lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4751
Symbol	NEK2
Synonymous	HsPK21\|NEK2A\|NLK1\|PPP1R111\|RP67
Full name	NIMA-related kinase 2
Gene description	NIMA (never in mitosis gene a)-related kinase 2\|nimA-like protein kinase 1\|nimA-related protein kinase 2\|protein phosphatase 1, regulatory subunit 111\|serine/threonine-protein kinase Nek2
Cytoband	1q32.3
Gene type	protein-coding
Synonymous	MIM:604043; HGNC:HGNC:7745; Ensembl:ENSG00000117650; HPRD:04953; Vega:OTTHUMG00000037121

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.388C>G; p.R130G; 1:211673650-211673650	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.463G>A; p.V155I; 1:211673575-211673575	breast	carcinoma	Substitution - Missense
c.985+4A>G; p.?; 1:211669109-211669109	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.862C>A; p.R288R; 1:211669236-211669236	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.394G>A; p.D132N; 1:211673644-211673644	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1018C>A; p.L340I; 1:211667199-211667199	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1018C>A; p.L340I; 1:211667199-211667199	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1018C>A; p.L340I; 1:211667199-211667199	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1111G>T; p.E371*; 1:211667106-211667106	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.228C>A; p.D76E; 1:211674382-211674382	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.201C>T; p.I67I; 1:211674409-211674409	breast	carcinoma	Substitution - coding silent
c.219G>A; p.R73R; 1:211674391-211674391	skin	malignant_melanoma	Substitution - coding silent
c.746C>T; p.T249M; 1:211670300-211670300	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.715C>G; p.R239G; 1:211670331-211670331	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.368C>T; p.A123V; 1:211673670-211673670	skin	malignant_melanoma	Substitution - Missense
c.831C>A; p.D277E; 1:211669267-211669267	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.985C>T; p.Q329*; 1:211669113-211669113	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.153G>T; p.M51I; 1:211674457-211674457	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1163G>A; p.G388E; 1:211663601-211663601	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.985C>T; p.Q329*; 1:211669113-211669113	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.97-2A>G; p.?; 1:211674515-211674515	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Unknown
c.801G>T; p.E267D; 1:211669297-211669297	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.392G>A; p.S131N; 1:211673646-211673646	skin	malignant_melanoma	Substitution - Missense
c.1327G>T; p.G443C; 1:211663437-211663437	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.798T>G; p.L266L; 1:211669300-211669300	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.896C>T; p.S299F; 1:211669202-211669202	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.401G>A; p.G134D; 1:211673637-211673637	stomach	carcinoma	Substitution - Missense
c.31T>C; p.L11L; 1:211675449-211675449	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.839G>A; p.R280K; 1:211669259-211669259	urinary_tract; bladder	carcinoma	Substitution - Missense
c.970G>T; p.E324*; 1:211669128-211669128	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.784G>A; p.V262I; 1:211669314-211669314	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.784G>A; p.V262I; 1:211669314-211669314	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.784G>A; p.V262I; 1:211669314-211669314	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.711A>G; p.P237P; 1:211670335-211670335	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.314+2T>C; p.?; 1:211674294-211674294	stomach	carcinoma; adenocarcinoma	Unknown
c.832G>A; p.E278K; 1:211669266-211669266	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.709C>T; p.P237S; 1:211670337-211670337	skin	malignant_melanoma	Substitution - Missense
c.985+1G>A; p.?; 1:211669112-211669112	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.709C>T; p.P237S; 1:211670337-211670337	skin	malignant_melanoma	Substitution - Missense
c.312A>C; p.E104D; 1:211674298-211674298	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.418C>T; p.R140W; 1:211673620-211673620	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.862C>T; p.R288*; 1:211669236-211669236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.409G>A; p.V137I; 1:211673629-211673629	liver	carcinoma	Substitution - Missense
c.409G>A; p.V137I; 1:211673629-211673629	liver	carcinoma	Substitution - Missense
c.771C>T; p.Y257Y; 1:211669327-211669327	skin	malignant_melanoma	Substitution - coding silent
c.344G>A; p.R115Q; 1:211673694-211673694	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.667G>A; p.E223K; 1:211670379-211670379	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.344G>A; p.R115Q; 1:211673694-211673694	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.887C>T; p.S296L; 1:211669211-211669211	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.887C>T; p.S296L; 1:211669211-211669211	skin; scalp	malignant_melanoma	Substitution - Missense
c.887C>T; p.S296L; 1:211669211-211669211	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.887C>T; p.S296L; 1:211669211-211669211	skin	malignant_melanoma	Substitution - Missense
c.35A>G; p.Y12C; 1:211675445-211675445	breast	carcinoma	Substitution - Missense
c.504T>C; p.H168H; 1:211673534-211673534	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation