lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6185
Symbol	RPN2
Synonymous	RIBIIR\|RPN-II\|RPNII\|SWP1
Full name	ribophorin II
Gene description	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit\|dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2\|oligosaccharyltransferase complex subunit (non-catalytic)\|ribophorin-2
Cytoband	20q12-q13.1
Gene type	protein-coding
Synonymous	MIM:180490; HGNC:HGNC:10382; Ensembl:ENSG00000118705; HPRD:01609; Vega:OTTHUMG00000032409

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1839G>A; p.T613T; 20:37236665-37236665	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1839G>A; p.T613T; 20:37236665-37236665	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1015G>A; p.V339I; 20:37213788-37213788	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1511A>G; p.K504R; 20:37229989-37229989	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.127C>T; p.R43C; 20:37184293-37184293	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1461T>C; p.D487D; 20:37228711-37228711	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.781G>C; p.V261L; 20:37207363-37207363	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1722T>C; p.P574P; 20:37234064-37234064	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1726A>G; p.T576A; 20:37234068-37234068	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1096A>G; p.R366G; 20:37223881-37223881	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.308C>G; p.S103C; 20:37199054-37199054	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1343T>G; p.V448G; 20:37228593-37228593	breast	carcinoma	Substitution - Missense
c.99C>T; p.D33D; 20:37184265-37184265	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1536G>A; p.S512S; 20:37230014-37230014	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1031G>T; p.G344V; 20:37213804-37213804	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1242C>T; p.F414F; 20:37225745-37225745	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.104A>G; p.E35G; 20:37184270-37184270	pancreas	other; adenoma	Substitution - Missense
c.975C>T; p.F325F; 20:37210154-37210154	skin	malignant_melanoma	Substitution - coding silent
c.451C>T; p.R151C; 20:37199197-37199197	skin	malignant_melanoma	Substitution - Missense
c.211G>T; p.A71S; 20:37198400-37198400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1612C>T; p.P538S; 20:37232326-37232326	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1048G>T; p.V350F; 20:37213821-37213821	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.715G>A; p.A239T; 20:37207297-37207297	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.582C>T; p.L194L; 20:37204793-37204793	pancreas	carcinoma	Substitution - coding silent
c.1878C>G; p.V626V; 20:37236704-37236704	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.304-10T>G; p.?; 20:37199040-37199040	liver	carcinoma	Unknown
c.304-10T>G; p.?; 20:37199040-37199040	liver	carcinoma	Unknown
c.304-10T>G; p.?; 20:37199040-37199040	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.499A>G; p.T167A; 20:37203904-37203904	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1564C>A; p.P522T; 20:37230042-37230042	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.703C>T; p.Q235*; 20:37207285-37207285	skin	malignant_melanoma	Substitution - Nonsense
c.1309C>T; p.R437*; 20:37228559-37228559	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.825T>C; p.P275P; 20:37207407-37207407	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.825T>C; p.P275P; 20:37207407-37207407	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.803A>G; p.H268R; 20:37207385-37207385	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.989A>G; p.D330G; 20:37213762-37213762	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1371C>T; p.N457N; 20:37228621-37228621	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.199G>T; p.D67Y; 20:37184365-37184365	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.92A>G; p.K31R; 20:37184258-37184258	skin	malignant_melanoma	Substitution - Missense
c.1719T>C; p.A573A; 20:37234061-37234061	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.524C>G; p.A175G; 20:37203929-37203929	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.796C>T; p.R266C; 20:37207378-37207378	skin; sole	malignant_melanoma; acral_lentiginous	Substitution - Missense
c.1408A>G; p.I470V; 20:37228658-37228658	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.155T>C; p.F52S; 20:37184321-37184321	haematopoietic_and_lymphoid_tissue; breast	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1230C>T; p.S410S; 20:37225733-37225733	skin	malignant_melanoma	Substitution - coding silent
c.479C>T; p.A160V; 20:37199225-37199225	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1727C>T; p.T576M; 20:37234069-37234069	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1254C>T; p.F418F; 20:37225757-37225757	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1589T>C; p.F530S; 20:37232303-37232303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1464C>A; p.A488A; 20:37228714-37228714	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1704C>T; p.S568S; 20:37234046-37234046	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.166G>A; p.V56M; 20:37184332-37184332	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1701C>T; p.V567V; 20:37234043-37234043	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.567T>G; p.A189A; 20:37204778-37204778	skin	malignant_melanoma	Substitution - coding silent
c.1700T>C; p.V567A; 20:37234042-37234042	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.442C>T; p.L148F; 20:37199188-37199188	skin; trunk	malignant_melanoma	Substitution - Missense
c.1700T>C; p.V567A; 20:37234042-37234042	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.636G>C; p.V212V; 20:37204847-37204847	pancreas	carcinoma	Substitution - coding silent
c.1071G>A; p.R357R; 20:37213844-37213844	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.367A>G; p.T123A; 20:37199113-37199113	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1532C>A; p.P511H; 20:37230010-37230010	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.751G>A; p.E251K; 20:37207333-37207333	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.751G>A; p.E251K; 20:37207333-37207333	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.643A>C; p.T215P; 20:37204854-37204854	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1693G>T; p.A565S; 20:37234035-37234035	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1063G>T; p.D355Y; 20:37213836-37213836	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.654C>T; p.L218L; 20:37204865-37204865	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.654C>T; p.L218L; 20:37204865-37204865	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1579C>T; p.Q527*; 20:37230057-37230057	breast	carcinoma	Substitution - Nonsense
c.34T>C; p.L12L; 20:37184200-37184200	skin	malignant_melanoma	Substitution - coding silent
c.1565C>T; p.P522L; 20:37230043-37230043	skin; arm	malignant_melanoma	Substitution - Missense
c.71C>T; p.T24M; 20:37184237-37184237	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.301G>T; p.E101*; 20:37198490-37198490	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1701C>A; p.V567V; 20:37234043-37234043	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1372G>T; p.V458L; 20:37228622-37228622	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.135C>G; p.F45L; 20:37184301-37184301	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.215G>A; p.C72Y; 20:37198404-37198404	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.821T>A; p.V274E; 20:37207403-37207403	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1379A>C; p.K460T; 20:37228629-37228629	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.681C>T; p.S227S; 20:37204892-37204892	skin	malignant_melanoma	Substitution - coding silent
c.435C>G; p.L145L; 20:37199181-37199181	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.125A>G; p.D42G; 20:37184291-37184291	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.946A>G; p.R316G; 20:37210125-37210125	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1699G>A; p.V567I; 20:37234041-37234041	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.789G>A; p.S263S; 20:37207371-37207371	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.412C>T; p.P138S; 20:37199158-37199158	skin	malignant_melanoma	Substitution - Missense
c.1824C>T; p.I608I; 20:37236650-37236650	skin	malignant_melanoma	Substitution - coding silent
c.1304T>C; p.F435S; 20:37228554-37228554	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1656G>T; p.P552P; 20:37232370-37232370	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1611C>T; p.P537P; 20:37232325-37232325	skin	malignant_melanoma	Substitution - coding silent
c.1825C>T; p.L609L; 20:37236651-37236651	thyroid	other; neoplasm	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation