lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6424
Symbol	SFRP4
Synonymous	FRP-4\|FRPHE\|sFRP-4
Full name	secreted frizzled-related protein 4
Gene description	frizzled protein, human endometrium\|secreted frizzled-related protein 4; secreted frizzled-related protein 4
Cytoband	7p14.1
Gene type	protein-coding
Synonymous	MIM:606570; HGNC:HGNC:10778; Ensembl:ENSG00000106483; HPRD:07357; Vega:OTTHUMG00000023026

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.73G>A; p.E25K; 7:37916465-37916465	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.231C>G; p.L77L; 7:37916307-37916307	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.376G>T; p.D126Y; 7:37916162-37916162	oesophagus	carcinoma	Substitution - Missense
c.98G>T; p.R33L; 7:37916440-37916440	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.398G>A; p.R133H; 7:37916140-37916140	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.48G>A; p.A16A; 7:37916490-37916490	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.96C>G; p.C32W; 7:37916442-37916442	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.832G>T; p.D278Y; 7:37909640-37909640	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.653T>A; p.V218E; 7:37912257-37912257	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.917G>A; p.G306E; 7:37907603-37907603	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.309C>A; p.R103R; 7:37916229-37916229	thyroid	other; neoplasm	Substitution - coding silent
c.481G>A; p.V161I; 7:37914418-37914418	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.883C>T; p.R295W; 7:37907637-37907637	liver	carcinoma	Substitution - Missense
c.884G>A; p.R295Q; 7:37907636-37907636	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.317A>G; p.D106G; 7:37916221-37916221	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.444G>C; p.E148D; 7:37916094-37916094	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.594T>C; p.V198V; 7:37912316-37912316	stomach	adenocarcinoma	Substitution - coding silent
c.899A>G; p.D300G; 7:37907621-37907621	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.702A>T; p.Q234H; 7:37912208-37912208	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.367C>T; p.L123L; 7:37916171-37916171	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.313C>T; p.R105C; 7:37916225-37916225	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.319G>A; p.D107N; 7:37916219-37916219	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.695G>A; p.R232Q; 7:37912215-37912215	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.695G>A; p.R232Q; 7:37912215-37912215	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.360C>T; p.P120P; 7:37916178-37916178	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.695G>A; p.R232Q; 7:37912215-37912215	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.695G>A; p.R232Q; 7:37912215-37912215	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.695G>A; p.R232Q; 7:37912215-37912215	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.695G>A; p.R232Q; 7:37912215-37912215	skin; neck	malignant_melanoma	Substitution - Missense
c.695G>A; p.R232Q; 7:37912215-37912215	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.982C>T; p.P328S; 7:37907538-37907538	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.695G>A; p.R232Q; 7:37912215-37912215	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.367C>G; p.L123V; 7:37916171-37916171	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.695G>A; p.R232Q; 7:37912215-37912215	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.919C>T; p.R307C; 7:37907601-37907601	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.939C>T; p.P313P; 7:37907581-37907581	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.249C>G; p.P83P; 7:37916289-37916289	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.364A>G; p.S122G; 7:37916174-37916174	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.759T>C; p.D253D; 7:37912151-37912151	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.160G>A; p.A54T; 7:37916378-37916378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.736C>T; p.P246S; 7:37912174-37912174	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.908A>T; p.K303I; 7:37907612-37907612	skin	malignant_melanoma	Substitution - Missense
c.379G>A; p.E127K; 7:37916159-37916159	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1023A>G; p.T341T; 7:37907497-37907497	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.315C>T; p.R105R; 7:37916223-37916223	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.315C>T; p.R105R; 7:37916223-37916223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.687_688insC; p.I230fs*40; 7:37912222-37912223	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.315C>T; p.R105R; 7:37916223-37916223	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.315C>T; p.R105R; 7:37916223-37916223	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1016A>G; p.K339R; 7:37907504-37907504	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.844A>T; p.K282*; 7:37909628-37909628	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.951G>C; p.K317N; 7:37907569-37907569	breast	carcinoma	Substitution - Missense
c.14T>A; p.I5N; 7:37916524-37916524	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.150G>T; p.T50T; 7:37916388-37916388	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.885G>A; p.R295R; 7:37907635-37907635	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.529C>T; p.R177W; 7:37914276-37914276	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.529C>T; p.R177W; 7:37914276-37914276	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.529C>T; p.R177W; 7:37914276-37914276	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.83G>A; p.R28H; 7:37916455-37916455	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.656A>G; p.D219G; 7:37912254-37912254	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.83G>A; p.R28H; 7:37916455-37916455	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.916G>T; p.G306W; 7:37907604-37907604	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.245C>T; p.A82V; 7:37916293-37916293	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.958C>A; p.P320T; 7:37907562-37907562	skin	malignant_melanoma	Substitution - Missense
c.361G>A; p.E121K; 7:37916177-37916177	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.792-4_792-3insT; p.?; 7:37909683-37909684	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1029G>A; p.P343P; 7:37907491-37907491	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.413C>T; p.S138L; 7:37916125-37916125	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1029G>A; p.P343P; 7:37907491-37907491	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.975A>G; p.P325P; 7:37907545-37907545	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.744C>T; p.I248I; 7:37912166-37912166	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.929G>T; p.R310L; 7:37907591-37907591	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.320A>G; p.D107G; 7:37916218-37916218	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.937C>T; p.P313S; 7:37907583-37907583	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.937C>T; p.P313S; 7:37907583-37907583	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.210C>G; p.S70R; 7:37916328-37916328	oesophagus	carcinoma	Substitution - Missense
c.146G>A; p.S49N; 7:37916392-37916392	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.694C>T; p.R232*; 7:37912216-37912216	skin	malignant_melanoma	Substitution - Nonsense
c.694C>T; p.R232*; 7:37912216-37912216	skin	malignant_melanoma	Substitution - Nonsense
c.1019G>A; p.R340K; 7:37907501-37907501	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.732G>T; p.Q244H; 7:37912178-37912178	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.924C>T; p.T308T; 7:37907596-37907596	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1017G>A; p.K339K; 7:37907503-37907503	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.477G>T; p.M159I; 7:37914422-37914422	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.798G>T; p.M266I; 7:37909674-37909674	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.134A>T; p.H45L; 7:37916404-37916404	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.50T>C; p.L17P; 7:37916488-37916488	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.365G>A; p.S122N; 7:37916173-37916173	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.312G>A; p.A104A; 7:37916226-37916226	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.972A>C; p.K324N; 7:37907548-37907548	thyroid	other; neoplasm	Substitution - Missense
c.972A>C; p.K324N; 7:37907548-37907548	thyroid	other; neoplasm	Substitution - Missense
c.652G>A; p.V218M; 7:37912258-37912258	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.652G>A; p.V218M; 7:37912258-37912258	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.423C>A; p.A141A; 7:37916115-37916115	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.750C>A; p.P250P; 7:37912160-37912160	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.288G>A; p.P96P; 7:37916250-37916250	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.213C>T; p.A71A; 7:37916325-37916325	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.792G>A; p.R264R; 7:37909680-37909680	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.492G>A; p.R164R; 7:37914407-37914407	skin	malignant_melanoma	Substitution - coding silent
c.722C>A; p.S241Y; 7:37912188-37912188	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.722C>A; p.S241Y; 7:37912188-37912188	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.514C>T; p.R172C; 7:37914385-37914385	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.514C>T; p.R172C; 7:37914385-37914385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.514C>T; p.R172C; 7:37914385-37914385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.514C>T; p.R172C; 7:37914385-37914385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.514C>T; p.R172C; 7:37914385-37914385	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.514C>T; p.R172C; 7:37914385-37914385	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1009G>T; p.A337S; 7:37907511-37907511	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.74A>T; p.E25V; 7:37916464-37916464	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.311C>T; p.A104V; 7:37916227-37916227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.150G>A; p.T50T; 7:37916388-37916388	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.805G>A; p.E269K; 7:37909667-37909667	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.217C>T; p.L73L; 7:37916321-37916321	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.254G>T; p.C85F; 7:37916284-37916284	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.66G>A; p.A22A; 7:37916472-37916472	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.722C>G; p.S241C; 7:37912188-37912188	breast	carcinoma	Substitution - Missense
c.487G>A; p.E163K; 7:37914412-37914412	skin	malignant_melanoma	Substitution - Missense
c.314G>A; p.R105H; 7:37916224-37916224	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.910A>G; p.T304A; 7:37907610-37907610	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.436C>A; p.L146I; 7:37916102-37916102	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.691C>T; p.P231S; 7:37912219-37912219	skin	malignant_melanoma	Substitution - Missense
c.75G>A; p.E25E; 7:37916463-37916463	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.861G>A; p.W287*; 7:37907659-37907659	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.642C>T; p.V214V; 7:37912268-37912268	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.551A>G; p.K184R; 7:37914254-37914254	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.551A>G; p.K184R; 7:37914254-37914254	skin	malignant_melanoma	Substitution - Missense
c.222C>T; p.R74R; 7:37916316-37916316	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.221G>A; p.R74H; 7:37916317-37916317	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.751C>T; p.H251Y; 7:37912159-37912159	skin	malignant_melanoma	Substitution - Missense
c.339G>C; p.K113N; 7:37916199-37916199	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.567G>A; p.T189T; 7:37914238-37914238	thyroid	other; neoplasm	Substitution - coding silent
c.61G>A; p.G21S; 7:37916477-37916477	oesophagus	carcinoma	Substitution - Missense
c.64G>A; p.A22T; 7:37916474-37916474	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.546G>T; p.K182N; 7:37914259-37914259	haematopoietic_and_lymphoid_tissue; breast	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.723T>G; p.S241S; 7:37912187-37912187	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.785G>A; p.R262H; 7:37912125-37912125	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.441G>A; p.P147P; 7:37916097-37916097	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.517C>G; p.L173V; 7:37914382-37914382	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.980G>T; p.S327I; 7:37907540-37907540	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.298G>T; p.V100L; 7:37916240-37916240	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1004G>A; p.R335K; 7:37907516-37907516	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.696A>G; p.R232R; 7:37912214-37912214	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.735T>A; p.C245*; 7:37912175-37912175	skin	malignant_melanoma	Substitution - Nonsense
c.514C>G; p.R172G; 7:37914385-37914385	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.514C>G; p.R172G; 7:37914385-37914385	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.484C>G; p.Q162E; 7:37914415-37914415	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.282C>G; p.I94M; 7:37916256-37916256	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.707C>T; p.P236L; 7:37912203-37912203	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.564A>T; p.A188A; 7:37914241-37914241	lung	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation