lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6199
Symbol	RPS6KB2
Synonymous	KLS\|P70-beta\|P70-beta-1\|P70-beta-2\|S6K-beta2\|S6K2\|SRK\|STK14B\|p70(S6K)-beta\|p70S6Kb
Full name	ribosomal protein S6 kinase, 70kDa, polypeptide 2
Gene description	70 kDa ribosomal protein S6 kinase 2\|P70S6K2\|S6 kinase-related kinase\|S6K-beta\|S6K-beta-2\|p70 S6 kinase beta\|p70 S6K-beta\|p70 S6KB\|p70 ribosomal S6 kinase beta\|p70-S6K 2\|ribosomal protein S6 kinase beta-2\|serine/threonine-protein kinase 14 beta\|serine/thr
Cytoband	11q13.2
Gene type	protein-coding
Synonymous	MIM:608939; HGNC:HGNC:10437; Ensembl:ENSG00000175634; HPRD:10203; Vega:OTTHUMG00000167673

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.669C>T; p.G223G; 11:67433004-67433004	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.543C>G; p.A181A; 11:67432764-67432764	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.1436G>A; p.R479H; 11:67435156-67435156	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.877A>C; p.T293P; 11:67433418-67433418	breast	carcinoma	Substitution - Missense
c.360G>A; p.R120R; 11:67431418-67431418	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.906G>C; p.K302N; 11:67433447-67433447	prostate	carcinoma	Substitution - Missense
c.90C>T; p.P30P; 11:67428993-67428993	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.405C>A; p.A135A; 11:67431463-67431463	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.165G>A; p.V55V; 11:67429165-67429165	breast	carcinoma	Substitution - coding silent
c.1049A>G; p.Q350R; 11:67434378-67434378	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1070A>T; p.Q357L; 11:67434399-67434399	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1361C>T; p.P454L; 11:67435081-67435081	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.984_985CC>TT; p.R329W; 11:67434212-67434213	skin	malignant_melanoma	Substitution - Missense
c.984_985CC>TT; p.R329W; 11:67434212-67434213	skin	malignant_melanoma	Substitution - Missense
c.986G>A; p.R329Q; 11:67434214-67434214	salivary_gland	carcinoma	Substitution - Missense
c.1098G>A; p.T366T; 11:67434427-67434427	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1156-9G>A; p.?; 11:67434573-67434573	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.182G>A; p.R61H; 11:67429182-67429182	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.672C>T; p.A224A; 11:67433007-67433007	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1320G>A; p.P440P; 11:67435040-67435040	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.647G>A; p.C216Y; 11:67432982-67432982	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.648C>T; p.C216C; 11:67432983-67432983	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1101G>A; p.P367P; 11:67434430-67434430	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1362G>T; p.P454P; 11:67435082-67435082	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.383A>G; p.H128R; 11:67431441-67431441	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.843C>T; p.I281I; 11:67433384-67433384	skin	malignant_melanoma	Substitution - coding silent
c.516C>T; p.C172C; 11:67432737-67432737	prostate	carcinoma	Substitution - coding silent
c.459T>G; p.G153G; 11:67432601-67432601	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1176G>A; p.P392P; 11:67434602-67434602	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1040C>A; p.P347H; 11:67434268-67434268	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1362G>A; p.P454P; 11:67435082-67435082	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1091G>A; p.R364Q; 11:67434420-67434420	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1097C>T; p.T366M; 11:67434426-67434426	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1402T>C; p.S468P; 11:67435122-67435122	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1066A>G; p.S356G; 11:67434395-67434395	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1066A>G; p.S356G; 11:67434395-67434395	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.529G>A; p.E177K; 11:67432750-67432750	breast	carcinoma	Substitution - Missense
c.198C>A; p.C66*; 11:67429198-67429198	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.515+2T>C; p.?; 11:67432659-67432659	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1155+1G>C; p.?; 11:67434485-67434485	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.698T>C; p.I233T; 11:67433033-67433033	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.326A>G; p.N109S; 11:67431384-67431384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.326A>G; p.N109S; 11:67431384-67431384	genital_tract; extragonadal	germ_cell_tumour; teratoma	Substitution - Missense
c.326A>G; p.N109S; 11:67431384-67431384	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.906+1G>T; p.?; 11:67433448-67433448	breast	carcinoma	Unknown
c.1143C>T; p.N381N; 11:67434472-67434472	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.851G>T; p.G284V; 11:67433392-67433392	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.835G>A; p.D279N; 11:67433376-67433376	skin	malignant_melanoma	Substitution - Missense
c.986G>T; p.R329L; 11:67434214-67434214	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.985C>T; p.R329W; 11:67434213-67434213	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.985C>T; p.R329W; 11:67434213-67434213	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.407A>G; p.Y136C; 11:67431465-67431465	stomach	carcinoma	Substitution - Missense
c.240+6G>A; p.?; 11:67429246-67429246	central_nervous_system; brain	glioma	Unknown
c.240+6G>A; p.?; 11:67429246-67429246	central_nervous_system; brain	glioma	Unknown
c.1086C>T; p.F362F; 11:67434415-67434415	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1086C>T; p.F362F; 11:67434415-67434415	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1378G>A; p.A460T; 11:67435098-67435098	breast	carcinoma	Substitution - Missense
c.923C>T; p.P308L; 11:67434011-67434011	skin	malignant_melanoma	Substitution - Missense
c.358C>T; p.R120W; 11:67431416-67431416	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1328C>T; p.T443M; 11:67435048-67435048	ovary	carcinoma; mucinous_carcinoma	Substitution - Missense
c.1328C>T; p.T443M; 11:67435048-67435048	ovary	carcinoma; mucinous_carcinoma	Substitution - Missense
c.979delT; p.F328fs*4; 11:67434207-67434207	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1019G>A; p.R340H; 11:67434247-67434247	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1259C>T; p.A420V; 11:67434685-67434685	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1259C>T; p.A420V; 11:67434685-67434685	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1259C>T; p.A420V; 11:67434685-67434685	breast	carcinoma	Substitution - Missense
c.245T>G; p.F82C; 11:67429531-67429531	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.840G>C; p.K280N; 11:67433381-67433381	breast	carcinoma	Substitution - Missense
c.1002C>T; p.D334D; 11:67434230-67434230	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.142G>T; p.V48L; 11:67429142-67429142	liver	carcinoma	Substitution - Missense
c.311C>T; p.A104V; 11:67431369-67431369	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.807C>T; p.F269F; 11:67433348-67433348	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1319C>T; p.P440L; 11:67435039-67435039	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.807C>T; p.F269F; 11:67433348-67433348	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.807C>T; p.F269F; 11:67433348-67433348	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1093C>T; p.Q365*; 11:67434422-67434422	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.135T>C; p.Y45Y; 11:67429135-67429135	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1090C>T; p.R364W; 11:67434419-67434419	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1090C>T; p.R364W; 11:67434419-67434419	thyroid	carcinoma	Substitution - Missense
c.907-8T>C; p.?; 11:67433987-67433987	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Unknown
c.733G>T; p.G245C; 11:67433151-67433151	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.606C>T; p.L202L; 11:67432827-67432827	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1339C>G; p.L447V; 11:67435059-67435059	breast	carcinoma	Substitution - Missense
c.673G>A; p.V225I; 11:67433008-67433008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.442C>T; p.L148F; 11:67431500-67431500	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation