lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5340
Symbol	PLG
Synonymous	-
Full name	plasminogen
Gene description	plasmin
Cytoband	6q26
Gene type	protein-coding
Synonymous	MIM:173350; HGNC:HGNC:9071; Ensembl:ENSG00000122194; HPRD:01417; Vega:OTTHUMG00000015957

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1200T>C; p.S400S; 6:160722511-160722511	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1656C>T; p.Y552Y; 6:160734063-160734063	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1656C>T; p.Y552Y; 6:160734063-160734063	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.316G>A; p.G106R; 6:160711100-160711100	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1993G>C; p.D665H; 6:160739183-160739183	breast	carcinoma	Substitution - Missense
c.165G>A; p.E55E; 6:160706522-160706522	skin	malignant_melanoma	Substitution - coding silent
c.1157G>A; p.R386Q; 6:160722468-160722468	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.957G>A; p.L319L; 6:160718699-160718699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1157G>A; p.R386Q; 6:160722468-160722468	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1157G>A; p.R386Q; 6:160722468-160722468	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.172G>T; p.E58*; 6:160706529-160706529	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.957G>A; p.L319L; 6:160718699-160718699	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.571G>T; p.E191*; 6:160714817-160714817	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1461A>T; p.K487N; 6:160731767-160731767	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2157C>T; p.A719A; 6:160752146-160752146	skin	malignant_melanoma	Substitution - coding silent
c.2157C>T; p.A719A; 6:160752146-160752146	skin	malignant_melanoma	Substitution - coding silent
c.346T>C; p.S116P; 6:160711130-160711130	skin	malignant_melanoma	Substitution - Missense
c.2083G>A; p.D695N; 6:160741375-160741375	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.480G>T; p.Q160H; 6:160713058-160713058	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2281G>A; p.G761R; 6:160752909-160752909	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1077G>A; p.T359T; 6:160718819-160718819	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1077G>A; p.T359T; 6:160718819-160718819	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1168_1169insCCA; p.T394_G395insT; 6:160722479-160722480	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - In frame
c.783C>A; p.R261R; 6:160716759-160716759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1875G>C; p.E625D; 6:160738610-160738610	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2240G>A; p.G747E; 6:160752229-160752229	breast	carcinoma	Substitution - Missense
c.583G>A; p.G195S; 6:160714829-160714829	pancreas	carcinoma	Substitution - Missense
c.583G>A; p.G195S; 6:160714829-160714829	pancreas	carcinoma	Substitution - Missense
c.583G>A; p.G195S; 6:160714829-160714829	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1851G>T; p.V617V; 6:160738586-160738586	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1732C>T; p.P578S; 6:160736937-160736937	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1183G>A; p.G395R; 6:160722494-160722494	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.763G>A; p.E255K; 6:160716739-160716739	skin; axilla	malignant_melanoma	Substitution - Missense
c.288G>T; p.K96N; 6:160707802-160707802	breast	carcinoma	Substitution - Missense
c.1066C>T; p.P356S; 6:160718808-160718808	skin	malignant_melanoma	Substitution - Missense
c.811C>T; p.P271S; 6:160718317-160718317	skin	malignant_melanoma	Substitution - Missense
c.2163C>T; p.L721L; 6:160752152-160752152	skin	malignant_melanoma	Substitution - coding silent
c.984C>A; p.D328E; 6:160718726-160718726	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1294G>C; p.D432H; 6:160731088-160731088	skin	malignant_melanoma	Substitution - Missense
c.139G>A; p.E47K; 6:160706496-160706496	skin	malignant_melanoma	Substitution - Missense
c.139G>A; p.E47K; 6:160706496-160706496	skin; trunk	malignant_melanoma	Substitution - Missense
c.1003T>C; p.C335R; 6:160718745-160718745	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2227G>A; p.E743K; 6:160752216-160752216	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2227G>A; p.E743K; 6:160752216-160752216	skin	malignant_melanoma	Substitution - Missense
c.1909C>A; p.L637M; 6:160739099-160739099	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2227G>A; p.E743K; 6:160752216-160752216	skin	malignant_melanoma	Substitution - Missense
c.761G>T; p.W254L; 6:160716737-160716737	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.457A>G; p.R153G; 6:160713035-160713035	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.832G>A; p.G278R; 6:160718338-160718338	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1896C>A; p.S632S; 6:160739086-160739086	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2079C>T; p.V693V; 6:160741371-160741371	skin	malignant_melanoma	Substitution - coding silent
c.667A>T; p.K223*; 6:160714913-160714913	skin	malignant_melanoma	Substitution - Nonsense
c.475C>T; p.P159S; 6:160713053-160713053	skin	malignant_melanoma	Substitution - Missense
c.2079C>T; p.V693V; 6:160741371-160741371	skin	malignant_melanoma	Substitution - coding silent
c.745G>A; p.D249N; 6:160716721-160716721	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.436G>A; p.G146R; 6:160713014-160713014	skin	malignant_melanoma	Substitution - Missense
c.911C>T; p.P304L; 6:160718417-160718417	skin	malignant_melanoma	Substitution - Missense
c.143A>G; p.E48G; 6:160706500-160706500	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2384G>A; p.R795H; 6:160753012-160753012	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1377G>C; p.A459A; 6:160731171-160731171	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2082T>C; p.A694A; 6:160741374-160741374	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2082T>C; p.A694A; 6:160741374-160741374	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.143A>G; p.E48G; 6:160706500-160706500	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.386C>T; p.S129F; 6:160711170-160711170	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.864T>A; p.A288A; 6:160718370-160718370	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1674T>C; p.P558P; 6:160734081-160734081	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2129C>A; p.T710N; 6:160752118-160752118	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.10A>G; p.K4E; 6:160702314-160702314	skin	malignant_melanoma	Substitution - Missense
c.22C>A; p.L8I; 6:160702326-160702326	breast	carcinoma	Substitution - Missense
c.1990A>C; p.K664Q; 6:160739180-160739180	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.972C>T; p.C324C; 6:160718714-160718714	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2087G>A; p.R696Q; 6:160741379-160741379	breast	carcinoma	Substitution - Missense
c.1582A>T; p.K528*; 6:160731888-160731888	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.2183T>C; p.V728A; 6:160752172-160752172	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.908C>A; p.T303N; 6:160718414-160718414	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2059C>G; p.P687A; 6:160741351-160741351	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1579_1580insA; p.N529fs*5; 6:160731885-160731886	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1458G>A; p.G486G; 6:160731764-160731764	skin	malignant_melanoma	Substitution - coding silent
c.876C>T; p.S292S; 6:160718382-160718382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.876C>T; p.S292S; 6:160718382-160718382	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1458G>A; p.G486G; 6:160731764-160731764	skin; upper_arm	malignant_melanoma	Substitution - coding silent
c.1051T>A; p.S351T; 6:160718793-160718793	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; large_cell	Substitution - Missense
c.2304G>T; p.E768D; 6:160752932-160752932	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2156C>T; p.A719V; 6:160752145-160752145	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2156C>T; p.A719V; 6:160752145-160752145	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2249C>T; p.A750V; 6:160752238-160752238	skin; upper_back	malignant_melanoma	Substitution - Missense
c.966C>A; p.N322K; 6:160718708-160718708	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.725G>A; p.R242Q; 6:160716701-160716701	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.725G>A; p.R242Q; 6:160716701-160716701	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.248C>T; p.S83F; 6:160707762-160707762	skin	malignant_melanoma	Substitution - Missense
c.1269G>A; p.M423I; 6:160731063-160731063	skin	malignant_melanoma	Substitution - Missense
c.1032G>A; p.W344*; 6:160718774-160718774	skin; trunk	malignant_melanoma	Substitution - Nonsense
c.2018+7G>T; p.?; 6:160739215-160739215	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Unknown
c.1408C>T; p.L470F; 6:160731202-160731202	skin	malignant_melanoma	Substitution - Missense
c.1321G>A; p.D441N; 6:160731115-160731115	skin	malignant_melanoma	Substitution - Missense
c.216A>G; p.Q72Q; 6:160707730-160707730	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1049C>T; p.P350L; 6:160718791-160718791	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1156C>T; p.R386*; 6:160722467-160722467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1683G>A; p.A561A; 6:160736888-160736888	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.449A>T; p.N150I; 6:160713027-160713027	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.637A>G; p.S213G; 6:160714883-160714883	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.74A>G; p.Y25C; 6:160706431-160706431	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.600C>A; p.T200T; 6:160714846-160714846	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1111A>G; p.T371A; 6:160722422-160722422	bone; ilium	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.870C>T; p.T290T; 6:160718376-160718376	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.870C>T; p.T290T; 6:160718376-160718376	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.716G>A; p.R239K; 6:160716692-160716692	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2024C>T; p.A675V; 6:160741316-160741316	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1438+2T>C; p.?; 6:160731234-160731234	stomach	carcinoma; adenocarcinoma	Unknown
c.1993G>T; p.D665Y; 6:160739183-160739183	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2323C>A; p.Q775K; 6:160752951-160752951	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1396C>T; p.P466S; 6:160731190-160731190	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.92C>T; p.A31V; 6:160706449-160706449	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2191C>T; p.R731C; 6:160752180-160752180	skin	malignant_melanoma	Substitution - Missense
c.646G>T; p.A216S; 6:160714892-160714892	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1595G>A; p.R532H; 6:160734002-160734002	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.187G>A; p.A63T; 6:160707701-160707701	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.342G>T; p.T114T; 6:160711126-160711126	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1765C>A; p.P589T; 6:160736970-160736970	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.546A>C; p.E182D; 6:160713124-160713124	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1785A>G; p.Q595Q; 6:160736990-160736990	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1256+1G>A; p.?; 6:160722568-160722568	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.628G>T; p.D210Y; 6:160714874-160714874	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.312G>A; p.K104K; 6:160711096-160711096	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.628G>T; p.D210Y; 6:160714874-160714874	ovary	carcinoma	Substitution - Missense
c.1974C>A; p.F658L; 6:160739164-160739164	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2026G>A; p.V676I; 6:160741318-160741318	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.984C>T; p.D328D; 6:160718726-160718726	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1892C>G; p.S631*; 6:160739082-160739082	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.984C>T; p.D328D; 6:160718726-160718726	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.931C>G; p.P311A; 6:160718437-160718437	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.13G>A; p.E5K; 6:160702317-160702317	skin	malignant_melanoma	Substitution - Missense
c.13G>A; p.E5K; 6:160702317-160702317	skin	malignant_melanoma	Substitution - Missense
c.2012T>A; p.L671Q; 6:160739202-160739202	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2113G>A; p.G705R; 6:160741405-160741405	skin	malignant_melanoma	Substitution - Missense
c.1070T>A; p.V357E; 6:160718812-160718812	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.163G>T; p.E55*; 6:160706520-160706520	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.548-1G>C; p.?; 6:160714793-160714793	breast	carcinoma	Unknown
c.459G>A; p.R153R; 6:160713037-160713037	skin	malignant_melanoma	Substitution - coding silent
c.218G>A; p.C73Y; 6:160707732-160707732	breast	carcinoma	Substitution - Missense
c.1691C>T; p.S564L; 6:160736896-160736896	skin	malignant_melanoma	Substitution - Missense
c.973C>A; p.R325S; 6:160718715-160718715	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.335G>T; p.R112I; 6:160711119-160711119	liver	carcinoma	Substitution - Missense
c.335G>T; p.R112I; 6:160711119-160711119	liver	carcinoma	Substitution - Missense
c.1292C>T; p.A431V; 6:160731086-160731086	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.266G>C; p.R89T; 6:160707780-160707780	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1548C>T; p.F516F; 6:160731854-160731854	skin	malignant_melanoma	Substitution - coding silent
c.1292C>T; p.A431V; 6:160731086-160731086	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1395G>A; p.P465P; 6:160731189-160731189	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.583G>T; p.G195C; 6:160714829-160714829	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.549G>A; p.E183E; 6:160714795-160714795	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.855G>A; p.G285G; 6:160718361-160718361	skin	malignant_melanoma	Substitution - coding silent
c.509A>C; p.E170A; 6:160713087-160713087	thyroid	carcinoma	Substitution - Missense
c.1849G>A; p.V617M; 6:160738584-160738584	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2349C>T; p.G783G; 6:160752977-160752977	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2019-1G>C; p.?; 6:160741310-160741310	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1562A>C; p.N521T; 6:160731868-160731868	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.758G>A; p.R253H; 6:160716734-160716734	pancreas	carcinoma	Substitution - Missense
c.853G>A; p.G285R; 6:160718359-160718359	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.758G>A; p.R253H; 6:160716734-160716734	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.354A>G; p.T118T; 6:160711138-160711138	skin	malignant_melanoma	Substitution - coding silent
c.2128A>T; p.T710S; 6:160752117-160752117	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.477G>A; p.P159P; 6:160713055-160713055	pancreas	carcinoma	Substitution - coding silent
c.1682-1G>A; p.?; 6:160736886-160736886	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.2065C>A; p.P689T; 6:160741357-160741357	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2075T>C; p.V692A; 6:160741367-160741367	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1115C>T; p.P372L; 6:160722426-160722426	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.49+5G>T; p.?; 6:160702358-160702358	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.479A>G; p.Q160R; 6:160713057-160713057	pancreas	carcinoma	Substitution - Missense
c.1745T>C; p.V582A; 6:160736950-160736950	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1881C>T; p.S627S; 6:160739071-160739071	skin	malignant_melanoma	Substitution - coding silent
c.1881C>T; p.S627S; 6:160739071-160739071	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - coding silent
c.625T>A; p.W209R; 6:160714871-160714871	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1294G>A; p.D432N; 6:160731088-160731088	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.942C>T; p.F314F; 6:160718448-160718448	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1294G>A; p.D432N; 6:160731088-160731088	skin	malignant_melanoma	Substitution - Missense
c.1324C>A; p.P442T; 6:160731118-160731118	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1438+7A>G; p.?; 6:160731239-160731239	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1887G>C; p.R629S; 6:160739077-160739077	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1957G>A; p.E653K; 6:160739147-160739147	NS	malignant_melanoma	Substitution - Missense
c.1304C>G; p.P435R; 6:160731098-160731098	liver	carcinoma	Substitution - Missense
c.1957G>A; p.E653K; 6:160739147-160739147	NS	malignant_melanoma	Substitution - Missense
c.2378A>C; p.Y793S; 6:160753006-160753006	skin	malignant_melanoma	Substitution - Missense
c.938A>C; p.N313T; 6:160718444-160718444	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.168C>T; p.D56D; 6:160706525-160706525	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2427_2430delTAAT; p.N810fs?; 6:160753055-160753058	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.950+1G>T; p.?; 6:160718457-160718457	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1944T>A; p.H648Q; 6:160739134-160739134	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.582C>T; p.D194D; 6:160714828-160714828	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.168C>T; p.D56D; 6:160706525-160706525	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.168C>T; p.D56D; 6:160706525-160706525	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1330G>A; p.V444I; 6:160731124-160731124	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1330G>A; p.V444I; 6:160731124-160731124	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.851G>A; p.R284H; 6:160718357-160718357	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.354delA; p.N120fs*110; 6:160711138-160711138	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1330G>A; p.V444I; 6:160731124-160731124	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.851G>A; p.R284H; 6:160718357-160718357	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.627G>A; p.W209*; 6:160714873-160714873	skin	malignant_melanoma	Substitution - Nonsense
c.1330G>A; p.V444I; 6:160731124-160731124	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.626G>T; p.W209L; 6:160714872-160714872	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1078G>A; p.E360K; 6:160718820-160718820	breast	carcinoma	Substitution - Missense
c.747C>A; p.D249E; 6:160716723-160716723	breast	carcinoma	Substitution - Missense
c.875C>G; p.S292C; 6:160718381-160718381	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1951G>A; p.E651K; 6:160739141-160739141	skin	malignant_melanoma	Substitution - Missense
c.1951G>A; p.E651K; 6:160739141-160739141	skin	malignant_melanoma	Substitution - Missense
c.528C>T; p.C176C; 6:160713106-160713106	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1001G>A; p.W334*; 6:160718743-160718743	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.496A>T; p.T166S; 6:160713074-160713074	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.509A>T; p.E170V; 6:160713087-160713087	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.632C>T; p.S211F; 6:160714878-160714878	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1278C>T; p.C426C; 6:160731072-160731072	breast	carcinoma	Substitution - coding silent
c.1573G>T; p.G525C; 6:160731879-160731879	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.293-1G>C; p.?; 6:160711076-160711076	skin	malignant_melanoma	Unknown
c.1184G>A; p.G395E; 6:160722495-160722495	NS	malignant_melanoma	Substitution - Missense
c.506C>G; p.P169R; 6:160713084-160713084	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.341C>T; p.T114M; 6:160711125-160711125	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1184G>A; p.G395E; 6:160722495-160722495	skin	malignant_melanoma	Substitution - Missense
c.1505G>A; p.C502Y; 6:160731811-160731811	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.422C>A; p.T141K; 6:160713000-160713000	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1431C>T; p.S477S; 6:160731225-160731225	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1247A>G; p.Y416C; 6:160722558-160722558	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1977G>A; p.L659L; 6:160739167-160739167	skin	malignant_melanoma	Substitution - coding silent
c.561T>C; p.H187H; 6:160714807-160714807	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1397C>T; p.P466L; 6:160731191-160731191	skin	malignant_melanoma	Substitution - Missense
c.794C>T; p.P265L; 6:160718300-160718300	skin	malignant_melanoma	Substitution - Missense
c.986G>A; p.G329E; 6:160718728-160718728	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.986G>A; p.G329E; 6:160718728-160718728	skin	malignant_melanoma	Substitution - Missense
c.426delC; p.S144fs*86; 6:160713004-160713004	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.472G>A; p.D158N; 6:160713050-160713050	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.472G>A; p.D158N; 6:160713050-160713050	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1388C>A; p.A463E; 6:160731182-160731182	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1657G>A; p.D553N; 6:160734064-160734064	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1646G>T; p.R549I; 6:160734053-160734053	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1838C>T; p.S613F; 6:160738573-160738573	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1657G>A; p.D553N; 6:160734064-160734064	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2250C>T; p.A750A; 6:160752239-160752239	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2041G>T; p.V681L; 6:160741333-160741333	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1388C>A; p.A463E; 6:160731182-160731182	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1936G>A; p.E646K; 6:160739126-160739126	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1595G>C; p.R532P; 6:160734002-160734002	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2332A>G; p.T778A; 6:160752960-160752960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2358C>T; p.R786R; 6:160752986-160752986	skin	malignant_melanoma	Substitution - coding silent
c.704G>A; p.R235H; 6:160716680-160716680	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.240G>A; p.R80R; 6:160707754-160707754	breast	carcinoma	Substitution - coding silent
c.949A>G; p.K317E; 6:160718455-160718455	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.704G>A; p.R235H; 6:160716680-160716680	prostate	carcinoma	Substitution - Missense
c.2226C>T; p.T742T; 6:160752215-160752215	central_nervous_system; brain	glioma	Substitution - coding silent
c.2137G>A; p.A713T; 6:160752126-160752126	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1725G>T; p.K575N; 6:160736930-160736930	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2322A>C; p.L774F; 6:160752950-160752950	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2161C>T; p.L721F; 6:160752150-160752150	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.645C>G; p.H215Q; 6:160714891-160714891	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1476G>C; p.K492N; 6:160731782-160731782	parathyroid	carcinoma	Substitution - Missense
c.4G>A; p.E2K; 6:160702308-160702308	skin	malignant_melanoma	Substitution - Missense
c.1988G>A; p.R663Q; 6:160739178-160739178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1618G>A; p.G540S; 6:160734025-160734025	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1988G>A; p.R663Q; 6:160739178-160739178	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1988G>A; p.R663Q; 6:160739178-160739178	skin; extremity	malignant_melanoma	Substitution - Missense
c.1988G>A; p.R663Q; 6:160739178-160739178	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1988G>A; p.R663Q; 6:160739178-160739178	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2175G>T; p.E725D; 6:160752164-160752164	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1988G>A; p.R663Q; 6:160739178-160739178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2119A>T; p.T707S; 6:160741411-160741411	skin	malignant_melanoma	Substitution - Missense
c.1742T>C; p.V581A; 6:160736947-160736947	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1977_1978GG>AA; p.E660K; 6:160739167-160739168	skin	malignant_melanoma	Substitution - Missense
c.2080G>T; p.A694S; 6:160741372-160741372	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1642C>T; p.P548S; 6:160734049-160734049	skin	malignant_melanoma	Substitution - Missense
c.1977_1978GG>AA; p.E660K; 6:160739167-160739168	skin	malignant_melanoma	Substitution - Missense
c.370T>C; p.C124R; 6:160711154-160711154	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.527G>C; p.C176S; 6:160713105-160713105	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1353_1354insA; p.C454fs*59; 6:160731147-160731148	oesophagus; lower_third	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1704G>A; p.G568G; 6:160736909-160736909	skin	malignant_melanoma	Substitution - coding silent
c.1233G>A; p.K411K; 6:160722544-160722544	skin	malignant_melanoma	Substitution - coding silent
c.1247A>T; p.Y416F; 6:160722558-160722558	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1339G>A; p.E447K; 6:160731133-160731133	skin	malignant_melanoma	Substitution - Missense
c.1503A>G; p.P501P; 6:160731809-160731809	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.901G>T; p.A301S; 6:160718407-160718407	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.744C>A; p.T248T; 6:160716720-160716720	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1588T>C; p.Y530H; 6:160733995-160733995	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1256C>T; p.A419V; 6:160722567-160722567	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2241G>A; p.G747G; 6:160752230-160752230	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.1256C>T; p.A419V; 6:160722567-160722567	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.199C>T; p.H67Y; 6:160707713-160707713	skin; abdomen	malignant_melanoma	Substitution - Missense
c.481G>T; p.G161W; 6:160713059-160713059	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.724C>T; p.R242W; 6:160716700-160716700	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2356C>T; p.R786C; 6:160752984-160752984	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.744C>T; p.T248T; 6:160716720-160716720	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.744C>T; p.T248T; 6:160716720-160716720	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1682C>T; p.A561V; 6:160736887-160736887	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.744C>T; p.T248T; 6:160716720-160716720	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2164C>A; p.P722T; 6:160752153-160752153	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.172G>A; p.E58K; 6:160706529-160706529	skin	malignant_melanoma	Substitution - Missense
c.544G>A; p.E182K; 6:160713122-160713122	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.172G>A; p.E58K; 6:160706529-160706529	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2134G>A; p.G712R; 6:160752123-160752123	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.471C>T; p.N157N; 6:160713049-160713049	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.673C>T; p.P225S; 6:160716649-160716649	skin	malignant_melanoma	Substitution - Missense
c.529G>A; p.D177N; 6:160713107-160713107	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.529G>A; p.D177N; 6:160713107-160713107	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2286T>G; p.G762G; 6:160752914-160752914	breast	carcinoma	Substitution - coding silent
c.1588-8G>T; p.?; 6:160733987-160733987	stomach	adenocarcinoma	Unknown
c.638G>A; p.S213N; 6:160714884-160714884	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1264A>T; p.T422S; 6:160731058-160731058	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.859G>C; p.V287L; 6:160718365-160718365	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.807T>A; p.S269S; 6:160718313-160718313	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1987C>T; p.R663*; 6:160739177-160739177	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1987C>T; p.R663*; 6:160739177-160739177	large_intestine	adenoma	Substitution - Nonsense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation