\|TRAN2B
Full name	transformer 2 beta homolog (Drosophila)
Gene description	TRA-2 beta\|protein phosphatase 1, regulatory subunit 156\|splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)\|transformer-2 protein homolog B\|transformer-2 protein homolog beta
Cytoband	3q26.2-q27
Gene type	protein-coding
Synonymous	MIM:602719; HGNC:HGNC:10781; HPRD:04097

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.31G>T; p.E11*; 3:185937830-185937830	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.31G>T; p.E11*; 3:185937830-185937830	oesophagus	carcinoma	Substitution - Nonsense
c.170+5G>C; p.?; 3:185926596-185926596	breast	carcinoma	Unknown
c.783-1G>A; p.?; 3:185918439-185918439	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.193C>T; p.R65*; 3:185925604-185925604	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.433G>T; p.A145S; 3:185923885-185923885	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.544A>T; p.M182L; 3:185922105-185922105	breast	carcinoma	Substitution - Missense
c.311G>A; p.R104H; 3:185925486-185925486	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.221G>A; p.R74H; 3:185925576-185925576	breast	carcinoma	Substitution - Missense
c.469C>T; p.R157C; 3:185923849-185923849	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.697C>T; p.R233W; 3:185921129-185921129	urinary_tract; bladder	carcinoma	Substitution - Missense
c.651C>T; p.R217R; 3:185921175-185921175	skin	malignant_melanoma	Substitution - coding silent
c.860G>A; p.R287H; 3:185917722-185917722	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.860G>A; p.R287H; 3:185917722-185917722	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.860G>A; p.R287H; 3:185917722-185917722	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.482T>C; p.F161S; 3:185923836-185923836	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.312C>T; p.R104R; 3:185925485-185925485	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.732T>A; p.G244G; 3:185919487-185919487	liver	carcinoma	Substitution - coding silent
c.332G>T; p.R111L; 3:185925465-185925465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.498delT; p.F166fs*4; 3:185923820-185923820	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.271C>G; p.R91G; 3:185925526-185925526	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.194G>A; p.R65Q; 3:185925603-185925603	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.194G>A; p.R65Q; 3:185925603-185925603	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.216G>A; p.R72R; 3:185925581-185925581	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.194G>A; p.R65Q; 3:185925603-185925603	urinary_tract; bladder	carcinoma	Substitution - Missense
c.382T>C; p.Y128H; 3:185923936-185923936	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.804C>A; p.Y268*; 3:185918417-185918417	prostate	carcinoma	Substitution - Nonsense
c.656G>T; p.R219L; 3:185921170-185921170	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.656G>T; p.R219L; 3:185921170-185921170	skin	malignant_melanoma	Substitution - Missense
c.470G>A; p.R157H; 3:185923848-185923848	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.27C>T; p.Y9Y; 3:185937834-185937834	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.27C>T; p.Y9Y; 3:185937834-185937834	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.539A>G; p.N180S; 3:185922110-185922110	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.539A>G; p.N180S; 3:185922110-185922110	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.747_748insGGA; p.G249_W250insG; 3:185919471-185919472	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - In frame
c.297T>G; p.S99S; 3:185925500-185925500	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.170+6A>T; p.?; 3:185926595-185926595	breast	carcinoma	Unknown
c.603G>A; p.T201T; 3:185922046-185922046	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.186A>G; p.R62R; 3:185925611-185925611	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.186A>G; p.R62R; 3:185925611-185925611	large_intestine; rectum	NS	Substitution - coding silent
c.184A>G; p.R62G; 3:185925613-185925613	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.184A>G; p.R62G; 3:185925613-185925613	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.147G>T; p.K49N; 3:185926624-185926624	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.62G>A; p.G21E; 3:185926709-185926709	breast	carcinoma	Substitution - Missense
c.787C>T; p.R263W; 3:185918434-185918434	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.602C>T; p.T201M; 3:185922047-185922047	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.334-1G>C; p.?; 3:185923985-185923985	breast	carcinoma	Unknown
c.856+1G>C; p.?; 3:185918364-185918364	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Unknown
c.856+1G>C; p.?; 3:185918364-185918364	urinary_tract; bladder	carcinoma	Unknown
c.649C>T; p.R217C; 3:185921177-185921177	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.649C>T; p.R217C; 3:185921177-185921177	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.220C>G; p.R74G; 3:185925577-185925577	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.43C>T; p.R15C; 3:185926728-185926728	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.84A>G; p.K28K; 3:185926687-185926687	liver	carcinoma	Substitution - coding silent
c.84A>G; p.K28K; 3:185926687-185926687	liver	carcinoma	Substitution - coding silent
c.574G>T; p.D192Y; 3:185922075-185922075	thyroid	other; neoplasm	Substitution - Missense
c.263G>A; p.R88Q; 3:185925534-185925534	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.263G>A; p.R88Q; 3:185925534-185925534	skin	malignant_melanoma	Substitution - Missense
c.346C>T; p.P116S; 3:185923972-185923972	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.545T>G; p.M182R; 3:185922104-185922104	central_nervous_system; brain	glioma	Substitution - Missense
c.311G>C; p.R104P; 3:185925486-185925486	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.311G>C; p.R104P; 3:185925486-185925486	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.851C>T; p.S284L; 3:185918370-185918370	urinary_tract; bladder	carcinoma	Substitution - Missense
c.851C>T; p.S284L; 3:185918370-185918370	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; essential_thrombocythaemia	Substitution - Missense
c.186A>C; p.R62S; 3:185925611-185925611	breast	carcinoma	Substitution - Missense
c.766A>G; p.R256G; 3:185919453-185919453	kidney	other; neoplasm	Substitution - Missense
c.11G>A; p.S4N; 3:185937850-185937850	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.559C>T; p.R187C; 3:185922090-185922090	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.559C>T; p.R187C; 3:185922090-185922090	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.559C>T; p.R187C; 3:185922090-185922090	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.559C>T; p.R187C; 3:185922090-185922090	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.856C>T; p.R286C; 3:185918365-185918365	pancreas	carcinoma	Substitution - Missense
c.316C>T; p.R106C; 3:185925481-185925481	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.316C>T; p.R106C; 3:185925481-185925481	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.220C>T; p.R74C; 3:185925577-185925577	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.812G>A; p.R271H; 3:185918409-185918409	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation