lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	55742
Symbol	PARVA
Synonymous	CH-ILKBP\|MXRA2
Full name	parvin, alpha
Gene description	actopaxin\|alpha-parvin\|calponin-like integrin-linked kinase-binding protein\|matrix-remodeling-associated protein 2
Cytoband	11p15.3
Gene type	protein-coding
Synonymous	MIM:608120; HGNC:HGNC:14652; HPRD:16283

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.766C>G; p.H256D; 11:12513328-12513328	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.900_901GG>TT; p.M300_G301>IW; 11:12517642-12517643	lung	carcinoma; adenocarcinoma	Complex - compound substitution
c.968A>C; p.K323T; 11:12517710-12517710	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.968A>C; p.K323T; 11:12517710-12517710	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.11C>T; p.S4F; 11:12377658-12377658	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.364G>T; p.D122Y; 11:12477913-12477913	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.938T>C; p.F313S; 11:12517680-12517680	skin	malignant_melanoma	Substitution - Missense
c.300A>G; p.V100V; 11:12477849-12477849	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.31G>A; p.V11I; 11:12377678-12377678	pancreas	carcinoma	Substitution - Missense
c.552C>T; p.A184A; 11:12504324-12504324	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.227-1G>T; p.?; 11:12473912-12473912	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.856C>G; p.L286V; 11:12514054-12514054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.762C>T; p.F254F; 11:12513324-12513324	skin	malignant_melanoma	Substitution - coding silent
c.1012_1013insATGGAG; p.G337_G338insDG; 11:12518487-12518488	breast	carcinoma; basal_(triple-negative)_carcinoma	Insertion - In frame
c.1012_1013insATGGAG; p.G337_G338insDG; 11:12518487-12518488	breast	carcinoma; basal_(triple-negative)_carcinoma	Insertion - In frame
c.1012_1013insATGGAG; p.G337_G338insDG; 11:12518487-12518488	breast	carcinoma; basal_(triple-negative)_carcinoma	Insertion - In frame
c.6C>T; p.A2A; 11:12377653-12377653	breast	carcinoma	Substitution - coding silent
c.79G>T; p.D27Y; 11:12377726-12377726	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.344T>C; p.I115T; 11:12477893-12477893	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.928C>G; p.L310V; 11:12517670-12517670	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.211G>A; p.E71K; 11:12473819-12473819	breast	carcinoma	Substitution - Missense
c.798+2T>G; p.?; 11:12513362-12513362	breast	carcinoma	Unknown
c.798+2T>G; p.?; 11:12513362-12513362	breast	carcinoma	Unknown
c.471G>T; p.L157L; 11:12496528-12496528	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1076G>A; p.R359Q; 11:12527882-12527882	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.818A>G; p.N273S; 11:12514016-12514016	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.797A>G; p.K266R; 11:12513359-12513359	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.577C>T; p.L193L; 11:12504349-12504349	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1111G>A; p.V371M; 11:12527917-12527917	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1111G>A; p.V371M; 11:12527917-12527917	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.798+10G>T; p.?; 11:12513370-12513370	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.605G>A; p.R202H; 11:12504377-12504377	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.605G>A; p.R202H; 11:12504377-12504377	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.661C>A; p.R221R; 11:12508587-12508587	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.611C>G; p.P204R; 11:12504383-12504383	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.669A>G; p.G223G; 11:12508595-12508595	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1032G>A; p.P344P; 11:12518507-12518507	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.606C>T; p.R202R; 11:12504378-12504378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.606C>T; p.R202R; 11:12504378-12504378	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.606C>T; p.R202R; 11:12504378-12504378	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.775G>A; p.D259N; 11:12513337-12513337	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.517A>G; p.R173G; 11:12496574-12496574	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.330T>C; p.V110V; 11:12477879-12477879	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1031C>T; p.P344L; 11:12518506-12518506	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.947C>A; p.T316N; 11:12517689-12517689	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.947C>A; p.T316N; 11:12517689-12517689	pancreas	carcinoma	Substitution - Missense
c.675C>T; p.L225L; 11:12508601-12508601	skin	malignant_melanoma	Substitution - coding silent
c.616C>T; p.R206*; 11:12504388-12504388	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.984C>T; p.S328S; 11:12518459-12518459	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1019A>G; p.E340G; 11:12518494-12518494	liver	carcinoma	Substitution - Missense
c.1019A>G; p.E340G; 11:12518494-12518494	liver	carcinoma	Substitution - Missense
c.1106G>A; p.R369H; 11:12527912-12527912	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1106G>A; p.R369H; 11:12527912-12527912	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.983C>T; p.S328F; 11:12518458-12518458	skin	malignant_melanoma	Substitution - Missense
c.1110C>T; p.N370N; 11:12527916-12527916	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - coding silent
c.219G>A; p.T73T; 11:12473827-12473827	liver	carcinoma	Substitution - coding silent
c.219G>A; p.T73T; 11:12473827-12473827	liver	carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation