lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5655
Symbol	KLK10
Synonymous	NES1\|PRSSL1
Full name	kallikrein-related peptidase 10
Gene description	breast normal epithelial cell associated serine protease\|kallikrein 10 protein 1\|kallikrein 10 protein 12\|kallikrein 10 protein 2\|kallikrein 10 protein 3\|kallikrein 10 protein 4\|kallikrein 10 protein 7\|kallikrein 10 protein 8\|kallikrein 10 protein 9\|kalli
Cytoband	19q13
Gene type	protein-coding
Synonymous	MIM:602673; HGNC:HGNC:6358; Ensembl:ENSG00000129451; HPRD:04054; Vega:OTTHUMG00000182916

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.54G>T; p.A18A; 19:51019077-51019077	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.751G>A; p.G251S; 19:51014880-51014880	skin	malignant_melanoma	Substitution - Missense
c.778A>T; p.T260S; 19:51014853-51014853	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.318A>C; p.G106G; 19:51016108-51016108	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.729C>A; p.L243L; 19:51014902-51014902	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.317G>T; p.G106V; 19:51016109-51016109	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.317G>T; p.G106V; 19:51016109-51016109	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.158C>T; p.A53V; 19:51017221-51017221	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.172C>T; p.P58S; 19:51017207-51017207	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.349G>T; p.V117F; 19:51016077-51016077	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.349G>T; p.V117F; 19:51016077-51016077	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.803G>A; p.W268*; 19:51014828-51014828	large_intestine; rectum	NS	Substitution - Nonsense
c.429G>A; p.L143L; 19:51015997-51015997	liver	carcinoma	Substitution - coding silent
c.368A>G; p.Q123R; 19:51016058-51016058	breast	carcinoma	Substitution - Missense
c.3G>A; p.M1I; 19:51019128-51019128	urinary_tract; bladder	carcinoma	Substitution - Missense
c.804G>C; p.W268C; 19:51014827-51014827	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.814G>T; p.V272F; 19:51014817-51014817	oesophagus	carcinoma	Substitution - Missense
c.780C>T; p.T260T; 19:51014851-51014851	skin	malignant_melanoma	Substitution - coding silent
c.617C>T; p.P206L; 19:51015478-51015478	skin	malignant_melanoma	Substitution - Missense
c.316G>A; p.G106R; 19:51016110-51016110	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.316G>A; p.G106R; 19:51016110-51016110	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.619G>T; p.G207C; 19:51015476-51015476	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.591C>A; p.S197R; 19:51015504-51015504	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.802T>C; p.W268R; 19:51014829-51014829	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.35C>G; p.S12C; 19:51019096-51019096	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.802T>C; p.W268R; 19:51014829-51014829	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.213C>T; p.C71C; 19:51017166-51017166	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.805A>G; p.I269V; 19:51014826-51014826	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.417G>A; p.M139I; 19:51016009-51016009	ovary	other; neoplasm	Substitution - Missense
c.163G>T; p.G55C; 19:51017216-51017216	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.447G>A; p.L149L; 19:51015979-51015979	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.108C>T; p.L36L; 19:51017271-51017271	skin	malignant_melanoma	Substitution - coding silent
c.423G>A; p.L141L; 19:51016003-51016003	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.804G>A; p.W268*; 19:51014827-51014827	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.34T>A; p.S12T; 19:51019097-51019097	prostate	carcinoma	Substitution - Missense
c.341G>A; p.R114H; 19:51016085-51016085	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.658C>T; p.R220W; 19:51015437-51015437	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.821G>A; p.R274H; 19:51014810-51014810	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.394C>T; p.R132*; 19:51016032-51016032	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.408C>T; p.H136H; 19:51016018-51016018	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.731C>T; p.S244L; 19:51014900-51014900	skin; neck	malignant_melanoma	Substitution - Missense
c.216G>T; p.A72A; 19:51017163-51017163	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - coding silent
c.163G>A; p.G55S; 19:51017216-51017216	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.303_308delGCTGCT; p.L103_L104delLL; 19:51016118-51016123	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - In frame
c.786C>A; p.I262I; 19:51014845-51014845	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.329G>A; p.R110H; 19:51016097-51016097	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.746C>T; p.P249L; 19:51014885-51014885	skin	malignant_melanoma	Substitution - Missense
c.746C>T; p.P249L; 19:51014885-51014885	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.803G>T; p.W268L; 19:51014828-51014828	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.803G>T; p.W268L; 19:51014828-51014828	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.585C>A; p.I195I; 19:51015510-51015510	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.314A>G; p.Q105R; 19:51016112-51016112	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.314A>G; p.Q105R; 19:51016112-51016112	large_intestine; colon	carcinoma	Substitution - Missense
c.314A>G; p.Q105R; 19:51016112-51016112	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.659G>A; p.R220Q; 19:51015436-51015436	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.727C>T; p.L243F; 19:51014904-51014904	skin	malignant_melanoma	Substitution - Missense
c.762G>A; p.Q254Q; 19:51014869-51014869	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.682G>A; p.D228N; 19:51014949-51014949	breast	carcinoma	Substitution - Missense
c.609C>T; p.V203V; 19:51015486-51015486	central_nervous_system; brain	glioma	Substitution - coding silent
c.336C>G; p.T112T; 19:51016090-51016090	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.336C>G; p.T112T; 19:51016090-51016090	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.336C>G; p.T112T; 19:51016090-51016090	thyroid	other; neoplasm	Substitution - coding silent
c.148T>G; p.S50A; 19:51017231-51017231	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.148T>G; p.S50A; 19:51017231-51017231	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.148T>G; p.S50A; 19:51017231-51017231	thyroid	other; neoplasm	Substitution - Missense
c.148T>G; p.S50A; 19:51017231-51017231	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.148T>G; p.S50A; 19:51017231-51017231	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.108C>A; p.L36L; 19:51017271-51017271	stomach	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation