lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5272
Symbol	SERPINB9
Synonymous	CAP-3\|CAP3\|PI-9\|PI9
Full name	serpin peptidase inhibitor, clade B (ovalbumin), member 9
Gene description	cytoplasmic antiproteinase 3\|peptidase inhibitor 9\|protease inhibitor 9 (ovalbumin type)\|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9\|serpin B9\|serpin peptidase inhibitor, clade B, member 9
Cytoband	6p25
Gene type	protein-coding
Synonymous	MIM:601799; HGNC:HGNC:8955; Ensembl:ENSG00000170542; HPRD:03480; Vega:OTTHUMG00000014131

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.200A>G; p.H67R; 6:2896159-2896159	urinary_tract; bladder	carcinoma	Substitution - Missense
c.170C>T; p.A57V; 6:2896189-2896189	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.979A>C; p.T327P; 6:2890315-2890315	breast	carcinoma	Substitution - Missense
c.127C>G; p.L43V; 6:2900485-2900485	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>T; p.V267F; 6:2890495-2890495	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.263C>T; p.T88M; 6:2896096-2896096	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.42C>T; p.R14R; 6:2900570-2900570	skin	malignant_melanoma	Substitution - coding silent
c.41G>A; p.R14H; 6:2900571-2900571	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.691C>T; p.L231L; 6:2891865-2891865	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.578G>T; p.R193M; 6:2891978-2891978	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.712G>C; p.E238Q; 6:2891844-2891844	central_nervous_system; brain	glioma	Substitution - Missense
c.40C>T; p.R14C; 6:2900572-2900572	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1015G>A; p.A339T; 6:2890279-2890279	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.100A>G; p.S34G; 6:2900512-2900512	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.606C>T; p.A202A; 6:2891950-2891950	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.598C>G; p.Q200E; 6:2891958-2891958	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.636G>T; p.V212V; 6:2891920-2891920	kidney	other; neoplasm	Substitution - coding silent
c.328C>A; p.Q110K; 6:2895487-2895487	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1124C>T; p.S375L; 6:2890170-2890170	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.880C>T; p.Q294*; 6:2890414-2890414	skin	malignant_melanoma	Substitution - Nonsense
c.942C>T; p.F314F; 6:2890352-2890352	skin	malignant_melanoma	Substitution - coding silent
c.942C>T; p.F314F; 6:2890352-2890352	skin	malignant_melanoma	Substitution - coding silent
c.667A>T; p.R223W; 6:2891889-2891889	oesophagus	carcinoma	Substitution - Missense
c.976G>T; p.G326C; 6:2890318-2890318	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.904G>A; p.A302T; 6:2890390-2890390	skin	malignant_melanoma	Substitution - Missense
c.758C>A; p.A253D; 6:2890536-2890536	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.994G>T; p.A332S; 6:2890300-2890300	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; essential_thrombocythaemia	Substitution - Missense
c.853C>T; p.R285W; 6:2890441-2890441	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.150C>T; p.T50T; 6:2900462-2900462	skin	malignant_melanoma	Substitution - coding silent
c.215C>T; p.S72L; 6:2896144-2896144	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.149C>T; p.T50I; 6:2900463-2900463	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1018G>C; p.E340Q; 6:2890276-2890276	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.92C>A; p.S31Y; 6:2900520-2900520	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.305C>T; p.S102L; 6:2896054-2896054	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.445C>T; p.P149S; 6:2893533-2893533	skin	malignant_melanoma	Substitution - Missense
c.926T>C; p.L309P; 6:2890368-2890368	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.738C>T; p.L246L; 6:2890556-2890556	breast	carcinoma	Substitution - coding silent
c.529G>A; p.E177K; 6:2893449-2893449	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.529G>A; p.E177K; 6:2893449-2893449	skin	malignant_melanoma	Substitution - Missense
c.423A>C; p.E141D; 6:2895392-2895392	pancreas	carcinoma	Substitution - Missense
c.423A>C; p.E141D; 6:2895392-2895392	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1026C>T; p.C342C; 6:2890268-2890268	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1029G>A; p.M343I; 6:2890265-2890265	skin	malignant_melanoma	Substitution - Missense
c.1061C>T; p.P354L; 6:2890233-2890233	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.250T>C; p.Y84H; 6:2896109-2896109	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.340G>C; p.A114P; 6:2895475-2895475	breast	carcinoma	Substitution - Missense
c.71C>T; p.P24L; 6:2900541-2900541	skin	malignant_melanoma	Substitution - Missense
c.29C>A; p.T10N; 6:2900583-2900583	urinary_tract; bladder	carcinoma	Substitution - Missense
c.702C>T; p.D234D; 6:2891854-2891854	breast	carcinoma	Substitution - coding silent
c.581C>T; p.P194L; 6:2891975-2891975	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.414A>G; p.K138K; 6:2895401-2895401	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.45T>G; p.L15L; 6:2900567-2900567	liver	carcinoma	Substitution - coding silent
c.45T>G; p.L15L; 6:2900567-2900567	liver	carcinoma	Substitution - coding silent
c.989C>T; p.A330V; 6:2890305-2890305	breast	carcinoma	Substitution - Missense
c.863G>A; p.G288E; 6:2890431-2890431	skin	malignant_melanoma	Substitution - Missense
c.198T>C; p.I66I; 6:2896161-2896161	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.159G>T; p.Q53H; 6:2900453-2900453	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1054G>A; p.D352N; 6:2890240-2890240	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1065C>T; p.F355F; 6:2890229-2890229	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1108T>C; p.C370R; 6:2890186-2890186	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.194A>G; p.D65G; 6:2896165-2896165	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.914C>T; p.A305V; 6:2890380-2890380	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.505G>A; p.G169R; 6:2893473-2893473	skin	malignant_melanoma	Substitution - Missense
c.487A>G; p.N163D; 6:2893491-2893491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.943G>A; p.V315M; 6:2890351-2890351	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.619G>T; p.A207S; 6:2891937-2891937	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1043G>T; p.R348M; 6:2890251-2890251	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.981C>T; p.T327T; 6:2890313-2890313	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.981C>T; p.T327T; 6:2890313-2890313	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.802C>A; p.L268I; 6:2890492-2890492	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.985G>T; p.A329S; 6:2890309-2890309	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.265G>A; p.A89T; 6:2896094-2896094	skin; mucosal	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation