lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5610
Symbol	EIF2AK2
Synonymous	EIF2AK1\|PKR\|PPP1R83\|PRKR
Full name	eukaryotic translation initiation factor 2-alpha kinase 2
Gene description	P1/eIF-2A protein kinase\|double stranded RNA activated protein kinase\|eIF-2A protein kinase 2\|interferon-induced, double-stranded RNA-activated protein kinase\|interferon-inducible elF2alpha kinase\|p68 kinase\|protein kinase R\|protein kinase, interferon-ind
Cytoband	2p22-p21
Gene type	protein-coding
Synonymous	MIM:176871; HGNC:HGNC:9437; Ensembl:ENSG00000055332; HPRD:01468

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.151G>T; p.E51*; 2:37146942-37146942	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.470C>T; p.A157V; 2:37139677-37139677	skin	malignant_melanoma	Substitution - Missense
c.151G>T; p.E51*; 2:37146942-37146942	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.417G>A; p.Q139Q; 2:37139730-37139730	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.846delC; p.F282fs*28; 2:37126351-37126351	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1214T>C; p.I405T; 2:37119993-37119993	breast	carcinoma	Substitution - Missense
c.1214T>C; p.I405T; 2:37119993-37119993	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.763A>G; p.T255A; 2:37135506-37135506	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1131G>C; p.W377C; 2:37120076-37120076	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1591G>A; p.E531K; 2:37107338-37107338	thyroid	carcinoma	Substitution - Missense
c.672T>G; p.S224R; 2:37138285-37138285	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.270G>A; p.T90T; 2:37141672-37141672	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1090A>G; p.I364V; 2:37120117-37120117	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.65G>A; p.G22E; 2:37147742-37147742	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1589C>A; p.S530Y; 2:37107340-37107340	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.708A>G; p.Q236Q; 2:37136997-37136997	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1282G>A; p.V428I; 2:37114826-37114826	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.534C>T; p.S178S; 2:37138568-37138568	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.465A>C; p.Q155H; 2:37139682-37139682	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1083C>T; p.C361C; 2:37120124-37120124	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.5C>A; p.A2D; 2:37147802-37147802	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.594-1G>C; p.?; 2:37138364-37138364	breast	carcinoma; lobular_carcinoma	Unknown
c.919C>T; p.R307C; 2:37122654-37122654	pancreas	NS	Substitution - Missense
c.1509C>G; p.I503M; 2:37107498-37107498	liver	carcinoma	Substitution - Missense
c.837C>T; p.G279G; 2:37126360-37126360	skin	malignant_melanoma	Substitution - coding silent
c.734C>T; p.P245L; 2:37135535-37135535	skin	malignant_melanoma	Substitution - Missense
c.5C>G; p.A2G; 2:37147802-37147802	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1315C>G; p.L439V; 2:37114793-37114793	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1315C>G; p.L439V; 2:37114793-37114793	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1315C>G; p.L439V; 2:37114793-37114793	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1315C>G; p.L439V; 2:37114793-37114793	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.915G>A; p.A305A; 2:37122658-37122658	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.194delA; p.N65fs*6; 2:37146899-37146899	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1531G>T; p.E511*; 2:37107476-37107476	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1484delT; p.F495fs*39; 2:37107523-37107523	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1653T>C; p.C551C; 2:37107276-37107276	skin	malignant_melanoma	Substitution - coding silent
c.1343G>A; p.S448N; 2:37114765-37114765	stomach	adenocarcinoma	Substitution - Missense
c.1501G>T; p.G501C; 2:37107506-37107506	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.838C>T; p.Q280*; 2:37126359-37126359	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1416C>T; p.Y472Y; 2:37109257-37109257	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1512A>G; p.S504S; 2:37107495-37107495	liver	carcinoma	Substitution - coding silent
c.1417G>A; p.A473T; 2:37109256-37109256	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.217G>C; p.E73Q; 2:37146876-37146876	urinary_tract; bladder	carcinoma	Substitution - Missense
