lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6256
Symbol	RXRA
Synonymous	NR2B1
Full name	retinoid X receptor, alpha
Gene description	nuclear receptor subfamily 2 group B member 1\|retinoic acid receptor RXR-alpha\|retinoid X nuclear receptor alpha
Cytoband	9q34.3
Gene type	protein-coding
Synonymous	MIM:180245; HGNC:HGNC:10477; HPRD:01577

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.256G>T; p.G86C; 9:134401859-134401859	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.762G>A; p.M254I; 9:134417309-134417309	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1307_1309delTCT; p.F439delF; 9:134436532-134436534	stomach	adenocarcinoma	Deletion - In frame
c.1098G>A; p.E366E; 9:134431959-134431959	stomach	adenocarcinoma	Substitution - coding silent
c.1125C>T; p.L375L; 9:134431986-134431986	thyroid	carcinoma	Substitution - coding silent
c.1277G>A; p.R426H; 9:134436502-134436502	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1277G>A; p.R426H; 9:134436502-134436502	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.495G>T; p.K165N; 9:134409004-134409004	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1017C>T; p.S339S; 9:134429214-134429214	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.171_172insC; p.I58fs*123; 9:134401774-134401775	prostate	carcinoma	Insertion - Frameshift
c.894C>T; p.V298V; 9:134421789-134421789	skin	malignant_melanoma	Substitution - coding silent
c.325C>T; p.P109S; 9:134408194-134408194	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.746A>T; p.Y249F; 9:134417293-134417293	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.746A>T; p.Y249F; 9:134417293-134417293	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1029C>T; p.G343G; 9:134429226-134429226	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.635G>A; p.G212D; 9:134417182-134417182	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.635G>A; p.G212D; 9:134417182-134417182	urinary_tract; bladder	carcinoma	Substitution - Missense
c.722_723CC>TT; p.A241V; 9:134417269-134417270	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1328G>A; p.G443E; 9:134436553-134436553	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.300C>T; p.P100P; 9:134408169-134408169	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1112G>A; p.R371H; 9:134431973-134431973	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.950C>T; p.S317F; 9:134429147-134429147	skin	malignant_melanoma	Substitution - Missense
c.1054G>T; p.E352*; 9:134431915-134431915	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.489G>A; p.V163V; 9:134408998-134408998	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.747C>T; p.Y249Y; 9:134417294-134417294	pancreas	carcinoma	Substitution - coding silent
c.747C>T; p.Y249Y; 9:134417294-134417294	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.649G>T; p.E217*; 9:134417196-134417196	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.209delC; p.M72fs*27; 9:134401812-134401812	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.80C>G; p.S27C; 9:134401683-134401683	urinary_tract; bladder	carcinoma	Substitution - Missense
c.910+1G>T; p.?; 9:134421806-134421806	ovary	carcinoma; serous_carcinoma	Unknown
c.744C>A; p.T248T; 9:134417291-134417291	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.972C>T; p.I324I; 9:134429169-134429169	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.947G>T; p.R316L; 9:134429144-134429144	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.595G>A; p.G199S; 9:134409104-134409104	central_nervous_system; brain	glioma	Substitution - Missense
c.1261C>T; p.R421C; 9:134436486-134436486	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.321C>T; p.I107I; 9:134408190-134408190	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.233C>T; p.S78L; 9:134401836-134401836	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.669C>T; p.T223T; 9:134417216-134417216	breast	carcinoma	Substitution - coding silent
c.485C>T; p.T162M; 9:134408994-134408994	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.485C>T; p.T162M; 9:134408994-134408994	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1260C>T; p.L420L; 9:134436485-134436485	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.69G>T; p.T23T; 9:134401672-134401672	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.72G>T; p.G24G; 9:134401675-134401675	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1260C>G; p.L420L; 9:134436485-134436485	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.885C>T; p.D295D; 9:134421780-134421780	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1375C>A; p.H459N; 9:134436600-134436600	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1159G>T; p.A387S; 9:134434125-134434125	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.931G>A; p.A311T; 9:134429128-134429128	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.571C>G; p.R191G; 9:134409080-134409080	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1343A>G; p.D448G; 9:134436568-134436568	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1188C>T; p.V396V; 9:134434154-134434154	prostate	carcinoma	Substitution - coding silent
c.532C>G; p.L178V; 9:134409041-134409041	urinary_tract; bladder	carcinoma	Substitution - Missense
c.73C>T; p.R25*; 9:134401676-134401676	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.73C>T; p.R25*; 9:134401676-134401676	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1371G>T; p.A457A; 9:134436596-134436596	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1371G>T; p.A457A; 9:134436596-134436596	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1269G>A; p.P423P; 9:134436494-134436494	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1242-1G>T; p.?; 9:134436466-134436466	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.312C>T; p.S104S; 9:134408181-134408181	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.692C>T; p.P231L; 9:134417239-134417239	breast	carcinoma	Substitution - Missense
c.692C>T; p.P231L; 9:134417239-134417239	prostate	carcinoma	Substitution - Missense
c.1336C>T; p.P446S; 9:134436561-134436561	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1246G>A; p.A416T; 9:134436471-134436471	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.325delC; p.L111fs*57; 9:134408194-134408194	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.325delC; p.L111fs*57; 9:134408194-134408194	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.139C>G; p.L47V; 9:134401742-134401742	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>T; p.S427F; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.905G>A; p.R302Q; 9:134421800-134421800	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1280C>A; p.S427Y; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>A; p.S427Y; 9:134436505-134436505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1280C>A; p.S427Y; 9:134436505-134436505	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.947G>A; p.R316H; 9:134429144-134429144	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.853C>T; p.R285W; 9:134421748-134421748	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1147C>T; p.L383F; 9:134434113-134434113	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.833C>T; p.T278I; 9:134421728-134421728	skin	malignant_melanoma	Substitution - Missense
c.1157_1158insCGG; p.P386_A387insG; 9:134434123-134434124	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Insertion - In frame
c.984C>A; p.T328T; 9:134429181-134429181	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.361G>A; p.A121T; 9:134408230-134408230	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.547C>T; p.Q183*; 9:134409056-134409056	skin	malignant_melanoma	Substitution - Nonsense
c.1003_1004insA; p.N335fs*13; 9:134429200-134429201	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.200T>C; p.V67A; 9:134401803-134401803	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1235C>A; p.P412Q; 9:134434201-134434201	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.431-6C>T; p.?; 9:134408934-134408934	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.1285G>C; p.G429R; 9:134436510-134436510	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1136-3C>T; p.?; 9:134434099-134434099	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Unknown
c.346G>A; p.V116I; 9:134408215-134408215	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.521A>T; p.N174I; 9:134409030-134409030	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.128C>T; p.S43F; 9:134401731-134401731	skin	malignant_melanoma	Substitution - Missense
c.748G>T; p.V250L; 9:134417295-134417295	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.508A>C; p.T170P; 9:134409017-134409017	thyroid	other; neoplasm	Substitution - Missense
c.491G>A; p.R164H; 9:134409000-134409000	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.491G>A; p.R164H; 9:134409000-134409000	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.189G>A; p.P63P; 9:134401792-134401792	central_nervous_system; brain	glioma	Substitution - coding silent
c.1190A>G; p.Y397C; 9:134434156-134434156	ovary	carcinoma; serous_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation