lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	57379
Symbol	AICDA
Synonymous	AID\|ARP2\|CDA2\|HEL-S-284\|HIGM2
Full name	activation-induced cytidine deaminase
Gene description	cytidine aminohydrolase\|epididymis secretory protein Li 284\|integrated into Burkitt's lymphoma cell line Ramos\|single-stranded DNA cytosine deaminase
Cytoband	12p13
Gene type	protein-coding
Synonymous	MIM:605257; HGNC:HGNC:13203; Ensembl:ENSG00000111732; HPRD:05585; Vega:OTTHUMG00000168676

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.532C>T; p.R178C; 12:8604818-8604818	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.532C>T; p.R178C; 12:8604818-8604818	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.532C>T; p.R178C; 12:8604818-8604818	ovary	carcinoma; clear_cell_carcinoma	Substitution - Missense
c.221G>A; p.R74H; 12:8605421-8605421	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.169G>A; p.V57M; 12:8605473-8605473	pancreas	carcinoma	Substitution - Missense
c.380G>A; p.R127Q; 12:8605262-8605262	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.213C>A; p.D71E; 12:8605429-8605429	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.506C>T; p.S169L; 12:8604844-8604844	skin	malignant_melanoma	Substitution - Missense
c.166C>T; p.H56Y; 12:8605476-8605476	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.424A>G; p.K142E; 12:8605218-8605218	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.379C>T; p.R127W; 12:8605263-8605263	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.332C>T; p.A111V; 12:8605310-8605310	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.188G>A; p.R63H; 12:8605454-8605454	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.544-2A>G; p.?; 12:8604339-8604339	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.355C>T; p.R119C; 12:8605287-8605287	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.355C>T; p.R119C; 12:8605287-8605287	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.331G>A; p.A111T; 12:8605311-8605311	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.331G>A; p.A111T; 12:8605311-8605311	pancreas	NS	Substitution - Missense
c.456A>T; p.V152V; 12:8604894-8604894	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.70C>T; p.R24W; 12:8606951-8606951	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.197C>T; p.S66L; 12:8605445-8605445	skin	malignant_melanoma	Substitution - Missense
c.240G>T; p.W80C; 12:8605402-8605402	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.285C>T; p.A95A; 12:8605357-8605357	pancreas	carcinoma	Substitution - coding silent
c.252G>A; p.W84*; 12:8605390-8605390	skin	malignant_melanoma	Substitution - Nonsense
c.333G>A; p.A111A; 12:8605309-8605309	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.22C>T; p.R8W; 12:8606999-8606999	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.159C>T; p.N53N; 12:8605483-8605483	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.286G>T; p.D96Y; 12:8605356-8605356	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.538C>A; p.L180I; 12:8604812-8604812	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.538C>A; p.L180I; 12:8604812-8604812	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.383G>A; p.R128Q; 12:8605259-8605259	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.383G>A; p.R128Q; 12:8605259-8605259	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.375G>A; p.G125G; 12:8605267-8605267	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.295C>T; p.R99*; 12:8605347-8605347	central_nervous_system; brain	glioma	Substitution - Nonsense
c.361G>A; p.A121T; 12:8605281-8605281	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.445A>G; p.N149D; 12:8604905-8604905	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.230G>A; p.R77H; 12:8605412-8605412	small_intestine	carcinoid-endocrine_tumour	Substitution - Missense
c.160G>A; p.G54S; 12:8605482-8605482	skin	malignant_melanoma	Substitution - Missense
c.160G>A; p.G54S; 12:8605482-8605482	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.267C>A; p.D89E; 12:8605375-8605375	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.237C>T; p.T79T; 12:8605405-8605405	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.391C>G; p.R131G; 12:8605251-8605251	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.391C>G; p.R131G; 12:8605251-8605251	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.382C>T; p.R128W; 12:8605260-8605260	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.186C>T; p.L62L; 12:8605456-8605456	skin	malignant_melanoma	Substitution - coding silent
c.186C>T; p.L62L; 12:8605456-8605456	skin	malignant_melanoma	Substitution - coding silent
c.511C>T; p.R171C; 12:8604839-8604839	skin	malignant_melanoma	Substitution - Missense
c.270T>C; p.C90C; 12:8605372-8605372	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.511C>T; p.R171C; 12:8604839-8604839	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.511C>T; p.R171C; 12:8604839-8604839	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.526C>T; p.L176F; 12:8604824-8604824	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.526C>T; p.L176F; 12:8604824-8604824	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.9-1G>A; p.?; 12:8607013-8607013	stomach	carcinoma; adenocarcinoma	Unknown
c.394G>A; p.A132T; 12:8605248-8605248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.145C>G; p.L49V; 12:8606876-8606876	urinary_tract; bladder	carcinoma	Substitution - Missense
c.231C>T; p.R77R; 12:8605411-8605411	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.319A>T; p.R107W; 12:8605323-8605323	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.231C>T; p.R77R; 12:8605411-8605411	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.545C>G; p.P182R; 12:8604336-8604336	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.466G>A; p.E156K; 12:8604884-8604884	skin	malignant_melanoma	Substitution - Missense
c.466G>A; p.E156K; 12:8604884-8604884	skin	malignant_melanoma	Substitution - Missense
c.466G>A; p.E156K; 12:8604884-8604884	skin	malignant_melanoma	Substitution - Missense
c.466G>A; p.E156K; 12:8604884-8604884	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.538C>T; p.L180F; 12:8604812-8604812	skin	malignant_melanoma	Substitution - Missense
c.430T>C; p.Y144H; 12:8604920-8604920	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.232G>A; p.V78I; 12:8605410-8605410	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.232G>A; p.V78I; 12:8605410-8605410	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.232G>A; p.V78I; 12:8605410-8605410	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.123C>G; p.S41S; 12:8606898-8606898	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.55C>T; p.R19C; 12:8606966-8606966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.300G>A; p.G100G; 12:8605342-8605342	skin	malignant_melanoma	Substitution - coding silent
c.431A>T; p.Y144F; 12:8604919-8604919	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.431A>T; p.Y144F; 12:8604919-8604919	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.431A>T; p.Y144F; 12:8604919-8604919	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.431A>T; p.Y144F; 12:8604919-8604919	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.431A>T; p.Y144F; 12:8604919-8604919	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.221G>T; p.R74L; 12:8605421-8605421	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.195C>T; p.I65I; 12:8605447-8605447	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.431A>G; p.Y144C; 12:8604919-8604919	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.264C>T; p.Y88Y; 12:8605378-8605378	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.264C>T; p.Y88Y; 12:8605378-8605378	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.470G>T; p.R157I; 12:8604880-8604880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.248C>T; p.S83F; 12:8605394-8605394	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.228C>T; p.Y76Y; 12:8605414-8605414	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation