lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5444
Symbol	PON1
Synonymous	ESA\|MVCD5\|PON
Full name	paraoxonase 1
Gene description	A-esterase 1\|K-45\|PON 1\|aromatic esterase 1\|arylesterase 1\|arylesterase B-type\|esterase A\|paraoxonase B-type\|serum aryldiakylphosphatase\|serum aryldialkylphosphatase 1\|serum paraoxonase/arylesterase 1
Cytoband	7q21.3
Gene type	protein-coding
Synonymous	MIM:168820; HGNC:HGNC:9204; HPRD:01351

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.801C>T; p.L267L; 7:95302313-95302313	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.347G>T; p.G116V; 7:95315345-95315345	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.560T>C; p.L187P; 7:95308149-95308149	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1042C>T; p.H348Y; 7:95298970-95298970	skin	malignant_melanoma	Substitution - Missense
c.489_491delTCT; p.L164delL; 7:95311457-95311459	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.235C>T; p.P79S; 7:95315457-95315457	skin	malignant_melanoma	Substitution - Missense
c.109G>A; p.V37I; 7:95318359-95318359	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.109G>A; p.V37I; 7:95318359-95318359	pancreas	NS	Substitution - Missense
c.805G>A; p.D269N; 7:95302309-95302309	skin	malignant_melanoma	Substitution - Missense
c.181G>A; p.G61R; 7:95316754-95316754	skin	malignant_melanoma	Substitution - Missense
c.181G>A; p.G61R; 7:95316754-95316754	skin	malignant_melanoma	Substitution - Missense
c.931C>T; p.L311L; 7:95299081-95299081	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.715G>C; p.E239Q; 7:95306350-95306350	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1019A>T; p.K340I; 7:95298993-95298993	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.868A>G; p.K290E; 7:95302246-95302246	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.488T>G; p.L163R; 7:95311460-95311460	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.380T>G; p.M127R; 7:95311568-95311568	pancreas	carcinoma; adenocarcinoma	Substitution - Missense
c.123C>G; p.N41K; 7:95318345-95318345	ovary	other; neoplasm	Substitution - Missense
c.950T>C; p.V317A; 7:95299062-95299062	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.838C>A; p.L280I; 7:95302276-95302276	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.821A>T; p.D274V; 7:95302293-95302293	breast	carcinoma	Substitution - Missense
c.793A>G; p.N265D; 7:95302321-95302321	liver	carcinoma	Substitution - Missense
c.1030G>A; p.G344S; 7:95298982-95298982	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.187G>A; p.A63T; 7:95316748-95316748	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.686C>T; p.S229L; 7:95308023-95308023	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.571T>C; p.L191L; 7:95308138-95308138	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.5C>T; p.A2V; 7:95324471-95324471	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.367G>A; p.E123K; 7:95315325-95315325	skin	malignant_melanoma	Substitution - Missense
c.736C>T; p.H246Y; 7:95306329-95306329	breast	carcinoma	Substitution - Missense
c.112G>T; p.E38*; 7:95318356-95318356	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.112G>T; p.E38*; 7:95318356-95318356	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.203G>A; p.G68E; 7:95315489-95315489	skin	malignant_melanoma	Substitution - Missense
c.203G>A; p.G68E; 7:95315489-95315489	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.6G>A; p.A2A; 7:95324470-95324470	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.436T>G; p.F146V; 7:95311512-95311512	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.146-1G>T; p.?; 7:95316790-95316790	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1051_1052CT>TC; p.L351S; 7:95298960-95298961	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.311G>A; p.G104E; 7:95315381-95315381	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.25C>T; p.L9F; 7:95324451-95324451	skin	malignant_melanoma	Substitution - Missense
c.79C>T; p.R27*; 7:95318389-95318389	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.79C>T; p.R27*; 7:95318389-95318389	central_nervous_system; brain	glioma	Substitution - Nonsense
c.731A>C; p.K244T; 7:95306334-95306334	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.274G>A; p.E92K; 7:95315418-95315418	skin	malignant_melanoma	Substitution - Missense
c.79C>T; p.R27*; 7:95318389-95318389	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.871A>C; p.I291L; 7:95302243-95302243	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.455C>T; p.S152L; 7:95311493-95311493	skin	malignant_melanoma	Substitution - Missense
c.31G>T; p.G11W; 7:95324445-95324445	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.497+4C>T; p.?; 7:95311447-95311447	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Unknown
c.494C>T; p.P165L; 7:95311454-95311454	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.760T>C; p.W254R; 7:95306305-95306305	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.689C>A; p.P230H; 7:95308020-95308020	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.676A>T; p.I226F; 7:95308033-95308033	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.342T>G; p.P114P; 7:95315350-95315350	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.694G>A; p.G232S; 7:95308015-95308015	skin	malignant_melanoma	Substitution - Missense
c.917G>A; p.R306Q; 7:95299095-95299095	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.917G>A; p.R306Q; 7:95299095-95299095	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.917G>A; p.R306Q; 7:95299095-95299095	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.917G>A; p.R306Q; 7:95299095-95299095	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.917G>A; p.R306Q; 7:95299095-95299095	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.917G>A; p.R306Q; 7:95299095-95299095	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.917G>A; p.R306Q; 7:95299095-95299095	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.421G>C; p.V141L; 7:95311527-95311527	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.475A>G; p.I159V; 7:95311473-95311473	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.260T>A; p.L87Q; 7:95315432-95315432	skin	malignant_melanoma	Substitution - Missense
c.640C>T; p.R214*; 7:95308069-95308069	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.14T>C; p.I5T; 7:95324462-95324462	skin	malignant_melanoma	Substitution - Missense
c.746A>G; p.E249G; 7:95306319-95306319	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.428T>C; p.L143S; 7:95311520-95311520	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.892A>T; p.N298Y; 7:95302222-95302222	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.892A>T; p.N298Y; 7:95302222-95302222	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.761G>A; p.W254*; 7:95306304-95306304	skin	malignant_melanoma	Substitution - Nonsense
c.477C>A; p.I159I; 7:95311471-95311471	central_nervous_system; brain	glioma	Substitution - coding silent
c.659T>C; p.F220S; 7:95308050-95308050	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.332C>A; p.S111*; 7:95315360-95315360	breast	carcinoma	Substitution - Nonsense
c.873C>T; p.I291I; 7:95302241-95302241	skin	malignant_melanoma	Substitution - coding silent
c.573A>T; p.L191F; 7:95308136-95308136	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.824C>T; p.P275L; 7:95302290-95302290	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.579C>T; p.S193S; 7:95308130-95308130	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.43G>A; p.A15T; 7:95324433-95324433	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.802G>A; p.V268M; 7:95302312-95302312	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.802G>A; p.V268M; 7:95302312-95302312	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.783C>T; p.S261S; 7:95302331-95302331	skin	malignant_melanoma	Substitution - coding silent
c.691G>A; p.D231N; 7:95308018-95308018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.724G>A; p.A242T; 7:95306341-95306341	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.691G>A; p.D231N; 7:95308018-95308018	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.870A>C; p.K290N; 7:95302244-95302244	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.780+7C>T; p.?; 7:95306278-95306278	pancreas	carcinoma	Unknown
c.597T>A; p.G199G; 7:95308112-95308112	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.839T>A; p.L280H; 7:95302275-95302275	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.608C>T; p.S203L; 7:95308101-95308101	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.575A>G; p.Q192R; 7:95308134-95308134	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.575A>G; p.Q192R; 7:95308134-95308134	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.575A>G; p.Q192R; 7:95308134-95308134	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.18G>A; p.A6A; 7:95324458-95324458	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.773C>T; p.P258L; 7:95306292-95306292	skin	malignant_melanoma	Substitution - Missense
c.377C>T; p.A126V; 7:95311571-95311571	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.916C>T; p.R306*; 7:95299096-95299096	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.650C>A; p.A217E; 7:95308059-95308059	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.916C>T; p.R306*; 7:95299096-95299096	skin	malignant_melanoma	Substitution - Nonsense
c.891G>T; p.E297D; 7:95302223-95302223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.452A>C; p.K151T; 7:95311496-95311496	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.743A>G; p.Y248C; 7:95306322-95306322	breast	carcinoma	Substitution - Missense
c.140G>A; p.G47E; 7:95318328-95318328	skin	malignant_melanoma	Substitution - Missense
c.456G>A; p.S152S; 7:95311492-95311492	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1051C>G; p.L351V; 7:95298961-95298961	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.165G>A; p.L55L; 7:95316770-95316770	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1010A>G; p.Y337C; 7:95299002-95299002	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.977_978delCA; p.T326fs*28; 7:95299034-95299035	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.591delT; p.L198fs*3; 7:95308118-95308118	autonomic_ganglia	neuroblastoma	Deletion - Frameshift
c.110T>C; p.V37A; 7:95318358-95318358	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.985C>T; p.Q329*; 7:95299027-95299027	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.560T>G; p.L187R; 7:95308149-95308149	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.560T>G; p.L187R; 7:95308149-95308149	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.474C>T; p.T158T; 7:95311474-95311474	skin	malignant_melanoma	Substitution - coding silent
c.560T>G; p.L187R; 7:95308149-95308149	pancreas	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation