lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	6041
Symbol	RNASEL
Synonymous	PRCA1\|RNS4
Full name	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Gene description	2',5'-oligoisoadenylate synthetase-dependent\|2-5A-dependent RNase\|2-5A-dependent ribonuclease\|RNase L\|interferon-induced 2-5A-dependent RNase\|ribonuclease 4
Cytoband	1q25
Gene type	protein-coding
Synonymous	MIM:180435; HGNC:HGNC:10050; Ensembl:ENSG00000135828; HPRD:01590; Vega:OTTHUMG00000035213

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1872A>T; p.E624D; 1:182581258-182581258	thyroid	other; neoplasm	Substitution - Missense
c.2190T>C; p.A730A; 1:182575428-182575428	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1019G>A; p.S340N; 1:182585788-182585788	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.265A>G; p.K89E; 1:182586542-182586542	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1524C>A; p.I508I; 1:182584123-182584123	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.123C>T; p.V41V; 1:182586684-182586684	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1842C>T; p.I614I; 1:182581288-182581288	skin	malignant_melanoma	Substitution - coding silent
c.827C>A; p.A276E; 1:182585980-182585980	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1955G>C; p.G652A; 1:182576340-182576340	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1978G>T; p.G660C; 1:182576317-182576317	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1654C>T; p.Q552*; 1:182582171-182582171	breast	carcinoma	Substitution - Nonsense
c.887G>T; p.G296V; 1:182585920-182585920	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.11G>T; p.R4M; 1:182586796-182586796	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1479A>C; p.I493I; 1:182585328-182585328	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1874A>T; p.H625L; 1:182581256-182581256	thyroid	other; neoplasm	Substitution - Missense
c.133C>A; p.L45M; 1:182586674-182586674	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.16C>G; p.H6D; 1:182586791-182586791	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1520G>A; p.S507N; 1:182584127-182584127	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.354C>T; p.V118V; 1:182586453-182586453	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.26C>T; p.P9L; 1:182586781-182586781	skin	malignant_melanoma	Substitution - Missense
c.928C>T; p.R310W; 1:182585879-182585879	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1385G>A; p.R462Q; 1:182585422-182585422	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.928C>T; p.R310W; 1:182585879-182585879	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1385G>A; p.R462Q; 1:182585422-182585422	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2201G>T; p.S734I; 1:182575417-182575417	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1198C>A; p.R400S; 1:182585609-182585609	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1388delA; p.N463fs*30; 1:182585419-182585419	ovary	carcinoma; mucinous_carcinoma	Deletion - Frameshift
c.1388delA; p.N463fs*30; 1:182585419-182585419	ovary	carcinoma; mucinous_carcinoma	Deletion - Frameshift
c.1545G>T; p.Q515H; 1:182584102-182584102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1335G>T; p.L445F; 1:182585472-182585472	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.282G>A; p.T94T; 1:182586525-182586525	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.282G>A; p.T94T; 1:182586525-182586525	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.945C>T; p.S315S; 1:182585862-182585862	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.670C>T; p.L224L; 1:182586137-182586137	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1809C>T; p.S603S; 1:182581321-182581321	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.589G>A; p.A197T; 1:182586218-182586218	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2148C>T; p.F716F; 1:182575470-182575470	skin	malignant_melanoma	Substitution - coding silent
c.2148C>T; p.F716F; 1:182575470-182575470	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2148C>T; p.F716F; 1:182575470-182575470	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1785G>A; p.T595T; 1:182581345-182581345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2148C>T; p.F716F; 1:182575470-182575470	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.464G>A; p.R155Q; 1:182586343-182586343	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1924A>G; p.K642E; 1:182576371-182576371	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1804G>C; p.E602Q; 1:182581326-182581326	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.502G>T; p.G168W; 1:182586305-182586305	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1358T>C; p.V453A; 1:182585449-182585449	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2060A>G; p.D687G; 1:182575558-182575558	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2059G>A; p.D687N; 1:182575559-182575559	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2060A>G; p.D687G; 1:182575558-182575558	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2060A>G; p.D687G; 1:182575558-182575558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1686C>A; p.L562L; 1:182582139-182582139	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.327A>C; p.K109N; 1:182586480-182586480	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1923G>A; p.M641I; 1:182576372-182576372	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1578G>A; p.R526R; 1:182582247-182582247	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.844G>T; p.E282*; 1:182585963-182585963	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1578G>A; p.R526R; 1:182582247-182582247	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.295G>A; p.A99T; 1:182586512-182586512	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1397C>T; p.S466L; 1:182585410-182585410	breast	carcinoma	Substitution - Missense
c.295G>A; p.A99T; 1:182586512-182586512	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.998C>A; p.A333D; 1:182585809-182585809	breast	carcinoma	Substitution - Missense
c.383C>T; p.A128V; 1:182586424-182586424	skin	malignant_melanoma	Substitution - Missense
c.1776C>T; p.R592R; 1:182581354-182581354	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.196G>A; p.A66T; 1:182586611-182586611	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1930_1931insA; p.M644fs*3; 1:182576364-182576365	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.901T>C; p.C301R; 1:182585906-182585906	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1616T>C; p.F539S; 1:182582209-182582209	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.429C>T; p.F143F; 1:182586378-182586378	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1750C>T; p.P584S; 1:182582075-182582075	skin	malignant_melanoma	Substitution - Missense
c.2027A>G; p.E676G; 1:182576268-182576268	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2027A>G; p.E676G; 1:182576268-182576268	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1823G>A; p.R608Q; 1:182581307-182581307	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Missense
c.1518G>C; p.K506N; 1:182584129-182584129	oesophagus	carcinoma	Substitution - Missense
c.1393C>T; p.L465L; 1:182585414-182585414	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1693C>T; p.R565C; 1:182582132-182582132	skin	malignant_melanoma	Substitution - Missense
c.664A>T; p.T222S; 1:182586143-182586143	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.719A>C; p.K240T; 1:182586088-182586088	skin	malignant_melanoma	Substitution - Missense
c.1854G>A; p.L618L; 1:182581276-182581276	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.195C>T; p.N65N; 1:182586612-182586612	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1281G>T; p.R427S; 1:182585526-182585526	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1951_1952insA; p.R651fs*11; 1:182576343-182576344	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1951_1952insA; p.R651fs*11; 1:182576343-182576344	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1845C>T; p.L615L; 1:182581285-182581285	skin	malignant_melanoma	Substitution - coding silent
c.233T>C; p.L78P; 1:182586574-182586574	stomach	carcinoma	Substitution - Missense
c.2204G>A; p.G735E; 1:182575414-182575414	skin	malignant_melanoma	Substitution - Missense
c.1787T>G; p.L596R; 1:182581343-182581343	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1937A>C; p.K646T; 1:182576358-182576358	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.561C>T; p.L187L; 1:182586246-182586246	skin	malignant_melanoma	Substitution - coding silent
c.52G>A; p.G18S; 1:182586755-182586755	skin	malignant_melanoma	Substitution - Missense
c.312C>T; p.S104S; 1:182586495-182586495	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.408T>C; p.G136G; 1:182586399-182586399	skin	malignant_melanoma	Substitution - coding silent
c.312C>T; p.S104S; 1:182586495-182586495	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.956T>C; p.V319A; 1:182585851-182585851	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2203G>T; p.G735W; 1:182575415-182575415	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1906-2_1906-1insT; p.?; 1:182576390-182576391	stomach	adenocarcinoma	Unknown
c.176G>A; p.G59D; 1:182586631-182586631	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1869T>C; p.S623S; 1:182581261-182581261	thyroid	other; neoplasm	Substitution - coding silent
c.1502T>C; p.L501P; 1:182584145-182584145	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1033delG; p.A345fs*3; 1:182585774-182585774	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1235G>A; p.R412Q; 1:182585572-182585572	central_nervous_system; brain	glioma	Substitution - Missense
c.652G>A; p.V218M; 1:182586155-182586155	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1443C>T; p.Y481Y; 1:182585364-182585364	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1626G>T; p.L542L; 1:182582199-182582199	skin	malignant_melanoma	Substitution - coding silent
c.698A>G; p.N233S; 1:182586109-182586109	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1912G>T; p.E638*; 1:182576383-182576383	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1146delG; p.F383fs*7; 1:182585661-182585661	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.463C>T; p.R155*; 1:182586344-182586344	skin	malignant_melanoma	Substitution - Nonsense
c.864C>T; p.I288I; 1:182585943-182585943	skin	malignant_melanoma	Substitution - coding silent
c.864C>T; p.I288I; 1:182585943-182585943	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.808G>T; p.D270Y; 1:182585999-182585999	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1312G>T; p.E438*; 1:182585495-182585495	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.333C>T; p.F111F; 1:182586474-182586474	skin	malignant_melanoma	Substitution - coding silent
c.523G>A; p.A175T; 1:182586284-182586284	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1287C>G; p.H429Q; 1:182585520-182585520	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1017G>C; p.Q339H; 1:182585790-182585790	pancreas	carcinoma	Substitution - Missense
c.1453G>T; p.D485Y; 1:182585354-182585354	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1539T>A; p.D513E; 1:182584108-182584108	liver	carcinoma	Substitution - Missense
c.1539T>A; p.D513E; 1:182584108-182584108	liver	carcinoma	Substitution - Missense
c.369T>G; p.F123L; 1:182586438-182586438	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1794T>C; p.N598N; 1:182581336-182581336	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.588C>T; p.N196N; 1:182586219-182586219	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1908T>G; p.I636M; 1:182576387-182576387	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2063C>A; p.P688H; 1:182575555-182575555	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1304C>A; p.T435N; 1:182585503-182585503	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.826G>T; p.A276S; 1:182585981-182585981	liver	carcinoma	Substitution - Missense
c.826G>T; p.A276S; 1:182585981-182585981	liver	carcinoma	Substitution - Missense
c.2225G>A; p.742; 1:182575393-182575393	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.157T>C; p.F53L; 1:182586650-182586650	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.98T>C; p.V33A; 1:182586709-182586709	skin	malignant_melanoma	Substitution - Missense
c.1288T>C; p.L430L; 1:182585519-182585519	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.115G>C; p.D39H; 1:182586692-182586692	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1556G>A; p.R519K; 1:182584091-182584091	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1651G>A; p.V551I; 1:182582174-182582174	skin	malignant_melanoma	Substitution - Missense
c.1928A>T; p.K643I; 1:182576367-182576367	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1906-3_1906-2insT; p.?; 1:182576391-182576392	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1906-3_1906-2insT; p.?; 1:182576391-182576392	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1906-3_1906-2insT; p.?; 1:182576391-182576392	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1404A>T; p.I468I; 1:182585403-182585403	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.506C>A; p.A169D; 1:182586301-182586301	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1225C>T; p.Q409*; 1:182585582-182585582	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.300G>A; p.A100A; 1:182586507-182586507	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1193G>T; p.S398I; 1:182585614-182585614	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.313G>A; p.V105M; 1:182586494-182586494	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1701C>T; p.F567F; 1:182582124-182582124	skin	malignant_melanoma	Substitution - coding silent
c.1380T>A; p.F460L; 1:182585427-182585427	skin	malignant_melanoma	Substitution - Missense
c.1626G>C; p.L542L; 1:182582199-182582199	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1199G>A; p.R400H; 1:182585608-182585608	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.991C>T; p.P331S; 1:182585816-182585816	skin	malignant_melanoma	Substitution - Missense
c.1742T>C; p.L581P; 1:182582083-182582083	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1584C>T; p.V528V; 1:182582241-182582241	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.305C>T; p.A102V; 1:182586502-182586502	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.305C>T; p.A102V; 1:182586502-182586502	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.541G>A; p.V181I; 1:182586266-182586266	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.338C>G; p.S113C; 1:182586469-182586469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2063C>T; p.P688L; 1:182575555-182575555	central_nervous_system; brain	glioma	Substitution - Missense
c.738A>C; p.A246A; 1:182586069-182586069	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1481-1G>T; p.?; 1:182584167-182584167	NS	NS	Unknown
c.2072A>G; p.Y691C; 1:182575546-182575546	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.105C>T; p.N35N; 1:182586702-182586702	stomach	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation