lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	56547
Symbol	MMP26
Synonymous	-
Full name	matrix metallopeptidase 26
Gene description	MMP-26\|endometase\|matrilysin 2\|matrilysin-2\|matrix metalloproteinase 26\|matrix metalloproteinase-26
Cytoband	11p15
Gene type	protein-coding
Synonymous	MIM:605470; HGNC:HGNC:14249; Ensembl:ENSG00000167346; HPRD:05683; Vega:OTTHUMG00000066442

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.133G>A; p.E45K; 11:4989681-4989681	skin	malignant_melanoma	Substitution - Missense
c.137C>T; p.S46L; 11:4989685-4989685	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.707G>C; p.R236T; 11:4992075-4992075	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193G>T; p.G65W; 11:4989741-4989741	breast	carcinoma	Substitution - Missense
c.469G>A; p.A157T; 11:4990746-4990746	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.62C>T; p.P21L; 11:4988273-4988273	skin	malignant_melanoma	Substitution - Missense
c.470-9C>T; p.?; 11:4991362-4991362	stomach	carcinoma; adenocarcinoma	Unknown
c.62C>T; p.P21L; 11:4988273-4988273	skin	malignant_melanoma	Substitution - Missense
c.470-9C>T; p.?; 11:4991362-4991362	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.470-9C>T; p.?; 11:4991362-4991362	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.259G>A; p.G87R; 11:4989807-4989807	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.364G>A; p.D122N; 11:4990641-4990641	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.750T>G; p.H250Q; 11:4992118-4992118	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.348G>A; p.K116K; 11:4990625-4990625	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.741G>A; p.R247R; 11:4992109-4992109	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.183C>T; p.F61F; 11:4989731-4989731	skin	malignant_melanoma	Substitution - coding silent
c.421C>G; p.Q141E; 11:4990698-4990698	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.164C>T; p.T55I; 11:4989712-4989712	thyroid	other; neoplasm	Substitution - Missense
c.699C>T; p.H233H; 11:4992067-4992067	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.699C>T; p.H233H; 11:4992067-4992067	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.113A>G; p.Q38R; 11:4989661-4989661	pancreas	carcinoma	Substitution - Missense
c.88G>A; p.D30N; 11:4988299-4988299	skin	malignant_melanoma	Substitution - Missense
c.740G>A; p.R247K; 11:4992108-4992108	skin	malignant_melanoma	Substitution - Missense
c.740G>A; p.R247K; 11:4992108-4992108	skin	malignant_melanoma	Substitution - Missense
c.10G>A; p.V4I; 11:4988221-4988221	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.188G>C; p.R63P; 11:4989736-4989736	pancreas	carcinoma	Substitution - Missense
c.188G>C; p.R63P; 11:4989736-4989736	pancreas	carcinoma	Substitution - Missense
c.188G>C; p.R63P; 11:4989736-4989736	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.660G>A; p.G220G; 11:4992028-4992028	skin	malignant_melanoma	Substitution - coding silent
c.49G>A; p.A17T; 11:4988260-4988260	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.49G>A; p.A17T; 11:4988260-4988260	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.369_370delTA; p.Y125fs*1; 11:4990646-4990647	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.490T>A; p.F164I; 11:4991391-4991391	central_nervous_system; brain	glioma	Substitution - Missense
c.335C>A; p.P112Q; 11:4990612-4990612	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.108C>T; p.F36F; 11:4989656-4989656	skin	malignant_melanoma	Substitution - coding silent
c.606G>T; p.L202L; 11:4991974-4991974	liver	carcinoma	Substitution - coding silent
c.606G>T; p.L202L; 11:4991974-4991974	liver	carcinoma	Substitution - coding silent
c.82G>A; p.G28R; 11:4988293-4988293	skin	malignant_melanoma	Substitution - Missense
c.546T>A; p.P182P; 11:4991447-4991447	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.435A>G; p.G145G; 11:4990712-4990712	liver	carcinoma	Substitution - coding silent
c.274A>T; p.I92F; 11:4989822-4989822	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.199G>A; p.D67N; 11:4989747-4989747	skin	malignant_melanoma	Substitution - Missense
c.138G>A; p.S46S; 11:4989686-4989686	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.279G>A; p.S93S; 11:4989827-4989827	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.720C>T; p.L240L; 11:4992088-4992088	skin	malignant_melanoma	Substitution - coding silent
c.647T>G; p.L216R; 11:4992015-4992015	pancreas	carcinoma	Substitution - Missense
c.193G>C; p.G65R; 11:4989741-4989741	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.343A>G; p.M115V; 11:4990620-4990620	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.355G>A; p.A119T; 11:4990632-4990632	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.444C>T; p.D148D; 11:4990721-4990721	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.455C>T; p.S152F; 11:4990732-4990732	skin	malignant_melanoma	Substitution - Missense
c.481G>T; p.G161C; 11:4991382-4991382	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.562G>T; p.D188Y; 11:4991463-4991463	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.83G>A; p.G28E; 11:4988294-4988294	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.610C>A; p.L204M; 11:4991978-4991978	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.687T>A; p.T229T; 11:4992055-4992055	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.64C>T; p.P22S; 11:4988275-4988275	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.612G>T; p.L204L; 11:4991980-4991980	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.700G>A; p.D234N; 11:4992068-4992068	skin	malignant_melanoma	Substitution - Missense
c.744C>T; p.I248I; 11:4992112-4992112	skin	malignant_melanoma	Substitution - coding silent
c.664C>T; p.Q222*; 11:4992032-4992032	skin	malignant_melanoma	Substitution - Nonsense
c.664C>T; p.Q222*; 11:4992032-4992032	skin	malignant_melanoma	Substitution - Nonsense
c.94G>A; p.V32I; 11:4988305-4988305	large_intestine; colon	adenoma	Substitution - Missense
c.168G>T; p.Q56H; 11:4989716-4989716	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.260G>T; p.G87V; 11:4989808-4989808	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.747G>T; p.Q249H; 11:4992115-4992115	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.358G>C; p.V120L; 11:4990635-4990635	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>A; p.D243N; 11:4992095-4992095	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.517C>A; p.H173N; 11:4991418-4991418	liver	carcinoma	Substitution - Missense
c.297G>A; p.W99*; 11:4989845-4989845	skin	malignant_melanoma	Substitution - Nonsense
c.616G>A; p.A206T; 11:4991984-4991984	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.48C>T; p.F16F; 11:4988259-4988259	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.48C>T; p.F16F; 11:4988259-4988259	skin	malignant_melanoma	Substitution - coding silent
c.48C>T; p.F16F; 11:4988259-4988259	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.82G>T; p.G28*; 11:4988293-4988293	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.596G>A; p.G199E; 11:4991964-4991964	skin; extremity	malignant_melanoma	Substitution - Missense
c.748C>A; p.H250N; 11:4992116-4992116	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.684C>T; p.P228P; 11:4992052-4992052	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.556C>T; p.H186Y; 11:4991457-4991457	skin	malignant_melanoma	Substitution - Missense
c.144C>T; p.L48L; 11:4989692-4989692	skin	malignant_melanoma	Substitution - coding silent
c.6G>A; p.Q2Q; 11:4988217-4988217	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.6G>A; p.Q2Q; 11:4988217-4988217	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.741G>T; p.R247S; 11:4992109-4992109	thyroid	other; neoplasm	Substitution - Missense
c.73G>C; p.D25H; 11:4988284-4988284	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.417C>A; p.F139L; 11:4990694-4990694	breast	carcinoma	Substitution - Missense
c.278C>T; p.S93L; 11:4989826-4989826	breast	carcinoma	Substitution - Missense
c.278C>T; p.S93L; 11:4989826-4989826	skin	malignant_melanoma	Substitution - Missense
c.278C>T; p.S93L; 11:4989826-4989826	skin	malignant_melanoma	Substitution - Missense
c.278C>T; p.S93L; 11:4989826-4989826	skin	malignant_melanoma	Substitution - Missense
c.539G>A; p.G180E; 11:4991440-4991440	skin	malignant_melanoma	Substitution - Missense
c.539G>A; p.G180E; 11:4991440-4991440	skin	malignant_melanoma	Substitution - Missense
c.539G>A; p.G180E; 11:4991440-4991440	skin	malignant_melanoma	Substitution - Missense
c.539G>A; p.G180E; 11:4991440-4991440	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.539G>A; p.G180E; 11:4991440-4991440	skin	malignant_melanoma	Substitution - Missense
c.690C>A; p.Y230*; 11:4992058-4992058	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.536C>T; p.S179F; 11:4991437-4991437	skin	malignant_melanoma	Substitution - Missense
c.189G>A; p.R63R; 11:4989737-4989737	skin	malignant_melanoma	Substitution - coding silent
c.189G>A; p.R63R; 11:4989737-4989737	skin	malignant_melanoma	Substitution - coding silent
c.189G>A; p.R63R; 11:4989737-4989737	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.404delC; p.P136fs*2; 11:4990681-4990681	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.364G>T; p.D122Y; 11:4990641-4990641	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.245G>T; p.C82F; 11:4989793-4989793	ovary	carcinoma; adenocarcinoma	Substitution - Missense
c.595+2T>C; p.?; 11:4991498-4991498	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.92T>C; p.F31S; 11:4988303-4988303	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.315T>G; p.T105T; 11:4989863-4989863	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.782C>T; p.P261L; 11:4992238-4992238	skin	malignant_melanoma	Substitution - Missense
c.648G>T; p.L216L; 11:4992016-4992016	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.154G>A; p.E52K; 11:4989702-4989702	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.284G>A; p.G95E; 11:4989832-4989832	skin	malignant_melanoma	Substitution - Missense
c.121C>T; p.L41L; 11:4989669-4989669	skin	malignant_melanoma	Substitution - coding silent
c.547G>T; p.G183*; 11:4991448-4991448	pancreas	carcinoma	Substitution - Nonsense
c.481G>A; p.G161S; 11:4991382-4991382	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.354C>T; p.S118S; 11:4990631-4990631	skin	malignant_melanoma	Substitution - coding silent
c.620C>T; p.T207I; 11:4991988-4991988	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.273C>T; p.S91S; 11:4989821-4989821	skin	malignant_melanoma	Substitution - coding silent
c.515G>T; p.G172V; 11:4991416-4991416	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.68C>A; p.A23D; 11:4988279-4988279	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.145C>T; p.L49F; 11:4989693-4989693	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.406C>T; p.P136S; 11:4990683-4990683	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.97G>A; p.E33K; 11:4988308-4988308	skin	malignant_melanoma	Substitution - Missense
c.602A>T; p.N201I; 11:4991970-4991970	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation