lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	57016
Symbol	AKR1B10
Synonymous	AKR1B11\|AKR1B12\|ALDRLn\|ARL-1\|ARL1\|HIS\|HSI
Full name	aldo-keto reductase family 1, member B10 (aldose reductase)
Gene description	ARP\|SI reductase\|aldo-keto reductase family 1 member B10\|aldo-keto reductase family 1, member B11 (aldose reductase-like)\|aldose reductase-like 1\|aldose reductase-like peptide\|aldose reductase-related protein\|hARP\|small intestine reductase
Cytoband	7q33
Gene type	protein-coding
Synonymous	MIM:604707; HGNC:HGNC:382; Ensembl:ENSG00000198074; HPRD:05271; Vega:OTTHUMG00000155356

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.331C>A; p.H111N; 7:134532004-134532004	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.298C>A; p.L100M; 7:134531971-134531971	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.438_439GG>AA; p.E147K; 7:134536658-134536659	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.932C>A; p.P311H; 7:134541070-134541070	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.764A>C; p.Q255P; 7:134538216-134538216	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.724delA; p.T244fs*6; 7:134537644-134537644	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.724delA; p.T244fs*6; 7:134537644-134537644	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.576A>G; p.T192T; 7:134537074-134537074	thyroid	other; neoplasm	Substitution - coding silent
c.576A>G; p.T192T; 7:134537074-134537074	thyroid	other; neoplasm	Substitution - coding silent
c.576A>G; p.T192T; 7:134537074-134537074	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.576A>G; p.T192T; 7:134537074-134537074	thyroid	other; neoplasm	Substitution - coding silent
c.576A>G; p.T192T; 7:134537074-134537074	thyroid	other; neoplasm	Substitution - coding silent
c.576A>G; p.T192T; 7:134537074-134537074	breast	carcinoma	Substitution - coding silent
c.576A>G; p.T192T; 7:134537074-134537074	thyroid	other; neoplasm	Substitution - coding silent
c.738C>T; p.A246A; 7:134537658-134537658	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.876C>T; p.F292F; 7:134538985-134538985	skin	malignant_melanoma	Substitution - coding silent
c.289C>T; p.L97F; 7:134531962-134531962	skin	malignant_melanoma	Substitution - Missense
c.922G>T; p.E308*; 7:134541060-134541060	NS	NS	Substitution - Nonsense
c.241C>T; p.P81S; 7:134531914-134531914	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.339A>G; p.P113P; 7:134532012-134532012	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.835T>G; p.F279V; 7:134538944-134538944	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.762C>T; p.I254I; 7:134538214-134538214	skin	malignant_melanoma	Substitution - coding silent
c.197A>G; p.K66R; 7:134530773-134530773	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.531A>G; p.K177K; 7:134536751-134536751	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.468C>T; p.A156A; 7:134536688-134536688	skin	malignant_melanoma	Substitution - coding silent
c.750C>T; p.I250I; 7:134538202-134538202	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.713C>T; p.A238V; 7:134537633-134537633	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.295G>A; p.D99N; 7:134531968-134531968	bone; rib	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.114A>G; p.A38A; 7:134530690-134530690	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.911C>T; p.S304F; 7:134541049-134541049	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.167G>A; p.G56E; 7:134530743-134530743	skin	malignant_melanoma	Substitution - Missense
c.730A>C; p.T244P; 7:134537650-134537650	skin; upper_arm	malignant_melanoma	Substitution - Missense
c.355G>T; p.G119W; 7:134533007-134533007	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.9G>A; p.T3T; 7:134527920-134527920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.803C>A; p.A268E; 7:134538255-134538255	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.417G>A; p.L139L; 7:134533069-134533069	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.407C>T; p.A136V; 7:134533059-134533059	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.502G>A; p.E168K; 7:134536722-134536722	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.823C>A; p.Q275K; 7:134538275-134538275	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.344G>A; p.G115E; 7:134532017-134532017	skin	malignant_melanoma	Substitution - Missense
c.556G>C; p.E186Q; 7:134537054-134537054	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.282G>C; p.E94D; 7:134531955-134531955	urinary_tract; bladder	carcinoma	Substitution - Missense
c.908A>C; p.Q303P; 7:134539017-134539017	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.803C>T; p.A268V; 7:134538255-134538255	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.397G>A; p.G133S; 7:134533049-134533049	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.396C>T; p.I132I; 7:134533048-134533048	skin	malignant_melanoma	Substitution - coding silent
c.356G>T; p.G119V; 7:134533008-134533008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.534T>C; p.Y178Y; 7:134536754-134536754	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.34A>T; p.K12*; 7:134527945-134527945	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.34A>T; p.K12*; 7:134527945-134527945	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.75T>C; p.L25L; 7:134530651-134530651	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.75T>C; p.L25L; 7:134530651-134530651	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.75T>C; p.L25L; 7:134530651-134530651	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.785C>A; p.P262H; 7:134538237-134538237	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.214G>A; p.D72N; 7:134530790-134530790	skin	malignant_melanoma	Substitution - Missense
c.154G>T; p.E52*; 7:134530730-134530730	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.691G>A; p.D231N; 7:134537611-134537611	skin; neck	malignant_melanoma	Substitution - Missense
c.804A>C; p.A268A; 7:134538256-134538256	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - coding silent
c.283A>G; p.K95E; 7:134531956-134531956	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastoma	Substitution - Missense
c.283A>G; p.K95E; 7:134531956-134531956	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.270G>A; p.R90R; 7:134531943-134531943	skin	malignant_melanoma	Substitution - coding silent
c.225C>T; p.I75I; 7:134530801-134530801	skin	malignant_melanoma	Substitution - coding silent
c.778G>C; p.V260L; 7:134538230-134538230	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>T; p.P87S; 7:134531932-134531932	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.259C>T; p.P87S; 7:134531932-134531932	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.681C>G; p.S227S; 7:134537601-134537601	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.900C>T; p.N300N; 7:134539009-134539009	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.42C>T; p.P14P; 7:134527953-134527953	central_nervous_system; brain	glioma	Substitution - coding silent
c.67-8C>T; p.?; 7:134530635-134530635	skin; knee	malignant_melanoma	Unknown
c.104C>T; p.A35V; 7:134530680-134530680	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.489C>G; p.S163R; 7:134536709-134536709	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.733G>A; p.A245T; 7:134537653-134537653	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.895T>A; p.C299S; 7:134539004-134539004	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.587T>G; p.L196R; 7:134537085-134537085	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.400G>A; p.G134R; 7:134533052-134533052	skin; shoulder	malignant_melanoma	Substitution - Missense
c.400G>A; p.G134R; 7:134533052-134533052	skin	malignant_melanoma	Substitution - Missense
c.400G>A; p.G134R; 7:134533052-134533052	skin	malignant_melanoma	Substitution - Missense
c.806G>T; p.R269L; 7:134538258-134538258	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.8C>T; p.T3M; 7:134527919-134527919	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.189_190CC>TT; p.Q64*; 7:134530765-134530766	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.757C>T; p.H253Y; 7:134538209-134538209	skin	malignant_melanoma	Substitution - Missense
c.624G>A; p.T208T; 7:134537122-134537122	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.624G>A; p.T208T; 7:134537122-134537122	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.446T>G; p.V149G; 7:134536666-134536666	breast	carcinoma	Substitution - Missense
c.181G>T; p.E61*; 7:134530757-134530757	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.84G>T; p.V28V; 7:134530660-134530660	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.413T>C; p.F138S; 7:134533065-134533065	skin	malignant_melanoma	Substitution - Missense
c.582G>T; p.E194D; 7:134537080-134537080	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.388A>T; p.N130Y; 7:134533040-134533040	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.649G>A; p.D217N; 7:134537147-134537147	skin	malignant_melanoma	Substitution - Missense
c.721C>A; p.H241N; 7:134537641-134537641	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.742-2A>C; p.?; 7:134538192-134538192	skin; upper_arm	malignant_melanoma	Unknown
c.260C>T; p.P87L; 7:134531933-134531933	skin	malignant_melanoma	Substitution - Missense
c.765G>C; p.Q255H; 7:134538217-134538217	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.732C>A; p.T244T; 7:134537652-134537652	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.267G>A; p.V89V; 7:134531940-134531940	liver	carcinoma	Substitution - coding silent
c.706G>A; p.E236K; 7:134537626-134537626	skin	malignant_melanoma	Substitution - Missense
c.933C>A; p.P311P; 7:134541071-134541071	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.682C>T; p.L228L; 7:134537602-134537602	skin	malignant_melanoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation