Cancer metastasis database

Annotation category 5

Gene information

Gene ID 5605
Symbol

MAP2K2

Synonymous

CFC4|MAPKK2|MEK2|MKK2|PRKMK2

Full name

mitogen-activated protein kinase kinase 2

Gene description

ERK activator kinase 2|MAP kinase kinase 2|MAPK/ERK kinase 2|dual specificity mitogen-activated protein kinase kinase 2|mitogen-activated protein kinase kinase 2, p45

Cytoband

19p13.3

Gene type

protein-coding

Synonymous

MIM:601263; HGNC:HGNC:6842; Ensembl:ENSG00000126934; HPRD:03164; Vega:OTTHUMG00000134286

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.97A>C; p.N33H; 19:4117625-4117625

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.580+1G>A; p.?; 19:4101228-4101228

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.546G>A; p.A182A; 19:4101263-4101263

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.380C>T; p.S127L; 19:4110579-4110579

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.855C>T; p.D285D; 19:4099265-4099265

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.342G>T; p.Q114H; 19:4110617-4110617

 bonechondrosarcomaSubstitution - Missense

c.899C>T; p.P300L; 19:4099221-4099221

 kidneyother; neoplasmSubstitution - Missense

c.281C>T; p.S94L; 19:4117441-4117441

 pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.150G>C; p.Q50H; 19:4117572-4117572

 breastcarcinomaSubstitution - Missense

c.908G>A; p.R303H; 19:4099212-4099212

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.376A>G; p.N126D; 19:4110583-4110583

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.706-10T>C; p.?; 19:4099424-4099424

 large_intestinecarcinoma; adenocarcinomaUnknown

c.383C>T; p.P128L; 19:4110576-4110576

 skinmalignant_melanomaSubstitution - Missense

c.169T>G; p.F57V; 19:4117553-4117553

 skinmalignant_melanomaSubstitution - Missense

c.169T>G; p.F57V; 19:4117553-4117553

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.179A>C; p.Q60P; 19:4117543-4117543

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - Missense

c.179A>C; p.Q60P; 19:4117543-4117543

 skinmalignant_melanomaSubstitution - Missense

c.1163G>A; p.R388Q; 19:4090638-4090638

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.179A>C; p.Q60P; 19:4117543-4117543

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.179A>C; p.Q60P; 19:4117543-4117543

 skinmalignant_melanomaSubstitution - Missense

c.1021G>C; p.D341H; 19:4095413-4095413

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.158G>A; p.R53Q; 19:4117564-4117564

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.196G>A; p.E66K; 19:4117526-4117526

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.99_100CC>TT; p.(=); 19:4117622-4117623

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.453C>T; p.D151D; 19:4102451-4102451

 thyroidother; neoplasmSubstitution - coding silent

c.984G>T; p.E328D; 19:4097279-4097279

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1065G>A; p.A355A; 19:4094480-4094480

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.991C>A; p.P331T; 19:4095443-4095443

 oesophaguscarcinomaSubstitution - Missense

c.981C>T; p.N327N; 19:4097282-4097282

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.743C>T; p.S248L; 19:4099377-4099377

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.660C>A; p.I220I; 19:4101064-4101064

 breastcarcinomaSubstitution - coding silent

c.744G>T; p.S248S; 19:4099376-4099376

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.402C>T; p.Y134Y; 19:4110557-4110557

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.171T>A; p.F57L; 19:4117551-4117551

 pancreascarcinomaSubstitution - Missense

c.847G>A; p.V283M; 19:4099273-4099273

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.193G>A; p.G65S; 19:4117529-4117529

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.169T>C; p.F57L; 19:4117553-4117553

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - Missense

c.420C>T; p.D140D; 19:4110539-4110539

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.327G>A; p.P109P; 19:4110632-4110632

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.327G>A; p.P109P; 19:4110632-4110632

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1115C>T; p.S372F; 19:4090686-4090686

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.448A>T; p.M150L; 19:4110511-4110511

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.249C>T; p.G83G; 19:4117473-4117473

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.924C>T; p.H308H; 19:4097339-4097339

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.363C>A; p.V121V; 19:4110596-4110596

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.401A>G; p.Y134C; 19:4110558-4110558

 salivary_glandcarcinoma; adenoid_cystic_carcinomaSubstitution - Missense

c.363C>A; p.V121V; 19:4110596-4110596

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.334C>A; p.R112R; 19:4110625-4110625

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.471G>C; p.Q157H; 19:4102433-4102433

 ovaryother; neoplasmSubstitution - Missense

c.351C>T; p.R117R; 19:4110608-4110608

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.216C>T; p.F72F; 19:4117506-4117506

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1046G>A; p.C349Y; 19:4095388-4095388

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.136C>T; p.L46F; 19:4117586-4117586

 skinmalignant_melanomaSubstitution - Missense

c.216C>T; p.F72F; 19:4117506-4117506

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.270G>A; p.Q90Q; 19:4117452-4117452

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.846C>T; p.P282P; 19:4099274-4099274

 ovaryother; neoplasmSubstitution - coding silent

c.639C>T; p.F213F; 19:4101085-4101085

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.893C>T; p.P298L; 19:4099227-4099227

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.807G>A; p.P269P; 19:4099313-4099313

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.247G>A; p.G83S; 19:4117475-4117475

 breastcarcinomaSubstitution - Missense

c.581-3C>T; p.?; 19:4101146-4101146

 skin; head_neckcarcinoma; squamous_cell_carcinomaUnknown

c.843G>C; p.R281R; 19:4099277-4099277

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.875A>G; p.H292R; 19:4099245-4099245

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.159G>A; p.R53R; 19:4117563-4117563

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent