lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6317
Symbol	SERPINB3
Synonymous	HsT1196\|SCC\|SCCA-1\|SCCA-PD\|SCCA1\|T4-A
Full name	serpin peptidase inhibitor, clade B (ovalbumin), member 3
Gene description	protein T4-A\|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3\|serpin B3\|squamous cell carcinoma antigen 1
Cytoband	18q21.3
Gene type	protein-coding
Synonymous	MIM:600517; HGNC:HGNC:10569; Ensembl:ENSG00000057149; HPRD:02745; Vega:OTTHUMG00000060403

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.340C>T; p.L114L; 18:63659410-63659410	skin	malignant_melanoma	Substitution - coding silent
c.335C>T; p.T112M; 18:63659415-63659415	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.117G>A; p.G39G; 18:63661100-63661100	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.956G>A; p.G319E; 18:63655874-63655874	skin	malignant_melanoma	Substitution - Missense
c.627C>T; p.S209S; 18:63656972-63656972	skin	malignant_melanoma	Substitution - coding silent
c.336G>A; p.T112T; 18:63659414-63659414	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.336G>A; p.T112T; 18:63659414-63659414	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.336G>A; p.T112T; 18:63659414-63659414	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.92C>T; p.P31L; 18:63661125-63661125	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.801G>A; p.M267I; 18:63656029-63656029	skin	malignant_melanoma	Substitution - Missense
c.725G>A; p.S242N; 18:63656874-63656874	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.549A>C; p.K183N; 18:63657333-63657333	large_intestine; colon	carcinoma	Substitution - Missense
c.10C>G; p.L4V; 18:63661207-63661207	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1099C>G; p.H367D; 18:63655731-63655731	breast	carcinoma	Substitution - Missense
c.334A>G; p.T112A; 18:63659416-63659416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.218A>G; p.Y73C; 18:63660804-63660804	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.334A>G; p.T112A; 18:63659416-63659416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3G>A; p.M1I; 18:63661214-63661214	skin	malignant_melanoma	Substitution - Missense
c.181C>T; p.Q61*; 18:63660841-63660841	skin	malignant_melanoma	Substitution - Nonsense
c.181C>T; p.Q61*; 18:63660841-63660841	skin	malignant_melanoma	Substitution - Nonsense
c.902_903CC>TT; p.T301I; 18:63655927-63655928	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.703C>T; p.P235S; 18:63656896-63656896	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1012G>C; p.E338Q; 18:63655818-63655818	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.465G>T; p.T155T; 18:63658517-63658517	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.814T>C; p.L272L; 18:63656016-63656016	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1113C>A; p.F371L; 18:63655717-63655717	bone; pelvis	chondrosarcoma	Substitution - Missense
c.172C>T; p.H58Y; 18:63660850-63660850	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.658C>T; p.H220Y; 18:63656941-63656941	skin	malignant_melanoma	Substitution - Missense
c.340C>A; p.L114I; 18:63659410-63659410	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1107C>T; p.F369F; 18:63655723-63655723	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1107C>T; p.F369F; 18:63655723-63655723	skin	malignant_melanoma	Substitution - coding silent
c.24C>A; p.N8K; 18:63661193-63661193	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.636G>A; p.M212I; 18:63656963-63656963	skin	malignant_melanoma	Substitution - Missense
c.474_475insA; p.I159fs*2; 18:63657407-63657408	central_nervous_system; posterior_fossa	glioma; astrocytoma_Grade_IV	Insertion - Frameshift
c.954C>T; p.T318T; 18:63655876-63655876	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.61A>T; p.K21*; 18:63661156-63661156	skin	malignant_melanoma	Substitution - Nonsense
c.220C>A; p.H74N; 18:63660802-63660802	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1113C>T; p.F371F; 18:63655717-63655717	skin	malignant_melanoma	Substitution - coding silent
c.33C>A; p.F11L; 18:63661184-63661184	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.432A>G; p.R144R; 18:63658550-63658550	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.970G>A; p.V324M; 18:63655860-63655860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.753C>T; p.I251I; 18:63656846-63656846	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.753C>T; p.I251I; 18:63656846-63656846	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.753C>T; p.I251I; 18:63656846-63656846	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.753C>T; p.I251I; 18:63656846-63656846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.27C>T; p.T9T; 18:63661190-63661190	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.203G>A; p.G68E; 18:63660819-63660819	skin; trunk	malignant_melanoma	Substitution - Missense
c.244C>T; p.H82Y; 18:63659506-63659506	skin	malignant_melanoma	Substitution - Missense
c.949A>T; p.M317L; 18:63655881-63655881	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.352-1G>A; p.?; 18:63658631-63658631	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.352G>A; p.E118K; 18:63658630-63658630	skin	malignant_melanoma	Substitution - Missense
c.236G>A; p.G79E; 18:63659514-63659514	skin	malignant_melanoma	Substitution - Missense
c.977C>T; p.S326F; 18:63655853-63655853	skin	malignant_melanoma	Substitution - Missense
c.215C>T; p.T72I; 18:63660807-63660807	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.72G>A; p.E24E; 18:63661145-63661145	skin	malignant_melanoma	Substitution - coding silent
c.601T>G; p.W201G; 18:63657281-63657281	skin	malignant_melanoma	Substitution - Missense
c.601T>G; p.W201G; 18:63657281-63657281	skin	malignant_melanoma	Substitution - Missense
c.589G>C; p.E197Q; 18:63657293-63657293	breast	carcinoma	Substitution - Missense
c.279C>A; p.N93K; 18:63659471-63659471	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.303G>A; p.L101L; 18:63659447-63659447	skin	malignant_melanoma	Substitution - coding silent
c.26C>A; p.T9N; 18:63661191-63661191	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1012G>A; p.E338K; 18:63655818-63655818	skin	malignant_melanoma	Substitution - Missense
c.878A>G; p.Y293C; 18:63655952-63655952	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.475A>T; p.I159F; 18:63657407-63657407	skin	malignant_melanoma	Substitution - Missense
c.324C>T; p.F108F; 18:63659426-63659426	liver	carcinoma	Substitution - coding silent
c.324C>T; p.F108F; 18:63659426-63659426	liver	carcinoma	Substitution - coding silent
c.1149C>T; p.F383F; 18:63655681-63655681	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.889G>A; p.D297N; 18:63655941-63655941	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.889G>A; p.D297N; 18:63655941-63655941	skin	malignant_melanoma	Substitution - Missense
c.889G>A; p.D297N; 18:63655941-63655941	skin	malignant_melanoma	Substitution - Missense
c.1088T>C; p.F363S; 18:63655742-63655742	liver	carcinoma	Substitution - Missense
c.889G>A; p.D297N; 18:63655941-63655941	skin	malignant_melanoma	Substitution - Missense
c.1088T>C; p.F363S; 18:63655742-63655742	liver	carcinoma	Substitution - Missense
c.465G>A; p.T155T; 18:63658517-63658517	skin	malignant_melanoma	Substitution - coding silent
c.465G>A; p.T155T; 18:63658517-63658517	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.888G>T; p.K296N; 18:63655942-63655942	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.42C>T; p.D14D; 18:63661175-63661175	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.386C>G; p.T129S; 18:63658596-63658596	breast	carcinoma	Substitution - Missense
c.1018G>A; p.G340R; 18:63655812-63655812	skin	malignant_melanoma	Substitution - Missense
c.1090C>G; p.H364D; 18:63655740-63655740	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1069A>G; p.T357A; 18:63655761-63655761	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1069A>G; p.T357A; 18:63655761-63655761	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.351+5_351+6insA; p.?; 18:63659393-63659394	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.553C>T; p.Q185*; 18:63657329-63657329	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.421G>A; p.E141K; 18:63658561-63658561	skin	malignant_melanoma	Substitution - Missense
c.325G>A; p.G109R; 18:63659425-63659425	central_nervous_system; midbrain	glioma; oligoastrocytoma_Grade_III	Substitution - Missense
c.811A>C; p.S271R; 18:63656019-63656019	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.262C>A; p.L88I; 18:63659488-63659488	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.940C>G; p.L314V; 18:63655890-63655890	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1161C>A; p.F387L; 18:63655669-63655669	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1153G>T; p.G385C; 18:63655677-63655677	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.309C>T; p.I103I; 18:63659441-63659441	central_nervous_system; brain	glioma	Substitution - coding silent
c.490C>T; p.P164S; 18:63657392-63657392	skin	malignant_melanoma	Substitution - Missense
c.490C>T; p.P164S; 18:63657392-63657392	skin	malignant_melanoma	Substitution - Missense
c.490C>T; p.P164S; 18:63657392-63657392	skin	malignant_melanoma	Substitution - Missense
c.768+1G>A; p.?; 18:63656830-63656830	skin	malignant_melanoma	Unknown
c.729G>A; p.M243I; 18:63656870-63656870	skin; arm	malignant_melanoma	Substitution - Missense
c.4A>G; p.N2D; 18:63661213-63661213	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.348A>G; p.L116L; 18:63659402-63659402	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.285C>T; p.S95S; 18:63659465-63659465	skin	malignant_melanoma	Substitution - coding silent
c.697G>A; p.E233K; 18:63656902-63656902	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.278A>G; p.N93S; 18:63659472-63659472	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.883C>A; p.L295I; 18:63655947-63655947	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.482A>G; p.N161S; 18:63657400-63657400	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.760C>T; p.L254F; 18:63656839-63656839	skin	malignant_melanoma	Substitution - Missense
c.748G>A; p.E250K; 18:63656851-63656851	skin	malignant_melanoma	Substitution - Missense
c.253T>A; p.F85I; 18:63659497-63659497	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.748G>A; p.E250K; 18:63656851-63656851	skin	malignant_melanoma	Substitution - Missense
c.1050delA; p.G351fs*23; 18:63655780-63655780	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.144C>A; p.N48K; 18:63661073-63661073	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.431G>A; p.R144Q; 18:63658551-63658551	breast	carcinoma	Substitution - Missense
c.1041C>T; p.T347T; 18:63655789-63655789	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.431G>A; p.R144Q; 18:63658551-63658551	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.190G>A; p.E64K; 18:63660832-63660832	skin	malignant_melanoma	Substitution - Missense
c.952A>G; p.T318A; 18:63655878-63655878	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1053_1054insTGGC; p.F352fs*10; 18:63655776-63655777	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.695_706del12; p.L232_Y236>H; 18:63656893-63656904	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Complex - deletion inframe
c.857G>C; p.R286P; 18:63655973-63655973	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.109G>A; p.A37T; 18:63661108-63661108	skin	malignant_melanoma	Substitution - Missense
c.318G>A; p.K106K; 18:63659432-63659432	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1040C>T; p.T347I; 18:63655790-63655790	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.626C>A; p.S209Y; 18:63656973-63656973	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.893C>T; p.T298M; 18:63655937-63655937	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.613-1G>T; p.?; 18:63656987-63656987	ovary	carcinoma; serous_carcinoma	Unknown
c.563A>C; p.K188T; 18:63657319-63657319	skin; acral	malignant_melanoma	Substitution - Missense
c.428G>C; p.S143T; 18:63658554-63658554	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.79A>T; p.I27F; 18:63661138-63661138	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1168C>T; p.P390S; 18:63655662-63655662	skin	malignant_melanoma	Substitution - Missense
c.828A>T; p.R276S; 18:63656002-63656002	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.819G>A; p.Q273Q; 18:63656011-63656011	skin	malignant_melanoma	Substitution - coding silent
c.806_807GG>AA; p.W269*; 18:63656023-63656024	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.326G>T; p.G109V; 18:63659424-63659424	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.165G>A; p.K55K; 18:63661052-63661052	liver	carcinoma	Substitution - coding silent
c.165G>A; p.K55K; 18:63661052-63661052	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1136A>C; p.N379T; 18:63655694-63655694	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1136A>C; p.N379T; 18:63655694-63655694	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.881A>C; p.D294A; 18:63655949-63655949	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.430C>T; p.R144*; 18:63658552-63658552	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.430C>T; p.R144*; 18:63658552-63658552	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.131G>T; p.G44V; 18:63661086-63661086	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1091A>G; p.H364R; 18:63655739-63655739	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.592G>A; p.E198K; 18:63657290-63657290	skin	malignant_melanoma	Substitution - Missense
c.600T>G; p.F200L; 18:63657282-63657282	skin	malignant_melanoma	Substitution - Missense
c.592G>A; p.E198K; 18:63657290-63657290	skin	malignant_melanoma	Substitution - Missense
c.800T>G; p.M267R; 18:63656030-63656030	central_nervous_system; brain	glioma	Substitution - Missense
c.963C>T; p.R321R; 18:63655867-63655867	pancreas	carcinoma	Substitution - coding silent
c.871G>A; p.E291K; 18:63655959-63655959	urinary_tract; bladder	carcinoma	Substitution - Missense
c.871G>A; p.E291K; 18:63655959-63655959	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.841G>A; p.D281N; 18:63655989-63655989	skin	malignant_melanoma	Substitution - Missense
c.841G>A; p.D281N; 18:63655989-63655989	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.841G>A; p.D281N; 18:63655989-63655989	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.836G>A; p.R279H; 18:63655994-63655994	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.133G>A; p.A45T; 18:63661084-63661084	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.102C>T; p.I34I; 18:63661115-63661115	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1061C>A; p.S354*; 18:63655769-63655769	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.328G>A; p.E110K; 18:63659422-63659422	skin	malignant_melanoma	Substitution - Missense
c.30G>T; p.K10N; 18:63661187-63661187	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1159T>C; p.F387L; 18:63655671-63655671	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.170T>C; p.L57P; 18:63660852-63660852	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.908G>A; p.G303E; 18:63655922-63655922	skin	malignant_melanoma	Substitution - Missense
c.129A>T; p.L43F; 18:63661088-63661088	urinary_tract; bladder	carcinoma	Substitution - Missense
c.102C>A; p.I34I; 18:63661115-63661115	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.989A>G; p.H330R; 18:63655841-63655841	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.502A>G; p.I168V; 18:63657380-63657380	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.962G>A; p.R321H; 18:63655868-63655868	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.298G>A; p.E100K; 18:63659452-63659452	skin	malignant_melanoma	Substitution - Missense
c.502A>G; p.I168V; 18:63657380-63657380	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1094G>A; p.C365Y; 18:63655736-63655736	skin	malignant_melanoma	Substitution - Missense
c.286A>G; p.T96A; 18:63659464-63659464	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.979G>T; p.G327*; 18:63655851-63655851	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.711A>T; p.K237N; 18:63656888-63656888	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1089C>G; p.F363L; 18:63655741-63655741	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation