lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5782
Symbol	PTPN12
Synonymous	PTP-PEST\|PTPG1
Full name	protein tyrosine phosphatase, non-receptor type 12
Gene description	protein-tyrosine phosphatase G1\|tyrosine-protein phosphatase non-receptor type 12
Cytoband	7q11.23
Gene type	protein-coding
Synonymous	MIM:600079; HGNC:HGNC:9645; Ensembl:ENSG00000127947; HPRD:02513; Vega:OTTHUMG00000023501

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1334A>G; p.E445G; 7:77627013-77627013	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1829A>C; p.E610A; 7:77627508-77627508	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.300A>C; p.P100P; 7:77583569-77583569	skin	malignant_melanoma	Substitution - coding silent
c.522C>T; p.F174F; 7:77597871-77597871	breast	carcinoma	Substitution - coding silent
c.2265A>G; p.T755T; 7:77638715-77638715	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2265A>G; p.T755T; 7:77638715-77638715	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1361C>T; p.T454I; 7:77627040-77627040	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.611C>T; p.S204L; 7:77600722-77600722	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.2092G>C; p.E698Q; 7:77635799-77635799	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.2092G>C; p.E698Q; 7:77635799-77635799	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.824C>G; p.S275C; 7:77610826-77610826	breast	carcinoma	Substitution - Missense
c.263A>T; p.Y88F; 7:77581481-77581481	breast	carcinoma	Substitution - Missense
c.477delA; p.F160fs*36; 7:77592241-77592241	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.740C>T; p.T247M; 7:77607279-77607279	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4G>C; p.E2Q; 7:77537550-77537550	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.728C>T; p.A243V; 7:77607267-77607267	skin; mucosal	malignant_melanoma	Substitution - Missense
c.887A>C; p.K296T; 7:77610994-77610994	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.400C>T; p.R134*; 7:77585561-77585561	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1717A>G; p.T573A; 7:77627396-77627396	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1717A>G; p.T573A; 7:77627396-77627396	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2107C>T; p.Q703*; 7:77635814-77635814	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Nonsense
c.1335G>C; p.E445D; 7:77627014-77627014	pancreas	NS	Substitution - Missense
c.559C>T; p.R187C; 7:77600670-77600670	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1175T>C; p.V392A; 7:77626854-77626854	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2115G>T; p.Q705H; 7:77635822-77635822	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.606T>A; p.V202V; 7:77600717-77600717	liver	carcinoma	Substitution - coding silent
c.683G>T; p.C228F; 7:77600794-77600794	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2033C>T; p.P678L; 7:77632384-77632384	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1327C>T; p.L443F; 7:77627006-77627006	skin	malignant_melanoma	Substitution - Missense
c.1427C>G; p.S476C; 7:77627106-77627106	breast	carcinoma	Substitution - Missense
c.171A>C; p.E57D; 7:77571149-77571149	breast	carcinoma	Substitution - Missense
c.1926T>A; p.T642T; 7:77627605-77627605	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1448C>T; p.S483L; 7:77627127-77627127	skin; back	malignant_melanoma	Substitution - Missense
c.1924A>G; p.T642A; 7:77627603-77627603	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1108delC; p.P371fs*56; 7:77626787-77626787	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - Frameshift
c.688C>A; p.H230N; 7:77600799-77600799	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1507T>A; p.S503T; 7:77627186-77627186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.77A>C; p.D26A; 7:77537623-77537623	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.657T>C; p.Y219Y; 7:77600768-77600768	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.657T>C; p.Y219Y; 7:77600768-77600768	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2129delA; p.K712fs*5; 7:77635836-77635836	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2129delA; p.K712fs*5; 7:77635836-77635836	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2129delA; p.K712fs*5; 7:77635836-77635836	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.340G>T; p.V114L; 7:77583609-77583609	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1828G>T; p.E610*; 7:77627507-77627507	skin	malignant_melanoma	Substitution - Nonsense
c.2183C>T; p.A728V; 7:77638633-77638633	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.607C>T; p.P203S; 7:77600718-77600718	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.841-1G>A; p.?; 7:77610947-77610947	lung	carcinoma; adenocarcinoma	Unknown
c.964G>A; p.V322I; 7:77618504-77618504	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.99G>A; p.M33I; 7:77537645-77537645	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.964G>A; p.V322I; 7:77618504-77618504	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.648G>A; p.M216I; 7:77600759-77600759	urinary_tract; bladder	carcinoma	Substitution - Missense
c.950A>T; p.N317I; 7:77618490-77618490	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.422A>G; p.K141R; 7:77592186-77592186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.859C>G; p.H287D; 7:77610966-77610966	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.697G>A; p.A233T; 7:77607236-77607236	pancreas	carcinoma	Substitution - Missense
c.697G>A; p.A233T; 7:77607236-77607236	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1026-1G>A; p.?; 7:77626704-77626704	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.456A>G; p.E152E; 7:77592220-77592220	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2119C>T; p.R707*; 7:77635826-77635826	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1641A>T; p.I547I; 7:77627320-77627320	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1283A>C; p.K428T; 7:77626962-77626962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1283A>C; p.K428T; 7:77626962-77626962	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.689A>G; p.H230R; 7:77600800-77600800	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.304G>T; p.A102S; 7:77583573-77583573	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.166G>T; p.E56*; 7:77571144-77571144	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1003C>T; p.P335S; 7:77618543-77618543	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.166G>T; p.E56*; 7:77571144-77571144	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.166G>T; p.E56*; 7:77571144-77571144	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1785C>T; p.L595L; 7:77627464-77627464	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.319C>G; p.Q107E; 7:77583588-77583588	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.191A>G; p.Y64C; 7:77571169-77571169	prostate	carcinoma	Substitution - Missense
c.2294G>A; p.R765Q; 7:77639231-77639231	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2294G>A; p.R765Q; 7:77639231-77639231	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2294G>A; p.R765Q; 7:77639231-77639231	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.292T>C; p.Y98H; 7:77583561-77583561	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1411A>G; p.I471V; 7:77627090-77627090	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1474C>T; p.Q492*; 7:77627153-77627153	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.658C>G; p.Q220E; 7:77600769-77600769	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.658C>G; p.Q220E; 7:77600769-77600769	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1463G>A; p.G488D; 7:77627142-77627142	skin; extremity	malignant_melanoma	Substitution - Missense
c.1751_1753delATG; p.D585delD; 7:77627430-77627432	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Deletion - In frame
c.2016T>C; p.D672D; 7:77632367-77632367	skin	malignant_melanoma	Substitution - coding silent
c.183G>T; p.K61N; 7:77571161-77571161	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1461C>G; p.V487V; 7:77627140-77627140	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.841-9C>T; p.?; 7:77610939-77610939	skin; trunk	malignant_melanoma; nodular	Unknown
c.1378C>T; p.H460Y; 7:77627057-77627057	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.100C>T; p.R34W; 7:77571078-77571078	liver	carcinoma	Substitution - Missense
c.271G>A; p.A91T; 7:77581489-77581489	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.100C>T; p.R34W; 7:77571078-77571078	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.842A>T; p.E281V; 7:77610949-77610949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.221G>A; p.R74Q; 7:77581439-77581439	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.130A>G; p.T44A; 7:77571108-77571108	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1508_1511delCAAA; p.N504fs*30; 7:77627187-77627190	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1695_1696delTG; p.V566fs*11; 7:77627374-77627375	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.2142A>G; p.E714E; 7:77635849-77635849	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.802G>T; p.E268*; 7:77610804-77610804	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1960A>G; p.N654D; 7:77627639-77627639	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.963G>A; p.M321I; 7:77618503-77618503	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1969G>T; p.G657*; 7:77627648-77627648	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.650G>T; p.R217M; 7:77600761-77600761	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.991G>A; p.D331N; 7:77618531-77618531	urinary_tract; bladder	carcinoma	Substitution - Missense
c.202C>T; p.L68L; 7:77571180-77571180	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.938T>G; p.V313G; 7:77611045-77611045	skin; knee	malignant_melanoma	Substitution - Missense
c.2043delT; p.P682fs*6; 7:77632394-77632394	liver	carcinoma	Deletion - Frameshift
c.821A>G; p.H274R; 7:77610823-77610823	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.193A>G; p.K65E; 7:77571171-77571171	pancreas	carcinoma	Substitution - Missense
c.193A>G; p.K65E; 7:77571171-77571171	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.148A>C; p.T50P; 7:77571126-77571126	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.220C>T; p.R74*; 7:77581438-77581438	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1078C>T; p.H360Y; 7:77626757-77626757	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2063C>T; p.A688V; 7:77632414-77632414	breast	carcinoma	Substitution - Missense
c.1026-8T>C; p.?; 7:77626697-77626697	liver	carcinoma	Unknown
c.2263A>G; p.T755A; 7:77638713-77638713	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2263A>G; p.T755A; 7:77638713-77638713	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.392T>C; p.M131T; 7:77585553-77585553	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2263A>G; p.T755A; 7:77638713-77638713	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.688C>T; p.H230Y; 7:77600799-77600799	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.409G>C; p.E137Q; 7:77585570-77585570	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.509G>A; p.R170K; 7:77597858-77597858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1104T>G; p.P368P; 7:77626783-77626783	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1190C>T; p.S397L; 7:77626869-77626869	skin	malignant_melanoma	Substitution - Missense
c.1942A>G; p.M648V; 7:77627621-77627621	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2140G>A; p.E714K; 7:77635847-77635847	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1942A>G; p.M648V; 7:77627621-77627621	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2314C>T; p.P772S; 7:77639251-77639251	skin; upper_back	malignant_melanoma	Substitution - Missense
c.1047T>G; p.A349A; 7:77626726-77626726	breast	carcinoma	Substitution - coding silent
c.2120G>A; p.R707Q; 7:77635827-77635827	kidney	other; neoplasm	Substitution - Missense
c.2120G>A; p.R707Q; 7:77635827-77635827	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2260C>T; p.P754S; 7:77638710-77638710	skin	malignant_melanoma	Substitution - Missense
c.2120G>A; p.R707Q; 7:77635827-77635827	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1294C>T; p.R432*; 7:77626973-77626973	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1295G>A; p.R432Q; 7:77626974-77626974	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1294C>T; p.R432*; 7:77626973-77626973	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1387A>T; p.K463*; 7:77627066-77627066	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.352T>C; p.W118R; 7:77583621-77583621	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.169G>T; p.E57*; 7:77571147-77571147	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1844G>T; p.G615V; 7:77627523-77627523	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.785T>C; p.V262A; 7:77610787-77610787	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.690T>C; p.H230H; 7:77600801-77600801	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.854T>G; p.L285R; 7:77610961-77610961	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.577C>T; p.H193Y; 7:77600688-77600688	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation