lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	55789
Symbol	DEPDC1B
Synonymous	BRCC3\|XTP1
Full name	DEP domain containing 1B
Gene description	DEP domain-containing protein 1B\|HBV X-transactivated gene 8 protein\|HBV XAg-transactivated protein 8\|HBxAg transactivated protein 1\|breast cancer cell 3
Cytoband	5q12.1
Gene type	protein-coding
Synonymous	MIM:616073; HGNC:HGNC:24902; Ensembl:ENSG00000035499; HPRD:16794; Vega:OTTHUMG00000097083

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.351G>T; p.K117N; 5:60647497-60647497	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.605C>T; p.S202F; 5:60644849-60644849	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.237C>T; p.F79F; 5:60687039-60687039	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.625G>A; p.V209I; 5:60644829-60644829	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.625G>A; p.V209I; 5:60644829-60644829	pancreas	carcinoma; adenocarcinoma	Substitution - Missense
c.444T>A; p.V148V; 5:60647404-60647404	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.181C>T; p.Q61*; 5:60687095-60687095	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.472C>G; p.R158G; 5:60645598-60645598	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.472C>G; p.R158G; 5:60645598-60645598	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.498G>A; p.V166V; 5:60645572-60645572	pancreas	carcinoma	Substitution - coding silent
c.181C>A; p.Q61K; 5:60687095-60687095	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.557G>T; p.W186L; 5:60645513-60645513	liver	carcinoma	Substitution - Missense
c.1429-3_1429-2insT; p.?; 5:60597916-60597917	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.751G>A; p.A251T; 5:60642818-60642818	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.302G>A; p.R101H; 5:60686974-60686974	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.641C>T; p.S214L; 5:60644813-60644813	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.563C>T; p.S188F; 5:60645507-60645507	breast	carcinoma	Substitution - Missense
c.592C>G; p.L198V; 5:60644862-60644862	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1105G>A; p.D369N; 5:60603528-60603528	skin	malignant_melanoma	Substitution - Missense
c.661G>A; p.V221I; 5:60644793-60644793	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.939G>C; p.Q313H; 5:60605816-60605816	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.86C>T; p.P29L; 5:60687190-60687190	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1582C>T; p.R528*; 5:60597761-60597761	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1582C>T; p.R528*; 5:60597761-60597761	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.181C>G; p.Q61E; 5:60687095-60687095	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1155G>A; p.L385L; 5:60603478-60603478	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.283G>T; p.E95*; 5:60686993-60686993	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.142G>A; p.E48K; 5:60687134-60687134	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.760C>T; p.P254S; 5:60638888-60638888	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1111G>A; p.V371M; 5:60603522-60603522	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.875T>G; p.F292C; 5:60638773-60638773	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1512A>G; p.K504K; 5:60597831-60597831	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.156G>A; p.W52*; 5:60687120-60687120	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1580T>C; p.F527S; 5:60597763-60597763	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.851A>C; p.E284A; 5:60638797-60638797	skin	malignant_melanoma	Substitution - Missense
c.559A>C; p.K187Q; 5:60645511-60645511	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1205C>G; p.S402C; 5:60603428-60603428	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1510A>G; p.K504E; 5:60597833-60597833	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1217G>A; p.R406H; 5:60603416-60603416	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1440C>T; p.S480S; 5:60597903-60597903	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1574G>C; p.R525T; 5:60597769-60597769	urinary_tract; bladder	carcinoma	Substitution - Missense
c.106C>T; p.R36C; 5:60687170-60687170	skin	malignant_melanoma	Substitution - Missense
c.100C>T; p.R34C; 5:60687176-60687176	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1568G>T; p.R523I; 5:60597775-60597775	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.956T>C; p.L319P; 5:60605799-60605799	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.74G>A; p.R25H; 5:60687202-60687202	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1146A>C; p.V382V; 5:60603487-60603487	pancreas	carcinoma; adenocarcinoma	Substitution - coding silent
c.716delT; p.P240fs*8; 5:60642853-60642853	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Deletion - Frameshift
c.1058G>A; p.R353Q; 5:60605697-60605697	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.29C>A; p.P10Q; 5:60700065-60700065	lung	carcinoid-endocrine_tumour; typical	Substitution - Missense
c.60C>A; p.T20T; 5:60687216-60687216	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1186C>T; p.P396S; 5:60603447-60603447	skin	malignant_melanoma	Substitution - Missense
c.1082C>T; p.S361F; 5:60603551-60603551	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.1186C>T; p.P396S; 5:60603447-60603447	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1082C>T; p.S361F; 5:60603551-60603551	skin	malignant_melanoma	Substitution - Missense
c.148G>T; p.V50L; 5:60687128-60687128	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.285A>T; p.E95D; 5:60686991-60686991	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.190G>T; p.G64C; 5:60687086-60687086	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.758-1G>T; p.?; 5:60638891-60638891	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1297C>A; p.R433S; 5:60599206-60599206	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.206G>T; p.R69L; 5:60687070-60687070	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1539A>G; p.A513A; 5:60597804-60597804	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.813C>A; p.V271V; 5:60638835-60638835	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.85C>T; p.P29S; 5:60687191-60687191	skin	malignant_melanoma	Substitution - Missense
c.1132G>C; p.A378P; 5:60603501-60603501	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1329A>G; p.Q443Q; 5:60599174-60599174	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.196G>A; p.E66K; 5:60687080-60687080	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1528C>T; p.L510L; 5:60597815-60597815	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.86C>G; p.P29R; 5:60687190-60687190	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1108G>T; p.E370*; 5:60603525-60603525	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.351G>A; p.K117K; 5:60647497-60647497	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.330A>G; p.S110S; 5:60647518-60647518	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.101G>A; p.R34H; 5:60687175-60687175	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.101G>A; p.R34H; 5:60687175-60687175	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.101G>A; p.R34H; 5:60687175-60687175	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.315-2A>C; p.?; 5:60647535-60647535	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.192C>T; p.G64G; 5:60687084-60687084	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1583G>A; p.R528Q; 5:60597760-60597760	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1583G>A; p.R528Q; 5:60597760-60597760	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.235_236insA; p.F79fs*8; 5:60687040-60687041	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.910A>C; p.K304Q; 5:60605845-60605845	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.519_520CC>TT; p.R174C; 5:60645550-60645551	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.216G>T; p.T72T; 5:60687060-60687060	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.121G>A; p.E41K; 5:60687155-60687155	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.523A>G; p.R175G; 5:60645547-60645547	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1255G>T; p.G419*; 5:60599248-60599248	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.659A>T; p.N220I; 5:60644795-60644795	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1446T>C; p.P482P; 5:60597897-60597897	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.501A>T; p.P167P; 5:60645569-60645569	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.521G>A; p.R174H; 5:60645549-60645549	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.899-10delT; p.?; 5:60605866-60605866	liver	carcinoma	Unknown
c.396T>C; p.N132N; 5:60647452-60647452	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.49-1G>C; p.?; 5:60687228-60687228	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.624C>T; p.D208D; 5:60644830-60644830	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.362delA; p.N121fs*25; 5:60647486-60647486	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.319C>T; p.P107S; 5:60647529-60647529	genital_tract; extragonadal	germ_cell_tumour; seminoma	Substitution - Missense
c.1177C>T; p.L393L; 5:60603456-60603456	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.350_351insA; p.K118fs*10; 5:60647497-60647498	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.559A>G; p.K187E; 5:60645511-60645511	liver	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation