lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4929
Symbol	NR4A2
Synonymous	HZF-3\|NOT\|NURR1\|RNR1\|TINUR
Full name	nuclear receptor subfamily 4, group A, member 2
Gene description	NGFI-B/nur77 beta-type transcription factor homolog\|T-cell nuclear receptor NOT\|immediate-early response protein NOT\|intermediate-early receptor protein\|nuclear receptor related 1\|nuclear receptor subfamily 4 group A member 2\|nur related protein-1, human
Cytoband	2q22-q23
Gene type	protein-coding
Synonymous	MIM:601828; HGNC:HGNC:7981; Ensembl:ENSG00000153234; HPRD:03493; Vega:OTTHUMG00000131950

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1511C>T; p.S504F; 2:156326179-156326179	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.16G>A; p.A6T; 2:156330171-156330171	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.452A>G; p.N151S; 2:156329735-156329735	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.810G>T; p.A270A; 2:156329377-156329377	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1714C>G; p.R572G; 2:156325827-156325827	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1042A>C; p.K348Q; 2:156327967-156327967	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1042A>C; p.K348Q; 2:156327967-156327967	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1042A>C; p.K348Q; 2:156327967-156327967	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1705G>T; p.G569W; 2:156325836-156325836	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1705G>T; p.G569W; 2:156325836-156325836	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.251C>T; p.S84F; 2:156329936-156329936	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1455C>T; p.S485S; 2:156326235-156326235	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1252C>T; p.R418W; 2:156326827-156326827	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Missense
c.327G>A; p.Q109Q; 2:156329860-156329860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1306G>T; p.D436Y; 2:156326773-156326773	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.583G>A; p.D195N; 2:156329604-156329604	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.881delA; p.N294fs*7; 2:156328517-156328517	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.881delA; p.N294fs*7; 2:156328517-156328517	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.881delA; p.N294fs*7; 2:156328517-156328517	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.881delA; p.N294fs*7; 2:156328517-156328517	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.881delA; p.N294fs*7; 2:156328517-156328517	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.881delA; p.N294fs*7; 2:156328517-156328517	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.941G>T; p.R314L; 2:156328457-156328457	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.941G>T; p.R314L; 2:156328457-156328457	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.214G>A; p.D72N; 2:156329973-156329973	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1611C>G; p.D537E; 2:156325930-156325930	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1614C>T; p.H538H; 2:156325927-156325927	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1614C>T; p.H538H; 2:156325927-156325927	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1614C>T; p.H538H; 2:156325927-156325927	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.611C>T; p.P204L; 2:156329576-156329576	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.325_326insC; p.Q109fs*3; 2:156329861-156329862	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.325_326insC; p.Q109fs*3; 2:156329861-156329862	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.325_326insC; p.Q109fs*3; 2:156329861-156329862	ovary	carcinoma; serous_carcinoma	Insertion - Frameshift
c.325_326insC; p.Q109fs*3; 2:156329861-156329862	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1242G>A; p.M414I; 2:156326837-156326837	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1722C>G; p.F574L; 2:156325819-156325819	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1120G>A; p.D374N; 2:156327889-156327889	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.877A>C; p.K293Q; 2:156328521-156328521	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.528C>T; p.F176F; 2:156329659-156329659	skin	malignant_melanoma	Substitution - coding silent
c.1119C>T; p.V373V; 2:156327890-156327890	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.923A>G; p.D308G; 2:156328475-156328475	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.923A>G; p.D308G; 2:156328475-156328475	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.955C>T; p.R319*; 2:156328443-156328443	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1030C>T; p.R344C; 2:156327979-156327979	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.866G>A; p.R289H; 2:156328532-156328532	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.866G>A; p.R289H; 2:156328532-156328532	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.866G>A; p.R289H; 2:156328532-156328532	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.387G>A; p.T129T; 2:156329800-156329800	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.323C>T; p.P108L; 2:156329864-156329864	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.52G>A; p.A18T; 2:156330135-156330135	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.52G>A; p.A18T; 2:156330135-156330135	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1454C>T; p.S485F; 2:156326236-156326236	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1454C>T; p.S485F; 2:156326236-156326236	skin	malignant_melanoma	Substitution - Missense
c.953G>A; p.C318Y; 2:156328445-156328445	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1031G>A; p.R344H; 2:156327978-156327978	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.325delC; p.Q109fs*5; 2:156329862-156329862	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.325delC; p.Q109fs*5; 2:156329862-156329862	thyroid	carcinoma; anaplastic_carcinoma	Deletion - Frameshift
c.377C>T; p.S126L; 2:156329810-156329810	skin	malignant_melanoma	Substitution - Missense
c.1080_1081insTA; p.P361fs*3; 2:156327928-156327929	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.283A>T; p.I95F; 2:156329904-156329904	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.262T>C; p.S88P; 2:156329925-156329925	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1232C>T; p.T411I; 2:156326847-156326847	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1765G>C; p.D589H; 2:156325776-156325776	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.299A>G; p.Y100C; 2:156329888-156329888	breast	carcinoma	Substitution - Missense
c.1260G>T; p.W420C; 2:156326819-156326819	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.153C>T; p.I51I; 2:156330034-156330034	kidney	other; neoplasm	Substitution - coding silent
c.542C>T; p.S181L; 2:156329645-156329645	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.258G>A; p.Q86Q; 2:156329929-156329929	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1414A>T; p.R472W; 2:156326276-156326276	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.237C>A; p.Y79*; 2:156329950-156329950	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1300G>A; p.D434N; 2:156326779-156326779	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.297C>G; p.N99K; 2:156329890-156329890	skin; mucosal	malignant_melanoma	Substitution - Missense
c.951C>T; p.Y317Y; 2:156328447-156328447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1495G>A; p.D499N; 2:156326195-156326195	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1379G>A; p.G460D; 2:156326311-156326311	thyroid	carcinoma	Substitution - Missense
c.1150T>C; p.Y384H; 2:156327859-156327859	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1495G>A; p.D499N; 2:156326195-156326195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1495G>A; p.D499N; 2:156326195-156326195	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.663C>T; p.P221P; 2:156329524-156329524	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.18G>A; p.A6A; 2:156330169-156330169	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.433G>A; p.D145N; 2:156329754-156329754	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.232T>C; p.L78L; 2:156329955-156329955	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.490G>A; p.E164K; 2:156329697-156329697	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1511C>A; p.S504Y; 2:156326179-156326179	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1057C>T; p.Q353*; 2:156327952-156327952	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1105G>A; p.V369I; 2:156327904-156327904	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.5C>A; p.P2H; 2:156330182-156330182	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.443C>G; p.S148C; 2:156329744-156329744	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1092G>C; p.L364L; 2:156327917-156327917	pancreas	carcinoma	Substitution - coding silent
c.718G>A; p.A240T; 2:156329469-156329469	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.383C>T; p.P128L; 2:156329804-156329804	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.203G>T; p.S68I; 2:156329984-156329984	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1124C>T; p.S375F; 2:156327885-156327885	central_nervous_system; brain	glioma	Substitution - Missense
c.1124C>T; p.S375F; 2:156327885-156327885	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.976G>T; p.V326F; 2:156328422-156328422	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1145T>G; p.L382R; 2:156327864-156327864	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1243G>A; p.E415K; 2:156326836-156326836	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1141A>C; p.S381R; 2:156327868-156327868	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1077G>A; p.S359S; 2:156327932-156327932	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.897T>C; p.C299C; 2:156328501-156328501	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.897T>C; p.C299C; 2:156328501-156328501	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.253G>A; p.G85R; 2:156329934-156329934	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.897T>C; p.C299C; 2:156328501-156328501	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1266G>A; p.E422E; 2:156326813-156326813	skin	malignant_melanoma	Substitution - coding silent
c.1597A>C; p.N533H; 2:156325944-156325944	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1361G>T; p.R454M; 2:156326718-156326718	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1445G>A; p.W482*; 2:156326245-156326245	skin	malignant_melanoma	Substitution - Nonsense
c.1230G>T; p.L410L; 2:156326849-156326849	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.928C>T; p.R310C; 2:156328470-156328470	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.928C>T; p.R310C; 2:156328470-156328470	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1507T>C; p.F503L; 2:156326183-156326183	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1240A>G; p.M414V; 2:156326839-156326839	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.52G>T; p.A18S; 2:156330135-156330135	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.326_327insC; p.Q109fs*3; 2:156329860-156329861	stomach	adenocarcinoma	Insertion - Frameshift
c.872T>C; p.V291A; 2:156328526-156328526	breast	carcinoma	Substitution - Missense
c.1635delG; p.L546fs*1; 2:156325906-156325906	stomach	adenocarcinoma	Deletion - Frameshift
c.1028G>T; p.G343V; 2:156327981-156327981	breast	carcinoma	Substitution - Missense
c.1020C>T; p.G340G; 2:156327989-156327989	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1634G>A; p.G545E; 2:156325907-156325907	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.366C>A; p.Y122*; 2:156329821-156329821	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.674G>A; p.R225H; 2:156329513-156329513	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.865C>T; p.R289C; 2:156328533-156328533	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.588delG; p.L198fs*5; 2:156329599-156329599	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.588delG; p.L198fs*5; 2:156329599-156329599	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.825C>T; p.Y275Y; 2:156329362-156329362	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.825C>G; p.Y275*; 2:156329362-156329362	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1714C>T; p.R572C; 2:156325827-156325827	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1025G>T; p.R342I; 2:156327984-156327984	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.590C>T; p.P197L; 2:156329597-156329597	thyroid	other; neoplasm	Substitution - Missense
c.432C>T; p.D144D; 2:156329755-156329755	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.691G>T; p.G231C; 2:156329496-156329496	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1707G>A; p.G569G; 2:156325834-156325834	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1707G>A; p.G569G; 2:156325834-156325834	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.91A>T; p.S31C; 2:156330096-156330096	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1688G>A; p.R563H; 2:156325853-156325853	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1688G>A; p.R563H; 2:156325853-156325853	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1026A>G; p.R342R; 2:156327983-156327983	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1687C>T; p.R563C; 2:156325854-156325854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1687C>T; p.R563C; 2:156325854-156325854	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1534G>T; p.V512F; 2:156326156-156326156	liver	carcinoma	Substitution - Missense
c.1534G>T; p.V512F; 2:156326156-156326156	liver	carcinoma	Substitution - Missense
c.1238C>T; p.S413F; 2:156326841-156326841	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1663C>T; p.L555L; 2:156325878-156325878	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1001G>A; p.R334H; 2:156328008-156328008	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.833G>A; p.R278H; 2:156329354-156329354	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.935G>A; p.R312Q; 2:156328463-156328463	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1061delA; p.E354fs*9; 2:156327948-156327948	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.578G>A; p.R193H; 2:156329609-156329609	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.578G>A; p.R193H; 2:156329609-156329609	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1402G>T; p.V468L; 2:156326288-156326288	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1104C>T; p.L368L; 2:156327905-156327905	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.431A>G; p.D144G; 2:156329756-156329756	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.431A>G; p.D144G; 2:156329756-156329756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1756G>A; p.A586T; 2:156325785-156325785	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.548delC; p.P183fs*20; 2:156329639-156329639	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.157G>A; p.A53T; 2:156330030-156330030	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.870A>C; p.T290T; 2:156328528-156328528	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1251C>T; p.I417I; 2:156326828-156326828	skin	malignant_melanoma	Substitution - coding silent
c.1669G>A; p.G557R; 2:156325872-156325872	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1669G>A; p.G557R; 2:156325872-156325872	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.934C>T; p.R312W; 2:156328464-156328464	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1022G>A; p.R341Q; 2:156327987-156327987	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1022G>A; p.R341Q; 2:156327987-156327987	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.462G>A; p.Q154Q; 2:156329725-156329725	skin	malignant_melanoma	Substitution - coding silent
c.892G>A; p.V298M; 2:156328506-156328506	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1041G>A; p.S347S; 2:156327968-156327968	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.585C>T; p.D195D; 2:156329602-156329602	prostate	carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation