lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4760
Symbol	NEUROD1
Synonymous	BETA2\|BHF-1\|MODY6\|NEUROD\|bHLHa3
Full name	neuronal differentiation 1
Gene description	basic helix-loop-helix transcription factor\|beta-cell E-box transactivator 2\|class A basic helix-loop-helix protein 3\|neurogenic differentiation factor 1\|neurogenic helix-loop-helix protein NEUROD
Cytoband	2q32
Gene type	protein-coding
Synonymous	MIM:601724; HGNC:HGNC:7762; Ensembl:ENSG00000162992; HPRD:03428; Vega:OTTHUMG00000132583

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.779C>T; p.P260L; 2:181678082-181678082	prostate	carcinoma	Substitution - Missense
c.1069T>C; p.*357Q; 2:181677792-181677792	large_intestine; colon	carcinoma; adenocarcinoma	Nonstop extension
c.485G>A; p.S162N; 2:181678376-181678376	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.293G>A; p.R98H; 2:181678568-181678568	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.549G>A; p.L183L; 2:181678312-181678312	skin	malignant_melanoma	Substitution - coding silent
c.637T>G; p.S213A; 2:181678224-181678224	urinary_tract; bladder	carcinoma	Substitution - Missense
c.637T>G; p.S213A; 2:181678224-181678224	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.254G>A; p.G85D; 2:181678607-181678607	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.431G>A; p.R144H; 2:181678430-181678430	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.431G>A; p.R144H; 2:181678430-181678430	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.917C>T; p.A306V; 2:181677944-181677944	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.484delA; p.S162fs*100; 2:181678377-181678377	thyroid	carcinoma; anaplastic_carcinoma	Deletion - Frameshift
c.917C>T; p.A306V; 2:181677944-181677944	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.819C>T; p.L273L; 2:181678042-181678042	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.554C>T; p.A185V; 2:181678307-181678307	urinary_tract; bladder	carcinoma	Substitution - Missense
c.257C>T; p.P86L; 2:181678604-181678604	skin	malignant_melanoma	Substitution - Missense
c.145G>A; p.E49K; 2:181678716-181678716	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.714T>C; p.H238H; 2:181678147-181678147	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.714T>C; p.H238H; 2:181678147-181678147	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.867G>A; p.P289P; 2:181677994-181677994	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.431G>T; p.R144L; 2:181678430-181678430	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.741C>T; p.H247H; 2:181678120-181678120	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.457C>G; p.L153V; 2:181678404-181678404	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.232G>A; p.D78N; 2:181678629-181678629	skin	malignant_melanoma	Substitution - Missense
c.1009G>A; p.D337N; 2:181677852-181677852	skin	malignant_melanoma	Substitution - Missense
c.653C>A; p.P218H; 2:181678208-181678208	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.329A>G; p.E110G; 2:181678532-181678532	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.276T>A; p.T92T; 2:181678585-181678585	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.609G>T; p.M203I; 2:181678252-181678252	breast	carcinoma	Substitution - Missense
c.275C>A; p.T92N; 2:181678586-181678586	skin	malignant_melanoma	Substitution - Missense
c.561C>T; p.C187C; 2:181678300-181678300	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.251G>A; p.R84H; 2:181678610-181678610	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.828G>A; p.P276P; 2:181678033-181678033	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.267G>A; p.K89K; 2:181678594-181678594	breast	carcinoma	Substitution - coding silent
c.751G>A; p.A251T; 2:181678110-181678110	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.12G>A; p.S4S; 2:181678849-181678849	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.312G>A; p.M104I; 2:181678549-181678549	skin	malignant_melanoma	Substitution - Missense
c.634G>A; p.A212T; 2:181678227-181678227	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.969C>G; p.A323A; 2:181677892-181677892	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.969C>G; p.A323A; 2:181677892-181677892	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.825G>A; p.P275P; 2:181678036-181678036	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.842G>A; p.G281D; 2:181678019-181678019	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.616_617insC; p.H206fs*38; 2:181678244-181678245	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.943G>A; p.G315R; 2:181677918-181677918	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.616_617insC; p.H206fs*38; 2:181678244-181678245	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.328G>A; p.E110K; 2:181678533-181678533	skin	malignant_melanoma	Substitution - Missense
c.1036A>G; p.M346V; 2:181677825-181677825	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.709T>C; p.S237P; 2:181678152-181678152	skin	malignant_melanoma	Substitution - Missense
c.253G>A; p.G85S; 2:181678608-181678608	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.332G>C; p.R111P; 2:181678529-181678529	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.332G>C; p.R111P; 2:181678529-181678529	urinary_tract; bladder	carcinoma	Substitution - Missense
c.984C>T; p.I328I; 2:181677877-181677877	skin	malignant_melanoma	Substitution - coding silent
c.924G>A; p.L308L; 2:181677937-181677937	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.159G>T; p.L53L; 2:181678702-181678702	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.217G>A; p.E73K; 2:181678644-181678644	skin	malignant_melanoma	Substitution - Missense
c.654_655insC; p.Y219fs*25; 2:181678206-181678207	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.644C>T; p.P215L; 2:181678217-181678217	breast	carcinoma	Substitution - Missense
c.354C>T; p.N118N; 2:181678507-181678507	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.844A>T; p.N282Y; 2:181678017-181678017	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.151G>T; p.D51Y; 2:181678710-181678710	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.883A>G; p.K295E; 2:181677978-181677978	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.48C>A; p.P16P; 2:181678813-181678813	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.184G>A; p.E62K; 2:181678677-181678677	skin	malignant_melanoma	Substitution - Missense
c.184G>A; p.E62K; 2:181678677-181678677	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.789T>A; p.D263E; 2:181678072-181678072	breast	carcinoma	Substitution - Missense
c.338G>A; p.R113H; 2:181678523-181678523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.338G>A; p.R113H; 2:181678523-181678523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.115A>T; p.K39*; 2:181678746-181678746	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.472C>A; p.R158S; 2:181678389-181678389	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.452G>T; p.W151L; 2:181678409-181678409	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.940C>A; p.H314N; 2:181677921-181677921	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.441G>T; p.K147N; 2:181678420-181678420	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.441G>T; p.K147N; 2:181678420-181678420	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.862G>T; p.E288*; 2:181677999-181677999	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.427C>G; p.L143V; 2:181678434-181678434	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1063C>T; p.H355Y; 2:181677798-181677798	skin	malignant_melanoma	Substitution - Missense
c.223G>T; p.E75*; 2:181678638-181678638	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.634G>T; p.A212S; 2:181678227-181678227	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.73G>C; p.E25Q; 2:181678788-181678788	urinary_tract; bladder	carcinoma	Substitution - Missense
c.133A>G; p.T45A; 2:181678728-181678728	prostate	adenoma	Substitution - Missense
c.133A>G; p.T45A; 2:181678728-181678728	thyroid	other; neoplasm	Substitution - Missense
c.973C>T; p.R325C; 2:181677888-181677888	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.116A>G; p.K39R; 2:181678745-181678745	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.116A>G; p.K39R; 2:181678745-181678745	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.450C>T; p.I150I; 2:181678411-181678411	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.450C>T; p.I150I; 2:181678411-181678411	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.546C>T; p.N182N; 2:181678315-181678315	breast	carcinoma	Substitution - coding silent
c.346G>C; p.G116R; 2:181678515-181678515	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.985C>T; p.P329S; 2:181677876-181677876	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.741C>G; p.H247Q; 2:181678120-181678120	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.72C>T; p.D24D; 2:181678789-181678789	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.72C>T; p.D24D; 2:181678789-181678789	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.616delC; p.H206fs*56; 2:181678245-181678245	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.530C>T; p.S177F; 2:181678331-181678331	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.681C>A; p.P227P; 2:181678180-181678180	ovary	other; neoplasm	Substitution - coding silent
c.681C>A; p.P227P; 2:181678180-181678180	ovary	other; neoplasm	Substitution - coding silent
c.226G>T; p.D76Y; 2:181678635-181678635	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.681C>A; p.P227P; 2:181678180-181678180	ovary	other; neoplasm	Substitution - coding silent
c.374G>A; p.R125H; 2:181678487-181678487	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.73G>A; p.E25K; 2:181678788-181678788	pancreas	carcinoma	Substitution - Missense
c.745T>C; p.Y249H; 2:181678116-181678116	liver	carcinoma	Substitution - Missense
c.73G>A; p.E25K; 2:181678788-181678788	pancreas	carcinoma	Substitution - Missense
c.683G>T; p.S228I; 2:181678178-181678178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.683G>T; p.S228I; 2:181678178-181678178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.560G>A; p.C187Y; 2:181678301-181678301	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.437C>T; p.A146V; 2:181678424-181678424	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.726T>A; p.V242V; 2:181678135-181678135	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.346G>A; p.G116R; 2:181678515-181678515	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1042G>T; p.A348S; 2:181677819-181677819	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.284G>A; p.R95H; 2:181678577-181678577	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1024C>T; p.H342Y; 2:181677837-181677837	skin	malignant_melanoma	Substitution - Missense
c.357G>A; p.A119A; 2:181678504-181678504	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.485G>C; p.S162T; 2:181678376-181678376	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.126C>T; p.D42D; 2:181678735-181678735	prostate	adenoma	Substitution - coding silent
c.687G>A; p.P229P; 2:181678174-181678174	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.597G>A; p.Q199Q; 2:181678264-181678264	skin	malignant_melanoma	Substitution - coding silent
c.102C>T; p.H34H; 2:181678759-181678759	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.326G>T; p.R109L; 2:181678535-181678535	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.138G>T; p.M46I; 2:181678723-181678723	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.934C>G; p.Q312E; 2:181677927-181677927	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.871G>A; p.A291T; 2:181677990-181677990	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.172G>C; p.E58Q; 2:181678689-181678689	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.117G>T; p.K39N; 2:181678744-181678744	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.94G>A; p.E32K; 2:181678767-181678767	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.141C>T; p.N47N; 2:181678720-181678720	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.555G>A; p.A185A; 2:181678306-181678306	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.782T>C; p.L261P; 2:181678079-181678079	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.141C>T; p.N47N; 2:181678720-181678720	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.141C>T; p.N47N; 2:181678720-181678720	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.141C>T; p.N47N; 2:181678720-181678720	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.664_665insC; p.Q222fs*22; 2:181678196-181678197	ovary	carcinoma; serous_carcinoma	Insertion - Frameshift
c.555G>A; p.A185A; 2:181678306-181678306	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1046A>C; p.Q349P; 2:181677815-181677815	skin	malignant_melanoma	Substitution - Missense
c.141C>T; p.N47N; 2:181678720-181678720	pancreas	carcinoma	Substitution - coding silent
c.264G>T; p.K88N; 2:181678597-181678597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.872C>T; p.A291V; 2:181677989-181677989	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.264G>T; p.K88N; 2:181678597-181678597	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.912T>A; p.P304P; 2:181677949-181677949	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.420C>T; p.I140I; 2:181678441-181678441	skin	malignant_melanoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation