lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5800
Symbol	PTPRO
Synonymous	GLEPP1\|NPHS6\|PTP-OC\|PTP-U2\|PTPROT\|PTPU2\|R-PTP-O
Full name	protein tyrosine phosphatase, receptor type, O
Gene description	PTP phi\|PTPase U2\|glomerular epithelial protein 1\|osteoclastic transmembrane protein-tyrosine phosphatase\|phosphotyrosine phosphatase U2\|protein tyrosine phosphatase PTP-U2\|receptor-type tyrosine-protein phosphatase O
Cytoband	12p13.3-p13.2\|12p13-p12
Gene type	protein-coding
Synonymous	MIM:600579; HGNC:HGNC:9678; Ensembl:ENSG00000151490; HPRD:02784; Vega:OTTHUMG00000168786

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1626T>C; p.G542G; 12:15516803-15516803	thyroid	other; neoplasm	Substitution - coding silent
c.127T>C; p.S43P; 12:15484025-15484025	thyroid	carcinoma	Substitution - Missense
c.1228C>T; p.R410*; 12:15504030-15504030	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.356T>A; p.L119Q; 12:15497251-15497251	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.3036G>A; p.G1012G; 12:15580735-15580735	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1228C>T; p.R410*; 12:15504030-15504030	skin	malignant_melanoma	Substitution - Nonsense
c.412C>A; p.L138M; 12:15497307-15497307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3012C>A; p.P1004P; 12:15580711-15580711	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2305G>A; p.E769K; 12:15549094-15549094	skin	malignant_melanoma	Substitution - Missense
c.1133A>G; p.D378G; 12:15503935-15503935	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2644G>T; p.A882S; 12:15560209-15560209	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.2910C>A; p.N970K; 12:15578933-15578933	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2608G>A; p.G870R; 12:15557504-15557504	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.796C>T; p.H266Y; 12:15501754-15501754	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.796C>T; p.H266Y; 12:15501754-15501754	skin	malignant_melanoma	Substitution - Missense
c.3417C>T; p.G1139G; 12:15589461-15589461	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1798C>A; p.P600T; 12:15520219-15520219	breast	carcinoma	Substitution - Missense
c.2731A>T; p.K911*; 12:15565612-15565612	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2429C>A; p.S810*; 12:15549218-15549218	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.675T>C; p.P225P; 12:15501633-15501633	central_nervous_system; brain	glioma	Substitution - coding silent
c.2751G>A; p.P917P; 12:15569420-15569420	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.230C>T; p.T77I; 12:15484128-15484128	skin	malignant_melanoma	Substitution - Missense
c.1444G>A; p.E482K; 12:15508747-15508747	skin; chest	malignant_melanoma	Substitution - Missense
c.1465-4A>C; p.?; 12:15515494-15515494	liver	carcinoma	Unknown
c.129A>G; p.S43S; 12:15484027-15484027	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2021G>A; p.G674E; 12:15524943-15524943	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1749_1750AG>TT; p.A584S; 12:15516926-15516927	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1775C>T; p.S592F; 12:15516952-15516952	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1017C>T; p.S339S; 12:15501975-15501975	skin	malignant_melanoma	Substitution - coding silent
c.144C>T; p.D48D; 12:15484042-15484042	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.405A>C; p.T135T; 12:15497300-15497300	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1560T>G; p.P520P; 12:15515593-15515593	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1982C>T; p.S661F; 12:15524904-15524904	skin	malignant_melanoma	Substitution - Missense
c.1735A>G; p.T579A; 12:15516912-15516912	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2088C>A; p.G696G; 12:15526186-15526186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3176C>T; p.A1059V; 12:15581722-15581722	skin	malignant_melanoma	Substitution - Missense
c.1602G>A; p.K534K; 12:15516779-15516779	skin	malignant_melanoma	Substitution - coding silent
c.823C>T; p.P275S; 12:15501781-15501781	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2302C>T; p.Q768*; 12:15546706-15546706	skin	malignant_melanoma	Substitution - Nonsense
c.1355C>T; p.S452F; 12:15508658-15508658	skin	malignant_melanoma	Substitution - Missense
c.778G>A; p.G260R; 12:15501736-15501736	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2814T>G; p.F938L; 12:15569483-15569483	skin; upper_arm	malignant_melanoma	Substitution - Missense
c.3003C>T; p.Y1001Y; 12:15580702-15580702	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3476A>C; p.H1159P; 12:15589520-15589520	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2814T>G; p.F938L; 12:15569483-15569483	skin; upper_arm	malignant_melanoma	Substitution - Missense
c.691C>A; p.R231S; 12:15501649-15501649	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1714A>G; p.T572A; 12:15516891-15516891	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1843G>A; p.D615N; 12:15520264-15520264	parathyroid	carcinoma	Substitution - Missense
c.1843G>A; p.D615N; 12:15520264-15520264	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2541G>A; p.K847K; 12:15551654-15551654	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1053A>G; p.P351P; 12:15502011-15502011	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2423C>T; p.A808V; 12:15549212-15549212	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2487T>C; p.L829L; 12:15551600-15551600	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.216G>A; p.E72E; 12:15484114-15484114	skin	malignant_melanoma	Substitution - coding silent
c.3053G>A; p.R1018K; 12:15580752-15580752	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1088T>A; p.I363N; 12:15502046-15502046	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.686C>T; p.S229F; 12:15501644-15501644	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1904C>T; p.P635L; 12:15524826-15524826	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2257G>A; p.E753K; 12:15546661-15546661	skin	malignant_melanoma	Substitution - Missense
c.868G>T; p.D290Y; 12:15501826-15501826	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1973C>T; p.T658M; 12:15524895-15524895	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2899C>T; p.R967C; 12:15578922-15578922	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.3594G>A; p.K1198K; 12:15594984-15594984	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2879C>A; p.P960Q; 12:15578902-15578902	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.1106-1G>C; p.?; 12:15503907-15503907	urinary_tract; bladder	carcinoma	Unknown
c.2879C>A; p.P960Q; 12:15578902-15578902	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2535G>A; p.R845R; 12:15551648-15551648	skin	malignant_melanoma	Substitution - coding silent
c.291G>A; p.L97L; 12:15484189-15484189	pancreas	carcinoma	Substitution - coding silent
c.2138C>T; p.T713I; 12:15526236-15526236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1339A>G; p.T447A; 12:15508642-15508642	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1183delA; p.K395fs*4; 12:15503985-15503985	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.3410G>T; p.S1137I; 12:15587051-15587051	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.310G>T; p.V104L; 12:15484208-15484208	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.764C>T; p.S255L; 12:15501722-15501722	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1684G>T; p.V562L; 12:15516861-15516861	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2717A>T; p.K906I; 12:15565598-15565598	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2921A>G; p.Y974C; 12:15580039-15580039	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2785G>A; p.D929N; 12:15569454-15569454	skin; trunk	malignant_melanoma	Substitution - Missense
c.3262G>A; p.E1088K; 12:15586903-15586903	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.963C>T; p.Y321Y; 12:15501921-15501921	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.379T>C; p.Y127H; 12:15497274-15497274	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.4G>T; p.G2W; 12:15322730-15322730	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2741T>G; p.L914R; 12:15565622-15565622	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.295G>C; p.V99L; 12:15484193-15484193	breast	carcinoma	Substitution - Missense
c.3208G>T; p.E1070*; 12:15581754-15581754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2342C>T; p.S781F; 12:15549131-15549131	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2805C>A; p.D935E; 12:15569474-15569474	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.19G>A; p.G7R; 12:15322745-15322745	skin	malignant_melanoma	Substitution - Missense
c.204C>T; p.F68F; 12:15484102-15484102	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1929C>T; p.F643F; 12:15524851-15524851	skin	malignant_melanoma	Substitution - coding silent
c.3623T>A; p.V1208D; 12:15595013-15595013	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.953C>T; p.P318L; 12:15501911-15501911	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3363C>T; p.V1121V; 12:15587004-15587004	skin; abdomen	malignant_melanoma	Substitution - coding silent
c.2321C>T; p.S774F; 12:15549110-15549110	skin; face	malignant_melanoma	Substitution - Missense
c.3272A>C; p.D1091A; 12:15586913-15586913	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1244C>A; p.A415E; 12:15504046-15504046	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.265C>T; p.H89Y; 12:15484163-15484163	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.839C>A; p.S280Y; 12:15501797-15501797	skin	malignant_melanoma	Substitution - Missense
c.839C>A; p.S280Y; 12:15501797-15501797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.839C>A; p.S280Y; 12:15501797-15501797	skin	malignant_melanoma	Substitution - Missense
c.2427C>G; p.V809V; 12:15549216-15549216	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.297G>T; p.V99V; 12:15484195-15484195	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2099A>C; p.N700T; 12:15526197-15526197	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2469C>A; p.I823I; 12:15551582-15551582	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3177C>T; p.A1059A; 12:15581723-15581723	skin	malignant_melanoma	Substitution - coding silent
c.814C>T; p.P272S; 12:15501772-15501772	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1588C>T; p.P530S; 12:15516765-15516765	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2353C>T; p.P785S; 12:15549142-15549142	skin	malignant_melanoma	Substitution - Missense
c.1568C>T; p.P523L; 12:15515601-15515601	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1536G>A; p.R512R; 12:15515569-15515569	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1536G>A; p.R512R; 12:15515569-15515569	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2289G>A; p.Q763Q; 12:15546693-15546693	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.278A>T; p.Y93F; 12:15484176-15484176	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1961G>A; p.G654E; 12:15524883-15524883	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.848G>A; p.W283*; 12:15501806-15501806	liver	carcinoma	Substitution - Nonsense
c.3223G>A; p.D1075N; 12:15581769-15581769	skin; face	malignant_melanoma	Substitution - Missense
c.3128G>A; p.R1043K; 12:15580827-15580827	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.527C>A; p.T176K; 12:15499460-15499460	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1754C>T; p.A585V; 12:15516931-15516931	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2467A>C; p.I823L; 12:15551580-15551580	breast	carcinoma	Substitution - Missense
c.769G>A; p.D257N; 12:15501727-15501727	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2480C>T; p.A827V; 12:15551593-15551593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2783A>G; p.K928R; 12:15569452-15569452	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2502T>C; p.I834I; 12:15551615-15551615	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2783A>G; p.K928R; 12:15569452-15569452	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2502T>C; p.I834I; 12:15551615-15551615	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2472C>T; p.S824S; 12:15551585-15551585	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3408C>T; p.C1136C; 12:15587049-15587049	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1486A>G; p.I496V; 12:15515519-15515519	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3214G>T; p.E1072*; 12:15581760-15581760	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3488A>G; p.D1163G; 12:15589532-15589532	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2569G>T; p.A857S; 12:15557465-15557465	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.3364C>A; p.R1122R; 12:15587005-15587005	liver	carcinoma	Substitution - coding silent
c.1781G>A; p.R594K; 12:15520202-15520202	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3210G>A; p.E1070E; 12:15581756-15581756	skin	malignant_melanoma	Substitution - coding silent
c.3211G>A; p.E1071K; 12:15581757-15581757	skin	malignant_melanoma	Substitution - Missense
c.128C>T; p.S43L; 12:15484026-15484026	breast	carcinoma	Substitution - Missense
c.2900G>A; p.R967H; 12:15578923-15578923	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1501C>T; p.P501S; 12:15515534-15515534	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2900G>A; p.R967H; 12:15578923-15578923	thyroid	other; neoplasm	Substitution - Missense
c.533T>G; p.F178C; 12:15499466-15499466	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2751G>T; p.P917P; 12:15569420-15569420	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.154C>T; p.P52S; 12:15484052-15484052	skin	malignant_melanoma	Substitution - Missense
c.2040G>C; p.K680N; 12:15524962-15524962	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2599G>T; p.E867*; 12:15557495-15557495	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1296G>T; p.L432L; 12:15508599-15508599	breast	carcinoma	Substitution - coding silent
c.2952G>A; p.M984I; 12:15580070-15580070	skin	malignant_melanoma	Substitution - Missense
c.1313A>C; p.H438P; 12:15508616-15508616	skin	malignant_melanoma	Substitution - Missense
c.1147G>T; p.E383*; 12:15503949-15503949	breast	carcinoma	Substitution - Nonsense
c.904A>C; p.S302R; 12:15501862-15501862	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3475C>T; p.H1159Y; 12:15589519-15589519	skin	malignant_melanoma	Substitution - Missense
c.2760G>T; p.L920L; 12:15569429-15569429	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.175A>G; p.K59E; 12:15484073-15484073	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2445G>A; p.E815E; 12:15551558-15551558	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1106-10T>A; p.?; 12:15503898-15503898	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.697G>A; p.V233I; 12:15501655-15501655	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.3261C>T; p.D1087D; 12:15586902-15586902	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2968G>T; p.A990S; 12:15580086-15580086	thyroid	other; neoplasm	Substitution - Missense
c.445G>A; p.V149I; 12:15497340-15497340	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.688G>A; p.V230I; 12:15501646-15501646	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.202T>G; p.F68V; 12:15484100-15484100	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.688G>A; p.V230I; 12:15501646-15501646	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2078T>G; p.L693W; 12:15526176-15526176	bone; pelvis	chondrosarcoma	Substitution - Missense
c.688G>A; p.V230I; 12:15501646-15501646	oesophagus	carcinoma	Substitution - Missense
c.991G>C; p.E331Q; 12:15501949-15501949	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.488T>C; p.F163S; 12:15497383-15497383	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1429G>A; p.E477K; 12:15508732-15508732	skin	malignant_melanoma	Substitution - Missense
c.2810A>G; p.K937R; 12:15569479-15569479	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2834T>G; p.L945W; 12:15578857-15578857	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1495C>A; p.L499M; 12:15515528-15515528	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.828G>A; p.S276S; 12:15501786-15501786	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.696C>T; p.I232I; 12:15501654-15501654	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2473G>A; p.V825M; 12:15551586-15551586	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2719A>C; p.N907H; 12:15565600-15565600	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1516C>T; p.Q506*; 12:15515549-15515549	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2443G>C; p.E815Q; 12:15551556-15551556	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2364C>A; p.A788A; 12:15549153-15549153	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2324C>A; p.S775Y; 12:15549113-15549113	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2324C>A; p.S775Y; 12:15549113-15549113	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.300A>G; p.V100V; 12:15484198-15484198	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1276G>A; p.G426R; 12:15508579-15508579	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1330T>G; p.L444V; 12:15508633-15508633	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2425G>A; p.V809I; 12:15549214-15549214	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1314C>T; p.H438H; 12:15508617-15508617	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.121G>C; p.V41L; 12:15484019-15484019	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2519C>T; p.T840I; 12:15551632-15551632	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.3009A>G; p.S1003S; 12:15580708-15580708	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1260T>G; p.F420L; 12:15504062-15504062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.310G>C; p.V104L; 12:15484208-15484208	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.814C>A; p.P272T; 12:15501772-15501772	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.208G>A; p.E70K; 12:15484106-15484106	skin	malignant_melanoma	Substitution - Missense
c.208G>A; p.E70K; 12:15484106-15484106	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2245G>T; p.A749S; 12:15546649-15546649	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3159C>T; p.F1053F; 12:15581705-15581705	skin	malignant_melanoma	Substitution - coding silent
c.3418G>A; p.V1140M; 12:15589462-15589462	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2560G>A; p.E854K; 12:15557456-15557456	skin; arm	malignant_melanoma	Substitution - Missense
c.3121G>C; p.E1041Q; 12:15580820-15580820	urinary_tract; bladder	carcinoma	Substitution - Missense
c.691C>T; p.R231C; 12:15501649-15501649	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.691C>T; p.R231C; 12:15501649-15501649	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.691C>T; p.R231C; 12:15501649-15501649	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2560G>A; p.E854K; 12:15557456-15557456	skin; arm	malignant_melanoma	Substitution - Missense
c.691C>T; p.R231C; 12:15501649-15501649	pancreas	carcinoma	Substitution - Missense
c.633C>G; p.V211V; 12:15499566-15499566	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1056C>A; p.P352P; 12:15502014-15502014	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1378T>G; p.Y460D; 12:15508681-15508681	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1727A>G; p.E576G; 12:15516904-15516904	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2711+1G>T; p.?; 12:15560277-15560277	liver	carcinoma	Unknown
c.784G>A; p.E262K; 12:15501742-15501742	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2711+1G>T; p.?; 12:15560277-15560277	liver	carcinoma	Unknown
c.1008C>T; p.G336G; 12:15501966-15501966	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2830G>A; p.E944K; 12:15578853-15578853	skin	malignant_melanoma	Substitution - Missense
c.3453G>A; p.R1151R; 12:15589497-15589497	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2224C>A; p.L742M; 12:15546628-15546628	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1464G>A; p.Q488Q; 12:15508767-15508767	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1464G>C; p.Q488H; 12:15508767-15508767	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.1533A>G; p.L511L; 12:15515566-15515566	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3616A>G; p.S1206G; 12:15595006-15595006	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.398C>T; p.P133L; 12:15497293-15497293	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.692G>A; p.R231H; 12:15501650-15501650	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.447T>G; p.V149V; 12:15497342-15497342	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2152C>T; p.L718F; 12:15526250-15526250	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3508G>A; p.E1170K; 12:15589552-15589552	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2424C>A; p.A808A; 12:15549213-15549213	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2363C>A; p.A788D; 12:15549152-15549152	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2594C>T; p.S865F; 12:15557490-15557490	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1176G>A; p.G392G; 12:15503978-15503978	skin	malignant_melanoma	Substitution - coding silent
c.2390G>A; p.S797N; 12:15549179-15549179	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.204C>A; p.F68L; 12:15484102-15484102	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.204C>A; p.F68L; 12:15484102-15484102	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1372G>A; p.E458K; 12:15508675-15508675	skin	malignant_melanoma	Substitution - Missense
c.3469C>T; p.R1157W; 12:15589513-15589513	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3365G>A; p.R1122Q; 12:15587006-15587006	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1995G>A; p.M665I; 12:15524917-15524917	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1176G>A; p.G392G; 12:15503978-15503978	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3506C>T; p.S1169L; 12:15589550-15589550	skin; abdomen	malignant_melanoma	Substitution - Missense
c.805G>A; p.E269K; 12:15501763-15501763	NS	NS	Substitution - Missense
c.2137A>G; p.T713A; 12:15526235-15526235	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1135G>A; p.E379K; 12:15503937-15503937	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1835C>T; p.T612M; 12:15520256-15520256	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1835C>T; p.T612M; 12:15520256-15520256	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.395C>G; p.S132C; 12:15497290-15497290	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.121G>A; p.V41I; 12:15484019-15484019	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3364C>T; p.R1122*; 12:15587005-15587005	skin; abdomen	malignant_melanoma	Substitution - Nonsense
c.3364C>T; p.R1122*; 12:15587005-15587005	skin; abdomen	malignant_melanoma	Substitution - Nonsense
c.1105G>A; p.E369K; 12:15502063-15502063	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.120C>T; p.I40I; 12:15484018-15484018	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.120C>T; p.I40I; 12:15484018-15484018	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1492A>T; p.N498Y; 12:15515525-15515525	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1274C>T; p.S425L; 12:15508577-15508577	skin	malignant_melanoma	Substitution - Missense
c.509-1G>T; p.?; 12:15499441-15499441	stomach	carcinoma; adenocarcinoma	Unknown
c.509-1G>T; p.?; 12:15499441-15499441	breast	carcinoma	Unknown
c.3246G>A; p.R1082R; 12:15581792-15581792	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1254C>T; p.L418L; 12:15504056-15504056	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.496A>T; p.M166L; 12:15497391-15497391	skin	malignant_melanoma	Substitution - Missense
c.1792C>T; p.L598L; 12:15520213-15520213	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3245G>A; p.R1082Q; 12:15581791-15581791	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1147G>A; p.E383K; 12:15503949-15503949	skin	malignant_melanoma	Substitution - Missense
c.2711G>T; p.W904L; 12:15560276-15560276	liver	carcinoma	Substitution - Missense
c.2711G>T; p.W904L; 12:15560276-15560276	liver	carcinoma	Substitution - Missense
c.2956G>A; p.E986K; 12:15580074-15580074	skin	malignant_melanoma	Substitution - Missense
c.2324C>T; p.S775F; 12:15549113-15549113	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3010C>T; p.P1004S; 12:15580709-15580709	NS	malignant_melanoma	Substitution - Missense
c.2249A>G; p.D750G; 12:15546653-15546653	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.490C>T; p.R164W; 12:15497385-15497385	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.851C>T; p.P284L; 12:15501809-15501809	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.357A>G; p.L119L; 12:15497252-15497252	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3206C>T; p.S1069L; 12:15581752-15581752	skin	malignant_melanoma	Substitution - Missense
c.357A>G; p.L119L; 12:15497252-15497252	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2698T>C; p.Y900H; 12:15560263-15560263	thyroid	carcinoma	Substitution - Missense
c.1810T>C; p.Y604H; 12:15520231-15520231	breast	carcinoma	Substitution - Missense
c.824C>T; p.P275L; 12:15501782-15501782	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1632G>A; p.T544T; 12:15516809-15516809	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2707C>T; p.P903S; 12:15560272-15560272	skin	malignant_melanoma	Substitution - Missense
c.881C>T; p.T294M; 12:15501839-15501839	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2830-1G>A; p.?; 12:15578852-15578852	skin	malignant_melanoma	Unknown
c.452C>A; p.T151K; 12:15497347-15497347	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2988C>A; p.N996K; 12:15580106-15580106	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3417C>A; p.G1139G; 12:15589461-15589461	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation