lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4803
Symbol	NGF
Synonymous	Beta-NGF\|HSAN5\|NGFB
Full name	nerve growth factor (beta polypeptide)
Gene description	beta-nerve growth factor\|nerve growth factor, beta subunit
Cytoband	1p13.1
Gene type	protein-coding
Synonymous	MIM:162030; HGNC:HGNC:7808; Ensembl:ENSG00000134259; HPRD:08874; Vega:OTTHUMG00000011880

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.189G>A; p.V63V; 1:115286607-115286607	skin	malignant_melanoma	Substitution - coding silent
c.497A>C; p.N166T; 1:115286299-115286299	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.193G>C; p.G65R; 1:115286603-115286603	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.316G>A; p.E106K; 1:115286480-115286480	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.173C>T; p.A58V; 1:115286623-115286623	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.394G>A; p.E132K; 1:115286402-115286402	skin	malignant_melanoma	Substitution - Missense
c.394G>A; p.E132K; 1:115286402-115286402	skin	malignant_melanoma	Substitution - Missense
c.394G>A; p.E132K; 1:115286402-115286402	skin	malignant_melanoma	Substitution - Missense
c.394G>A; p.E132K; 1:115286402-115286402	skin	malignant_melanoma	Substitution - Missense
c.114T>C; p.T38T; 1:115286682-115286682	breast	carcinoma	Substitution - coding silent
c.284G>A; p.R95H; 1:115286512-115286512	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.284G>A; p.R95H; 1:115286512-115286512	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.128C>T; p.S43F; 1:115286668-115286668	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.281C>T; p.P94L; 1:115286515-115286515	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.134A>C; p.D45A; 1:115286662-115286662	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.286G>A; p.E96K; 1:115286510-115286510	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.585G>A; p.K195K; 1:115286211-115286211	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.510C>G; p.F170L; 1:115286286-115286286	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.510C>G; p.F170L; 1:115286286-115286286	urinary_tract; bladder	carcinoma	Substitution - Missense
c.104C>T; p.A35V; 1:115286692-115286692	skin	malignant_melanoma	Substitution - Missense
c.104C>T; p.A35V; 1:115286692-115286692	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.185G>A; p.R62H; 1:115286611-115286611	pancreas	carcinoma	Substitution - Missense
c.185G>A; p.R62H; 1:115286611-115286611	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.159C>A; p.S53R; 1:115286637-115286637	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.591G>A; p.W197*; 1:115286205-115286205	skin	malignant_melanoma	Substitution - Nonsense
c.249delT; p.S84fs*74; 1:115286547-115286547	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.402G>A; p.S134S; 1:115286394-115286394	breast	carcinoma	Substitution - coding silent
c.189G>T; p.V63V; 1:115286607-115286607	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.145C>T; p.R49C; 1:115286651-115286651	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.145C>T; p.R49C; 1:115286651-115286651	skin	malignant_melanoma	Substitution - Missense
c.145C>T; p.R49C; 1:115286651-115286651	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.145C>T; p.R49C; 1:115286651-115286651	skin	malignant_melanoma	Substitution - Missense
c.629C>T; p.A210V; 1:115286167-115286167	stomach	adenocarcinoma	Substitution - Missense
c.10T>C; p.L4L; 1:115286786-115286786	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.160G>A; p.A54T; 1:115286636-115286636	haematopoietic_and_lymphoid_tissue; breast	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.146G>A; p.R49H; 1:115286650-115286650	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.444C>T; p.T148T; 1:115286352-115286352	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.282C>T; p.P94P; 1:115286514-115286514	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.257G>A; p.R86H; 1:115286539-115286539	urinary_tract; bladder	carcinoma	Substitution - Missense
c.238C>T; p.R80W; 1:115286558-115286558	breast	carcinoma	Substitution - Missense
c.238C>T; p.R80W; 1:115286558-115286558	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.238C>T; p.R80W; 1:115286558-115286558	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.42C>T; p.I14I; 1:115286754-115286754	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.22C>T; p.L8L; 1:115286774-115286774	skin	malignant_melanoma	Substitution - coding silent
c.321C>T; p.V107V; 1:115286475-115286475	skin	malignant_melanoma	Substitution - coding silent
c.111G>T; p.W37C; 1:115286685-115286685	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.297C>T; p.D99D; 1:115286499-115286499	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.128_129CC>TT; p.S43F; 1:115286667-115286668	skin	malignant_melanoma	Substitution - Missense
c.458A>G; p.K153R; 1:115286338-115286338	thyroid	carcinoma	Substitution - Missense
c.361C>T; p.R121W; 1:115286435-115286435	breast	carcinoma	Substitution - Missense
c.568C>T; p.R190W; 1:115286228-115286228	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.256C>T; p.R86C; 1:115286540-115286540	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.568C>G; p.R190G; 1:115286228-115286228	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.248G>A; p.R83H; 1:115286548-115286548	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.77T>C; p.V26A; 1:115286719-115286719	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.164delC; p.P55fs*5; 1:115286632-115286632	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.164C>T; p.P55L; 1:115286632-115286632	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.567C>T; p.C189C; 1:115286229-115286229	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.106C>A; p.H36N; 1:115286690-115286690	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.241C>T; p.R81*; 1:115286555-115286555	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.241C>T; p.R81*; 1:115286555-115286555	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.120T>C; p.L40L; 1:115286676-115286676	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.693_696delTGTG; p.V232fs*6; 1:115286100-115286103	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.184C>T; p.R62C; 1:115286612-115286612	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.420C>T; p.S140S; 1:115286376-115286376	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.721G>A; p.A241T; 1:115286075-115286075	skin	malignant_melanoma	Substitution - Missense
c.445G>A; p.A149T; 1:115286351-115286351	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.445G>A; p.A149T; 1:115286351-115286351	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.721G>A; p.A241T; 1:115286075-115286075	skin	malignant_melanoma	Substitution - Missense
c.315C>T; p.F105F; 1:115286481-115286481	skin	malignant_melanoma	Substitution - coding silent
c.202C>T; p.R68C; 1:115286594-115286594	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.671G>A; p.R224Q; 1:115286125-115286125	urinary_tract; bladder	carcinoma	Substitution - Missense
c.661C>T; p.R221W; 1:115286135-115286135	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.661C>T; p.R221W; 1:115286135-115286135	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.421G>A; p.V141M; 1:115286375-115286375	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.284G>T; p.R95L; 1:115286512-115286512	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.695_696delTG; p.V232fs*>10; 1:115286100-115286101	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.284G>T; p.R95L; 1:115286512-115286512	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.284G>T; p.R95L; 1:115286512-115286512	liver	carcinoma	Substitution - Missense
c.44G>A; p.G15D; 1:115286752-115286752	skin	malignant_melanoma	Substitution - Missense
c.280C>T; p.P94S; 1:115286516-115286516	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.280C>T; p.P94S; 1:115286516-115286516	liver	carcinoma	Substitution - Missense
c.586C>T; p.H196Y; 1:115286210-115286210	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.242G>A; p.R81Q; 1:115286554-115286554	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.242G>A; p.R81Q; 1:115286554-115286554	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.283C>T; p.R95C; 1:115286513-115286513	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.432G>A; p.G144G; 1:115286364-115286364	skin	malignant_melanoma	Substitution - coding silent
c.336delC; p.F113fs*45; 1:115286460-115286460	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.382T>C; p.F128L; 1:115286414-115286414	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.465G>A; p.K155K; 1:115286331-115286331	liver	carcinoma	Substitution - coding silent
c.465G>A; p.K155K; 1:115286331-115286331	liver	carcinoma	Substitution - coding silent
c.726A>C; p.*242C; 1:115286070-115286070	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Nonstop extension
c.726A>C; p.*242C; 1:115286070-115286070	skin; trunk	malignant_melanoma	Nonstop extension
c.362G>A; p.R121Q; 1:115286434-115286434	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.161C>T; p.A54V; 1:115286635-115286635	skin	malignant_melanoma	Substitution - Missense
c.374A>G; p.H125R; 1:115286422-115286422	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.723C>T; p.A241A; 1:115286073-115286073	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.112A>G; p.T38A; 1:115286684-115286684	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.401C>T; p.S134L; 1:115286395-115286395	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation