lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	50484
Symbol	RRM2B
Synonymous	MTDPS8A\|MTDPS8B\|P53R2
Full name	ribonucleotide reductase M2 B (TP53 inducible)
Gene description	TP53-inducible ribonucleotide reductase M2 B\|p53-inducible ribonucleotide reductase small subunit 2 homolog\|p53-inducible ribonucleotide reductase small subunit 2 short form beta\|p53-inducible ribonucleotide reductase small subunit 2-like protein\|ribonucl
Cytoband	8q23.1
Gene type	protein-coding
Synonymous	MIM:604712; HGNC:HGNC:17296; Ensembl:ENSG00000048392; HPRD:05276; Vega:OTTHUMG00000164776

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.517T>C; p.L173L; 8:102224079-102224079	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.520C>T; p.R174*; 8:102224076-102224076	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.235A>G; p.N79D; 8:102226004-102226004	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.969C>A; p.F323L; 8:102208220-102208220	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.969C>A; p.F323L; 8:102208220-102208220	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.969C>A; p.F323L; 8:102208220-102208220	breast	carcinoma	Substitution - Missense
c.362G>A; p.R121H; 8:102224978-102224978	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.343G>C; p.V115L; 8:102224997-102224997	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.923C>T; p.P308L; 8:102208266-102208266	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.610G>T; p.A204S; 8:102218888-102218888	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.713T>A; p.M238K; 8:102214130-102214130	skin	malignant_melanoma	Substitution - Missense
c.450G>T; p.K150N; 8:102224890-102224890	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.50G>C; p.R17T; 8:102232303-102232303	pancreas	carcinoma	Substitution - Missense
c.584G>T; p.G195V; 8:102218914-102218914	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.226C>A; p.P76T; 8:102226013-102226013	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.204+4C>T; p.?; 8:102232145-102232145	pancreas	carcinoma	Unknown
c.997C>T; p.R333C; 8:102208192-102208192	pancreas	carcinoma	Substitution - Missense
c.498G>C; p.K166N; 8:102224098-102224098	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.539A>T; p.K180I; 8:102224057-102224057	skin	malignant_melanoma	Substitution - Missense
c.470A>G; p.N157S; 8:102224126-102224126	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.922C>T; p.P308S; 8:102208267-102208267	skin	malignant_melanoma	Substitution - Missense
c.922C>T; p.P308S; 8:102208267-102208267	skin; mucosal	malignant_melanoma	Substitution - Missense
c.240G>T; p.K80N; 8:102225999-102225999	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.6C>T; p.G2G; 8:102238869-102238869	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.473C>T; p.A158V; 8:102224123-102224123	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.731A>G; p.N244S; 8:102214112-102214112	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.979C>T; p.R327*; 8:102208210-102208210	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.669C>A; p.L223L; 8:102218829-102218829	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.980G>C; p.R327P; 8:102208209-102208209	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.328C>T; p.R110C; 8:102225012-102225012	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.225C>T; p.L75L; 8:102226014-102226014	skin	malignant_melanoma	Substitution - coding silent
c.756G>A; p.R252R; 8:102214087-102214087	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.239A>G; p.K80R; 8:102226000-102226000	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.403T>C; p.S135P; 8:102224937-102224937	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.790G>A; p.E264K; 8:102212889-102212889	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.773C>T; p.A258V; 8:102214070-102214070	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.177A>G; p.A59A; 8:102232176-102232176	skin	malignant_melanoma	Substitution - coding silent
c.73A>G; p.S25G; 8:102232280-102232280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.73A>G; p.S25G; 8:102232280-102232280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.73A>G; p.S25G; 8:102232280-102232280	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.73A>G; p.S25G; 8:102232280-102232280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.802G>A; p.E268K; 8:102212877-102212877	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1046C>T; p.A349V; 8:102208143-102208143	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.49-1G>A; p.?; 8:102232305-102232305	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.271C>T; p.H91Y; 8:102225968-102225968	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4G>T; p.G2C; 8:102238871-102238871	liver	carcinoma	Substitution - Missense
c.4G>T; p.G2C; 8:102238871-102238871	liver	carcinoma	Substitution - Missense
c.313G>A; p.E105K; 8:102225926-102225926	liver	carcinoma	Substitution - Missense
c.116C>A; p.S39Y; 8:102232237-102232237	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.497A>G; p.K166R; 8:102224099-102224099	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.140T>C; p.I47T; 8:102232213-102232213	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.32G>C; p.G11A; 8:102238843-102238843	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.463T>G; p.L155V; 8:102224133-102224133	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.551G>T; p.G184V; 8:102218947-102218947	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.361C>T; p.R121C; 8:102224979-102224979	ovary	other; neoplasm	Substitution - Missense
c.947C>G; p.S316C; 8:102208242-102208242	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.838A>G; p.I280V; 8:102212841-102212841	skin	malignant_melanoma	Substitution - Missense
c.212T>A; p.L71*; 8:102226027-102226027	skin	malignant_melanoma	Substitution - Nonsense
c.22G>A; p.E8K; 8:102238853-102238853	parathyroid	carcinoma	Substitution - Missense
c.574G>T; p.A192S; 8:102218924-102218924	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.700T>A; p.F234I; 8:102214143-102214143	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.789+7C>T; p.?; 8:102214047-102214047	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.969C>G; p.F323L; 8:102208220-102208220	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.846G>C; p.M282I; 8:102212833-102212833	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.947C>A; p.S316Y; 8:102208242-102208242	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.606T>C; p.F202F; 8:102218892-102218892	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation