lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	57761
Symbol	TRIB3
Synonymous	C20orf97\|NIPK\|SINK\|SKIP3\|TRB3
Full name	tribbles pseudokinase 3
Gene description	TRB-3\|neuronal cell death inducible putative kinase\|neuronal cell death-inducible putative kinase\|p65-interacting inhibitor of NF-kappa-B\|p65-interacting inhibitor of NF-kappaB\|tribbles homolog 3
Cytoband	20p13-p12.2
Gene type	protein-coding
Synonymous	MIM:607898; HGNC:HGNC:16228; Ensembl:ENSG00000101255; HPRD:09836; Vega:OTTHUMG00000031627

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.110G>A; p.S37N; 20:388120-388120	skin; trunk	malignant_melanoma	Substitution - Missense
c.777C>T; p.Y259Y; 20:396390-396390	pancreas	carcinoma	Substitution - coding silent
c.777C>T; p.Y259Y; 20:396390-396390	pancreas	carcinoma	Substitution - coding silent
c.458G>A; p.R153H; 20:391453-391453	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.251A>G; p.Q84R; 20:388261-388261	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.251A>G; p.Q84R; 20:388261-388261	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.617C>T; p.S206F; 20:396230-396230	urinary_tract; bladder	carcinoma	Substitution - Missense
c.337C>G; p.R113G; 20:391332-391332	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.184G>C; p.V62L; 20:388194-388194	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.504C>T; p.T168T; 20:391499-391499	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.402C>T; p.Y134Y; 20:391397-391397	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; large_cell	Substitution - coding silent
c.288C>T; p.C96C; 20:388298-388298	central_nervous_system; brain	glioma	Substitution - coding silent
c.288C>T; p.C96C; 20:388298-388298	central_nervous_system; brain	glioma	Substitution - coding silent
c.86G>A; p.R29H; 20:388096-388096	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.86G>A; p.R29H; 20:388096-388096	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.86G>A; p.R29H; 20:388096-388096	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.164C>T; p.A55V; 20:388174-388174	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.164C>T; p.A55V; 20:388174-388174	ovary	other; neoplasm	Substitution - Missense
c.164C>T; p.A55V; 20:388174-388174	ovary	other; neoplasm	Substitution - Missense
c.130delC; p.C46fs*5; 20:388140-388140	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.96G>C; p.Q32H; 20:388106-388106	breast	carcinoma	Substitution - Missense
c.107G>A; p.R36Q; 20:388117-388117	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.865C>T; p.R289C; 20:396478-396478	skin	malignant_melanoma	Substitution - Missense
c.242G>A; p.R81Q; 20:388252-388252	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.892C>T; p.R298W; 20:396505-396505	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.892C>T; p.R298W; 20:396505-396505	urinary_tract; bladder	carcinoma	Substitution - Missense
c.892C>T; p.R298W; 20:396505-396505	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.4C>T; p.R2*; 20:388014-388014	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.4C>T; p.R2*; 20:388014-388014	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.828G>A; p.G276G; 20:396441-396441	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.25C>G; p.P9A; 20:388035-388035	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.456C>T; p.H152H; 20:391451-391451	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.398T>C; p.L133P; 20:391393-391393	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1077G>T; p.*359Y; 20:396690-396690	lung	carcinoma; small_cell_carcinoma	Nonstop extension
c.166C>G; p.P56A; 20:388176-388176	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.918C>T; p.A306A; 20:396531-396531	breast	carcinoma	Substitution - coding silent
c.749C>T; p.A250V; 20:396362-396362	pancreas	carcinoma	Substitution - Missense
c.173G>A; p.R58H; 20:388183-388183	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.198C>T; p.S66S; 20:388208-388208	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.503C>T; p.T168I; 20:391498-391498	skin	malignant_melanoma	Substitution - Missense
c.727G>A; p.D243N; 20:396340-396340	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.509T>C; p.L170P; 20:391504-391504	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.653A>G; p.D218G; 20:396266-396266	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.333T>C; p.Y111Y; 20:391328-391328	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.333T>C; p.Y111Y; 20:391328-391328	breast	carcinoma	Substitution - coding silent
c.139C>T; p.L47L; 20:388149-388149	skin	malignant_melanoma	Substitution - coding silent
c.270A>T; p.T90T; 20:388280-388280	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.133C>T; p.P45S; 20:388143-388143	skin	malignant_melanoma	Substitution - Missense
c.74T>C; p.L25S; 20:388084-388084	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.700C>T; p.R234W; 20:396313-396313	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.445C>T; p.R149*; 20:391440-391440	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Nonsense
c.904G>A; p.E302K; 20:396517-396517	urinary_tract; bladder	carcinoma	Substitution - Missense
c.445C>T; p.R149*; 20:391440-391440	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.890G>A; p.R297H; 20:396503-396503	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.637G>A; p.D213N; 20:396250-396250	pancreas	carcinoma	Substitution - Missense
c.388A>G; p.T130A; 20:391383-391383	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.612G>A; p.E204E; 20:396225-396225	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.241C>T; p.R81W; 20:388251-388251	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.179C>T; p.T60I; 20:388189-388189	central_nervous_system; brain	glioma	Substitution - Missense
c.179C>T; p.T60I; 20:388189-388189	central_nervous_system; brain	glioma	Substitution - Missense
c.824G>A; p.R275H; 20:396437-396437	thyroid	carcinoma	Substitution - Missense
c.663G>A; p.A221A; 20:396276-396276	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.675C>T; p.Y225Y; 20:396288-396288	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.829G>A; p.A277T; 20:396442-396442	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.969C>T; p.A323A; 20:396582-396582	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.878G>A; p.R293H; 20:396491-396491	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.481G>A; p.V161M; 20:391476-391476	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.85C>T; p.R29C; 20:388095-388095	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.600G>A; p.L200L; 20:396213-396213	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.505G>A; p.A169T; 20:391500-391500	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.676G>A; p.V226M; 20:396289-396289	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.135C>A; p.P45P; 20:388145-388145	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.676G>A; p.V226M; 20:396289-396289	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.491G>A; p.R164H; 20:391486-391486	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.825C>T; p.R275R; 20:396438-396438	breast	carcinoma	Substitution - coding silent
c.584+9G>T; p.?; 20:391588-391588	liver	carcinoma	Unknown
c.584+9G>T; p.?; 20:391588-391588	liver	carcinoma	Unknown
c.825C>T; p.R275R; 20:396438-396438	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.834C>T; p.Y278Y; 20:396447-396447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.416G>A; p.R139Q; 20:391411-391411	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.416G>A; p.R139Q; 20:391411-391411	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1022G>T; p.G341V; 20:396635-396635	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.696C>A; p.S232R; 20:396309-396309	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.969C>A; p.A323A; 20:396582-396582	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.106C>T; p.R36*; 20:388116-388116	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.106C>T; p.R36*; 20:388116-388116	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.435C>T; p.H145H; 20:391430-391430	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.186G>A; p.V62V; 20:388196-388196	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.631G>A; p.G211R; 20:396244-396244	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.342_343insC; p.H117fs*9; 20:391337-391338	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.176C>T; p.A59V; 20:388186-388186	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1039G>A; p.E347K; 20:396652-396652	central_nervous_system; spinal_cord	glioma; ependymoma	Substitution - Missense
c.745G>T; p.V249L; 20:396358-396358	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.854C>T; p.S285L; 20:396467-396467	ovary	other; neoplasm	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation