Cancer metastasis database

Annotation category 5

Gene information

Gene ID 5753
Symbol

PTK6

Synonymous

BRK

Full name

protein tyrosine kinase 6

Gene description

PTK6 protein tyrosine kinase 6|breast tumor kinase|protein-tyrosine kinase 6|protein-tyrosine kinase BRK|tyrosine-protein kinase BRK

Cytoband

20q13.3

Gene type

protein-coding

Synonymous

MIM:602004; HGNC:HGNC:9617; Ensembl:ENSG00000101213; HPRD:03594; Vega:OTTHUMG00000033039

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1103_1104CC>TT; p.S368F; 20:63530142-63530143

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.985G>C; p.G329R; 20:63530775-63530775

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.968delA; p.N323fs*11; 20:63530792-63530792

 oesophaguscarcinoma; adenocarcinomaDeletion - Frameshift

c.255_258delCTCG; p.S86fs*17; 20:63535032-63535035

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.699G>A; p.Q233Q; 20:63532659-63532659

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.643C>T; p.Q215*; 20:63533578-63533578

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.957C>T; p.L319L; 20:63530803-63530803

 breastcarcinomaSubstitution - coding silent

c.741C>T; p.I247I; 20:63532617-63532617

 skinmalignant_melanomaSubstitution - coding silent

c.233G>T; p.W78L; 20:63535057-63535057

 thyroidcarcinoma; medullary_carcinomaSubstitution - Missense

c.668G>A; p.R223Q; 20:63533553-63533553

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.751T>C; p.Y251H; 20:63532607-63532607

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.392G>T; p.R131L; 20:63534276-63534276

 stomachcarcinomaSubstitution - Missense

c.1063G>T; p.A355S; 20:63530183-63530183

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.390G>C; p.W130C; 20:63534278-63534278

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.969C>T; p.N323N; 20:63530791-63530791

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1166C>T; p.P389L; 20:63530080-63530080

 skinmalignant_melanomaSubstitution - Missense

c.271C>A; p.R91R; 20:63535019-63535019

 ovaryother; neoplasmSubstitution - coding silent

c.161G>A; p.G54D; 20:63537154-63537154

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.13G>T; p.D5Y; 20:63537302-63537302

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.861G>A; p.S287S; 20:63530899-63530899

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.659T>A; p.V220E; 20:63533562-63533562

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1338C>T; p.S446S; 20:63529554-63529554

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.713C>A; p.A238D; 20:63532645-63532645

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.753C>T; p.Y251Y; 20:63532605-63532605

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.507C>T; p.P169P; 20:63534161-63534161

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.756C>T; p.A252A; 20:63532602-63532602

 breastcarcinomaSubstitution - coding silent

c.646G>A; p.V216M; 20:63533575-63533575

 skinmalignant_melanomaSubstitution - Missense

c.897C>A; p.G299G; 20:63530863-63530863

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - coding silent

c.392G>C; p.R131P; 20:63534276-63534276

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.950A>G; p.N317S; 20:63530810-63530810

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.353-8C>T; p.?; 20:63534323-63534323

 pancreascarcinomaUnknown

c.671-7C>T; p.?; 20:63532694-63532694

 skin; upper_legmalignant_melanomaUnknown

c.179G>T; p.G60V; 20:63537136-63537136

 skinmalignant_melanomaSubstitution - Missense

c.757G>A; p.V253M; 20:63532601-63532601

 upper_aerodigestive_tract; sinonasal_and_nasal_cavitycarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.909G>A; p.L303L; 20:63530851-63530851

 ovaryother; neoplasmSubstitution - coding silent

c.45_46CC>TT; p.G15_L16>GF; 20:63537269-63537270

 kidneycarcinoma; papillary_renal_cell_carcinomaComplex - compound substitution

c.45_46CC>TT; p.G15_L16>GF; 20:63537269-63537270

 kidneycarcinoma; papillary_renal_cell_carcinomaComplex - compound substitution

c.874A>G; p.I292V; 20:63530886-63530886

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.70G>A; p.D24N; 20:63537245-63537245

 skinmalignant_melanomaSubstitution - Missense

c.269G>T; p.R90L; 20:63535021-63535021

 oesophaguscarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1241C>A; p.P414H; 20:63529651-63529651

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.253C>T; p.R85C; 20:63535037-63535037

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.588G>T; p.K196N; 20:63533633-63533633

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1A>G; p.M1V; 20:63537314-63537314

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.948G>A; p.R316R; 20:63530812-63530812

 skinmalignant_melanomaSubstitution - coding silent

c.322G>A; p.E108K; 20:63534968-63534968

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.973C>A; p.L325I; 20:63530787-63530787

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1027C>T; p.L343F; 20:63530219-63530219

 skin; scalpcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1159C>T; p.P387S; 20:63530087-63530087

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.858T>C; p.V286V; 20:63530902-63530902

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.575C>T; p.T192M; 20:63533646-63533646

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.561G>A; p.P187P; 20:63533660-63533660

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1107C>G; p.D369E; 20:63530139-63530139

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.24C>A; p.H8Q; 20:63537291-63537291

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.24C>A; p.H8Q; 20:63537291-63537291

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.158C>T; p.A53V; 20:63537157-63537157

 skinmalignant_melanomaSubstitution - Missense

c.690G>A; p.Q230Q; 20:63532668-63532668

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.258G>C; p.S86S; 20:63535032-63535032

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.742C>T; p.L248L; 20:63532616-63532616

 breastcarcinomaSubstitution - coding silent

c.585G>A; p.R195R; 20:63533636-63533636

 skinmalignant_melanomaSubstitution - coding silent

c.832G>A; p.D278N; 20:63532526-63532526

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1302C>A; p.F434L; 20:63529590-63529590

 soft_tissue; blood_vesselangiosarcomaSubstitution - Missense

c.558G>A; p.R186R; 20:63533663-63533663

 skinmalignant_melanomaSubstitution - coding silent

c.119A>C; p.K40T; 20:63537196-63537196

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.50G>T; p.W17L; 20:63537265-63537265

 oesophaguscarcinomaSubstitution - Missense

c.852G>A; p.L284L; 20:63530908-63530908

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.629G>A; p.W210*; 20:63533592-63533592

 skin; armmalignant_melanomaSubstitution - Nonsense

c.111G>A; p.V37V; 20:63537204-63537204

 skinmalignant_melanomaSubstitution - coding silent

c.618C>T; p.F206F; 20:63533603-63533603

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.978C>T; p.C326C; 20:63530782-63530782

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent