Cancer metastasis database

Annotation category 5

Gene information

Gene ID 4925
Symbol

NUCB2

Synonymous

HEL-S-109|NEFA

Full name

nucleobindin 2

Gene description

DNA-binding protein NEFA|epididymis secretory protein Li 109|gastric cancer antigen Zg4|nesfatin 1|nesfatin-1|nucleobindin-2|nucleobinding 2|prepronefastin|prepronesfatin

Cytoband

11p15.1

Gene type

protein-coding

Synonymous

MIM:608020; HGNC:HGNC:8044; Ensembl:ENSG00000070081; HPRD:09726

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1045G>A; p.E349K; 11:17330169-17330169

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.913-6A>G; p.?; 11:17315380-17315380

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.520C>A; p.H174N; 11:17310861-17310861

 skinmalignant_melanomaSubstitution - Missense

c.553G>T; p.E185*; 11:17310894-17310894

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.999G>T; p.W333C; 11:17315472-17315472

 livercarcinomaSubstitution - Missense

c.999G>T; p.W333C; 11:17315472-17315472

 livercarcinomaSubstitution - Missense

c.140C>A; p.P47Q; 11:17295463-17295463

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - Missense

c.578A>G; p.K193R; 11:17310919-17310919

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1138G>A; p.D380N; 11:17330262-17330262

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.401C>T; p.A134V; 11:17309593-17309593

 skinmalignant_melanomaSubstitution - Missense

c.707C>G; p.T236S; 11:17311230-17311230

 thyroidother; neoplasmSubstitution - Missense

c.851A>G; p.E284G; 11:17312059-17312059

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1014G>A; p.Q338Q; 11:17330138-17330138

 livercarcinomaSubstitution - coding silent

c.589G>A; p.E197K; 11:17310930-17310930

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1129C>T; p.R377C; 11:17330253-17330253

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.691G>T; p.E231*; 11:17311214-17311214

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1203_1205delACA; p.Q403delQ; 11:17330931-17330933

 thyroidcarcinoma; medullary_carcinomaDeletion - In frame

c.705G>A; p.E235E; 11:17311228-17311228

 thyroidother; neoplasmSubstitution - coding silent

c.597G>C; p.K199N; 11:17310938-17310938

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.379G>T; p.D127Y; 11:17301870-17301870

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.145G>C; p.D49H; 11:17296104-17296104

 soft_tissue; fibrous_tissue_and_uncertain_ogastrointestinal_stromal_tumourSubstitution - Missense

c.713G>A; p.G238E; 11:17311236-17311236

 skinmalignant_melanomaSubstitution - Missense

c.477C>A; p.I159I; 11:17309669-17309669

 breastcarcinomaSubstitution - coding silent

c.842A>C; p.K281T; 11:17312050-17312050

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.269A>C; p.K90T; 11:17301760-17301760

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.968delA; p.E326fs*11; 11:17315441-17315441

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.614C>T; p.S205F; 11:17310955-17310955

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.650A>C; p.H217P; 11:17310991-17310991

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1078G>A; p.E360K; 11:17330202-17330202

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1078G>A; p.E360K; 11:17330202-17330202

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1040T>C; p.L347P; 11:17330164-17330164

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.391G>A; p.D131N; 11:17309583-17309583

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1045G>T; p.E349*; 11:17330169-17330169

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1193delA; p.K400fs*15; 11:17330921-17330921

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.1193delA; p.K400fs*15; 11:17330921-17330921

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1193delA; p.K400fs*15; 11:17330921-17330921

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1193delA; p.K400fs*15; 11:17330921-17330921

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.529T>G; p.F177V; 11:17310870-17310870

 breastcarcinomaSubstitution - Missense

c.664C>T; p.H222Y; 11:17311005-17311005

 skin; trunkmalignant_melanomaSubstitution - Missense

c.1012C>G; p.Q338E; 11:17330136-17330136

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.419A>G; p.D140G; 11:17309611-17309611

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IIISubstitution - Missense

c.174C>T; p.L58L; 11:17296133-17296133

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.568G>T; p.E190*; 11:17310909-17310909

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.488C>T; p.T163I; 11:17310829-17310829

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.552G>T; p.K184N; 11:17310893-17310893

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1102C>A; p.L368I; 11:17330226-17330226

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.744_745insT; p.K251fs*4; 11:17311267-17311268

 large_intestine; caecumcarcinoma; adenocarcinomaInsertion - Frameshift

c.679G>T; p.D227Y; 11:17311202-17311202

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.440C>T; p.P147L; 11:17309632-17309632

 pancreascarcinomaSubstitution - Missense

c.372C>T; p.S124S; 11:17301863-17301863

 skinmalignant_melanomaSubstitution - coding silent

c.508G>T; p.D170Y; 11:17310849-17310849

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.6G>A; p.R2R; 11:17295329-17295329

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.518G>A; p.R173H; 11:17310859-17310859

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.991G>T; p.D331Y; 11:17315464-17315464

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.596A>C; p.K199T; 11:17310937-17310937

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.797T>C; p.L266S; 11:17311908-17311908

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.698G>T; p.W233L; 11:17311221-17311221

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.775G>T; p.G259*; 11:17311886-17311886

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.114C>T; p.H38H; 11:17295437-17295437

 skinmalignant_melanomaSubstitution - coding silent