c.229A>T; p.K77*; 2:37146864-37146864	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.788T>C; p.F263S; 2:37126409-37126409	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.786-2A>G; p.?; 2:37126413-37126413	autonomic_ganglia	neuroblastoma	Unknown
c.835G>C; p.G279R; 2:37126362-37126362	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1630G>T; p.E544*; 2:37107299-37107299	thyroid	other; neoplasm	Substitution - Nonsense
c.835G>C; p.G279R; 2:37126362-37126362	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1249-6delT; p.?; 2:37114865-37114865	skin	malignant_melanoma	Unknown
c.613G>A; p.E205K; 2:37138344-37138344	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.1534-1G>A; p.?; 2:37107396-37107396	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.415C>T; p.Q139*; 2:37139732-37139732	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.30C>G; p.F10L; 2:37147777-37147777	breast	carcinoma	Substitution - Missense
c.880G>A; p.V294I; 2:37126317-37126317	pancreas	carcinoma	Substitution - Missense
c.722+3G>T; p.?; 2:37136980-37136980	kidney	other; neoplasm	Unknown
c.160G>A; p.E54K; 2:37146933-37146933	breast	carcinoma	Substitution - Missense
c.34G>C; p.E12Q; 2:37147773-37147773	urinary_tract; bladder	carcinoma	Substitution - Missense
c.309C>G; p.G103G; 2:37141633-37141633	liver	carcinoma	Substitution - coding silent
c.21A>T; p.A7A; 2:37147786-37147786	liver	carcinoma	Substitution - coding silent
c.21A>T; p.A7A; 2:37147786-37147786	liver	carcinoma	Substitution - coding silent
c.328C>G; p.Q110E; 2:37141614-37141614	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.873G>T; p.K291N; 2:37126324-37126324	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.930A>G; p.K310K; 2:37122643-37122643	skin	malignant_melanoma	Substitution - coding silent
c.369G>A; p.S123S; 2:37141573-37141573	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.237G>T; p.K79N; 2:37146856-37146856	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1446T>G; p.L482L; 2:37109227-37109227	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.67G>A; p.V23I; 2:37147740-37147740	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.333G>T; p.K111N; 2:37141609-37141609	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1074G>T; p.K358N; 2:37120133-37120133	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.915_916GG>TT; p.E306*; 2:37122657-37122658	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.925G>C; p.V309L; 2:37122648-37122648	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.195_196insA; p.A66fs*8; 2:37146897-37146898	skin; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.553A>G; p.T185A; 2:37138549-37138549	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.776T>C; p.V259A; 2:37135493-37135493	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.906C>G; p.N302K; 2:37126291-37126291	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.1316T>C; p.L439P; 2:37114792-37114792	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.717A>C; p.A239A; 2:37136988-37136988	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.282A>G; p.E94E; 2:37141660-37141660	ovary	other; neoplasm	Substitution - coding silent
c.297G>A; p.G99G; 2:37141645-37141645	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.275C>A; p.S92Y; 2:37141667-37141667	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.810A>G; p.I270M; 2:37126387-37126387	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.890G>A; p.R297H; 2:37126307-37126307	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1070C>T; p.S357L; 2:37120137-37120137	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.908A>T; p.E303V; 2:37126289-37126289	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1642C>T; p.R548*; 2:37107287-37107287	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1408G>T; p.D470Y; 2:37109265-37109265	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1649C>T; p.T550I; 2:37107280-37107280	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.101G>A; p.G34E; 2:37147706-37147706	skin	malignant_melanoma	Substitution - Missense
c.681G>T; p.L227F; 2:37138276-37138276	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.542C>T; p.S181F; 2:37138560-37138560	skin	malignant_melanoma	Substitution - Missense
c.1608G>C; p.L536F; 2:37107321-37107321	breast	carcinoma	Substitution - Missense
c.1198A>C; p.K400Q; 2:37120009-37120009	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1064C>G; p.S355*; 2:37122509-37122509	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1334G>A; p.R445Q; 2:37114774-37114774	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1150G>A; p.E384K; 2:37120057-37120057	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation