lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5268
Symbol	SERPINB5
Synonymous	PI5\|maspin
Full name	serpin peptidase inhibitor, clade B (ovalbumin), member 5
Gene description	PI-5\|peptidase inhibitor 5\|protease inhibitor 5 (maspin)\|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5\|serpin B5
Cytoband	18q21.33
Gene type	protein-coding
Synonymous	MIM:154790; HGNC:HGNC:8949; Ensembl:ENSG00000206075; HPRD:01111; Vega:OTTHUMG00000141307

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.601G>A; p.E201K; 18:63499153-63499153	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.665delA; p.N223fs*59; 18:63499217-63499217	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.736-3C>T; p.?; 18:63503327-63503327	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.597C>G; p.N199K; 18:63499149-63499149	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.181G>A; p.E61K; 18:63486958-63486958	skin	malignant_melanoma	Substitution - Missense
c.622A>T; p.N208Y; 18:63499174-63499174	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.533C>A; p.S178*; 18:63493061-63493061	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.973G>A; p.E325K; 18:63503567-63503567	skin	malignant_melanoma	Substitution - Missense
c.671A>G; p.K224R; 18:63499223-63499223	skin	malignant_melanoma	Substitution - Missense
c.551C>T; p.P184L; 18:63493079-63493079	skin	malignant_melanoma	Substitution - Missense
c.551C>T; p.P184L; 18:63493079-63493079	skin	malignant_melanoma	Substitution - Missense
c.920T>C; p.M307T; 18:63503514-63503514	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.920T>C; p.M307T; 18:63503514-63503514	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.333G>C; p.P111P; 18:63489373-63489373	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.333G>C; p.P111P; 18:63489373-63489373	thyroid	other; neoplasm	Substitution - coding silent
c.493G>A; p.A165T; 18:63493021-63493021	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1083C>A; p.N361K; 18:63503677-63503677	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.526T>C; p.S176P; 18:63493054-63493054	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.526T>C; p.S176P; 18:63493054-63493054	thyroid	other; neoplasm	Substitution - Missense
c.422A>C; p.D141A; 18:63489462-63489462	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1015G>A; p.A339T; 18:63503609-63503609	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.383C>T; p.T128M; 18:63489423-63489423	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.383C>T; p.T128M; 18:63489423-63489423	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.19G>A; p.A7T; 18:63484447-63484447	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.110C>T; p.T37I; 18:63484538-63484538	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.245C>T; p.S82F; 18:63487022-63487022	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.271C>T; p.R91W; 18:63487048-63487048	lung; left_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.324G>A; p.T108T; 18:63489364-63489364	skin	malignant_melanoma	Substitution - coding silent
c.524T>C; p.F175S; 18:63493052-63493052	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.323C>T; p.T108M; 18:63489363-63489363	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.226G>A; p.D76N; 18:63487003-63487003	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.226G>A; p.D76N; 18:63487003-63487003	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.221C>T; p.T74I; 18:63486998-63486998	liver	carcinoma	Substitution - Missense
c.145G>A; p.D49N; 18:63484573-63484573	skin; trunk	malignant_melanoma	Substitution - Missense
c.925G>C; p.E309Q; 18:63503519-63503519	urinary_tract; bladder	carcinoma	Substitution - Missense
c.519G>T; p.K173N; 18:63493047-63493047	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.169G>C; p.V57L; 18:63486946-63486946	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.645G>C; p.K215N; 18:63499197-63499197	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.424+1G>A; p.?; 18:63489465-63489465	stomach	carcinoma; adenocarcinoma	Unknown
c.955A>G; p.I319V; 18:63503549-63503549	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.850C>T; p.P284S; 18:63503444-63503444	skin	malignant_melanoma	Substitution - Missense
c.329G>T; p.R110I; 18:63489369-63489369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>A; p.K268K; 18:63503398-63503398	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.632G>A; p.S211N; 18:63499184-63499184	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.285C>A; p.D95E; 18:63487062-63487062	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.371A>C; p.K124T; 18:63489411-63489411	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.516G>A; p.M172I; 18:63493044-63493044	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.888C>A; p.I296I; 18:63503482-63503482	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.8C>T; p.A3V; 18:63484436-63484436	prostate	carcinoma	Substitution - Missense
c.200C>T; p.P67L; 18:63486977-63486977	skin	malignant_melanoma	Substitution - Missense
c.205G>A; p.G69R; 18:63486982-63486982	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1044G>C; p.L348F; 18:63503638-63503638	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.252C>A; p.Y84*; 18:63487029-63487029	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.919A>G; p.M307V; 18:63503513-63503513	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.919A>G; p.M307V; 18:63503513-63503513	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.919A>T; p.M307L; 18:63503513-63503513	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.384G>A; p.T128T; 18:63489424-63489424	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1023C>A; p.I341I; 18:63503617-63503617	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.379G>A; p.E127K; 18:63489419-63489419	ovary	other; neoplasm	Substitution - Missense
c.379G>A; p.E127K; 18:63489419-63489419	skin	malignant_melanoma	Substitution - Missense
c.506G>C; p.G169A; 18:63493034-63493034	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272G>A; p.R91Q; 18:63487049-63487049	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.307G>A; p.E103K; 18:63489347-63489347	skin	malignant_melanoma	Substitution - Missense
c.476T>G; p.I159S; 18:63493004-63493004	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.124_125GC>TT; p.A42F; 18:63484552-63484553	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.630C>A; p.D210E; 18:63499182-63499182	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.225G>A; p.S75S; 18:63487002-63487002	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.28G>T; p.A10S; 18:63484456-63484456	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.425G>T; p.G142V; 18:63492953-63492953	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.559G>C; p.V187L; 18:63493087-63493087	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation