lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	56852
Symbol	RAD18
Synonymous	RNF73
Full name	RAD18 E3 ubiquitin protein ligase
Gene description	E3 ubiquitin-protein ligase RAD18\|RAD18 homolog\|RAD18, S. cerevisiae, homolog\|RING finger protein 73\|hHR18\|hRAD18\|postreplication repair protein RAD18\|postreplication repair protein hRAD18p
Cytoband	3p25.3
Gene type	protein-coding
Synonymous	MIM:605256; HGNC:HGNC:18278; Ensembl:ENSG00000070950; HPRD:09242; Vega:OTTHUMG00000090545

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1467A>G; p.R489R; 3:8881378-8881378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.604+1G>A; p.?; 3:8941466-8941466	skin	malignant_melanoma	Unknown
c.604+1G>A; p.?; 3:8941466-8941466	skin	malignant_melanoma	Unknown
c.1331C>T; p.S444L; 3:8890443-8890443	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.797C>T; p.S266F; 3:8935963-8935963	skin	malignant_melanoma	Substitution - Missense
c.1475G>A; p.R492H; 3:8881370-8881370	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.534C>T; p.I178I; 3:8941537-8941537	skin	malignant_melanoma	Substitution - coding silent
c.310_312delCCT; p.P104delP; 3:8941759-8941761	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.535G>A; p.A179T; 3:8941536-8941536	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1239G>A; p.L413L; 3:8898977-8898977	ovary	other; neoplasm	Substitution - coding silent
c.1348C>T; p.L450F; 3:8890426-8890426	breast	carcinoma	Substitution - Missense
c.45C>T; p.V15V; 3:8963341-8963341	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.45C>T; p.V15V; 3:8963341-8963341	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.725C>T; p.P242L; 3:8936035-8936035	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.107T>C; p.M36T; 3:8958946-8958946	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.36C>T; p.G12G; 3:8963350-8963350	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.193G>A; p.V65M; 3:8948511-8948511	thyroid	carcinoma	Substitution - Missense
c.755C>G; p.S252C; 3:8936005-8936005	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1323T>C; p.S441S; 3:8890451-8890451	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.269A>T; p.N90I; 3:8941802-8941802	breast	carcinoma	Substitution - Missense
c.454G>T; p.E152*; 3:8941617-8941617	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.904C>T; p.R302*; 3:8913706-8913706	breast	carcinoma	Substitution - Nonsense
c.227G>A; p.R76H; 3:8947259-8947259	pancreas	carcinoma	Substitution - Missense
c.760C>T; p.R254C; 3:8936000-8936000	skin	malignant_melanoma	Substitution - Missense
c.1173G>A; p.Q391Q; 3:8899043-8899043	skin	malignant_melanoma	Substitution - coding silent
c.418G>T; p.E140*; 3:8941653-8941653	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1393C>G; p.L465V; 3:8881452-8881452	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1234G>A; p.E412K; 3:8898982-8898982	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.452A>T; p.K151I; 3:8941619-8941619	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.206A>G; p.E69G; 3:8947280-8947280	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1430G>A; p.R477H; 3:8881415-8881415	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.823A>C; p.I275L; 3:8935937-8935937	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1466G>A; p.R489K; 3:8881379-8881379	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1103C>T; p.S368L; 3:8902445-8902445	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>A; p.L465I; 3:8881452-8881452	breast	carcinoma	Substitution - Missense
c.1285G>T; p.E429*; 3:8898931-8898931	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.818A>C; p.Q273P; 3:8935942-8935942	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1078G>A; p.G360R; 3:8902470-8902470	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.23G>A; p.R8Q; 3:8963363-8963363	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.406T>A; p.F136I; 3:8941665-8941665	skin	malignant_melanoma	Substitution - Missense
c.1134_1136delTGA; p.D378delD; 3:8902412-8902414	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.484G>T; p.E162*; 3:8941587-8941587	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1466G>C; p.R489T; 3:8881379-8881379	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.504G>A; p.K168K; 3:8941567-8941567	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.857A>G; p.N286S; 3:8935903-8935903	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.868G>C; p.D290H; 3:8935892-8935892	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.604+1G>A; p.?; 3:8941466-8941466	skin	malignant_melanoma	Unknown
c.604+1G>A; p.?; 3:8941466-8941466	skin	malignant_melanoma	Unknown
c.299C>T; p.P100L; 3:8941772-8941772	skin	malignant_melanoma	Substitution - Missense
c.808A>C; p.N270H; 3:8935952-8935952	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1465A>G; p.R489G; 3:8881380-8881380	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1465A>G; p.R489G; 3:8881380-8881380	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1465A>G; p.R489G; 3:8881380-8881380	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1307C>A; p.S436*; 3:8898909-8898909	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.155A>C; p.K52T; 3:8948549-8948549	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.155A>C; p.K52T; 3:8948549-8948549	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.155A>C; p.K52T; 3:8948549-8948549	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.88G>C; p.E30Q; 3:8958965-8958965	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.88G>C; p.E30Q; 3:8958965-8958965	urinary_tract; bladder	carcinoma	Substitution - Missense
c.700A>G; p.R234G; 3:8939558-8939558	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1426C>A; p.R476S; 3:8881419-8881419	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.386G>A; p.G129E; 3:8941685-8941685	skin	malignant_melanoma	Substitution - Missense
c.386G>A; p.G129E; 3:8941685-8941685	skin	malignant_melanoma	Substitution - Missense
c.387G>T; p.G129G; 3:8941684-8941684	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.387G>T; p.G129G; 3:8941684-8941684	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.386G>T; p.G129V; 3:8941685-8941685	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.616G>T; p.V206F; 3:8939642-8939642	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1126A>G; p.K376E; 3:8902422-8902422	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1017C>T; p.H339H; 3:8912322-8912322	prostate	carcinoma	Substitution - coding silent
c.679G>A; p.E227K; 3:8939579-8939579	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.679G>A; p.E227K; 3:8939579-8939579	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.704+2T>C; p.?; 3:8939552-8939552	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.838G>T; p.E280*; 3:8935922-8935922	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.838G>T; p.E280*; 3:8935922-8935922	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.938G>A; p.R313H; 3:8913672-8913672	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1115T>A; p.V372E; 3:8902433-8902433	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.853T>C; p.Y285H; 3:8935907-8935907	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.177G>A; p.Q59Q; 3:8948527-8948527	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.41C>T; p.A14V; 3:8963345-8963345	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1016A>G; p.H339R; 3:8912323-8912323	meninges	meningioma; secretory	Substitution - Missense
c.330G>T; p.K110N; 3:8941741-8941741	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.265C>T; p.R89W; 3:8947221-8947221	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.265C>T; p.R89W; 3:8947221-8947221	pancreas	carcinoma	Substitution - Missense
c.117T>G; p.P39P; 3:8958936-8958936	liver	carcinoma	Substitution - coding silent
c.154A>C; p.K52Q; 3:8948550-8948550	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.44T>C; p.V15A; 3:8963342-8963342	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation