lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5144
Symbol	PDE4D
Synonymous	ACRDYS2\|DPDE3\|HSPDE4D\|PDE43\|PDE4DN2\|STRK1
Full name	phosphodiesterase 4D, cAMP-specific
Gene description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D\|cAMP-specific phosphodiesterase PDE4D6\|phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Cytoband	5q12
Gene type	protein-coding
Synonymous	MIM:600129; HGNC:HGNC:8783; Ensembl:ENSG00000113448; HPRD:02530; Vega:OTTHUMG00000162218

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.212C>T; p.S71F; 5:59215804-59215804	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1779T>G; p.G593G; 5:58974907-58974907	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1859T>G; p.V620G; 5:58974827-58974827	breast	carcinoma	Substitution - Missense
c.1360G>A; p.E454K; 5:58976412-58976412	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1487G>A; p.R496H; 5:58975775-58975775	breast	carcinoma	Substitution - Missense
c.740G>T; p.R247M; 5:58991872-58991872	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1477C>T; p.Q493*; 5:58975785-58975785	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1552A>G; p.M518V; 5:58975710-58975710	liver	carcinoma	Substitution - Missense
c.1916C>A; p.S639Y; 5:58974770-58974770	kidney	other; neoplasm	Substitution - Missense
c.293G>A; p.R98Q; 5:59185246-59185246	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.293G>A; p.R98Q; 5:59185246-59185246	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.542C>A; p.T181N; 5:58993437-58993437	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.753A>C; p.K251N; 5:58991859-58991859	skin	malignant_melanoma	Substitution - Missense
c.308A>T; p.N103I; 5:59185231-59185231	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.85C>T; p.P29S; 5:59215931-59215931	skin	malignant_melanoma	Substitution - Missense
c.1286T>G; p.M429R; 5:58977204-58977204	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.165C>T; p.F55F; 5:59215851-59215851	skin	malignant_melanoma	Substitution - coding silent
c.497A>G; p.E166G; 5:59038875-59038875	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.79C>T; p.R27W; 5:59215937-59215937	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1496C>T; p.T499M; 5:58975766-58975766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.931T>C; p.Y311H; 5:58989868-58989868	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1496C>T; p.T499M; 5:58975766-58975766	breast	carcinoma	Substitution - Missense
c.1573G>A; p.D525N; 5:58975689-58975689	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1476C>T; p.L492L; 5:58975786-58975786	skin	malignant_melanoma	Substitution - coding silent
c.98T>C; p.M33T; 5:59215918-59215918	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.702G>T; p.L234F; 5:58991910-58991910	skin	malignant_melanoma	Substitution - Missense
c.1813G>C; p.E605Q; 5:58974873-58974873	breast	carcinoma	Substitution - Missense
c.113C>T; p.S38F; 5:59215903-59215903	skin	malignant_melanoma	Substitution - Missense
c.1186G>C; p.E396Q; 5:58977304-58977304	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1289T>C; p.V430A; 5:58977201-58977201	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1246C>G; p.Q416E; 5:58977244-58977244	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.504C>T; p.A168A; 5:59038868-59038868	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.553G>A; p.E185K; 5:58993426-58993426	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.527T>C; p.L176P; 5:58993452-58993452	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1290C>A; p.V430V; 5:58977200-58977200	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.883C>T; p.R295W; 5:58989916-58989916	breast	carcinoma	Substitution - Missense
c.883C>T; p.R295W; 5:58989916-58989916	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1409C>T; p.S470F; 5:58976363-58976363	skin	malignant_melanoma	Substitution - Missense
c.1703A>G; p.N568S; 5:58974983-58974983	urinary_tract; bladder	carcinoma	Substitution - Missense
c.244G>A; p.G82R; 5:59193532-59193532	central_nervous_system; brain	glioma	Substitution - Missense
c.1512G>T; p.E504D; 5:58975750-58975750	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1706G>A; p.R569H; 5:58974980-58974980	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1396_1398delCTT; p.L466delL; 5:58976374-58976376	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.603C>A; p.F201L; 5:58993376-58993376	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.183C>T; p.S61S; 5:59215833-59215833	thyroid	carcinoma	Substitution - coding silent
c.1579C>A; p.H527N; 5:58975683-58975683	liver	carcinoma	Substitution - Missense
c.1868A>T; p.D623V; 5:58974818-58974818	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1868A>T; p.D623V; 5:58974818-58974818	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1868A>T; p.D623V; 5:58974818-58974818	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1045-1G>A; p.?; 5:58988593-58988593	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.1964A>G; p.E655G; 5:58974722-58974722	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.702G>C; p.L234F; 5:58991910-58991910	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.239+7A>G; p.?; 5:59215770-59215770	pancreas	carcinoma	Unknown
c.239+7A>G; p.?; 5:59215770-59215770	pancreas	carcinoma	Unknown
c.239+7A>G; p.?; 5:59215770-59215770	pancreas	carcinoma	Unknown
c.1437G>T; p.M479I; 5:58975825-58975825	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.988C>A; p.H330N; 5:58989811-58989811	liver	carcinoma	Substitution - Missense
c.988C>A; p.H330N; 5:58989811-58989811	liver	carcinoma	Substitution - Missense
c.494G>A; p.S165N; 5:59038878-59038878	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1827G>T; p.E609D; 5:58974859-58974859	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1050G>C; p.V350V; 5:58988587-58988587	pancreas	carcinoma	Substitution - coding silent
c.239T>C; p.I80T; 5:59215777-59215777	breast	carcinoma	Substitution - Missense
c.55G>A; p.V19M; 5:59215961-59215961	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1864G>A; p.E622K; 5:58974822-58974822	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.172C>T; p.R58*; 5:59215844-59215844	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.649delG; p.E217fs*18; 5:58991963-58991963	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.771C>T; p.V257V; 5:58991841-58991841	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1410C>T; p.S470S; 5:58976362-58976362	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.295A>G; p.T99A; 5:59185244-59185244	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.330G>T; p.L110F; 5:59185209-59185209	liver	carcinoma	Substitution - Missense
c.1927C>T; p.P643S; 5:58974759-58974759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.488C>A; p.S163Y; 5:59038884-59038884	breast	carcinoma	Substitution - Missense
c.1283A>G; p.K428R; 5:58977207-58977207	breast	carcinoma	Substitution - Missense
c.1926T>C; p.I642I; 5:58974760-58974760	breast	carcinoma	Substitution - coding silent
c.22C>T; p.P8S; 5:59586354-59586354	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.912A>T; p.P304P; 5:58989887-58989887	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.175T>A; p.S59T; 5:59215841-59215841	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1914G>A; p.E638E; 5:58974772-58974772	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1502G>A; p.R501Q; 5:58975760-58975760	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.121A>G; p.I41V; 5:59215895-59215895	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1505T>A; p.I502K; 5:58975757-58975757	skin	malignant_melanoma	Substitution - Missense
c.781-1G>T; p.?; 5:58990903-58990903	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.679C>G; p.Q227E; 5:58991933-58991933	oesophagus	carcinoma	Substitution - Missense
c.821G>C; p.R274T; 5:58990862-58990862	liver	carcinoma	Substitution - Missense
c.880-8_880-7insT; p.?; 5:58989926-58989927	liver	carcinoma	Unknown
c.1880G>C; p.S627T; 5:58974806-58974806	pancreas	other; adenoma	Substitution - Missense
c.1591G>A; p.V531M; 5:58975671-58975671	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.178G>A; p.D60N; 5:59215838-59215838	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1411G>A; p.D471N; 5:58976361-58976361	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1604A>T; p.Q535L; 5:58975658-58975658	kidney	other; neoplasm	Substitution - Missense
c.245G>A; p.G82E; 5:59193531-59193531	skin	malignant_melanoma	Substitution - Missense
c.162C>T; p.S54S; 5:59215854-59215854	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1916C>G; p.S639C; 5:58974770-58974770	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1865A>C; p.E622A; 5:58974821-58974821	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.302G>A; p.R101Q; 5:59185237-59185237	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.302G>A; p.R101Q; 5:59185237-59185237	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1732C>T; p.Q578*; 5:58974954-58974954	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1471C>T; p.P491S; 5:58975791-58975791	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1660G>T; p.V554F; 5:58975026-58975026	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1878C>T; p.C626C; 5:58974808-58974808	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1323delA; p.K441fs*3; 5:58976449-58976449	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.562C>T; p.R188W; 5:58993417-58993417	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation