lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	56287
Symbol	GKN1
Synonymous	AMP18\|BRICD1\|CA11\|FOV\|foveolin
Full name	gastrokine 1
Gene description	18 kDa antrum mucosa protein\|AMP-18\|BRICHOS domain containing 1\|gastrokine-1
Cytoband	2p13.3
Gene type	protein-coding
Synonymous	MIM:606402; HGNC:HGNC:23217; Ensembl:ENSG00000169605; HPRD:16217; Vega:OTTHUMG00000129574

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.354G>T; p.K118N; 2:68978978-68978978	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.542C>T; p.T181M; 2:68980765-68980765	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.182A>C; p.N61T; 2:68977710-68977710	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.426C>T; p.V142V; 2:68979981-68979981	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.255_256insA; p.A86fs*27; 2:68978879-68978880	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.567C>T; p.D189D; 2:68980790-68980790	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.533C>A; p.T178K; 2:68980756-68980756	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.267C>T; p.L89L; 2:68978891-68978891	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.483A>G; p.T161T; 2:68980038-68980038	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.248G>A; p.G83D; 2:68978872-68978872	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.31C>T; p.R11C; 2:68974666-68974666	skin	malignant_melanoma	Substitution - Missense
c.31C>T; p.R11C; 2:68974666-68974666	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.438C>A; p.S146R; 2:68979993-68979993	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.57T>C; p.I19I; 2:68977497-68977497	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.289G>A; p.V97M; 2:68978913-68978913	breast	carcinoma	Substitution - Missense
c.438C>T; p.S146S; 2:68979993-68979993	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.110A>G; p.N37S; 2:68977638-68977638	skin	malignant_melanoma	Substitution - Missense
c.99A>T; p.L33L; 2:68977539-68977539	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.427G>T; p.D143Y; 2:68979982-68979982	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.533C>T; p.T178M; 2:68980756-68980756	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.353A>C; p.K118T; 2:68978977-68978977	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.517_518insT; p.Y175fs*>26; 2:68980740-68980741	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.227C>T; p.S76F; 2:68977755-68977755	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.353A>G; p.K118R; 2:68978977-68978977	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.592G>A; p.E198K; 2:68980815-68980815	skin	malignant_melanoma	Substitution - Missense
c.388C>T; p.P130S; 2:68979943-68979943	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.352A>G; p.K118E; 2:68978976-68978976	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.352A>G; p.K118E; 2:68978976-68978976	large_intestine; rectum	NS	Substitution - Missense
c.310G>T; p.V104F; 2:68978934-68978934	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.384A>G; p.P128P; 2:68979939-68979939	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.452A>T; p.N151I; 2:68980007-68980007	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.445G>A; p.G149R; 2:68980000-68980000	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.258A>G; p.A86A; 2:68978882-68978882	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.455T>C; p.I152T; 2:68980010-68980010	pancreas	carcinoma	Substitution - Missense
c.332T>A; p.L111H; 2:68978956-68978956	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.177A>G; p.E59E; 2:68977705-68977705	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.41A>G; p.K14R; 2:68974676-68974676	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.465G>A; p.M155I; 2:68980020-68980020	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.514C>T; p.L172L; 2:68980737-68980737	skin	malignant_melanoma	Substitution - coding silent
c.116A>T; p.N39I; 2:68977644-68977644	skin	malignant_melanoma	Substitution - Missense
c.238T>A; p.Y80N; 2:68977766-68977766	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.130A>G; p.N44D; 2:68977658-68977658	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.213G>A; p.W71*; 2:68977741-68977741	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.434T>A; p.L145Q; 2:68979989-68979989	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.434T>A; p.L145Q; 2:68979989-68979989	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.427G>A; p.D143N; 2:68979982-68979982	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.444C>T; p.F148F; 2:68979999-68979999	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.444C>T; p.F148F; 2:68979999-68979999	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.392A>G; p.K131R; 2:68979947-68979947	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.469C>A; p.R157S; 2:68980024-68980024	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.446G>A; p.G149E; 2:68980001-68980001	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.446G>A; p.G149E; 2:68980001-68980001	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation