lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6258
Symbol	RXRG
Synonymous	NR2B3\|RXRC
Full name	retinoid X receptor, gamma
Gene description	nuclear receptor subfamily 2 group B member 3\|retinoic acid receptor RXR-gamma
Cytoband	1q22-q23
Gene type	protein-coding
Synonymous	MIM:180247; HGNC:HGNC:10479; Ensembl:ENSG00000143171; HPRD:01579; Vega:OTTHUMG00000034626

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.513C>T; p.L171L; 1:165417150-165417150	breast	carcinoma	Substitution - coding silent
c.1230G>A; p.P410P; 1:165406826-165406826	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.832T>A; p.F278I; 1:165410783-165410783	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.136A>G; p.T46A; 1:165428880-165428880	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.113C>G; p.P38R; 1:165428903-165428903	liver	carcinoma	Substitution - Missense
c.79A>T; p.M27L; 1:165428937-165428937	oesophagus	carcinoma	Substitution - Missense
c.232G>C; p.G78R; 1:165428784-165428784	breast	carcinoma	Substitution - Missense
c.159A>C; p.P53P; 1:165428857-165428857	breast	carcinoma	Substitution - coding silent
c.589C>T; p.Q197*; 1:165417074-165417074	breast	carcinoma	Substitution - Nonsense
c.1029C>T; p.V343V; 1:165409575-165409575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.453C>A; p.Y151*; 1:165417210-165417210	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.777G>A; p.E259E; 1:165410955-165410955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1371G>T; p.E457D; 1:165401284-165401284	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.166C>T; p.L56L; 1:165428850-165428850	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1330G>T; p.G444W; 1:165401325-165401325	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.408A>T; p.K136N; 1:165419904-165419904	central_nervous_system; brain	glioma	Substitution - Missense
c.1186A>C; p.K396Q; 1:165406870-165406870	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.241T>A; p.S81T; 1:165428775-165428775	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.735T>G; p.A245A; 1:165410997-165410997	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1114C>T; p.R372*; 1:165408251-165408251	ovary	other; neoplasm	Substitution - Nonsense
c.1017C>T; p.H339H; 1:165409587-165409587	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.922G>T; p.E308*; 1:165409682-165409682	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.36C>A; p.P12P; 1:165444858-165444858	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.583C>T; p.R195C; 1:165417080-165417080	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.583C>T; p.R195C; 1:165417080-165417080	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1102C>A; p.L368M; 1:165408263-165408263	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1224G>C; p.K408N; 1:165406832-165406832	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.486C>A; p.F162L; 1:165417177-165417177	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.486C>A; p.F162L; 1:165417177-165417177	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.224C>A; p.S75Y; 1:165428792-165428792	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1150C>A; p.L384M; 1:165406906-165406906	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.178G>A; p.G60R; 1:165428838-165428838	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.394G>A; p.G132R; 1:165419918-165419918	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.469G>A; p.E157K; 1:165417194-165417194	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1357A>T; p.M453L; 1:165401298-165401298	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.950G>T; p.R317L; 1:165409654-165409654	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.914-1_914GG>AA; p.?; 1:165409690-165409691	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.971G>T; p.G324V; 1:165409633-165409633	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1340C>A; p.P447H; 1:165401315-165401315	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.747G>T; p.K249N; 1:165410985-165410985	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.747G>T; p.K249N; 1:165410985-165410985	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1376C>T; p.P459L; 1:165401279-165401279	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1264C>A; p.R422S; 1:165401391-165401391	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.791A>G; p.D264G; 1:165410824-165410824	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.677G>A; p.C226Y; 1:165411055-165411055	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.856C>T; p.R286C; 1:165410759-165410759	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.262C>A; p.P88T; 1:165428754-165428754	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1329C>T; p.I443I; 1:165401326-165401326	skin	malignant_melanoma	Substitution - coding silent
c.949C>A; p.R317S; 1:165409655-165409655	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.526C>T; p.R176W; 1:165417137-165417137	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.526C>T; p.R176W; 1:165417137-165417137	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.420C>T; p.A140A; 1:165419892-165419892	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.55C>A; p.P19T; 1:165428961-165428961	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.365G>A; p.G122E; 1:165419947-165419947	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.697G>C; p.D233H; 1:165411035-165411035	kidney	other; neoplasm	Substitution - Missense
c.1136C>A; p.P379Q; 1:165408229-165408229	skin	malignant_melanoma	Substitution - Missense
c.669G>T; p.E223D; 1:165411063-165411063	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1110C>T; p.C370C; 1:165408255-165408255	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.92C>A; p.A31E; 1:165428924-165428924	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.104C>A; p.T35K; 1:165428912-165428912	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.379C>G; p.P127A; 1:165419933-165419933	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.150G>C; p.V50V; 1:165428866-165428866	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1025G>T; p.G342V; 1:165409579-165409579	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.352C>T; p.L118F; 1:165419960-165419960	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.258G>A; p.A86A; 1:165428758-165428758	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.29A>C; p.K10T; 1:165444865-165444865	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.782C>T; p.S261L; 1:165410950-165410950	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.390C>T; p.S130S; 1:165419922-165419922	central_nervous_system; brain	glioma	Substitution - coding silent
c.393C>T; p.P131P; 1:165419919-165419919	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.607G>A; p.G203S; 1:165417056-165417056	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.497C>T; p.T166M; 1:165417166-165417166	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.961G>T; p.V321L; 1:165409643-165409643	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.557G>A; p.R186H; 1:165417106-165417106	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.648_649CC>AT; p.S216_R217>R*; 1:165411083-165411084	lung	carcinoma; adenocarcinoma	Complex - compound substitution
c.139G>A; p.D47N; 1:165428877-165428877	skin	malignant_melanoma	Substitution - Missense
c.840C>T; p.L280L; 1:165410775-165410775	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.830T>A; p.L277H; 1:165410785-165410785	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1219C>A; p.Q407K; 1:165406837-165406837	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.426_427delTG; p.C142fs*15; 1:165419885-165419886	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.302A>C; p.N101T; 1:165420010-165420010	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1377G>A; p.P459P; 1:165401278-165401278	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.97T>G; p.L33V; 1:165428919-165428919	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.51C>A; p.G17G; 1:165428965-165428965	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.841G>A; p.V281I; 1:165410774-165410774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1375C>A; p.P459T; 1:165401280-165401280	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.756C>T; p.S252S; 1:165410976-165410976	breast	carcinoma	Substitution - coding silent
c.756C>T; p.S252S; 1:165410976-165410976	skin	malignant_melanoma	Substitution - coding silent
c.161G>A; p.R54Q; 1:165428855-165428855	skin	malignant_melanoma	Substitution - Missense
c.161G>A; p.R54Q; 1:165428855-165428855	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.257C>T; p.A86V; 1:165428759-165428759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.950G>A; p.R317H; 1:165409654-165409654	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.154G>A; p.A52T; 1:165428862-165428862	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.563G>A; p.R188H; 1:165417100-165417100	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.656G>A; p.R219Q; 1:165411076-165411076	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.928C>T; p.L310L; 1:165409676-165409676	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.187C>T; p.L63F; 1:165428829-165428829	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.562C>T; p.R188C; 1:165417101-165417101	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.25A>G; p.M9V; 1:165444869-165444869	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1279C>T; p.R427C; 1:165401376-165401376	pancreas	carcinoma	Substitution - Missense
c.562C>T; p.R188C; 1:165417101-165417101	pancreas	carcinoma	Substitution - Missense
c.562C>T; p.R188C; 1:165417101-165417101	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.650G>T; p.R217L; 1:165411082-165411082	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.750A>G; p.T250T; 1:165410982-165410982	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.454G>T; p.G152W; 1:165417209-165417209	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.967G>T; p.D323Y; 1:165409637-165409637	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1333G>A; p.D445N; 1:165401322-165401322	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1278G>A; p.L426L; 1:165401377-165401377	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.574C>T; p.Q192*; 1:165417089-165417089	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1014C>T; p.A338A; 1:165409590-165409590	skin	malignant_melanoma	Substitution - coding silent
c.949C>T; p.R317C; 1:165409655-165409655	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.608G>A; p.G203D; 1:165417055-165417055	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.608G>A; p.G203D; 1:165417055-165417055	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.1364T>C; p.M455T; 1:165401291-165401291	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.398C>T; p.S133F; 1:165419914-165419914	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.123C>T; p.S41S; 1:165428893-165428893	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1290C>A; p.G430G; 1:165401365-165401365	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.41G>T; p.G14V; 1:165444853-165444853	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.141T>G; p.D47E; 1:165428875-165428875	central_nervous_system; brain	glioma	Substitution - Missense
c.338A>C; p.K113T; 1:165419974-165419974	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1253A>G; p.K418R; 1:165401402-165401402	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.349G>A; p.G117R; 1:165419963-165419963	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.211C>T; p.R71*; 1:165428805-165428805	skin; extremity	malignant_melanoma	Substitution - Nonsense
c.211C>T; p.R71*; 1:165428805-165428805	skin	malignant_melanoma	Substitution - Nonsense
c.206C>A; p.P69Q; 1:165428810-165428810	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1164T>C; p.S388S; 1:165406892-165406892	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1326C>T; p.L442L; 1:165401329-165401329	breast	carcinoma	Substitution - coding silent
c.53C>A; p.S18Y; 1:165428963-165428963	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.262C>G; p.P88A; 1:165428754-165428754	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.888G>T; p.E296D; 1:165410727-165410727	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.503G>A; p.R168K; 1:165417160-165417160	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147G>T; p.G383C; 1:165406909-165406909	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1320C>G; p.F440L; 1:165401335-165401335	urinary_tract; bladder	carcinoma	Substitution - Missense
c.650G>A; p.R217Q; 1:165411082-165411082	urinary_tract; bladder	carcinoma	Substitution - Missense
c.561G>T; p.Q187H; 1:165417102-165417102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.30G>A; p.K10K; 1:165444864-165444864	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.844G>T; p.E282*; 1:165410771-165410771	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1168G>A; p.V390M; 1:165406888-165406888	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.230T>G; p.M77R; 1:165428786-165428786	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1294A>G; p.K432E; 1:165401361-165401361	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1276C>G; p.L426V; 1:165401379-165401379	liver	carcinoma	Substitution - Missense
c.1276C>G; p.L426V; 1:165401379-165401379	liver	carcinoma	Substitution - Missense
c.179G>T; p.G60V; 1:165428837-165428837	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.617G>A; p.R206K; 1:165417046-165417046	skin	malignant_melanoma	Substitution - Missense
c.623C>T; p.A208V; 1:165411109-165411109	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1387A>C; p.T463P; 1:165401268-165401268	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1098G>A; p.S366S; 1:165408267-165408267	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.712A>G; p.R238G; 1:165411020-165411020	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1098G>A; p.S366S; 1:165408267-165408267	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.264A>T; p.P88P; 1:165428752-165428752	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.452A>G; p.Y151C; 1:165417211-165417211	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1280G>A; p.R427H; 1:165401375-165401375	urinary_tract; bladder	carcinoma	Substitution - Missense
c.527G>A; p.R176Q; 1:165417136-165417136	central_nervous_system; brain	glioma	Substitution - Missense
c.502A>G; p.R168G; 1:165417161-165417161	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1265G>A; p.R422H; 1:165401390-165401390	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1265G>A; p.R422H; 1:165401390-165401390	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation