lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	55771
Symbol	PRR11
Synonymous	-
Full name	proline rich 11
Gene description	proline-rich protein 11\|transcription repressor of MHCII
Cytoband	17q22
Gene type	protein-coding
Synonymous	MIM:615920; HGNC:HGNC:25619; HPRD:07726

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.502G>T; p.D168Y; 17:59193591-59193591	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.984G>A; p.V328V; 17:59197759-59197759	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.984G>A; p.V328V; 17:59197759-59197759	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.784G>A; p.V262I; 17:59195370-59195370	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1064G>A; p.S355N; 17:59201612-59201612	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.399G>A; p.L133L; 17:59185559-59185559	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.766C>T; p.R256W; 17:59195352-59195352	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.199C>T; p.P67S; 17:59185124-59185124	skin	malignant_melanoma	Substitution - Missense
c.417T>G; p.S139R; 17:59193506-59193506	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.140C>A; p.S47Y; 17:59185065-59185065	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.917+1G>T; p.?; 17:59197604-59197604	liver	carcinoma	Unknown
c.780_785delTACCGT; p.T261_V262delTV; 17:59195366-59195371	breast	carcinoma; ductal_carcinoma	Deletion - In frame
c.917+1G>T; p.?; 17:59197604-59197604	liver	carcinoma	Unknown
c.933C>T; p.T311T; 17:59197708-59197708	skin	malignant_melanoma	Substitution - coding silent
c.412G>A; p.E138K; 17:59193501-59193501	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.907G>A; p.D303N; 17:59197593-59197593	skin	malignant_melanoma	Substitution - Missense
c.354G>C; p.Q118H; 17:59185514-59185514	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.553C>T; p.P185S; 17:59193642-59193642	skin	malignant_melanoma	Substitution - Missense
c.888G>A; p.R296R; 17:59197574-59197574	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.839G>T; p.R280L; 17:59195425-59195425	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.994G>T; p.A332S; 17:59197769-59197769	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.19C>T; p.R7*; 17:59169771-59169771	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.422C>T; p.S141F; 17:59193511-59193511	skin	malignant_melanoma	Substitution - Missense
c.422C>T; p.S141F; 17:59193511-59193511	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.310C>T; p.P104S; 17:59185470-59185470	skin	malignant_melanoma	Substitution - Missense
c.362delT; p.L122fs*12; 17:59185522-59185522	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.989C>T; p.T330M; 17:59197764-59197764	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.158A>G; p.Q53R; 17:59185083-59185083	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.483C>T; p.C161C; 17:59193572-59193572	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.127A>T; p.R43*; 17:59169879-59169879	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.193A>T; p.N65Y; 17:59185118-59185118	breast	carcinoma	Substitution - Missense
c.286G>A; p.E96K; 17:59185446-59185446	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.900delA; p.V302fs*3; 17:59197586-59197586	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.767G>A; p.R256Q; 17:59195353-59195353	pancreas	other; adenoma	Substitution - Missense
c.335T>C; p.L112P; 17:59185495-59185495	breast	carcinoma	Substitution - Missense
c.419C>A; p.S140Y; 17:59193508-59193508	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.419C>A; p.S140Y; 17:59193508-59193508	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.915G>C; p.E305D; 17:59197601-59197601	pancreas	carcinoma	Substitution - Missense
c.46G>A; p.E16K; 17:59169798-59169798	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.903A>G; p.K301K; 17:59197589-59197589	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.778_783delGTTACC; p.T261_V262delTV; 17:59195364-59195369	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Deletion - In frame
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.58delA; p.E23fs*9; 17:59169810-59169810	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.632C>T; p.A211V; 17:59193721-59193721	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.632C>T; p.A211V; 17:59193721-59193721	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.497C>T; p.P166L; 17:59193586-59193586	skin	malignant_melanoma	Substitution - Missense
c.906C>T; p.V302V; 17:59197592-59197592	skin	malignant_melanoma	Substitution - coding silent
c.906C>T; p.V302V; 17:59197592-59197592	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.657delA; p.D222fs*6; 17:59194768-59194768	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.419C>T; p.S140F; 17:59193508-59193508	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.981A>G; p.P327P; 17:59197756-59197756	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.133G>C; p.G45R; 17:59185058-59185058	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.552_554delTCC; p.P192delP; 17:59193641-59193643	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.57_58insA; p.E23fs*46; 17:59169809-59169810	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.57_58insA; p.E23fs*46; 17:59169809-59169810	lung	carcinoma; small_cell_carcinoma	Insertion - Frameshift
c.57_58insA; p.E23fs*46; 17:59169809-59169810	oesophagus; lower_third	carcinoma; adenocarcinoma	Insertion - Frameshift
c.57_58insA; p.E23fs*46; 17:59169809-59169810	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1060A>T; p.S354C; 17:59201608-59201608	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.484G>T; p.V162F; 17:59193573-59193573	liver	carcinoma	Substitution - Missense
c.1004G>A; p.R335K; 17:59197779-59197779	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.25C>T; p.R9*; 17:59169777-59169777	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.532C>G; p.P178A; 17:59193621-59193621	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.132C>T; p.V44V; 17:59185057-59185057	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.42A>G; p.K14K; 17:59169794-59169794	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.26G>C; p.R9P; 17:59169778-59169778	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.917G>C; p.R306T; 17:59197603-59197603	central_nervous_system; brain	glioma	Substitution - Missense
c.917G>C; p.R306T; 17:59197603-59197603	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.886C>T; p.R296W; 17:59197572-59197572	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.133G>A; p.G45S; 17:59185058-59185058	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.108T>A; p.P36P; 17:59169860-59169860	liver	carcinoma	Substitution - coding silent
c.108T>A; p.P36P; 17:59169860-59169860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.108T>A; p.P36P; 17:59169860-59169860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1015-3T>A; p.?; 17:59201560-59201560	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Unknown
c.541G>A; p.A181T; 17:59193630-59193630	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.871A>T; p.S291C; 17:59197557-59197557	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.575C>T; p.P192L; 17:59193664-59193664	pancreas	carcinoma	Substitution - Missense
c.181_197del17; p.W62fs*1; 17:59185106-59185122	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.316C>T; p.R106C; 17:59185476-59185476	skin	malignant_melanoma	Substitution - Missense
c.47A>T; p.E16V; 17:59169799-59169799	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation