lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4923
Symbol	NTSR1
Synonymous	NTR
Full name	neurotensin receptor 1 (high affinity)
Gene description	NT-R-1\|NTR1\|NTRH\|high-affinity levocabastine-insensitive neurotensin receptor\|neurotensin receptor type 1
Cytoband	20q13
Gene type	protein-coding
Synonymous	MIM:162651; HGNC:HGNC:8039; Ensembl:ENSG00000101188; HPRD:01218; Vega:OTTHUMG00000032932

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.896G>A; p.R299Q; 20:62754866-62754866	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.195G>A; p.L65L; 20:62709402-62709402	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.475G>T; p.V159L; 20:62709682-62709682	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.230G>T; p.G77V; 20:62709437-62709437	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.973A>G; p.M325V; 20:62758322-62758322	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.292C>T; p.Q98*; 20:62709499-62709499	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.592C>A; p.L198M; 20:62709799-62709799	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.901G>T; p.G301C; 20:62754871-62754871	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.409G>A; p.G137S; 20:62709616-62709616	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.409G>A; p.G137S; 20:62709616-62709616	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.661G>A; p.G221S; 20:62709868-62709868	urinary_tract; bladder	carcinoma	Substitution - Missense
c.661G>A; p.G221S; 20:62709868-62709868	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1162C>T; p.R388C; 20:62760172-62760172	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.144G>T; p.A48A; 20:62709351-62709351	oesophagus	carcinoma	Substitution - coding silent
c.1153G>T; p.V385L; 20:62760163-62760163	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1143C>G; p.C381W; 20:62760153-62760153	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.418G>A; p.G140S; 20:62709625-62709625	prostate	carcinoma	Substitution - Missense
c.1050C>T; p.N350N; 20:62760060-62760060	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.460G>A; p.A154T; 20:62709667-62709667	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1239C>T; p.T413T; 20:62760249-62760249	skin	malignant_melanoma	Substitution - coding silent
c.1169G>C; p.R390T; 20:62760179-62760179	skin	malignant_melanoma	Substitution - Missense
c.267G>A; p.A89A; 20:62709474-62709474	breast	carcinoma	Substitution - coding silent
c.644A>G; p.D215G; 20:62709851-62709851	thyroid	other; neoplasm	Substitution - Missense
c.645C>T; p.D215D; 20:62709852-62709852	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1089G>T; p.L363L; 20:62760099-62760099	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.907C>T; p.R303C; 20:62754877-62754877	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1051G>A; p.A351T; 20:62760061-62760061	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.907C>T; p.R303C; 20:62754877-62754877	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.251C>T; p.T84M; 20:62709458-62709458	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.875C>T; p.P292L; 20:62754845-62754845	skin	malignant_melanoma	Substitution - Missense
c.30C>A; p.T10T; 20:62709237-62709237	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.589G>A; p.A197T; 20:62709796-62709796	skin	malignant_melanoma	Substitution - Missense
c.423C>T; p.C141C; 20:62709630-62709630	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1194_1195GG>AA; p.A399T; 20:62760204-62760205	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1115G>T; p.R372L; 20:62760125-62760125	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.758C>T; p.S253L; 20:62754728-62754728	skin	malignant_melanoma	Substitution - Missense
c.758C>T; p.S253L; 20:62754728-62754728	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1099G>T; p.V367F; 20:62760109-62760109	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1099G>T; p.V367F; 20:62760109-62760109	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.659G>A; p.G220D; 20:62709866-62709866	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.416C>T; p.A139V; 20:62709623-62709623	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.425G>A; p.R142H; 20:62709632-62709632	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.793G>A; p.V265I; 20:62754763-62754763	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.360G>A; p.M120I; 20:62709567-62709567	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.591C>T; p.A197A; 20:62709798-62709798	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1187C>T; p.S396L; 20:62760197-62760197	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.219C>T; p.L73L; 20:62709426-62709426	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.246G>A; p.T82T; 20:62709453-62709453	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.833C>T; p.T278M; 20:62754803-62754803	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.545G>A; p.R182Q; 20:62709752-62709752	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.545G>A; p.R182Q; 20:62709752-62709752	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.345C>A; p.T115T; 20:62709552-62709552	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.62G>T; p.R21L; 20:62709269-62709269	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.201C>A; p.T67T; 20:62709408-62709408	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.453C>A; p.C151*; 20:62709660-62709660	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.408C>T; p.F136F; 20:62709615-62709615	breast	carcinoma	Substitution - coding silent
c.916+1G>C; p.?; 20:62754887-62754887	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.931G>A; p.A311T; 20:62758280-62758280	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.200C>A; p.T67N; 20:62709407-62709407	central_nervous_system; medulla	primitive_neuroectodermal_tumour-medulloblastoma; classic	Substitution - Missense
c.808G>T; p.A270S; 20:62754778-62754778	lung	carcinoma; undifferentiated_carcinoma	Substitution - Missense
c.74G>A; p.G25E; 20:62709281-62709281	skin	malignant_melanoma	Substitution - Missense
c.1008-3C>A; p.?; 20:62760015-62760015	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.774C>T; p.I258I; 20:62754744-62754744	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1008-4G>A; p.?; 20:62760014-62760014	liver	carcinoma	Unknown
c.318C>A; p.G106G; 20:62709525-62709525	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.916+1G>A; p.?; 20:62754887-62754887	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.254C>T; p.A85V; 20:62709461-62709461	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.778G>A; p.A260T; 20:62754748-62754748	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.279G>A; p.S93S; 20:62709486-62709486	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.570C>T; p.S190S; 20:62709777-62709777	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.570C>T; p.S190S; 20:62709777-62709777	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.278C>T; p.S93L; 20:62709485-62709485	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1241G>A; p.R414H; 20:62760251-62760251	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.909C>T; p.R303R; 20:62754879-62754879	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.270G>A; p.R90R; 20:62709477-62709477	skin; abdomen	malignant_melanoma	Substitution - coding silent
c.909C>T; p.R303R; 20:62754879-62754879	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.464C>T; p.T155M; 20:62709671-62709671	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.583G>A; p.A195T; 20:62709790-62709790	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.583G>A; p.A195T; 20:62709790-62709790	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.411C>T; p.G137G; 20:62709618-62709618	liver	carcinoma	Substitution - coding silent
c.971T>G; p.L324R; 20:62758320-62758320	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.427G>A; p.G143S; 20:62709634-62709634	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.984C>A; p.Y328*; 20:62758333-62758333	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.836T>A; p.V279D; 20:62754806-62754806	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.541T>C; p.S181P; 20:62709748-62709748	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.813C>T; p.A271A; 20:62754783-62754783	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.838delG; p.G281fs*68; 20:62754808-62754808	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.398C>T; p.P133L; 20:62709605-62709605	skin	malignant_melanoma	Substitution - Missense
c.795C>T; p.V265V; 20:62754765-62754765	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.496C>T; p.R166C; 20:62709703-62709703	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.896G>T; p.R299L; 20:62754866-62754866	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.448G>A; p.A150T; 20:62709655-62709655	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.908G>A; p.R303H; 20:62754878-62754878	skin	malignant_melanoma	Substitution - Missense
c.443G>A; p.R148H; 20:62709650-62709650	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.426C>T; p.R142R; 20:62709633-62709633	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1243G>A; p.E415K; 20:62760253-62760253	skin; trunk	malignant_melanoma	Substitution - Missense
c.1167G>A; p.R389R; 20:62760177-62760177	skin	malignant_melanoma	Substitution - coding silent
c.1167G>A; p.R389R; 20:62760177-62760177	skin	malignant_melanoma	Substitution - coding silent
c.120C>G; p.G40G; 20:62709327-62709327	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.222C>T; p.F74F; 20:62709429-62709429	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.222C>T; p.F74F; 20:62709429-62709429	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.725T>C; p.F242S; 20:62754695-62754695	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.445G>A; p.D149N; 20:62709652-62709652	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1115G>A; p.R372H; 20:62760125-62760125	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1240C>T; p.R414C; 20:62760250-62760250	skin	malignant_melanoma	Substitution - Missense
c.415G>A; p.A139T; 20:62709622-62709622	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.587C>T; p.S196L; 20:62709794-62709794	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.803G>A; p.R268H; 20:62754773-62754773	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.662G>T; p.G221V; 20:62709869-62709869	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.662G>T; p.G221V; 20:62709869-62709869	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.662G>T; p.G221V; 20:62709869-62709869	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.662G>T; p.G221V; 20:62709869-62709869	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.662G>T; p.G221V; 20:62709869-62709869	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1146C>G; p.L382L; 20:62760156-62760156	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.99G>A; p.P33P; 20:62709306-62709306	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.729G>A; p.M243I; 20:62754699-62754699	eye; uveal_tract	malignant_melanoma; spindle	Substitution - Missense
c.910G>A; p.V304I; 20:62754880-62754880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.735C>T; p.F245F; 20:62754705-62754705	skin	malignant_melanoma	Substitution - coding silent
c.1242C>A; p.R414R; 20:62760252-62760252	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.658G>T; p.G220C; 20:62709865-62709865	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.438C>A; p.F146L; 20:62709645-62709645	bone	chondrosarcoma	Substitution - Missense
c.633C>A; p.N211K; 20:62709840-62709840	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.116C>T; p.S39L; 20:62709323-62709323	skin	malignant_melanoma	Substitution - Missense
c.1147T>C; p.C383R; 20:62760157-62760157	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.442C>T; p.R148C; 20:62709649-62709649	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.802C>A; p.R268S; 20:62754772-62754772	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation