lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5327
Symbol	PLAT
Synonymous	T-PA\|TPA
Full name	plasminogen activator, tissue
Gene description	alteplase\|plasminogen activator, tissue type\|reteplase\|t-plasminogen activator\|tissue plasminogen activator (t-PA)\|tissue-type plasminogen activator
Cytoband	8p12
Gene type	protein-coding
Synonymous	MIM:173370; HGNC:HGNC:9051; Ensembl:ENSG00000104368; HPRD:01419; Vega:OTTHUMG00000164072

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.903G>C; p.L301L; 8:42180672-42180672	breast	carcinoma	Substitution - coding silent
c.951C>T; p.A317A; 8:42180624-42180624	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.925T>A; p.F309I; 8:42180650-42180650	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.803G>T; p.R268L; 8:42182719-42182719	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.384C>T; p.Y128Y; 8:42187553-42187553	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1009G>A; p.G337R; 8:42180566-42180566	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.491G>A; p.R164Q; 8:42187446-42187446	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.491G>A; p.R164Q; 8:42187446-42187446	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.257G>A; p.C86Y; 8:42188013-42188013	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.613A>C; p.T205P; 8:42185099-42185099	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.463G>T; p.A155S; 8:42187474-42187474	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.613A>C; p.T205P; 8:42185099-42185099	thyroid	other; neoplasm	Substitution - Missense
c.85C>T; p.R29*; 8:42191402-42191402	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1538C>T; p.S513L; 8:42176144-42176144	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.72G>C; p.Q24H; 8:42193114-42193114	breast	carcinoma	Substitution - Missense
c.691G>A; p.E231K; 8:42182831-42182831	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1635G>A; p.V545V; 8:42176047-42176047	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1196A>G; p.D399G; 8:42180268-42180268	lung	carcinoid-endocrine_tumour; typical	Substitution - Missense
c.803G>A; p.R268Q; 8:42182719-42182719	soft_tissue; striated_muscle	rhabdoid_tumour	Substitution - Missense
c.20G>C; p.G7A; 8:42193166-42193166	urinary_tract; bladder	carcinoma	Substitution - Missense
c.166T>C; p.W56R; 8:42189021-42189021	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1016G>A; p.R339Q; 8:42180559-42180559	breast	carcinoma	Substitution - Missense
c.972G>A; p.W324*; 8:42180603-42180603	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1521C>T; p.D507D; 8:42178906-42178906	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.776_777insG; p.L261fs*5; 8:42182745-42182746	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Insertion - Frameshift
c.1571G>A; p.R524H; 8:42176111-42176111	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.197T>G; p.V66G; 8:42188990-42188990	breast	carcinoma	Substitution - Missense
c.1670G>C; p.R557P; 8:42176012-42176012	breast	carcinoma	Substitution - Missense
c.857T>C; p.L286P; 8:42181969-42181969	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.632-4C>G; p.?; 8:42182894-42182894	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1379C>T; p.S460L; 8:42179048-42179048	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1379C>T; p.S460L; 8:42179048-42179048	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.196G>A; p.V66M; 8:42188991-42188991	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.196G>A; p.V66M; 8:42188991-42188991	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.501C>T; p.D167D; 8:42187436-42187436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.922C>T; p.Q308*; 8:42180653-42180653	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.501C>T; p.D167D; 8:42187436-42187436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.243G>T; p.V81V; 8:42188944-42188944	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.825G>A; p.K275K; 8:42182001-42182001	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1021C>A; p.L341M; 8:42180554-42180554	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.153G>A; p.Q51Q; 8:42189034-42189034	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.465G>A; p.A155A; 8:42187472-42187472	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.95G>C; p.R32T; 8:42191392-42191392	skin	malignant_melanoma	Substitution - Missense
c.1189G>A; p.E397K; 8:42180275-42180275	skin	malignant_melanoma	Substitution - Missense
c.776T>C; p.L259P; 8:42182746-42182746	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.800G>T; p.C267F; 8:42182722-42182722	pancreas	carcinoma	Substitution - Missense
c.547G>C; p.D183H; 8:42185165-42185165	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1037T>C; p.L346P; 8:42180538-42180538	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1037T>C; p.L346P; 8:42180538-42180538	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.334G>A; p.E112K; 8:42187936-42187936	breast	carcinoma	Substitution - Missense
c.334G>A; p.E112K; 8:42187936-42187936	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1339T>C; p.S447P; 8:42179950-42179950	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.193C>T; p.R65W; 8:42188994-42188994	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>A; p.G174G; 8:42187415-42187415	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1507G>A; p.A503T; 8:42178920-42178920	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1358A>C; p.E453A; 8:42179931-42179931	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.478C>T; p.P160S; 8:42187459-42187459	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1458C>G; p.V486V; 8:42178969-42178969	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1458C>G; p.V486V; 8:42178969-42178969	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1263G>A; p.Q421Q; 8:42180026-42180026	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.173G>C; p.R58P; 8:42189014-42189014	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1066G>A; p.A356T; 8:42180509-42180509	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.426G>T; p.A142A; 8:42187511-42187511	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1066G>A; p.A356T; 8:42180509-42180509	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.716G>A; p.W239*; 8:42182806-42182806	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1209C>T; p.Y403Y; 8:42180255-42180255	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1312C>T; p.L438L; 8:42179977-42179977	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1522G>A; p.A508T; 8:42178905-42178905	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.890C>G; p.S297C; 8:42180685-42180685	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1010G>A; p.G337E; 8:42180565-42180565	skin	malignant_melanoma	Substitution - Missense
c.1596C>T; p.S532S; 8:42176086-42176086	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.152A>T; p.Q51L; 8:42189035-42189035	skin	malignant_melanoma	Substitution - Missense
c.943C>T; p.L315F; 8:42180632-42180632	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.903G>A; p.L301L; 8:42180672-42180672	breast	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1280G>A; p.R427H; 8:42180009-42180009	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.318C>T; p.F106F; 8:42187952-42187952	kidney	other; neoplasm	Substitution - coding silent
c.318C>T; p.F106F; 8:42187952-42187952	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1533C>T; p.G511G; 8:42176149-42176149	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1533C>T; p.G511G; 8:42176149-42176149	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.276C>A; p.F92L; 8:42187994-42187994	breast	carcinoma	Substitution - Missense
c.1674C>T; p.D558D; 8:42176008-42176008	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1237A>G; p.K413E; 8:42180052-42180052	skin	malignant_melanoma	Substitution - Missense
c.137C>T; p.T46M; 8:42189050-42189050	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.262G>A; p.E88K; 8:42188008-42188008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1587C>A; p.G529G; 8:42176095-42176095	stomach	adenocarcinoma	Substitution - coding silent
c.1685C>A; p.P562Q; 8:42175997-42175997	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.964C>T; p.H322Y; 8:42180611-42180611	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.614C>T; p.T205I; 8:42185098-42185098	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.148T>C; p.Y50H; 8:42189039-42189039	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.34C>T; p.L12L; 8:42193152-42193152	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.912delC; p.Y304fs*1; 8:42180663-42180663	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.55T>C; p.F19L; 8:42193131-42193131	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.902T>C; p.L301P; 8:42180673-42180673	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1451G>T; p.R484I; 8:42178976-42178976	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.239C>T; p.S80L; 8:42188948-42188948	pancreas	carcinoma	Substitution - Missense
c.1368T>C; p.S456S; 8:42179059-42179059	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.286A>G; p.T96A; 8:42187984-42187984	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1241C>T; p.S414L; 8:42180048-42180048	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1006C>T; p.P336S; 8:42180569-42180569	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1461C>A; p.T487T; 8:42178966-42178966	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1142G>A; p.G381D; 8:42180322-42180322	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1142G>A; p.G381D; 8:42180322-42180322	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.487G>A; p.G163R; 8:42187450-42187450	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1225C>T; p.L409L; 8:42180064-42180064	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.928C>T; p.R310C; 8:42180647-42180647	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1489C>G; p.R497G; 8:42178938-42178938	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.241G>C; p.V81L; 8:42188946-42188946	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.57C>T; p.F19F; 8:42193129-42193129	skin	malignant_melanoma	Substitution - coding silent
c.57C>T; p.F19F; 8:42193129-42193129	skin	malignant_melanoma	Substitution - coding silent
c.149A>G; p.Y50C; 8:42189038-42189038	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.67A>C; p.S23R; 8:42193119-42193119	ovary	other; neoplasm	Substitution - Missense
c.1423C>T; p.R475C; 8:42179004-42179004	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.966C>T; p.H322H; 8:42180609-42180609	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.966C>T; p.H322H; 8:42180609-42180609	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1490G>A; p.R497Q; 8:42178937-42178937	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.903G>T; p.L301L; 8:42180672-42180672	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1266G>T; p.E422D; 8:42180023-42180023	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.903G>T; p.L301L; 8:42180672-42180672	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation