lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	55124
Symbol	PIWIL2
Synonymous	CT80\|HILI\|PIWIL1L\|mili
Full name	piwi-like RNA-mediated gene silencing 2
Gene description	80kDa PIWIL2 short isoform\|Miwi like\|cancer/testis antigen 80\|piwi-like 2\|piwi-like protein 2\|piwil2-like protein
Cytoband	8p21.3
Gene type	protein-coding
Synonymous	MIM:610312; HGNC:HGNC:17644; Ensembl:ENSG00000197181; HPRD:11434; Vega:OTTHUMG00000097767

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1405C>T; p.Q469*; 8:22304818-22304818	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.926_927insA; p.I311fs*7; 8:22288606-22288607	breast	carcinoma	Insertion - Frameshift
c.926_927insA; p.I311fs*7; 8:22288606-22288607	breast	carcinoma	Insertion - Frameshift
c.2197G>A; p.D733N; 8:22315134-22315134	breast	carcinoma	Substitution - Missense
c.785A>C; p.K262T; 8:22287569-22287569	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.348C>T; p.L116L; 8:22281438-22281438	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.182G>A; p.R61K; 8:22279568-22279568	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1417A>G; p.I473V; 8:22304830-22304830	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1387A>G; p.T463A; 8:22304800-22304800	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.234G>A; p.L78L; 8:22281155-22281155	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1274G>A; p.R425H; 8:22304113-22304113	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1443T>C; p.D481D; 8:22304856-22304856	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2878C>G; p.H960D; 8:22355461-22355461	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1103G>A; p.R368Q; 8:22290268-22290268	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2763G>A; p.Q921Q; 8:22354376-22354376	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.160C>T; p.P54S; 8:22279546-22279546	breast	carcinoma	Substitution - Missense
c.396G>C; p.K132N; 8:22281486-22281486	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1942C>A; p.R648R; 8:22311253-22311253	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2016C>A; p.I672I; 8:22314354-22314354	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.73C>T; p.P25S; 8:22279459-22279459	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1084G>A; p.G362S; 8:22290249-22290249	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2430T>C; p.I810I; 8:22352985-22352985	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2684A>G; p.H895R; 8:22354297-22354297	pancreas	carcinoma	Substitution - Missense
c.1282C>T; p.R428C; 8:22304121-22304121	skin	malignant_melanoma	Substitution - Missense
c.1282C>T; p.R428C; 8:22304121-22304121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1282C>T; p.R428C; 8:22304121-22304121	skin	malignant_melanoma	Substitution - Missense
c.531G>A; p.P177P; 8:22283139-22283139	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.531G>A; p.P177P; 8:22283139-22283139	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.531G>A; p.P177P; 8:22283139-22283139	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1222G>A; p.E408K; 8:22304061-22304061	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2721C>A; p.V907V; 8:22354334-22354334	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.927_928insA; p.I311fs*7; 8:22288607-22288608	breast	carcinoma	Insertion - Frameshift
c.1889G>A; p.G630D; 8:22311200-22311200	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2088C>T; p.S696S; 8:22314426-22314426	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1356C>A; p.F452L; 8:22304195-22304195	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2360G>C; p.S787T; 8:22318232-22318232	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1283G>A; p.R428H; 8:22304122-22304122	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1129C>T; p.L377L; 8:22290294-22290294	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.199G>A; p.E67K; 8:22281120-22281120	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.628G>A; p.E210K; 8:22283236-22283236	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.628G>A; p.E210K; 8:22283236-22283236	skin	malignant_melanoma	Substitution - Missense
c.1748C>A; p.S583Y; 8:22310022-22310022	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1613G>T; p.R538I; 8:22308000-22308000	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1055T>G; p.L352R; 8:22289915-22289915	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2080G>A; p.V694M; 8:22314418-22314418	ovary	other; neoplasm	Substitution - Missense
c.2355G>A; p.V785V; 8:22318227-22318227	skin	malignant_melanoma	Substitution - coding silent
c.1904G>A; p.R635H; 8:22311215-22311215	prostate	carcinoma	Substitution - Missense
c.1950G>C; p.E650D; 8:22311261-22311261	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2795G>T; p.W932L; 8:22355378-22355378	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1630G>A; p.A544T; 8:22308017-22308017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2777A>G; p.K926R; 8:22355360-22355360	skin	malignant_melanoma	Substitution - Missense
c.1118G>T; p.G373V; 8:22290283-22290283	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.854T>C; p.L285P; 8:22287638-22287638	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2311T>C; p.W771R; 8:22318183-22318183	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1664G>A; p.R555H; 8:22308051-22308051	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.255G>C; p.K85N; 8:22281176-22281176	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.452C>T; p.A151V; 8:22283060-22283060	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.287-2A>G; p.?; 8:22281375-22281375	prostate	carcinoma	Unknown
c.1831C>A; p.P611T; 8:22311142-22311142	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.489C>T; p.I163I; 8:22283097-22283097	skin	malignant_melanoma	Substitution - coding silent
c.2208G>T; p.L736L; 8:22315145-22315145	thyroid	other; neoplasm	Substitution - coding silent
c.2701G>T; p.G901C; 8:22354314-22354314	NS	malignant_melanoma	Substitution - Missense
c.486T>A; p.G162G; 8:22283094-22283094	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.405G>T; p.E135D; 8:22281495-22281495	skin	malignant_melanoma	Substitution - Missense
c.405G>T; p.E135D; 8:22281495-22281495	skin	malignant_melanoma	Substitution - Missense
c.405G>T; p.E135D; 8:22281495-22281495	skin	malignant_melanoma	Substitution - Missense
c.2488_2489insT; p.P831fs*8; 8:22353043-22353044	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2539A>G; p.M847V; 8:22353094-22353094	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2544G>T; p.V848V; 8:22353099-22353099	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1273C>T; p.R425C; 8:22304112-22304112	large_intestine; colon	NS	Substitution - Missense
c.1655delG; p.L554fs*22; 8:22308042-22308042	pancreas	carcinoma; acinar_carcinoma	Deletion - Frameshift
c.699_700delAC; p.Q234fs*3; 8:22284228-22284229	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.439G>A; p.G147R; 8:22283047-22283047	skin	malignant_melanoma	Substitution - Missense
c.2286A>G; p.A762A; 8:22316322-22316322	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.516T>C; p.C172C; 8:22283124-22283124	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.828A>G; p.G276G; 8:22287612-22287612	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.734T>C; p.V245A; 8:22284263-22284263	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.412G>A; p.V138I; 8:22281502-22281502	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.412G>A; p.V138I; 8:22281502-22281502	prostate	carcinoma	Substitution - Missense
c.1715G>T; p.R572I; 8:22309989-22309989	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.218C>T; p.S73F; 8:22281139-22281139	skin	malignant_melanoma	Substitution - Missense
c.2737G>A; p.A913T; 8:22354350-22354350	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.602C>A; p.P201H; 8:22283210-22283210	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.373G>C; p.V125L; 8:22281463-22281463	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2226C>T; p.I742I; 8:22316262-22316262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.684G>A; p.L228L; 8:22284213-22284213	breast	carcinoma	Substitution - coding silent
c.2054A>C; p.K685T; 8:22314392-22314392	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2054A>C; p.K685T; 8:22314392-22314392	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2796G>A; p.W932*; 8:22355379-22355379	skin	malignant_melanoma	Substitution - Nonsense
c.2141C>T; p.A714V; 8:22315078-22315078	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1156C>T; p.R386W; 8:22290321-22290321	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1866C>T; p.V622V; 8:22311177-22311177	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2394G>T; p.K798N; 8:22318266-22318266	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.598C>T; p.R200C; 8:22283206-22283206	skin	malignant_melanoma	Substitution - Missense
c.598C>T; p.R200C; 8:22283206-22283206	skin	malignant_melanoma	Substitution - Missense
c.1652G>A; p.R551H; 8:22308039-22308039	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.32A>G; p.Q11R; 8:22279418-22279418	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2657+1G>A; p.?; 8:22353213-22353213	stomach	carcinoma; adenocarcinoma	Unknown
c.1022G>A; p.R341K; 8:22289882-22289882	skin	malignant_melanoma	Substitution - Missense
c.1276A>C; p.T426P; 8:22304115-22304115	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1279T>G; p.Y427D; 8:22304118-22304118	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2552T>C; p.V851A; 8:22353107-22353107	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2857C>A; p.L953M; 8:22355440-22355440	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2288G>A; p.S763N; 8:22316324-22316324	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1324T>G; p.F442V; 8:22304163-22304163	ovary	carcinoma	Substitution - Missense
c.1771G>A; p.E591K; 8:22310045-22310045	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.917T>A; p.I306N; 8:22288597-22288597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1260C>T; p.T420T; 8:22304099-22304099	skin	malignant_melanoma	Substitution - coding silent
c.2280C>T; p.F760F; 8:22316316-22316316	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2280C>T; p.F760F; 8:22316316-22316316	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.343G>A; p.E115K; 8:22281433-22281433	skin	malignant_melanoma	Substitution - Missense
c.741C>T; p.F247F; 8:22284270-22284270	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1823delT; p.Y610fs*19; 8:22311134-22311134	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.64G>A; p.V22I; 8:22279450-22279450	breast	carcinoma	Substitution - Missense
c.2148G>T; p.K716N; 8:22315085-22315085	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2760G>A; p.M920I; 8:22354373-22354373	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.229_230GG>AA; p.G77N; 8:22281150-22281151	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.649C>T; p.Q217*; 8:22284178-22284178	pancreas	carcinoma	Substitution - Nonsense
c.898G>A; p.A300T; 8:22288578-22288578	central_nervous_system; brain	glioma	Substitution - Missense
c.62C>T; p.A21V; 8:22279448-22279448	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1658G>T; p.G553V; 8:22308045-22308045	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.280C>T; p.P94S; 8:22281201-22281201	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2181T>C; p.G727G; 8:22315118-22315118	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.362G>T; p.W121L; 8:22281452-22281452	skin	malignant_melanoma	Substitution - Missense
c.2863G>A; p.G955R; 8:22355446-22355446	skin; extremity	malignant_melanoma	Substitution - Missense
c.2146A>G; p.K716E; 8:22315083-22315083	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.885G>A; p.R295R; 8:22288565-22288565	skin	malignant_melanoma	Substitution - coding silent
c.885G>A; p.R295R; 8:22288565-22288565	skin; abdomen	malignant_melanoma	Substitution - coding silent
c.2268C>T; p.S756S; 8:22316304-22316304	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1718T>G; p.I573S; 8:22309992-22309992	skin	malignant_melanoma	Substitution - Missense
c.2902G>A; p.E968K; 8:22355485-22355485	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1916C>T; p.P639L; 8:22311227-22311227	skin	malignant_melanoma	Substitution - Missense
c.2287A>C; p.S763R; 8:22316323-22316323	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2710A>G; p.T904A; 8:22354323-22354323	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.77G>A; p.G26D; 8:22279463-22279463	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.191C>T; p.A64V; 8:22279577-22279577	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.873delA; p.S293fs*16; 8:22288553-22288553	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.426-2A>G; p.?; 8:22283032-22283032	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Unknown
c.426-2A>G; p.?; 8:22283032-22283032	upper_aerodigestive_tract; mouth	carcinoma	Unknown
c.1A>G; p.M1V; 8:22279387-22279387	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1A>G; p.M1V; 8:22279387-22279387	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1A>G; p.M1V; 8:22279387-22279387	large_intestine; colon	carcinoma	Substitution - Missense
c.1A>G; p.M1V; 8:22279387-22279387	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1686+7C>A; p.?; 8:22308080-22308080	pancreas	carcinoma	Unknown
c.724C>T; p.Q242*; 8:22284253-22284253	skin	malignant_melanoma	Substitution - Nonsense
c.1350C>T; p.I450I; 8:22304189-22304189	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.652G>A; p.G218R; 8:22284181-22284181	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.768G>A; p.M256I; 8:22287552-22287552	skin	malignant_melanoma	Substitution - Missense
c.1504G>A; p.G502R; 8:22305975-22305975	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2393A>T; p.K798M; 8:22318265-22318265	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1464A>G; p.K488K; 8:22305935-22305935	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2220G>A; p.M740I; 8:22316256-22316256	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2803C>A; p.P935T; 8:22355386-22355386	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.758G>A; p.C253Y; 8:22287542-22287542	liver	carcinoma	Substitution - Missense
c.758G>A; p.C253Y; 8:22287542-22287542	liver	carcinoma	Substitution - Missense
c.2264G>A; p.R755H; 8:22316300-22316300	central_nervous_system; brain	glioma	Substitution - Missense
c.66A>T; p.V22V; 8:22279452-22279452	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.587A>G; p.H196R; 8:22283195-22283195	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2388A>T; p.L796F; 8:22318260-22318260	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.61G>A; p.A21T; 8:22279447-22279447	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1456-1G>A; p.?; 8:22305926-22305926	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1943G>T; p.R648L; 8:22311254-22311254	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2543T>C; p.V848A; 8:22353098-22353098	breast	carcinoma	Substitution - Missense
c.2502G>T; p.Q834H; 8:22353057-22353057	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1434G>A; p.E478E; 8:22304847-22304847	liver	carcinoma	Substitution - coding silent
c.1434G>A; p.E478E; 8:22304847-22304847	liver	carcinoma	Substitution - coding silent
c.364G>A; p.D122N; 8:22281454-22281454	skin	malignant_melanoma	Substitution - Missense
c.385G>T; p.G129W; 8:22281475-22281475	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1545G>T; p.K515N; 8:22306016-22306016	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.16C>A; p.P6T; 8:22279402-22279402	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2538G>T; p.K846N; 8:22353093-22353093	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.557C>T; p.S186L; 8:22283165-22283165	skin; extremity	malignant_melanoma	Substitution - Missense
c.1034A>G; p.D345G; 8:22289894-22289894	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1029T>G; p.F343L; 8:22289889-22289889	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.305G>C; p.R102P; 8:22281395-22281395	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2048C>T; p.A683V; 8:22314386-22314386	skin	malignant_melanoma	Substitution - Missense
c.2881G>A; p.E961K; 8:22355464-22355464	skin	malignant_melanoma	Substitution - Missense
c.382G>A; p.A128T; 8:22281472-22281472	thyroid	carcinoma	Substitution - Missense
c.2446G>A; p.G816R; 8:22353001-22353001	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.2866C>T; p.H956Y; 8:22355449-22355449	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2083C>T; p.P695S; 8:22314421-22314421	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1693G>A; p.G565R; 8:22309967-22309967	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation