lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4982
Symbol	TNFRSF11B
Synonymous	OCIF\|OPG\|TR1
Full name	tumor necrosis factor receptor superfamily, member 11b
Gene description	osteoclastogenesis inhibitory factor\|osteoprotegerin\|tumor necrosis factor receptor superfamily member 11B
Cytoband	8q24
Gene type	protein-coding
Synonymous	MIM:602643; HGNC:HGNC:11909; Ensembl:ENSG00000164761; HPRD:04032; Vega:OTTHUMG00000164969

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.797T>C; p.I266T; 8:118926514-118926514	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.679T>G; p.L227V; 8:118926632-118926632	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.726G>A; p.R242R; 8:118926585-118926585	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.255C>T; p.P85P; 8:118933076-118933076	skin	malignant_melanoma	Substitution - coding silent
c.931G>T; p.D311Y; 8:118924649-118924649	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.331C>T; p.R111C; 8:118933000-118933000	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.845A>G; p.Q282R; 8:118924735-118924735	prostate	carcinoma	Substitution - Missense
c.472G>A; p.A158T; 8:118928858-118928858	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.74C>T; p.P25L; 8:118933257-118933257	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.74C>T; p.P25L; 8:118933257-118933257	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.332G>A; p.R111H; 8:118932999-118932999	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1004A>T; p.K335I; 8:118924576-118924576	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.126C>T; p.D42D; 8:118933205-118933205	central_nervous_system; brain	glioma	Substitution - coding silent
c.952G>A; p.A318T; 8:118924628-118924628	skin	malignant_melanoma	Substitution - Missense
c.647C>T; p.T216M; 8:118926664-118926664	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.997C>T; p.R333*; 8:118924583-118924583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.997C>T; p.R333*; 8:118924583-118924583	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.997C>T; p.R333*; 8:118924583-118924583	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.653A>T; p.N218I; 8:118926658-118926658	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.1016A>G; p.Q339R; 8:118924564-118924564	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.286G>T; p.E96*; 8:118933045-118933045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.825C>T; p.D275D; 8:118924755-118924755	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.543C>T; p.H181H; 8:118928787-118928787	prostate	carcinoma	Substitution - coding silent
c.923_924insG; p.A309fs*5; 8:118924656-118924657	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.923_924insG; p.A309fs*5; 8:118924656-118924657	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.255C>G; p.P85P; 8:118933076-118933076	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1011C>T; p.G337G; 8:118924569-118924569	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1192A>C; p.I398L; 8:118924388-118924388	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.85C>T; p.L29F; 8:118933246-118933246	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.621C>T; p.F207F; 8:118926690-118926690	skin	malignant_melanoma	Substitution - coding silent
c.699C>T; p.N233N; 8:118926612-118926612	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.52T>C; p.W18R; 8:118933279-118933279	liver	carcinoma	Substitution - Missense
c.525G>C; p.Q175H; 8:118928805-118928805	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.80A>C; p.K27T; 8:118933251-118933251	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.462G>A; p.T154T; 8:118928868-118928868	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.991T>G; p.L331V; 8:118924589-118924589	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.846G>A; p.Q282Q; 8:118924734-118924734	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.623G>A; p.R208K; 8:118926688-118926688	skin	malignant_melanoma	Substitution - Missense
c.703G>T; p.E235*; 8:118926608-118926608	breast	carcinoma	Substitution - Nonsense
c.68C>A; p.T23K; 8:118933263-118933263	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.467C>A; p.S156Y; 8:118928863-118928863	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.541C>A; p.H181N; 8:118928789-118928789	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.97G>A; p.E33K; 8:118933234-118933234	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.879G>A; p.E293E; 8:118924701-118924701	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.747G>A; p.Q249Q; 8:118926564-118926564	skin	malignant_melanoma	Substitution - coding silent
c.1113C>T; p.F371F; 8:118924467-118924467	skin	malignant_melanoma	Substitution - coding silent
c.307C>T; p.R103C; 8:118933024-118933024	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.180C>T; p.T60T; 8:118933151-118933151	kidney	other; neoplasm	Substitution - coding silent
c.86T>G; p.L29R; 8:118933245-118933245	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.832G>A; p.E278K; 8:118924748-118924748	skin	malignant_melanoma	Substitution - Missense
c.439G>T; p.D147Y; 8:118928891-118928891	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.525G>T; p.Q175H; 8:118928805-118928805	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.525G>T; p.Q175H; 8:118928805-118928805	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.447C>A; p.F149L; 8:118928883-118928883	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.998G>A; p.R333Q; 8:118924582-118924582	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.544G>A; p.D182N; 8:118928786-118928786	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.413G>A; p.R138Q; 8:118928917-118928917	NS	malignant_melanoma	Substitution - Missense
c.316G>A; p.E106K; 8:118933015-118933015	skin	malignant_melanoma	Substitution - Missense
c.186C>T; p.C62C; 8:118933145-118933145	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.186C>T; p.C62C; 8:118933145-118933145	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1042G>A; p.A348T; 8:118924538-118924538	breast	carcinoma	Substitution - Missense
c.9C>G; p.N3K; 8:118951813-118951813	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.9C>G; p.N3K; 8:118951813-118951813	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.9C>G; p.N3K; 8:118951813-118951813	breast	carcinoma	Substitution - Missense
c.9C>G; p.N3K; 8:118951813-118951813	thyroid	other; neoplasm	Substitution - Missense
c.9C>G; p.N3K; 8:118951813-118951813	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.222G>A; p.W74*; 8:118933109-118933109	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.568G>A; p.E190K; 8:118928762-118928762	breast	carcinoma	Substitution - Missense
c.953C>G; p.A318G; 8:118924627-118924627	breast	carcinoma	Substitution - Missense
c.526A>T; p.K176*; 8:118928804-118928804	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.700G>A; p.A234T; 8:118926611-118926611	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1072C>T; p.P358S; 8:118924508-118924508	skin	malignant_melanoma	Substitution - Missense
c.700G>A; p.A234T; 8:118926611-118926611	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.277G>A; p.V93I; 8:118933054-118933054	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.909G>A; p.P303P; 8:118924671-118924671	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.886C>T; p.R296C; 8:118924694-118924694	skin	malignant_melanoma	Substitution - Missense
c.778C>T; p.Q260*; 8:118926533-118926533	skin	malignant_melanoma	Substitution - Nonsense
c.886C>T; p.R296C; 8:118924694-118924694	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.847C>T; p.R283W; 8:118924733-118924733	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1039C>A; p.H347N; 8:118924541-118924541	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1180C>A; p.Q394K; 8:118924400-118924400	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.687C>A; p.G229G; 8:118926624-118926624	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.404C>T; p.T135I; 8:118928926-118928926	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1193T>G; p.I398R; 8:118924387-118924387	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.804G>T; p.K268N; 8:118926507-118926507	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.452C>G; p.S151*; 8:118928878-118928878	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.431G>A; p.R144K; 8:118928899-118928899	skin	malignant_melanoma	Substitution - Missense
c.452C>G; p.S151*; 8:118928878-118928878	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.764A>C; p.K255T; 8:118926547-118926547	skin	malignant_melanoma	Substitution - Missense
c.218G>A; p.S73N; 8:118933113-118933113	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.648G>A; p.T216T; 8:118926663-118926663	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.234C>T; p.D78D; 8:118933097-118933097	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.218G>A; p.S73N; 8:118933113-118933113	skin	malignant_melanoma	Substitution - Missense
c.1180C>T; p.Q394*; 8:118924400-118924400	skin	malignant_melanoma	Substitution - Nonsense
c.104C>T; p.T35I; 8:118933227-118933227	skin	malignant_melanoma	Substitution - Missense
c.814C>T; p.Q272*; 8:118926497-118926497	skin	malignant_melanoma	Substitution - Nonsense
c.296G>A; p.R99H; 8:118933035-118933035	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.136C>T; p.P46S; 8:118933195-118933195	skin	malignant_melanoma	Substitution - Missense
c.1041C>T; p.H347H; 8:118924539-118924539	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.105C>G; p.T35T; 8:118933226-118933226	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation