lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5650
Symbol	KLK7
Synonymous	PRSS6\|SCCE\|hK7
Full name	kallikrein-related peptidase 7
Gene description	kallikrein 7 (chymotryptic, stratum corneum)\|kallikrein-7\|serine protease 6\|signal protein\|stratum corneum chymotryptic enzyme
Cytoband	19q13.41
Gene type	protein-coding
Synonymous	MIM:604438; HGNC:HGNC:6368; Ensembl:ENSG00000169035; HPRD:05115; Vega:OTTHUMG00000182917

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.323C>A; p.T108N; 19:50980386-50980386	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.323C>A; p.T108N; 19:50980386-50980386	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.323C>A; p.T108N; 19:50980386-50980386	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.323C>A; p.T108N; 19:50980386-50980386	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.337C>A; p.L113I; 19:50980372-50980372	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.418C>T; p.P140S; 19:50980291-50980291	skin	malignant_melanoma	Substitution - Missense
c.418C>T; p.P140S; 19:50980291-50980291	skin	malignant_melanoma	Substitution - Missense
c.377C>T; p.S126F; 19:50980332-50980332	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.290A>C; p.K97T; 19:50980419-50980419	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.290A>C; p.K97T; 19:50980419-50980419	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.610G>A; p.D204N; 19:50977688-50977688	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.99C>T; p.G33G; 19:50981889-50981889	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.681C>G; p.G227G; 19:50977617-50977617	breast	carcinoma	Substitution - coding silent
c.319C>A; p.Q107K; 19:50980390-50980390	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.567G>C; p.L189L; 19:50979827-50979827	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.549A>T; p.L183F; 19:50979845-50979845	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.78G>T; p.Q26H; 19:50981910-50981910	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.619G>A; p.G207R; 19:50977679-50977679	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.98G>A; p.G33D; 19:50981890-50981890	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.298C>T; p.R100C; 19:50980411-50980411	skin	malignant_melanoma	Substitution - Missense
c.298C>T; p.R100C; 19:50980411-50980411	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.24C>T; p.P8P; 19:50982376-50982376	skin	malignant_melanoma	Substitution - coding silent
c.441C>T; p.S147S; 19:50980268-50980268	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.714G>C; p.V238V; 19:50977584-50977584	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.678C>T; p.C226C; 19:50977620-50977620	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.393C>T; p.V131V; 19:50980316-50980316	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.678C>T; p.C226C; 19:50977620-50977620	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.522G>T; p.Q174H; 19:50979872-50979872	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.530C>T; p.T177M; 19:50979864-50979864	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.12C>A; p.S4S; 19:50982388-50982388	kidney	carcinoma; renal_cell_carcinoma	Substitution - coding silent
c.530C>T; p.T177M; 19:50979864-50979864	large_intestine; colon	carcinoma	Substitution - Missense
c.231C>T; p.T77T; 19:50980478-50980478	skin	malignant_melanoma	Substitution - coding silent
c.667A>C; p.T223P; 19:50977631-50977631	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.74-1G>A; p.?; 19:50981915-50981915	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Unknown
c.747G>A; p.M249I; 19:50977551-50977551	skin	malignant_melanoma	Substitution - Missense
c.560C>T; p.S187F; 19:50979834-50979834	skin	malignant_melanoma	Substitution - Missense
c.523G>T; p.D175Y; 19:50979871-50979871	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.305C>A; p.P102H; 19:50980404-50980404	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.579_580CC>TT; p.P194S; 19:50979814-50979815	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.304C>G; p.P102A; 19:50980405-50980405	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.469G>T; p.V157L; 19:50980240-50980240	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.411C>T; p.C137C; 19:50980298-50980298	liver	carcinoma	Substitution - coding silent
c.34T>C; p.L12L; 19:50982366-50982366	thyroid	other; neoplasm	Substitution - coding silent
c.251C>T; p.T84M; 19:50980458-50980458	breast	carcinoma	Substitution - Missense
c.716G>A; p.C239Y; 19:50977582-50977582	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.166G>T; p.G56*; 19:50981822-50981822	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.205G>T; p.A69S; 19:50981783-50981783	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.697G>A; p.G233R; 19:50977601-50977601	prostate	carcinoma	Substitution - Missense
c.512_513TC>AT; p.I171N; 19:50979881-50979882	skin; mucosal	malignant_melanoma	Substitution - Missense
c.405C>A; p.S135S; 19:50980304-50980304	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.287C>T; p.S96L; 19:50980422-50980422	skin	malignant_melanoma	Substitution - Missense
c.543G>T; p.K181N; 19:50979851-50979851	pancreas	carcinoma	Substitution - Missense
c.543G>T; p.K181N; 19:50979851-50979851	pancreas	carcinoma	Substitution - Missense
c.674C>T; p.P225L; 19:50977624-50977624	skin	malignant_melanoma	Substitution - Missense
c.559T>G; p.S187A; 19:50979835-50979835	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.665G>A; p.G222E; 19:50977633-50977633	skin	malignant_melanoma	Substitution - Missense
c.665G>A; p.G222E; 19:50977633-50977633	skin	malignant_melanoma	Substitution - Missense
c.531G>A; p.T177T; 19:50979863-50979863	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.208C>T; p.H70Y; 19:50981780-50981780	liver	carcinoma	Substitution - Missense
c.323C>T; p.T108I; 19:50980386-50980386	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.650G>A; p.G217D; 19:50977648-50977648	NS	malignant_melanoma	Substitution - Missense
c.752delA; p.K251fs*>3; 19:50977546-50977546	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.640A>G; p.T214A; 19:50977658-50977658	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.716G>T; p.C239F; 19:50977582-50977582	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.694C>A; p.P232T; 19:50977604-50977604	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.422G>A; p.G141E; 19:50980287-50980287	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.633C>A; p.C211*; 19:50977665-50977665	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.345C>G; p.L115L; 19:50980364-50980364	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.646C>T; p.Q216*; 19:50977652-50977652	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - Nonsense
c.646C>T; p.Q216*; 19:50977652-50977652	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Nonsense
c.673C>T; p.P225S; 19:50977625-50977625	skin	malignant_melanoma	Substitution - Missense
c.597C>T; p.N199N; 19:50979797-50979797	endometrium	carcinoma; serous_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation