lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5764
Symbol	PTN
Synonymous	HARP\|HBGF8\|HBNF\|NEGF1
Full name	pleiotrophin
Gene description	HB-GAM\|HBBM\|HBGF-8\|HBNF-1\|OSF-1\|heparin affin regulatory protein\|heparin binding growth factor 8\|heparin-binding brain mitogen\|heparin-binding growth factor 8\|heparin-binding growth-associated molecule\|heparin-binding neurite outgrowth-promoting factor 1\|
Cytoband	7q33
Gene type	protein-coding
Synonymous	MIM:162095; HGNC:HGNC:9630; Ensembl:ENSG00000105894; HPRD:01199; Vega:OTTHUMG00000155709

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.340G>A; p.A114T; 7:137251341-137251341	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.52T>C; p.L18L; 7:137254922-137254922	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.340G>A; p.A114T; 7:137251341-137251341	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.448C>T; p.Q150*; 7:137251233-137251233	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.200G>A; p.R67Q; 7:137253553-137253553	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.66C>T; p.F22F; 7:137254908-137254908	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.124_125insA; p.V42fs*5; 7:137253628-137253629	stomach	adenocarcinoma	Insertion - Frameshift
c.81G>T; p.V27V; 7:137254893-137254893	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.29G>A; p.R10H; 7:137254945-137254945	prostate	adenoma	Substitution - Missense
c.200G>T; p.R67L; 7:137253553-137253553	skin	malignant_melanoma	Substitution - Missense
c.393C>T; p.C131C; 7:137251288-137251288	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.388G>T; p.E130*; 7:137251293-137251293	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.458C>T; p.S153F; 7:137228069-137228069	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.131A>C; p.K44T; 7:137253622-137253622	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.131A>C; p.K44T; 7:137253622-137253622	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.131A>C; p.K44T; 7:137253622-137253622	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.131A>C; p.K44T; 7:137253622-137253622	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.131A>C; p.K44T; 7:137253622-137253622	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.131A>C; p.K44T; 7:137253622-137253622	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.425G>A; p.G142D; 7:137251256-137251256	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.288C>T; p.G96G; 7:137253465-137253465	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.288C>T; p.G96G; 7:137253465-137253465	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.454G>A; p.E152K; 7:137228073-137228073	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.454G>A; p.E152K; 7:137228073-137228073	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.454G>A; p.E152K; 7:137228073-137228073	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.160G>T; p.V54L; 7:137253593-137253593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.403G>T; p.V135F; 7:137251278-137251278	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.213G>A; p.R71R; 7:137253540-137253540	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.48C>A; p.A16A; 7:137254926-137254926	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.94G>T; p.A32S; 7:137254880-137254880	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.437A>C; p.K146T; 7:137251244-137251244	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.131A>T; p.K44M; 7:137253622-137253622	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.241A>G; p.K81E; 7:137253512-137253512	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.291G>A; p.A97A; 7:137251390-137251390	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.223G>C; p.E75Q; 7:137253530-137253530	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.223G>C; p.E75Q; 7:137253530-137253530	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.451+2T>A; p.?; 7:137251228-137251228	pancreas	carcinoma	Unknown
c.272G>A; p.W91*; 7:137253481-137253481	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.167T>C; p.V56A; 7:137253586-137253586	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.258G>T; p.K86N; 7:137253495-137253495	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.471A>G; p.K157K; 7:137228056-137228056	pancreas	carcinoma	Substitution - coding silent
c.388G>A; p.E130K; 7:137251293-137251293	skin	malignant_melanoma	Substitution - Missense
c.388G>A; p.E130K; 7:137251293-137251293	breast	carcinoma	Substitution - Missense
c.204G>C; p.E68D; 7:137253549-137253549	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.155G>C; p.W52S; 7:137253598-137253598	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.438G>T; p.K146N; 7:137251243-137251243	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.483G>A; p.K161K; 7:137228044-137228044	oesophagus	carcinoma	Substitution - coding silent
c.273G>T; p.W91C; 7:137253480-137253480	pancreas	carcinoma	Substitution - Missense
c.213G>T; p.R71R; 7:137253540-137253540	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.370C>T; p.R124*; 7:137251311-137251311	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.343C>T; p.L115L; 7:137251338-137251338	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.392G>T; p.C131F; 7:137251289-137251289	stomach	adenocarcinoma	Substitution - Missense
c.279G>A; p.K93K; 7:137253474-137253474	pancreas	NS	Substitution - coding silent
c.119A>T; p.K40I; 7:137253634-137253634	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.179G>A; p.G60E; 7:137253574-137253574	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5A>T; p.Q2L; 7:137254969-137254969	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.206G>T; p.G69V; 7:137253547-137253547	thyroid	carcinoma; medullary_carcinoma	Substitution - Missense
c.211C>G; p.R71G; 7:137253542-137253542	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.230A>T; p.K77M; 7:137253523-137253523	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.290C>T; p.A97V; 7:137251391-137251391	pancreas	carcinoma	Substitution - Missense
c.290C>T; p.A97V; 7:137251391-137251391	NS	NS	Substitution - Missense
c.225G>A; p.E75E; 7:137253528-137253528	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.123delA; p.V42fs*1; 7:137253630-137253630	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.123delA; p.V42fs*1; 7:137253630-137253630	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.123delA; p.V42fs*1; 7:137253630-137253630	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.320G>A; p.G107E; 7:137251361-137251361	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.263C>T; p.P88L; 7:137253490-137253490	skin	malignant_melanoma	Substitution - Missense
c.185G>A; p.C62Y; 7:137253568-137253568	central_nervous_system; brain	glioma	Substitution - Missense
c.246C>A; p.T82T; 7:137253507-137253507	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.322G>A; p.E108K; 7:137251359-137251359	urinary_tract; bladder	carcinoma	Substitution - Missense
c.149G>T; p.W50L; 7:137253604-137253604	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation