lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5467
Symbol	PPARD
Synonymous	FAAR\|NR1C2\|NUC1\|NUCI\|NUCII\|PPARB
Full name	peroxisome proliferator-activated receptor delta
Gene description	PPAR-beta\|PPAR-delta\|nuclear hormone receptor 1\|nuclear receptor subfamily 1 group C member 2\|peroxisome proliferator-activated nuclear receptor beta/delta variant 2\|peroxisome proliferator-activated receptor beta
Cytoband	6p21.2
Gene type	protein-coding
Synonymous	MIM:600409; HGNC:HGNC:9235; Ensembl:ENSG00000112033; HPRD:02679; Vega:OTTHUMG00000014567

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.952C>T; p.R318C; 6:35424653-35424653	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.637A>T; p.I213F; 6:35424338-35424338	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.835G>A; p.V279I; 6:35424536-35424536	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.774G>C; p.R258R; 6:35424475-35424475	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1185C>G; p.L395L; 6:35425938-35425938	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.430C>T; p.R144C; 6:35423951-35423951	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.16G>C; p.E6Q; 6:35411103-35411103	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.891C>T; p.I297I; 6:35424592-35424592	ovary	other; neoplasm	Substitution - coding silent
c.1220G>A; p.R407Q; 6:35425973-35425973	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.812G>A; p.S271N; 6:35424513-35424513	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.337C>T; p.R113C; 6:35421871-35421871	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.337C>T; p.R113C; 6:35421871-35421871	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.231C>T; p.C77C; 6:35420227-35420227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.503A>G; p.Y168C; 6:35424024-35424024	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.348G>T; p.K116N; 6:35421882-35421882	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.859C>T; p.H287Y; 6:35424560-35424560	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.859C>T; p.H287Y; 6:35424560-35424560	prostate	carcinoma	Substitution - Missense
c.746G>A; p.C249Y; 6:35424447-35424447	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.239A>C; p.K80T; 6:35420235-35420235	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1136G>A; p.R379H; 6:35425889-35425889	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1069C>T; p.L357L; 6:35424770-35424770	skin	malignant_melanoma	Substitution - coding silent
c.727G>A; p.V243M; 6:35424428-35424428	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.439_440CG>TC; p.R147>?; 6:35423960-35423961	lung	carcinoma; small_cell_carcinoma	Complex
c.431G>A; p.R144H; 6:35423952-35423952	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.298C>T; p.R100C; 6:35421832-35421832	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.438T>C; p.G146G; 6:35423959-35423959	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.237C>G; p.D79E; 6:35420233-35420233	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.836T>C; p.V279A; 6:35424537-35424537	skin	malignant_melanoma	Substitution - Missense
c.979A>T; p.I327F; 6:35424680-35424680	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.190G>A; p.G64R; 6:35420186-35420186	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.190G>A; p.G64R; 6:35420186-35420186	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.303G>A; p.T101T; 6:35421837-35421837	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.961C>T; p.R321C; 6:35424662-35424662	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.961C>T; p.R321C; 6:35424662-35424662	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.724A>G; p.S242G; 6:35424425-35424425	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.709C>T; p.P237S; 6:35424410-35424410	skin	malignant_melanoma	Substitution - Missense
c.296G>A; p.R99H; 6:35421830-35421830	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1106G>T; p.R369L; 6:35425859-35425859	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1314G>A; p.K438K; 6:35426067-35426067	breast	carcinoma	Substitution - coding silent
c.751T>C; p.C251R; 6:35424452-35424452	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1045G>A; p.A349T; 6:35424746-35424746	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1014C>T; p.F338F; 6:35424715-35424715	skin	malignant_melanoma	Substitution - coding silent
c.1030G>C; p.D344H; 6:35424731-35424731	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1030G>C; p.D344H; 6:35424731-35424731	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.696G>T; p.V232V; 6:35424397-35424397	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.222C>T; p.C74C; 6:35420218-35420218	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.548A>G; p.Y183C; 6:35424069-35424069	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1121A>G; p.Q374R; 6:35425874-35425874	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1121A>G; p.Q374R; 6:35425874-35425874	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1106G>A; p.R369Q; 6:35425859-35425859	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.210C>G; p.L70L; 6:35420206-35420206	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1053C>T; p.F351F; 6:35424754-35424754	skin	malignant_melanoma	Substitution - coding silent
c.480G>A; p.L160L; 6:35424001-35424001	oesophagus	carcinoma	Substitution - coding silent
c.688C>T; p.Q230*; 6:35424389-35424389	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.1083G>A; p.R361R; 6:35425836-35425836	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.856G>A; p.V286M; 6:35424557-35424557	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.433T>G; p.F145V; 6:35423954-35423954	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.386G>A; p.R129H; 6:35421920-35421920	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1284G>A; p.S428S; 6:35426037-35426037	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.1284G>A; p.S428S; 6:35426037-35426037	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1284G>A; p.S428S; 6:35426037-35426037	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.773G>A; p.R258Q; 6:35424474-35424474	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.828C>T; p.N276N; 6:35424529-35424529	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.772C>T; p.R258W; 6:35424473-35424473	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.641A>T; p.H214L; 6:35424342-35424342	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.654A>C; p.T218T; 6:35424355-35424355	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.937A>C; p.T313P; 6:35424638-35424638	breast	carcinoma	Substitution - Missense
c.941G>A; p.R314H; 6:35424642-35424642	breast	carcinoma	Substitution - Missense
c.536C>T; p.S179F; 6:35424057-35424057	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1169C>G; p.P390R; 6:35425922-35425922	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1169C>G; p.P390R; 6:35425922-35425922	urinary_tract; bladder	carcinoma	Substitution - Missense
c.194C>T; p.A65V; 6:35420190-35420190	skin	malignant_melanoma	Substitution - Missense
c.162G>A; p.L54L; 6:35420158-35420158	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.553G>A; p.A185T; 6:35424074-35424074	breast	carcinoma	Substitution - Missense
c.860A>G; p.H287R; 6:35424561-35424561	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.307C>T; p.R103C; 6:35421841-35421841	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1208T>C; p.M403T; 6:35425961-35425961	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.338G>A; p.R113H; 6:35421872-35421872	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.829G>C; p.D277H; 6:35424530-35424530	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.262G>A; p.V88I; 6:35420258-35420258	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.262G>A; p.V88I; 6:35420258-35420258	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.197C>T; p.S66L; 6:35420193-35420193	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.846C>G; p.L282L; 6:35424547-35424547	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1256G>A; p.R419Q; 6:35426009-35426009	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.819C>G; p.L273L; 6:35424520-35424520	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1276G>A; p.E426K; 6:35426029-35426029	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1276G>A; p.E426K; 6:35426029-35426029	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1076G>C; p.G359A; 6:35424777-35424777	urinary_tract; bladder	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation