lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4837
Symbol	NNMT
Synonymous	-
Full name	nicotinamide N-methyltransferase
Gene description	-
Cytoband	11q23.1
Gene type	protein-coding
Synonymous	MIM:600008; HGNC:HGNC:7861; Ensembl:ENSG00000166741; HPRD:02478; Vega:OTTHUMG00000168245

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.382G>T; p.E128*; 11:114312064-114312064	skin	malignant_melanoma	Substitution - Nonsense
c.77A>G; p.K26R; 11:114296633-114296633	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.364G>C; p.V122L; 11:114312046-114312046	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.262G>A; p.D88N; 11:114298058-114298058	pancreas	carcinoma	Substitution - Missense
c.262G>A; p.D88N; 11:114298058-114298058	pancreas	carcinoma	Substitution - Missense
c.262G>A; p.D88N; 11:114298058-114298058	pancreas	carcinoma	Substitution - Missense
c.594G>A; p.A198A; 11:114312276-114312276	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.739G>A; p.A247T; 11:114312421-114312421	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.150C>T; p.C50C; 11:114296706-114296706	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.696C>T; p.I232I; 11:114312378-114312378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.696C>T; p.I232I; 11:114312378-114312378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.582G>A; p.V194V; 11:114312264-114312264	skin	malignant_melanoma	Substitution - coding silent
c.55G>A; p.D19N; 11:114296611-114296611	skin	malignant_melanoma	Substitution - Missense
c.274C>T; p.Q92*; 11:114298070-114298070	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.504C>T; p.A168A; 11:114312186-114312186	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.459C>T; p.P153P; 11:114312141-114312141	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.459C>T; p.P153P; 11:114312141-114312141	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.246C>T; p.V82V; 11:114298042-114298042	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.457C>T; p.P153S; 11:114312139-114312139	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.240G>C; p.E80D; 11:114298036-114298036	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.593C>T; p.A198V; 11:114312275-114312275	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.728C>T; p.S243F; 11:114312410-114312410	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.167G>A; p.G56E; 11:114297963-114297963	skin; mucosal	malignant_melanoma	Substitution - Missense
c.569G>T; p.G190V; 11:114312251-114312251	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.440A>G; p.Q147R; 11:114312122-114312122	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.650G>T; p.G217V; 11:114312332-114312332	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.697G>A; p.E233K; 11:114312379-114312379	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.697G>A; p.E233K; 11:114312379-114312379	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.697G>A; p.E233K; 11:114312379-114312379	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.697G>A; p.E233K; 11:114312379-114312379	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.697G>A; p.E233K; 11:114312379-114312379	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.748G>A; p.E250K; 11:114312430-114312430	skin	malignant_melanoma	Substitution - Missense
c.748G>A; p.E250K; 11:114312430-114312430	skin	malignant_melanoma	Substitution - Missense
c.60C>A; p.Y20*; 11:114296616-114296616	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.133C>A; p.L45I; 11:114296689-114296689	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.673G>A; p.V225M; 11:114312355-114312355	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.188G>A; p.G63D; 11:114297984-114297984	skin	malignant_melanoma	Substitution - Missense
c.616A>C; p.I206L; 11:114312298-114312298	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.344G>T; p.C115F; 11:114298140-114298140	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.4G>A; p.E2K; 11:114296560-114296560	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.231C>T; p.S77S; 11:114298027-114298027	skin	malignant_melanoma	Substitution - coding silent
c.141G>A; p.K47K; 11:114296697-114296697	skin	malignant_melanoma	Substitution - coding silent
c.254A>G; p.D85G; 11:114298050-114298050	skin	malignant_melanoma	Substitution - Missense
c.675G>C; p.V225V; 11:114312357-114312357	breast	carcinoma	Substitution - coding silent
c.416T>C; p.L139P; 11:114312098-114312098	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.464C>T; p.P155L; 11:114312146-114312146	skin	malignant_melanoma	Substitution - Missense
c.670G>T; p.A224S; 11:114312352-114312352	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.644C>T; p.P215L; 11:114312326-114312326	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.500A>G; p.D167G; 11:114312182-114312182	skin	malignant_melanoma	Substitution - Missense
c.681G>A; p.E227E; 11:114312363-114312363	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.234T>C; p.F78F; 11:114298030-114298030	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.448G>A; p.G150R; 11:114312130-114312130	central_nervous_system; brain	glioma	Substitution - Missense
c.238G>A; p.E80K; 11:114298034-114298034	skin	malignant_melanoma	Substitution - Missense
c.200C>T; p.T67I; 11:114297996-114297996	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.86C>G; p.S29C; 11:114296642-114296642	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.765G>T; p.L255L; 11:114312447-114312447	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.357G>A; p.G119G; 11:114298153-114298153	skin	malignant_melanoma	Substitution - coding silent
c.357G>A; p.G119G; 11:114298153-114298153	skin	malignant_melanoma	Substitution - coding silent
c.664G>C; p.E222Q; 11:114312346-114312346	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.221C>T; p.A74V; 11:114298017-114298017	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.336C>A; p.T112T; 11:114298132-114298132	breast	carcinoma	Substitution - coding silent
c.118C>T; p.H40Y; 11:114296674-114296674	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.642_643CC>TT; p.P215S; 11:114312324-114312325	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.322T>C; p.S108P; 11:114298118-114298118	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.243C>T; p.I81I; 11:114298039-114298039	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.243C>T; p.I81I; 11:114298039-114298039	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.243C>T; p.I81I; 11:114298039-114298039	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.251C>T; p.T84I; 11:114298047-114298047	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.300_301delAG; p.E101fs*5; 11:114298096-114298097	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.208C>A; p.Q70K; 11:114298004-114298004	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.181G>A; p.D61N; 11:114297977-114297977	urinary_tract; bladder	carcinoma	Substitution - Missense
c.87T>C; p.S29S; 11:114296643-114296643	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.697G>T; p.E233*; 11:114312379-114312379	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.565C>T; p.P189S; 11:114312247-114312247	skin	malignant_melanoma	Substitution - Missense
c.85T>C; p.S29P; 11:114296641-114296641	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.213C>T; p.L71L; 11:114298009-114298009	thyroid	carcinoma; anaplastic_carcinoma	Substitution - coding silent
c.694A>G; p.I232V; 11:114312376-114312376	liver	carcinoma	Substitution - Missense
c.64G>T; p.E22*; 11:114296620-114296620	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.585C>T; p.I195I; 11:114312267-114312267	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation