lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5478
Symbol	PPIA
Synonymous	CYPA\|CYPH\|HEL-S-69p
Full name	peptidylprolyl isomerase A (cyclophilin A)
Gene description	PPIase A\|T cell cyclophilin\|cyclosporin A-binding protein\|epididymis secretory sperm binding protein Li 69p\|peptidyl-prolyl cis-trans isomerase A\|rotamase A
Cytoband	7p13
Gene type	protein-coding
Synonymous	MIM:123840; HGNC:HGNC:9253; Ensembl:ENSG00000196262; HPRD:00457; HPRD:17376; Vega:OTTHUMG00000023687

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.332A>G; p.Q111R; 7:44799844-44799844	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.109C>T; p.R37C; 7:44799400-44799400	skin	malignant_melanoma	Substitution - Missense
c.286G>T; p.G96C; 7:44799798-44799798	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.24C>T; p.F8F; 7:44796748-44796748	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.339C>T; p.F113F; 7:44799851-44799851	skin	malignant_melanoma	Substitution - coding silent
c.440C>T; p.S147F; 7:44801364-44801364	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.70-23_70-7del17; p.?; 7:44799224-44799240	breast	carcinoma	Unknown
c.62C>T; p.S21F; 7:44796786-44796786	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.253G>A; p.D85N; 7:44799765-44799765	urinary_tract; bladder	carcinoma	Substitution - Missense
c.234C>G; p.I78M; 7:44799746-44799746	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.234C>G; p.I78M; 7:44799746-44799746	urinary_tract; bladder	carcinoma	Substitution - Missense
c.93G>A; p.K31K; 7:44799270-44799270	pancreas	carcinoma	Substitution - coding silent
c.93G>A; p.K31K; 7:44799270-44799270	pancreas	carcinoma	Substitution - coding silent
c.93G>A; p.K31K; 7:44799270-44799270	pancreas	carcinoma	Substitution - coding silent
c.93G>A; p.K31K; 7:44799270-44799270	pancreas	carcinoma	Substitution - coding silent
c.160C>G; p.H54D; 7:44799451-44799451	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.430C>T; p.R144C; 7:44801354-44801354	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.200T>C; p.F67S; 7:44799712-44799712	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense