lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5530
Symbol	PPP3CA
Synonymous	CALN\|CALNA\|CALNA1\|CCN1\|CNA1\|PPP2B
Full name	protein phosphatase 3, catalytic subunit, alpha isozyme
Gene description	CAM-PRP catalytic subunit\|calcineurin A alpha\|calmodulin-dependent calcineurin A subunit alpha isoform\|protein phosphatase 2B, catalytic subunit, alpha isoform\|protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform\|serine/threonine-protein
Cytoband	4q24
Gene type	protein-coding
Synonymous	MIM:114105; HGNC:HGNC:9314; Ensembl:ENSG00000138814; HPRD:00234; Vega:OTTHUMG00000133839

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.531C>A; p.A177A; 4:101098478-101098478	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.531C>A; p.A177A; 4:101098478-101098478	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.64C>A; p.P22T; 4:101196111-101196111	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1451C>T; p.P484L; 4:101025980-101025980	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1451C>T; p.P484L; 4:101025980-101025980	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.300G>A; p.K100K; 4:101109038-101109038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1451C>T; p.P484L; 4:101025980-101025980	stomach	adenocarcinoma	Substitution - Missense
c.734A>G; p.Q245R; 4:101093824-101093824	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1018C>T; p.P340S; 4:101063295-101063295	skin	malignant_melanoma	Substitution - Missense
c.985A>G; p.M329V; 4:101063328-101063328	urinary_tract; bladder	carcinoma	Substitution - Missense
c.451C>A; p.H151N; 4:101099656-101099656	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.848C>G; p.A283G; 4:101083198-101083198	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.668C>A; p.A223E; 4:101093890-101093890	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1349A>G; p.E450G; 4:101029186-101029186	breast	carcinoma	Substitution - Missense
c.1006T>C; p.C336R; 4:101063307-101063307	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1190G>A; p.R397K; 4:101040533-101040533	skin	malignant_melanoma	Substitution - Missense
c.1432C>T; p.R478*; 4:101025999-101025999	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1432C>T; p.R478*; 4:101025999-101025999	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.70C>T; p.P24S; 4:101196105-101196105	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1371T>A; p.A457A; 4:101026060-101026060	skin	malignant_melanoma	Substitution - coding silent
c.1195A>C; p.K399Q; 4:101040528-101040528	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.841C>T; p.H281Y; 4:101083205-101083205	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1410C>T; p.F470F; 4:101026021-101026021	breast	carcinoma	Substitution - coding silent
c.884A>G; p.Q295R; 4:101080603-101080603	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1459A>G; p.R487G; 4:101025972-101025972	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1042G>T; p.D348Y; 4:101063271-101063271	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.925C>T; p.P309S; 4:101080562-101080562	skin	malignant_melanoma	Substitution - Missense
c.1482C>A; p.A494A; 4:101025949-101025949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1025G>T; p.W342L; 4:101063288-101063288	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.789G>A; p.P263P; 4:101083257-101083257	pancreas	carcinoma	Substitution - coding silent
c.789G>A; p.P263P; 4:101083257-101083257	pancreas	carcinoma	Substitution - coding silent
c.789G>A; p.P263P; 4:101083257-101083257	pancreas	carcinoma	Substitution - coding silent
c.7G>A; p.E3K; 4:101346790-101346790	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1358A>G; p.E453G; 4:101029177-101029177	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1565G>A; p.522; 4:101025866-101025866	skin	malignant_melanoma	Substitution - coding silent
c.502A>C; p.I168L; 4:101098507-101098507	pancreas	carcinoma	Substitution - Missense
c.230delA; p.N77fs*22; 4:101195945-101195945	stomach	adenocarcinoma	Deletion - Frameshift
c.1523A>G; p.N508S; 4:101025908-101025908	liver	carcinoma	Substitution - Missense
c.126T>C; p.R42R; 4:101196049-101196049	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.520G>T; p.V174L; 4:101098489-101098489	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.893G>A; p.G298D; 4:101080594-101080594	skin	malignant_melanoma	Substitution - Missense
c.1480G>A; p.A494T; 4:101025951-101025951	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.73C>T; p.P25S; 4:101196102-101196102	skin	malignant_melanoma	Substitution - Missense
c.1087G>C; p.E363Q; 4:101061156-101061156	breast	carcinoma	Substitution - Missense
c.451C>T; p.H151Y; 4:101099656-101099656	skin	malignant_melanoma	Substitution - Missense
c.451C>T; p.H151Y; 4:101099656-101099656	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1456C>T; p.R486C; 4:101025975-101025975	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1456C>T; p.R486C; 4:101025975-101025975	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1396A>G; p.K466E; 4:101026035-101026035	urinary_tract; bladder	carcinoma	Substitution - Missense
c.172G>T; p.E58*; 4:101196003-101196003	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1240A>T; p.R414*; 4:101040483-101040483	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1418C>A; p.A473D; 4:101026013-101026013	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1242-1G>T; p.?; 4:101032365-101032365	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.312C>T; p.V104V; 4:101109026-101109026	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.335G>A; p.R112H; 4:101109003-101109003	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1444A>T; p.R482W; 4:101025987-101025987	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.592G>T; p.V198L; 4:101098417-101098417	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.840C>G; p.A280A; 4:101083206-101083206	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1013_1015delCTC; p.P338delP; 4:101063298-101063300	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.75A>T; p.P25P; 4:101196100-101196100	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.853G>A; p.D285N; 4:101083193-101083193	skin	malignant_melanoma	Substitution - Missense
c.555T>G; p.L185L; 4:101098454-101098454	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.956-3delT; p.?; 4:101063360-101063360	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.349G>T; p.G117W; 4:101108989-101108989	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.674G>C; p.G225A; 4:101093884-101093884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1360G>A; p.A454T; 4:101029175-101029175	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.144G>A; p.A48A; 4:101196031-101196031	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.846A>C; p.E282D; 4:101083200-101083200	breast	carcinoma	Substitution - Missense
c.588G>C; p.L196L; 4:101098421-101098421	breast	carcinoma	Substitution - coding silent
c.1439A>T; p.N480I; 4:101025992-101025992	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1293G>T; p.M431I; 4:101032313-101032313	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.395A>T; p.Y132F; 4:101099712-101099712	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.101T>C; p.V34A; 4:101196074-101196074	breast	carcinoma	Substitution - Missense
c.1304G>T; p.G435V; 4:101032302-101032302	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.408G>A; p.L136L; 4:101099699-101099699	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.408G>A; p.L136L; 4:101099699-101099699	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.541G>A; p.A181T; 4:101098468-101098468	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.209C>G; p.S70*; 4:101195966-101195966	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.874A>G; p.R292G; 4:101080613-101080613	liver	carcinoma	Substitution - Missense
c.1395_1396insA; p.I467fs*3; 4:101026035-101026036	soft_tissue; blood_vessel	angiosarcoma	Insertion - Frameshift
c.1429G>C; p.D477H; 4:101026002-101026002	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.97G>T; p.E33*; 4:101196078-101196078	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1254G>C; p.E418D; 4:101032352-101032352	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1265C>T; p.T422M; 4:101032341-101032341	breast	carcinoma	Substitution - Missense
c.218G>A; p.R73Q; 4:101195957-101195957	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.570G>A; p.L190L; 4:101098439-101098439	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1348G>C; p.E450Q; 4:101029187-101029187	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.913A>T; p.I305F; 4:101080574-101080574	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.955+9T>A; p.?; 4:101080523-101080523	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.836G>A; p.R279Q; 4:101083210-101083210	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>T; p.E220*; 4:101093900-101093900	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.650G>T; p.R217L; 4:101093908-101093908	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.248C>T; p.A83V; 4:101195927-101195927	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1296_1297CC>TT; p.P433S; 4:101032309-101032310	skin	malignant_melanoma	Substitution - Missense
c.1296_1297CC>TT; p.P433S; 4:101032309-101032310	skin	malignant_melanoma	Substitution - Missense
c.1172C>T; p.A391V; 4:101040551-101040551	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1417G>T; p.A473S; 4:101026014-101026014	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.493G>A; p.E165K; 4:101099614-101099614	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation