lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	54578
Symbol	UGT1A6
Synonymous	GNT1\|HLUGP\|HLUGP1\|UDPGT\|UDPGT 1-6\|UGT1\|UGT1A6S\|UGT1F
Full name	UDP glucuronosyltransferase 1 family, polypeptide A6
Gene description	UDP glycosyltransferase 1 family, polypeptide A6\|UDP-glucuronosyltransferase 1 family polypeptide A6s\|UDP-glucuronosyltransferase 1-6\|UDP-glucuronosyltransferase 1-F\|UDP-glucuronosyltransferase 1A6\|UGT-1F\|UGT1*6\|UGT1-06\|UGT1.6\|phenol-metabolizing UDP-gluc
Cytoband	2q37
Gene type	protein-coding
Synonymous	MIM:606431; HGNC:HGNC:12538; Ensembl:ENSG00000167165; HPRD:07071; Vega:OTTHUMG00000059122

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.474C>T; p.I158I; 2:233693478-233693478	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.315A>C; p.L105L; 2:233693319-233693319	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.708C>T; p.V236V; 2:233693712-233693712	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.742C>T; p.Q248*; 2:233693746-233693746	skin	malignant_melanoma	Substitution - Nonsense
c.591_592delAA; p.K198fs*17; 2:233693595-233693596	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1273G>T; p.A425S; 2:233768411-233768411	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.625G>C; p.V209L; 2:233693629-233693629	central_nervous_system; brain	glioma	Substitution - Missense
c.94G>T; p.V32F; 2:233693098-233693098	breast	carcinoma	Substitution - Missense
c.1191G>A; p.M397I; 2:233768329-233768329	skin	malignant_melanoma	Substitution - Missense
c.1407C>T; p.G469G; 2:233772367-233772367	breast	carcinoma	Substitution - coding silent
c.490G>T; p.G164C; 2:233693494-233693494	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.101A>T; p.Q34L; 2:233693105-233693105	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1246G>A; p.E416K; 2:233768384-233768384	skin; extremity	malignant_melanoma	Substitution - Missense
c.1292A>G; p.N431S; 2:233768430-233768430	liver	carcinoma	Substitution - Missense
c.1273G>A; p.A425T; 2:233768411-233768411	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.623G>T; p.R208L; 2:233693627-233693627	thyroid	other; neoplasm	Substitution - Missense
c.994-1G>A; p.?; 2:233767848-233767848	stomach	carcinoma; adenocarcinoma	Unknown
c.80A>C; p.D27A; 2:233693084-233693084	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.680C>T; p.S227L; 2:233693684-233693684	skin	malignant_melanoma	Substitution - Missense
c.1004G>A; p.R335Q; 2:233767859-233767859	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.58C>T; p.L20F; 2:233693062-233693062	skin	malignant_melanoma	Substitution - Missense
c.502G>A; p.V168M; 2:233693506-233693506	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1474G>A; p.G492S; 2:233772434-233772434	skin	malignant_melanoma	Substitution - Missense
c.400G>A; p.D134N; 2:233693404-233693404	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1540C>T; p.R514W; 2:233772500-233772500	prostate	adenoma	Substitution - Missense
c.1540C>T; p.R514W; 2:233772500-233772500	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.850G>T; p.D284Y; 2:233693854-233693854	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1461C>A; p.S487S; 2:233772421-233772421	breast	carcinoma	Substitution - coding silent
c.106G>A; p.G36R; 2:233693110-233693110	skin	malignant_melanoma	Substitution - Missense
c.513C>T; p.F171F; 2:233693517-233693517	skin	malignant_melanoma	Substitution - coding silent
c.1487C>T; p.A496V; 2:233772447-233772447	skin	malignant_melanoma	Substitution - Missense
c.531C>T; p.S177S; 2:233693535-233693535	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1425C>T; p.P475P; 2:233772385-233772385	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.985C>T; p.P329S; 2:233767157-233767157	skin	malignant_melanoma	Substitution - Missense
c.1128T>C; p.G376G; 2:233768266-233768266	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.709C>T; p.L237F; 2:233693713-233693713	skin	malignant_melanoma	Substitution - Missense
c.907G>A; p.V303I; 2:233767079-233767079	skin	malignant_melanoma	Substitution - Missense
c.220A>G; p.T74A; 2:233693224-233693224	breast	carcinoma	Substitution - Missense
c.1411C>T; p.P471S; 2:233772371-233772371	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.269G>A; p.R90H; 2:233693273-233693273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.129G>T; p.K43N; 2:233693133-233693133	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1322G>A; p.R441H; 2:233772282-233772282	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>T; p.M268I; 2:233693808-233693808	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1320G>A; p.M440I; 2:233772280-233772280	breast	carcinoma	Substitution - Missense
c.205G>T; p.E69*; 2:233693209-233693209	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1408G>A; p.A470T; 2:233772368-233772368	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.221C>A; p.T74K; 2:233693225-233693225	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.552A>C; p.R184S; 2:233693556-233693556	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.552A>C; p.R184S; 2:233693556-233693556	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.552A>C; p.R184S; 2:233693556-233693556	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1555A>G; p.K519E; 2:233772515-233772515	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.622C>G; p.R208G; 2:233693626-233693626	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.622C>G; p.R208G; 2:233693626-233693626	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1489G>A; p.V497I; 2:233772449-233772449	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1426G>A; p.A476T; 2:233772386-233772386	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1489G>A; p.V497I; 2:233772449-233772449	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.961A>G; p.I321V; 2:233767133-233767133	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1554G>A; p.G518G; 2:233772514-233772514	skin	malignant_melanoma	Substitution - coding silent
c.862G>A; p.E288K; 2:233767034-233767034	skin	malignant_melanoma	Substitution - Missense
c.1003C>T; p.R335W; 2:233767858-233767858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.701C>T; p.S234L; 2:233693705-233693705	skin	malignant_melanoma	Substitution - Missense
c.3G>T; p.M1I; 2:233693007-233693007	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.706G>A; p.V236I; 2:233693710-233693710	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.661C>A; p.L221I; 2:233693665-233693665	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1407C>G; p.G469G; 2:233772367-233772367	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1542G>A; p.R514R; 2:233772502-233772502	skin	malignant_melanoma	Substitution - coding silent
c.1153G>A; p.V385I; 2:233768291-233768291	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.696C>T; p.L232L; 2:233693700-233693700	central_nervous_system; brain	glioma	Substitution - coding silent
c.105C>T; p.D35D; 2:233693109-233693109	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1401C>T; p.H467H; 2:233772361-233772361	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.909_914delTTTCTC; p.F304_S305delFS; 2:233767081-233767086	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - In frame
c.1162G>A; p.V388M; 2:233768300-233768300	skin	malignant_melanoma	Substitution - Missense
c.1426G>T; p.A476S; 2:233772386-233772386	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1097G>A; p.R366H; 2:233768235-233768235	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.451C>T; p.P151S; 2:233693455-233693455	skin	malignant_melanoma	Substitution - Missense
c.88C>A; p.L30M; 2:233693092-233693092	skin	malignant_melanoma	Substitution - Missense
c.414C>T; p.F138F; 2:233693418-233693418	skin	malignant_melanoma	Substitution - coding silent
c.1026G>A; p.S342S; 2:233767881-233767881	skin	malignant_melanoma	Substitution - coding silent
c.876C>T; p.Y292Y; 2:233767048-233767048	liver	carcinoma	Substitution - coding silent
c.819C>T; p.F273F; 2:233693823-233693823	skin	malignant_melanoma	Substitution - coding silent
c.1555delA; p.R522fs*>11; 2:233772515-233772515	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1555delA; p.R522fs*>11; 2:233772515-233772515	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.876C>T; p.Y292Y; 2:233767048-233767048	liver	carcinoma	Substitution - coding silent
c.460C>T; p.P154S; 2:233693464-233693464	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Missense
c.1215T>C; p.T405T; 2:233768353-233768353	kidney	other; neoplasm	Substitution - coding silent
c.384C>T; p.S128S; 2:233693388-233693388	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1205G>A; p.R402H; 2:233768343-233768343	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1125T>A; p.H375Q; 2:233768263-233768263	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.857C>T; p.S286F; 2:233693861-233693861	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1317C>T; p.I439I; 2:233772277-233772277	skin	malignant_melanoma	Substitution - coding silent
c.532C>A; p.L178M; 2:233693536-233693536	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.512T>A; p.F171Y; 2:233693516-233693516	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1151G>A; p.G384D; 2:233768289-233768289	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.790C>T; p.P264S; 2:233693794-233693794	urinary_tract; bladder	carcinoma	Substitution - Missense
c.677T>G; p.F226C; 2:233693681-233693681	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1389T>C; p.F463F; 2:233772349-233772349	breast	carcinoma	Substitution - coding silent
c.622C>T; p.R208*; 2:233693626-233693626	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.622C>T; p.R208*; 2:233693626-233693626	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.640G>C; p.V214L; 2:233693644-233693644	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1473T>C; p.I491I; 2:233772433-233772433	breast	carcinoma	Substitution - coding silent
c.640G>C; p.V214L; 2:233693644-233693644	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1245G>A; p.L415L; 2:233768383-233768383	skin	malignant_melanoma	Substitution - coding silent
c.1435G>A; p.D479N; 2:233772395-233772395	skin	malignant_melanoma	Substitution - Missense
c.1435G>A; p.D479N; 2:233772395-233772395	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1081+8delG; p.?; 2:233767944-233767944	thyroid	carcinoma; anaplastic_carcinoma	Unknown
c.1082G>T; p.G361V; 2:233768220-233768220	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1025C>T; p.S342L; 2:233767880-233767880	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1025C>T; p.S342L; 2:233767880-233767880	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1025C>T; p.S342L; 2:233767880-233767880	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1025C>T; p.S342L; 2:233767880-233767880	skin	malignant_melanoma	Substitution - Missense
c.627G>T; p.V209V; 2:233693631-233693631	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.372C>T; p.I124I; 2:233693376-233693376	skin	malignant_melanoma	Substitution - coding silent
c.147C>A; p.L49L; 2:233693151-233693151	breast	carcinoma	Substitution - coding silent
c.74T>A; p.V25E; 2:233693078-233693078	thyroid	other; neoplasm	Substitution - Missense
c.537G>A; p.E179E; 2:233693541-233693541	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1071C>T; p.N357N; 2:233767926-233767926	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1152C>T; p.G384G; 2:233768290-233768290	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1474G>T; p.G492C; 2:233772434-233772434	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.514A>G; p.R172G; 2:233693518-233693518	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.965C>A; p.A322D; 2:233767137-233767137	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.154C>T; p.R52W; 2:233693158-233693158	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.605A>T; p.H202L; 2:233693609-233693609	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1467C>T; p.D489D; 2:233772427-233772427	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.541A>G; p.T181A; 2:233693545-233693545	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1440C>T; p.L480L; 2:233772400-233772400	breast	carcinoma	Substitution - coding silent
c.371T>C; p.I124T; 2:233693375-233693375	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.732C>A; p.I244I; 2:233693736-233693736	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.994-1G>C; p.?; 2:233767848-233767848	liver	carcinoma	Unknown
c.1180G>T; p.G394C; 2:233768318-233768318	breast	carcinoma	Substitution - Missense
c.1044G>A; p.T348T; 2:233767899-233767899	skin	malignant_melanoma	Substitution - coding silent
c.1035G>A; p.A345A; 2:233767890-233767890	breast	carcinoma	Substitution - coding silent
c.19T>G; p.S7A; 2:233693023-233693023	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1035G>A; p.A345A; 2:233767890-233767890	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.19T>G; p.S7A; 2:233693023-233693023	thyroid	other; neoplasm	Substitution - Missense
c.19T>G; p.S7A; 2:233693023-233693023	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.315A>G; p.L105L; 2:233693319-233693319	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.169G>T; p.V57L; 2:233693173-233693173	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.315A>G; p.L105L; 2:233693319-233693319	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1468G>A; p.V490M; 2:233772428-233772428	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.299C>A; p.A100D; 2:233693303-233693303	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1330A>G; p.S444G; 2:233772290-233772290	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.989A>C; p.Q330P; 2:233767161-233767161	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1330A>G; p.S444G; 2:233772290-233772290	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation