lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6097
Symbol	RORC
Synonymous	NR1F3\|RORG\|RZR-GAMMA\|RZRG\|TOR
Full name	RAR-related orphan receptor C
Gene description	RAR-related orphan nuclear receptor variant 2\|nuclear receptor ROR-gamma\|nuclear receptor RZR-gamma\|nuclear receptor subfamily 1 group F member 3\|retinoic acid-binding receptor gamma\|retinoid-related orphan receptor gamma
Cytoband	1q21
Gene type	protein-coding
Synonymous	MIM:602943; HGNC:HGNC:10260; Ensembl:ENSG00000143365; HPRD:04250; Vega:OTTHUMG00000013053

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1455C>T; p.I485I; 1:151807574-151807574	skin	malignant_melanoma	Substitution - coding silent
c.963C>A; p.A321A; 1:151813591-151813591	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1106A>G; p.Y369C; 1:151813307-151813307	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.807G>T; p.E269D; 1:151814917-151814917	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.516T>C; p.C172C; 1:151815208-151815208	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.291_292CC>TT; p.R98*; 1:151816670-151816671	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.590G>A; p.G197E; 1:151815134-151815134	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.1488C>A; p.A496A; 1:151807541-151807541	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1002C>T; p.F334F; 1:151813552-151813552	skin	malignant_melanoma	Substitution - coding silent
c.1241A>T; p.E414V; 1:151812991-151812991	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.130G>A; p.G44R; 1:151817221-151817221	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.754G>T; p.G252C; 1:151814970-151814970	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.700G>A; p.E234K; 1:151815024-151815024	skin	malignant_melanoma	Substitution - Missense
c.666C>T; p.S222S; 1:151815058-151815058	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1120C>T; p.R374C; 1:151813293-151813293	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1120C>T; p.R374C; 1:151813293-151813293	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1211C>T; p.S404F; 1:151813021-151813021	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1211C>T; p.S404F; 1:151813021-151813021	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1504T>A; p.Y502N; 1:151807525-151807525	liver	carcinoma	Substitution - Missense
c.1288C>T; p.R430W; 1:151811432-151811432	kidney	other; neoplasm	Substitution - Missense
c.40G>A; p.E14K; 1:151831725-151831725	breast	carcinoma	Substitution - Missense
c.292C>T; p.R98*; 1:151816670-151816670	pancreas	carcinoma	Substitution - Nonsense
c.1008G>A; p.K336K; 1:151813546-151813546	liver	carcinoma	Substitution - coding silent
c.1010G>A; p.R337K; 1:151813544-151813544	skin	malignant_melanoma	Substitution - Missense
c.518C>T; p.P173L; 1:151815206-151815206	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.310G>A; p.G104S; 1:151815414-151815414	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.310G>A; p.G104S; 1:151815414-151815414	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1130T>A; p.F377Y; 1:151813283-151813283	skin	malignant_melanoma	Substitution - Missense
c.1285C>T; p.H429Y; 1:151812947-151812947	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.725G>T; p.G242V; 1:151814999-151814999	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.625G>A; p.G209S; 1:151815099-151815099	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.465C>T; p.D155D; 1:151815259-151815259	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.465C>T; p.D155D; 1:151815259-151815259	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.465C>T; p.D155D; 1:151815259-151815259	pancreas	carcinoma	Substitution - coding silent
c.461C>T; p.P154L; 1:151815263-151815263	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.114G>A; p.S38S; 1:151817237-151817237	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1146C>T; p.Y382Y; 1:151813267-151813267	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1203T>A; p.F401L; 1:151813029-151813029	skin	malignant_melanoma	Substitution - Missense
c.1146C>T; p.Y382Y; 1:151813267-151813267	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.551C>T; p.P184L; 1:151815173-151815173	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.794C>T; p.A265V; 1:151814930-151814930	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1481T>C; p.V494A; 1:151807548-151807548	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1200C>A; p.I400I; 1:151813032-151813032	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.488C>T; p.S163L; 1:151815236-151815236	skin	malignant_melanoma	Substitution - Missense
c.278C>A; p.A93E; 1:151816684-151816684	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.35C>T; p.S12L; 1:151831730-151831730	skin	malignant_melanoma	Substitution - Missense
c.1476C>T; p.I492I; 1:151807553-151807553	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.278C>A; p.A93E; 1:151816684-151816684	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.661G>A; p.G221S; 1:151815063-151815063	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myelomonocytic_leukaemia	Substitution - Missense
c.1162T>C; p.F388L; 1:151813251-151813251	skin	malignant_melanoma	Substitution - Missense
c.624G>A; p.R208R; 1:151815100-151815100	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1148G>A; p.G383D; 1:151813265-151813265	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1034G>A; p.C345Y; 1:151813520-151813520	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.1318G>A; p.E440K; 1:151811402-151811402	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1155G>A; p.M385I; 1:151813258-151813258	skin	malignant_melanoma	Substitution - Missense
c.531G>A; p.L177L; 1:151815193-151815193	breast	carcinoma	Substitution - coding silent
c.502G>A; p.E168K; 1:151815222-151815222	breast	carcinoma	Substitution - Missense
c.1488C>T; p.A496A; 1:151807541-151807541	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1532A>T; p.E511V; 1:151807497-151807497	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.501T>A; p.P167P; 1:151815223-151815223	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.263T>C; p.L88P; 1:151816699-151816699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.29G>A; p.R10Q; 1:151831736-151831736	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.695G>A; p.R232H; 1:151815029-151815029	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.999G>A; p.E333E; 1:151813555-151813555	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.942G>A; p.W314*; 1:151813612-151813612	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1067-2A>G; p.?; 1:151813348-151813348	ovary	other; neoplasm	Unknown
c.1169C>T; p.A390V; 1:151813244-151813244	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.1480G>T; p.V494F; 1:151807549-151807549	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1114G>A; p.D372N; 1:151813299-151813299	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1262C>T; p.T421I; 1:151812970-151812970	liver	carcinoma	Substitution - Missense
c.1262C>T; p.T421I; 1:151812970-151812970	liver	carcinoma	Substitution - Missense
c.1178G>A; p.C393Y; 1:151813054-151813054	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1482C>T; p.V494V; 1:151807547-151807547	skin	malignant_melanoma	Substitution - coding silent
c.1256T>A; p.L419H; 1:151812976-151812976	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1256T>A; p.L419H; 1:151812976-151812976	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1256T>A; p.L419H; 1:151812976-151812976	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1256T>A; p.L419H; 1:151812976-151812976	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1256T>A; p.L419H; 1:151812976-151812976	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1256T>A; p.L419H; 1:151812976-151812976	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1256T>A; p.L419H; 1:151812976-151812976	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1256T>A; p.L419H; 1:151812976-151812976	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1183G>A; p.E395K; 1:151813049-151813049	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1530C>T; p.T510T; 1:151807499-151807499	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	Substitution - coding silent
c.1530C>T; p.T510T; 1:151807499-151807499	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - coding silent
c.863G>A; p.R288Q; 1:151814644-151814644	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.223_224insA; p.I75fs*91; 1:151816738-151816739	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1288C>A; p.R430R; 1:151811432-151811432	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.105G>A; p.G35G; 1:151817246-151817246	skin	malignant_melanoma	Substitution - coding silent
c.651C>A; p.F217L; 1:151815073-151815073	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.655A>G; p.S219G; 1:151815069-151815069	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1275C>T; p.L425L; 1:151812957-151812957	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1275C>T; p.L425L; 1:151812957-151812957	skin	malignant_melanoma	Substitution - coding silent
c.48G>T; p.L16L; 1:151829451-151829451	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.428G>A; p.G143E; 1:151815296-151815296	skin	malignant_melanoma	Substitution - Missense
c.829G>A; p.V277I; 1:151814678-151814678	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.423C>T; p.A141A; 1:151815301-151815301	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1193G>A; p.S398N; 1:151813039-151813039	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.683G>A; p.R228Q; 1:151815041-151815041	skin	malignant_melanoma	Substitution - Missense
c.683G>A; p.R228Q; 1:151815041-151815041	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.683G>A; p.R228Q; 1:151815041-151815041	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.683G>A; p.R228Q; 1:151815041-151815041	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1266C>T; p.A422A; 1:151812966-151812966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.39G>A; p.R13R; 1:151831726-151831726	skin	malignant_melanoma	Substitution - coding silent
c.636G>A; p.E212E; 1:151815088-151815088	skin	malignant_melanoma	Substitution - coding silent
c.1477G>A; p.V493M; 1:151807552-151807552	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.13_14CC>TT; p.P5L; 1:151831751-151831752	skin; scalp	malignant_melanoma	Substitution - Missense
c.1124C>T; p.T375M; 1:151813289-151813289	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.980C>A; p.A327D; 1:151813574-151813574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.129C>T; p.Y43Y; 1:151817222-151817222	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.504G>T; p.E168D; 1:151815220-151815220	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.112T>C; p.S38P; 1:151817239-151817239	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.979G>T; p.A327S; 1:151813575-151813575	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.157G>A; p.G53S; 1:151816805-151816805	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1531G>T; p.E511*; 1:151807498-151807498	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.557A>T; p.Y186F; 1:151815167-151815167	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1099C>T; p.R367W; 1:151813314-151813314	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.755G>A; p.G252D; 1:151814969-151814969	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.1099C>T; p.R367W; 1:151813314-151813314	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1045C>A; p.Q349K; 1:151813509-151813509	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.372G>C; p.Q124H; 1:151815352-151815352	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.149_150GG>AA; p.G50E; 1:151817201-151817202	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1246G>A; p.E416K; 1:151812986-151812986	urinary_tract; bladder	carcinoma	Substitution - Missense
c.779C>T; p.P260L; 1:151814945-151814945	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.828C>T; p.S276S; 1:151814679-151814679	pancreas	carcinoma	Substitution - coding silent
c.617C>A; p.P206H; 1:151815107-151815107	large_intestine; colon	carcinoma	Substitution - Missense
c.617C>A; p.P206H; 1:151815107-151815107	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.779C>T; p.P260L; 1:151814945-151814945	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1032C>G; p.L344L; 1:151813522-151813522	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1032C>G; p.L344L; 1:151813522-151813522	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.933G>A; p.K311K; 1:151814574-151814574	skin	malignant_melanoma	Substitution - coding silent
c.229C>T; p.R77C; 1:151816733-151816733	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.170G>A; p.R57Q; 1:151816792-151816792	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.902C>T; p.S301F; 1:151814605-151814605	pancreas	carcinoma	Substitution - Missense
c.170G>A; p.R57Q; 1:151816792-151816792	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.902C>T; p.S301F; 1:151814605-151814605	pancreas	carcinoma	Substitution - Missense
c.4G>A; p.D2N; 1:151831761-151831761	skin	malignant_melanoma	Substitution - Missense
c.166C>T; p.R56C; 1:151816796-151816796	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.41-1G>A; p.?; 1:151829459-151829459	urinary_tract; bladder	carcinoma	Unknown
c.1049T>G; p.I350S; 1:151813505-151813505	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.433G>C; p.D145H; 1:151815291-151815291	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1336C>A; p.L446M; 1:151811384-151811384	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.847G>A; p.E283K; 1:151814660-151814660	breast	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation